R Yehuda

Summary

Country: USA

Publications

  1. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 30:1173-80. 2005
  2. ncbi request reprint The ACTH response to dexamethasone in PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, USA
    Am J Psychiatry 161:1397-403. 2004
  3. ncbi request reprint Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 164:163-6. 2007
  4. ncbi request reprint Hypothalamic-pituitary-adrenal alterations in PTSD: are they relevant to understanding cortisol alterations in cancer?
    Rachel Yehuda
    Psychiatry Department and Division of Traumatic Stress Studies, Mount Sinai School of Medicine and Bronx Veterans Affairs, NY, USA
    Brain Behav Immun 17:S73-83. 2003
  5. ncbi request reprint Effect of sertraline on glucocorticoid sensitivity of mononuclear leukocytes in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 31:189-96. 2006
  6. ncbi request reprint Relationship between 24-hour urinary-free cortisol excretion and salivary cortisol levels sampled from awakening to bedtime in healthy subjects
    Rachel Yehuda
    Psychiatry OOMH, Mount Sinai School of Medicine and Bronx Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Life Sci 73:349-58. 2003
  7. ncbi request reprint Are adult offspring reliable informants about parental PTSD? A validation study
    Rachel Yehuda
    Psychiatry 116A, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:484-7. 2006
  8. ncbi request reprint Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
    Rachel Yehuda
    The Traumatic Stress Studies Program of the Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY 10468, USA
    J Psychiatr Res 37:471-7. 2003
  9. ncbi request reprint Developing an agenda for translational studies of resilience and vulnerability following trauma exposure
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:379-96. 2006
  10. ncbi request reprint Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:137-66. 2006

Research Grants

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 30:1173-80. 2005
    ..Future studies should explore the temporal relationship between HPA activity, sleep disturbances, and psychopathology after a traumatic event...
  2. ncbi request reprint The ACTH response to dexamethasone in PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, USA
    Am J Psychiatry 161:1397-403. 2004
    ....
  3. ncbi request reprint Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 164:163-6. 2007
    ....
  4. ncbi request reprint Hypothalamic-pituitary-adrenal alterations in PTSD: are they relevant to understanding cortisol alterations in cancer?
    Rachel Yehuda
    Psychiatry Department and Division of Traumatic Stress Studies, Mount Sinai School of Medicine and Bronx Veterans Affairs, NY, USA
    Brain Behav Immun 17:S73-83. 2003
    ..This review considers the extent to which neuroendocrine alterations observed in PTSD may be useful in understanding cortisol alterations involved in cancer...
  5. ncbi request reprint Effect of sertraline on glucocorticoid sensitivity of mononuclear leukocytes in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 31:189-96. 2006
    ..Insofar as increased sensitivity to glucocorticoids has been linked with PTSD, the actions of SER on the lysozyme IC(50-DEX) suggest that this medication may target a biologic alteration associated with PTSD pathophysiology...
  6. ncbi request reprint Relationship between 24-hour urinary-free cortisol excretion and salivary cortisol levels sampled from awakening to bedtime in healthy subjects
    Rachel Yehuda
    Psychiatry OOMH, Mount Sinai School of Medicine and Bronx Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Life Sci 73:349-58. 2003
    ..In addition, subject compliance is a serious consideration in designing studies that employ home salivary collections...
  7. ncbi request reprint Are adult offspring reliable informants about parental PTSD? A validation study
    Rachel Yehuda
    Psychiatry 116A, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:484-7. 2006
    ..Further studies are warranted to examine the psychometric properties of this measure...
  8. ncbi request reprint Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
    Rachel Yehuda
    The Traumatic Stress Studies Program of the Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY 10468, USA
    J Psychiatr Res 37:471-7. 2003
    ....
  9. ncbi request reprint Developing an agenda for translational studies of resilience and vulnerability following trauma exposure
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:379-96. 2006
    ..Understanding why this is so will provide clues for the development of therapeutic interventions for those people who do develop stress-related psychopathology, or even for the prevention of adverse outcomes...
  10. ncbi request reprint Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:137-66. 2006
    ..This article summarizes important neuroendocrine observations in cortisol and provides strategies for understanding what has emerged over the past two decades, to be a complex and sometimes contradictory literature...
  11. ncbi request reprint Clinical correlates of DHEA associated with post-traumatic stress disorder
    R Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx, NY, USA
    Acta Psychiatr Scand 114:187-93. 2006
    ....
  12. ncbi request reprint Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, Bronx VAMC, OOMH PTSD 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 29:389-404. 2004
    ....
  13. ncbi request reprint Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, and the Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 31:447-51. 2006
    ..The authors therefore examined the change in ACTH and cortisol before and after cortisol administration, which acts at central feedback sites in addition to peripheral targets...
  14. ncbi request reprint Effect of topiramate on glucocorticoid receptor mediated action
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neuropsychopharmacology 29:433-9. 2004
    ..In conclusion, further investigation of the actions of TPM on GR and other neuroendocrine systems may prove useful in understanding some of the other established clinical effects of this agent...
  15. ncbi request reprint Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, and the Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Biol Psychiatry 59:660-3. 2006
    ..There is emerging interest in examining the role of plasma neuropeptide Y (NPY) as a protective stress factor...
  16. ncbi request reprint Risk and resilience in posttraumatic stress disorder
    Rachel Yehuda
    Bronx VA Medical Center, Mt Sinai School of Medicine, Bronx, NY, USA
    J Clin Psychiatry 65:29-36. 2004
    ..In addition, however, neuroendocrine changes, such as lower cortisol levels, also may influence formation and processing of traumatic memories and may be associated with the underlying pathology of PTSD...
  17. ncbi request reprint Learning and memory in aging combat veterans with PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of MedicineNew York, NY, USA
    J Clin Exp Neuropsychol 27:504-15. 2005
    ..However, increased severity of rapid forgetting may be a specific alteration in older combat veterans, likely reflecting aspects of both combat exposure and aging...
  18. ncbi request reprint Protective and damaging effects of the biobehavioral stress response: cognitive, systemic and clinical aspects: ISPNE XXXIV meeting summary
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, NY 10468, USA
    Psychoneuroendocrinology 29:1212-22. 2004
  19. ncbi request reprint Pathological responses to terrorism
    Rachel Yehuda
    Psychiatry OOMH, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Neuropsychopharmacology 30:1793-805. 2005
    ....
  20. ncbi request reprint Current status of cortisol findings in post-traumatic stress disorder
    Rachel Yehuda
    Psychiatry Department, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Psychiatr Clin North Am 25:341-68, vii. 2002
    ..Sources of variance caused by methodologic and interpretative differences are highlighted, but the disparate findings are explained as illustrating a more complