Rachel Yehuda

Summary

Country: USA

Publications

  1. ncbi request reprint Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: relation to risk and resilience factors
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, New York, NY, United States
    J Psychiatr Res 41:435-45. 2007
  2. ncbi request reprint Longitudinal assessment of cognitive performance in Holocaust survivors with and without PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York 10468, USA
    Biol Psychiatry 60:714-21. 2006
  3. doi request reprint Changes in relative glucose metabolic rate following cortisol administration in aging veterans with posttraumatic stress disorder: an FDG-PET neuroimaging study
    Rachel Yehuda
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    J Neuropsychiatry Clin Neurosci 21:132-43. 2009
  4. ncbi request reprint Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Biol Psychiatry 55:1110-6. 2004
  5. ncbi request reprint Effect of sertraline on glucocorticoid sensitivity of mononuclear leukocytes in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 31:189-96. 2006
  6. doi request reprint Dissociation versus posttraumatic stress: cortisol and physiological correlates in adults highly exposed to the World Trade Center attack on 9/11
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 161:325-9. 2008
  7. ncbi request reprint Enhanced effects of cortisol administration on episodic and working memory in aging veterans with PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 32:2581-91. 2007
  8. pmc Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 61:966-73. 2007
  9. ncbi request reprint Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1071:410-21. 2006
  10. ncbi request reprint The ACTH response to dexamethasone in PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, USA
    Am J Psychiatry 161:1397-403. 2004

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: relation to risk and resilience factors
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, New York, NY, United States
    J Psychiatr Res 41:435-45. 2007
    ....
  2. ncbi request reprint Longitudinal assessment of cognitive performance in Holocaust survivors with and without PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York 10468, USA
    Biol Psychiatry 60:714-21. 2006
    ..It is therefore unclear whether relationships between memory and symptoms differ over time among older persons with and without PTSD...
  3. doi request reprint Changes in relative glucose metabolic rate following cortisol administration in aging veterans with posttraumatic stress disorder: an FDG-PET neuroimaging study
    Rachel Yehuda
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    J Neuropsychiatry Clin Neurosci 21:132-43. 2009
    ..The restorative effects of HCORT on metabolism and working memory provide a rationale for examining the therapeutic benefits of glucocorticoid manipulation in aging PTSD patients...
  4. ncbi request reprint Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Biol Psychiatry 55:1110-6. 2004
    ..The aim of this study was to determine whether there is increased responsiveness to corticosteroids in posttraumatic stress disorder (PTSD) by examining the differential effects of dexamethasone (DEX) on the inhibition of lysozyme activity...
  5. ncbi request reprint Effect of sertraline on glucocorticoid sensitivity of mononuclear leukocytes in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 31:189-96. 2006
    ..Insofar as increased sensitivity to glucocorticoids has been linked with PTSD, the actions of SER on the lysozyme IC(50-DEX) suggest that this medication may target a biologic alteration associated with PTSD pathophysiology...
  6. doi request reprint Dissociation versus posttraumatic stress: cortisol and physiological correlates in adults highly exposed to the World Trade Center attack on 9/11
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 161:325-9. 2008
    ..This small study emphasizes the importance of dissecting the neurobiology of posttraumatic stress versus dissociative traumatic responses...
  7. ncbi request reprint Enhanced effects of cortisol administration on episodic and working memory in aging veterans with PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 32:2581-91. 2007
    ..The findings suggest that there may be opportunities for developing therapeutic strategies using glucocorticoids in the treatment of aging combat veterans...
  8. pmc Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 61:966-73. 2007
    ..This study investigated basal and stress-induced hypothalamic-pituitary-adrenal (HPA)-axis alterations in dissociative disorders (DDs)...
  9. ncbi request reprint Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1071:410-21. 2006
    ....
  10. ncbi request reprint The ACTH response to dexamethasone in PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, USA
    Am J Psychiatry 161:1397-403. 2004
    ....
  11. doi request reprint Trauma and violence: are women the weaker sex?
    Laura C Pratchett
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatr Clin North Am 33:465-74. 2010
    ..Risk and resilience can perhaps more appropriately be considered specific to symptom picture rather than merely development of pathology...
  12. ncbi request reprint Memory for trauma-related information in Holocaust survivors with PTSD
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 121:133-43. 2003
    ..This trauma-related facilitation of explicit memory, together with generally poorer explicit memory, may help to explain the bi-directional nature of the memory impairments in PTSD...
  13. pmc Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks
    Matthew N Hill
    The Hotchkiss Brain Institute, Department of Cell Biology and Anatomy and Psychiatry, University of Calgary, Calgary, AB, Canada Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA Electronic address
    Psychoneuroendocrinology 38:2952-61. 2013
    ..Future work will aim to replicate these findings and extend their relevance to clinical pathophysiology, as well as to neuroendocrine and molecular markers of PTSD. ..
  14. ncbi request reprint Memory performance in Holocaust survivors with posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:1682-8. 2002
    ..The authors evaluated memory performance in Holocaust survivors and its association with posttraumatic stress disorder (PTSD) and age...
  15. ncbi request reprint Learning and memory in aging combat veterans with PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of MedicineNew York, NY, USA
    J Clin Exp Neuropsychol 27:504-15. 2005
    ..However, increased severity of rapid forgetting may be a specific alteration in older combat veterans, likely reflecting aspects of both combat exposure and aging...
  16. ncbi request reprint Clinical correlates of 24-h cortisol and norepinephrine excretion among subjects seeking treatment following the world trade center attacks on 9/11
    Linda M Bierer
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1071:514-20. 2006
    ....
  17. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  18. ncbi request reprint Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatry Res 139:53-64. 2005
    ..Larger temporal lobe volumes may be associated with early traumatization and survival or may reflect some other characteristic of Holocaust survivors...
  19. ncbi request reprint Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, and the Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 31:447-51. 2006
    ..The authors therefore examined the change in ACTH and cortisol before and after cortisol administration, which acts at central feedback sites in addition to peripheral targets...
  20. ncbi request reprint Factors associated with resilience in healthy adults
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychoneuroendocrinology 32:1149-52. 2007
    ..We conclude that in young adults without manifest psychiatric disorder, resilience was associated with developmental, biological, and cognitive measures which merit further investigation...
  21. ncbi request reprint Differentiating biological correlates of risk, PTSD, and resilience following trauma exposure
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, New York, and Department of Psychiatry, Bronx VAMC, Bronx, NY 10468, USA
    J Trauma Stress 20:435-47. 2007
    ....
  22. ncbi request reprint Longitudinal assessment of dissociation in Holocaust survivors with and without PTSD and nonexposed aged Jewish adults
    Ellen Labinsky
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1228, New York, NY 10029 6574, USA
    Ann N Y Acad Sci 1071:459-62. 2006
    ..A similar pattern was shown with The Clinician Administered PTSD Scale (CAPS) scores. Different symptoms related to PTSD show different trajectories of change with age, with dissociation appearing to be less prominent with age...
  23. ncbi request reprint Effect of topiramate on glucocorticoid receptor mediated action
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 29:433-9. 2004
    ..In conclusion, further investigation of the actions of TPM on GR and other neuroendocrine systems may prove useful in understanding some of the other established clinical effects of this agent...
  24. ncbi request reprint History of past sexual abuse in married observant Jewish women
    Rachel Yehuda
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 164:1700-6. 2007
    ..The authors examined instances of past sexual abuse and related demographic characteristics in the self-reports of a select group of married observant Jewish women...
  25. ncbi request reprint Protective and damaging effects of the biobehavioral stress response: cognitive, systemic and clinical aspects: ISPNE XXXIV meeting summary
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, NY 10468, USA
    Psychoneuroendocrinology 29:1212-22. 2004
  26. ncbi request reprint Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment
    Amir Garakani
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    J Affect Disord 146:262-5. 2013
    ..The goal of this study was to compare the CSF levels of glutamate, glutamine and CRH between patients with depression and healthy controls...
  27. ncbi request reprint Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, and the Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Biol Psychiatry 59:660-3. 2006
    ..There is emerging interest in examining the role of plasma neuropeptide Y (NPY) as a protective stress factor...
  28. doi request reprint Status of glucocorticoid alterations in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1179:56-69. 2009
    ..Results of these studies have provided an important rationale for using glucocorticoid strategies in the treatment of PTSD...
  29. ncbi request reprint The memory paradox
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine, New York, New York, USA
    Nat Rev Neurosci 11:837-9. 2010
    ..The absence of memory or the inability to recall memories properly in an emotional context leads to dysfunction but, paradoxically, memories that generate too much emotion can be equally disabling...
  30. doi request reprint The effect of trauma on stress reactivity in aggressive youth
    Iliyani Ivanov
    Mount Sinai School of Medicine, New York, United States
    Psychiatry Res 189:396-402. 2011
    ..These results suggest that aggressive youth with personal history of trauma may exhibit unique biological characteristics, which may have important implications for classification and treatment...
  31. ncbi request reprint Response variation following trauma: a translational neuroscience approach to understanding PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Mount Sinai School of Medicine, James J Peters Veteran Affairs, New York, NY 10468, USA
    Neuron 56:19-32. 2007
    ..We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD...
  32. ncbi request reprint The ACTH response to dexamethasone in Persian Gulf War veterans
    Julia A Golier
    Bronx VA Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:448-53. 2006
    ....
  33. ncbi request reprint Are adult offspring reliable informants about parental PTSD? A validation study
    Rachel Yehuda
    Psychiatry 116A, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:484-7. 2006
    ..Further studies are warranted to examine the psychometric properties of this measure...
  34. doi request reprint Using biological markers to inform a clinically meaningful treatment response
    Rachel Yehuda
    Department of Psychiatry, James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
    Ann N Y Acad Sci 1208:158-63. 2010
    ..We propose that future studies consider the unique consequences of combat trauma and develop treatments that incorporate the complex nature of the exposure and response characteristic of a veteran population...
  35. ncbi request reprint Association between alexithymia and neuroendocrine response to psychological stress in police academy recruits
    Shannon E McCaslin
    PTSD Research Program, University of California, San Francisco, VAMC 4150 Clement Street 116P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:425-7. 2006
    ..Alexithymia scores were negatively associated with catecholamine response to the video challenge but no association was found between alexithymia scores and cortisol reactivity...
  36. doi request reprint Pituitary response to metyrapone in Gulf War veterans: relationship to deployment, PTSD and unexplained health symptoms
    Julia A Golier
    Departments of Psychiatry, James J Peters VA Medical Center, Bronx, NY 10468, United States of America
    Psychoneuroendocrinology 34:1338-45. 2009
    ..The metyrapone stimulation test was performed to further characterize hypothalamic-pituitary activity in Gulf War veterans (GWV) and its relationship to unexplained medical symptoms and post-traumatic stress disorder (PTSD)...
  37. ncbi request reprint Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 164:163-6. 2007
    ....
  38. pmc Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Psychiatry 116 A OOMH, Bronx, NY 10468 3904, USA
    Psychoneuroendocrinology 34:1304-13. 2009
    ....
  39. doi request reprint Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks
    Rachel Yehuda
    Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Bronx, New York 10458, USA
    Biol Psychiatry 66:708-11. 2009
    ....
  40. ncbi request reprint Cognitive-behavioral psychology: implications for disaster and terrorism response
    Josefi Ruzek
    National Center for Post Traumatic Stress Disorder, Veterans Administration Palo Alto Health Care System, Menlo Park, California 94025, USA
    Prehosp Disaster Med 23:397-410. 2008
    ....
  41. pmc Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Bronx Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    J Psychiatr Res 43:877-83. 2009
    ....
  42. ncbi request reprint Is trauma a causal agent of psychopathologic symptoms in posttraumatic stress disorder? Findings from identical twins discordant for combat exposure
    Mark W Gilbertson
    Department of Research Service, Manchester VA Medical Center, 718 Smyth Rd, Manchester, NH 03104, USA
    J Clin Psychiatry 71:1324-30. 2010
    ..The current study tests this hypothesis...
  43. ncbi request reprint Transgenerational transmission of cortisol and PTSD risk
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, James J Peters VAMC, 116 A, OOMH PTSD, Bronx, NY 10468, USA
    Prog Brain Res 167:121-35. 2008
    ..Since low cortisol levels are particularly associated with the presence of maternal PTSD the findings suggest the involvement of epigenetic mechanisms...
  44. pmc The relevance of epigenetics to PTSD: implications for the DSM-V
    Rachel Yehuda
    PTSD Clinic and Research Program, James J Peters VAMC, Bronx, NY 10468, USA
    J Trauma Stress 22:427-34. 2009
    ..The relevance of epigenetic mechanisms to formulations of PTSD for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) is described...
  45. ncbi request reprint Ten-year follow-up study of cortisol levels in aging holocaust survivors with and without PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Department of Psychiatry, Mount Sinai School of Medicine, Bronx NY, USA
    J Trauma Stress 20:757-61. 2007
    ..The authors conclude that cortisol levels are affected by change in PTSD status and age...
  46. doi request reprint Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD
    Rachel Yehuda
    Department of Psychiatry, James J Peters Veterans Affairs Medical Center, 526 OOMH, 130 W Kingsbridge Rd, Bronx, NY, USA
    Psychopharmacology (Berl) 212:405-17. 2010
    ..Given similarities between neuroendocrine aspects of PTSD and ELS, such as in reduced cortisol signaling and glucocorticoid receptor (GR) responsiveness, some aspects of the biology of PTSD may reflect biological correlates of risk...
  47. ncbi request reprint Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Bronx, NY, USA
    Arch Gen Psychiatry 64:1040-8. 2007
    ....
  48. pmc Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, United States
    J Psychiatr Res 42:1104-11. 2008
    ..Two recent reports linking maternal PTSD and low offspring cortisol prompted us to examine the relative contributions of maternal vs. paternal PTSD in the prediction of PTSD and other psychiatric diagnoses in offspring...
  49. ncbi request reprint Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 62:1175-8. 2007
    ....
  50. doi request reprint Hydrocortisone responsiveness in Gulf War veterans with PTSD: effects on ACTH, declarative memory hippocampal [(18)F]FDG uptake on PET
    Rachel Yehuda
    James J Peters Veterans Affairs Medical Center, Bronx, NY, USA
    Psychiatry Res 184:117-27. 2010
    ..Differences in brain metabolic responses between GW veterans with and without PTSD may reflect differences in peripheral and central GR responsiveness...
  51. ncbi request reprint Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 31:1181-9. 2006
    ..To examine whether PTSD or post-deployment health symptoms in veterans of the first Gulf War (Operation Desert Shield/Storm) are associated with enhanced suppression of the pituitary-adrenal axis to low-dose dexamethasone (DEX)...
  52. ncbi request reprint Circadian rhythm of salivary cortisol in Holocaust survivors with and without PTSD
    Rachel Yehuda
    Mount Sinai School of Medicine, USA
    Am J Psychiatry 162:998-1000. 2005
    ..The authors' goal was to determine whether cortisol circadian rhythm alterations observed in younger subjects with posttraumatic stress disorder (PTSD) are also present in geriatric trauma survivors with PTSD...
  53. ncbi request reprint Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, Bronx VAMC, OOMH PTSD 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 29:389-404. 2004
    ....
  54. ncbi request reprint Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
    Rachel Yehuda
    The Traumatic Stress Studies Program of the Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY 10468, USA
    J Psychiatr Res 37:471-7. 2003
    ....
  55. ncbi request reprint Relationship between 24-hour urinary-free cortisol excretion and salivary cortisol levels sampled from awakening to bedtime in healthy subjects
    Rachel Yehuda
    Psychiatry OOMH, Mount Sinai School of Medicine and Bronx Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Life Sci 73:349-58. 2003
    ..In addition, subject compliance is a serious consideration in designing studies that employ home salivary collections...
  56. ncbi request reprint Hypothalamic-pituitary-adrenal alterations in PTSD: are they relevant to understanding cortisol alterations in cancer?
    Rachel Yehuda
    Psychiatry Department and Division of Traumatic Stress Studies, Mount Sinai School of Medicine and Bronx Veterans Affairs, NY, USA
    Brain Behav Immun 17:S73-83. 2003
    ..This review considers the extent to which neuroendocrine alterations observed in PTSD may be useful in understanding cortisol alterations involved in cancer...
  57. ncbi request reprint Pathological responses to terrorism
    Rachel Yehuda
    Psychiatry OOMH, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Neuropsychopharmacology 30:1793-805. 2005
    ....
  58. ncbi request reprint Neuropsychological processes in post-traumatic stress disorder
    Julia Golier
    Bronx VA Medical Center, 130 West Kingsbridge Road 116A, Bronx, NY 10468, USA
    Psychiatr Clin North Am 25:295-315, vi. 2002
    ..The implications of these findings for the course and pathophysiology of PTSD are also discussed...
  59. ncbi request reprint Predictors of posttraumatic stress in police and other first responders
    Charles R Marmar
    San Francisco Veterans Affairs Medical Center, 4150 Clement St 116 P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:1-18. 2006
    ..Next steps in this line of research will be to test this model prospectively in a sample of 400 police academy recruits assessed during training and currently being followed for the first 2 years of police service...
  60. ncbi request reprint Memory performance in older trauma survivors: implications for the longitudinal course of PTSD
    Julia A Golier
    James J Peters VA Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:54-66. 2006
    ..PTSD is associated with considerable cognitive burden with age. Longitudinal studies of older subjects are warranted to examine whether PTSD is associated with accelerated aging or progressive memory loss...
  61. ncbi request reprint Clinical relevance of biologic findings in PTSD
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, NY, USA
    Psychiatr Q 73:123-33. 2002
    ..This review will discuss these new findings and their treatment implications...
  62. ncbi request reprint Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:137-66. 2006
    ..This article summarizes important neuroendocrine observations in cortisol and provides strategies for understanding what has emerged over the past two decades, to be a complex and sometimes contradictory literature...
  63. ncbi request reprint Cortisol levels in adult offspring of Holocaust survivors: relation to PTSD symptom severity in the parent and child
    Rachel Yehuda
    Bronx Veteran Affairs Medical Center, Psychiatry OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 27:171-80. 2002
    ....
  64. ncbi request reprint Developing an agenda for translational studies of resilience and vulnerability following trauma exposure
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:379-96. 2006
    ..Understanding why this is so will provide clues for the development of therapeutic interventions for those people who do develop stress-related psychopathology, or even for the prevention of adverse outcomes...
  65. ncbi request reprint Risk and resilience in posttraumatic stress disorder
    Rachel Yehuda
    Bronx VA Medical Center, Mt Sinai School of Medicine, Bronx, NY, USA
    J Clin Psychiatry 65:29-36. 2004
    ..In addition, however, neuroendocrine changes, such as lower cortisol levels, also may influence formation and processing of traumatic memories and may be associated with the underlying pathology of PTSD...
  66. ncbi request reprint The use of biomarkers in the military: from theory to practice
    Rachel Yehuda
    Department of Psychiatry, James J Peters Veterans Affairs Medical Center, Bronx, NY, United States Department of Psychiatry and Neuroscience, Mount Sinai School of Medicine, New York, NY, United States Electronic address
    Psychoneuroendocrinology 38:1912-22. 2013
    ....
  67. doi request reprint Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis
    Rachel Yehuda
    Mount Sinai School of Medicine, Department of Psychiatry, Traumatology and Stress Studies Division, New York, New York 10029, USA
    Endocrinology 152:4496-503. 2011
    ..This notion implies a vulnerable early-life phenotype may be discernable and indicates potential therapy by modest glucocorticoid replacement. Indeed, early clinical trials with cortisol have shown a modicum of promise...
  68. ncbi request reprint Basal norepinephrine in depersonalization disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Psychiatry Res 121:93-7. 2003
    ..The findings are in concordance with the few reports on autonomic blunting in dissociation and merit further investigation...
  69. pmc Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: Evidence for an intergenerational effect of maternal trauma exposure
    Linda M Bierer
    James J Peters VA Medical Center, Bronx, NY, United States Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
    Psychoneuroendocrinology 48:1-10. 2014
    ....
  70. doi request reprint Cortisol response to cosyntropin administration in military veterans with or without posttraumatic stress disorder
    Julia A Golier
    Departments of Psychiatry, James J Peters VA Medical Center, Bronx, NY, United States Mount Sinai School of Medicine, New York, NY, United States Electronic address
    Psychoneuroendocrinology 40:151-8. 2014
    ..A significant main effect of group was also observed on peak cortisol levels. These findings suggest that war-zone exposure itself has persistent effects on adrenocortical activity. ..
  71. doi request reprint Spontaneous brain activity in combat related PTSD
    Xiaodan Yan
    Steven and Alexandra Cohen Veterans Center for the Study of Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, NYU School of Medicine, New York, NY, USA
    Neurosci Lett 547:1-5. 2013
    ....
  72. doi request reprint Proinflammatory and "resiliency" proteins in the CSF of patients with major depression
    Jose M Martinez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Depress Anxiety 29:32-8. 2012
    ....
  73. ncbi request reprint Current status of cortisol findings in post-traumatic stress disorder
    Rachel Yehuda
    Psychiatry Department, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Psychiatr Clin North Am 25:341-68, vii. 2002
    ..Sources of variance caused by methodologic and interpretative differences are highlighted, but the disparate findings are explained as illustrating a more complex neuroendocrinology of PTSD than has previously been described...
  74. ncbi request reprint Neuroimaging studies in post-traumatic stress disorder
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Psychiatr Clin North Am 25:317-40, vi. 2002
    ....
  75. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  76. doi request reprint Neuroendocrine response to CRF stimulation in veterans with and without PTSD in consideration of war zone era
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, Bronx, NY, USA
    Psychoneuroendocrinology 37:350-7. 2012
    ....
  77. ncbi request reprint Childhood abuse, nonadherence, and medical outcome in pediatric liver transplant recipients
    Eyal Shemesh
    Department of Psychiatry, Recanati Miller Transplant Institute at Mount Sinai Medical Center, New York, NY, USA
    J Am Acad Child Adolesc Psychiatry 46:1280-9. 2007
    ..The study assessed the relationship between a history of child abuse, nonadherence to medications, and medical outcome in children who had a liver transplant...
  78. ncbi request reprint The impact of terrorism on brain, and behavior: what we know and what we need to know
    Rachel Yehuda
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 30:1773-80. 2005
    ....
  79. ncbi request reprint Psychological trauma associated with the World Trade Center attacks and its effect on pregnancy outcome
    Stephanie Mulherin Engel
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Paediatr Perinat Epidemiol 19:334-41. 2005
    ..Long-term follow-up of infants exposed to extreme trauma in utero is needed to evaluate the persistence of these effects...
  80. ncbi request reprint Assessing dissociation as a risk factor for posttraumatic stress disorder: a study of adult offspring of holocaust survivors
    Sarah L Halligan
    The Division of Traumatic Stress Studies, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Nerv Ment Dis 190:429-36. 2002
    ..The results suggest that dissociative symptoms are related to current psychiatric symptomatology, including PTSD, rather than representing an enduring trait or preexisting risk factor for the development of PTSD...
  81. ncbi request reprint Understanding heterogeneous effects of trauma exposure: relevance to postmortem studies of PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, New York, USA
    Psychiatry 67:391-7. 2004
  82. ncbi request reprint Assessment of posttraumatic stress symptoms in children who are medically ill and children presenting to a child trauma program
    Eyal Shemesh
    Department of Psychiatry, Box 1230, Mount Sinai Medical Center, 1 Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1071:472-7. 2006
    ..In conclusion, the U-PTSD-I performs better among general trauma versus medically ill patients. Intrusion symptoms should be focused on when assessing PTSD in medically ill children...
  83. pmc Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure
    Roger K Pitman
    Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1071:242-54. 2006
    ..These results support the conclusion that the latter abnormalities represent antecedent, familial vulnerability factors for developing chronic PTSD upon exposure to a traumatic event...
  84. ncbi request reprint Electrophysiological responses to affective stimuli in American Indians experiencing trauma with and without PTSD
    Cindy L Ehlers
    The Scripps Research Institute, 10550 N Torrey Pines Road, CVN 14, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1071:125-36. 2006
    ..They also partially confirm ERP data reported in combat victims with PTSD suggesting that PTSD may induce neurobiological consequences that transcend type of eliciting trauma as well as ethnic and cultural factors...
  85. ncbi request reprint Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program
    John W Mason
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychosom Med 64:238-46. 2002
    ....
  86. ncbi request reprint Longitudinal course of salivary cortisol in post-traumatic stress disorder
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany
    Acta Psychiatr Scand 105:153-5; discussion 155-6. 2002
    ..However, so far no longitudinal data on the natural course or on the effect of therapy are available...
  87. ncbi request reprint The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Program and the Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Biol Psychiatry 52:393-403. 2002
    ....
  88. ncbi request reprint Learning and memory in Holocaust survivors with posttraumatic stress disorder
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Bronx Veterans Affairs, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Biol Psychiatry 55:291-5. 2004
    ..Impairments in explicit memory have been observed in Holocaust survivors with posttraumatic stress disorder...
  89. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part II: the adrenergic response
    Elizabeth J Videlock
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:373-80. 2008
    ..Peripheral levels of NE, shortly after traumatic events, are poor risk indicators of subsequent PTSD among civilian trauma victims. Simplified biological models may not properly capture the complex aetiology of PTSD...
  90. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responses
    Arieh Y Shalev
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:365-72. 2008
    ..Female subjects had lower ACTH levels than males. PTSD in females was associated with higher levels of ACTH. In unselected cohorts of trauma survivors, PTSD is not preceded by a detectable abnormality of peripheral HPA axis hormones...
  91. ncbi request reprint PTSD symptoms predict waking salivary cortisol levels in police officers
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 30:373-81. 2005
    ....
  92. pmc Cortisol levels are positively correlated with hippocampal N-acetylaspartate
    Thomas C Neylan
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 54:1118-21. 2003
    ..This study examined the relationship of hypothalamic-pituitary-adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects...
  93. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 30:1173-80. 2005
    ..Future studies should explore the temporal relationship between HPA activity, sleep disturbances, and psychopathology after a traumatic event...
  94. ncbi request reprint Salivary cortisol responses to dexamethasone in adolescents with posttraumatic stress disorder
    Deborah S Lipschitz
    Yale University School of Medicine, 100 York Street, New Haven, CT 06511, USA
    J Am Acad Child Adolesc Psychiatry 42:1310-7. 2003
    ..The purpose of the present study was to investigate salivary cortisol responses to low-dose dexamethasone in adolescents with PTSD...
  95. ncbi request reprint Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder
    Omer Bonne
    The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
    Psychiatry Res 119:171-5. 2003
    ..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects...
  96. ncbi request reprint Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression
    Robert Grossman
    Department of Psychatry Bronx VeteransAffairs medical Center, Bronx, NY, USA
    Am J Psychiatry 160:1291-8. 2003
    ..To investigate the effect of PTSD, the authors conducted a 0.5-mg DST, which is more sensitive than the 1.0-mg DST for detection of increased cortisol suppression, in a group of subjects with personality disorders...
  97. ncbi request reprint The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD
    Lisa Tischler
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:405-9. 2006
    ....
  98. ncbi request reprint Twenty-four-hour urine cortisol in combat veterans with PTSD and comorbid borderline personality disorder
    Steven M Southwick
    Clinical Neurosciences Division, National Center for PTSD 116 A, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, Connecticut 06516, USA
    J Nerv Ment Dis 191:261-2. 2003
  99. pmc Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors
    Michael G Griffin
    University of Missouri St Louis, Center for Trauma Recovery, St Louis, MO 63121, USA
    Am J Psychiatry 162:1192-9. 2005
    ..The authors compared responses of female domestic violence survivors and a matched group of nontraumatized participants to a low-dose (0.5 mg) dexamethasone suppression test (DST)...
  100. ncbi request reprint Salivary cortisol levels and the cortisol response to dexamethasone before and after EMDR: a case report
    Ruth Heber
    Mount Sinai School of Medicine, USA
    J Clin Psychol 58:1521-30. 2002
    ..These results suggest the potential utility of including neuroendocrine measures in the assessment of treatment outcome in PTSD...
  101. ncbi request reprint Association between childhood trauma and catecholamine response to psychological stress in police academy recruits
    Christian Otte
    Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biol Psychiatry 57:27-32. 2005
    ..Childhood trauma is a risk factor for anxiety disorders in adulthood. One possible mechanism for this association is an increased neuroendocrine response to stress in adults with a history of childhood trauma...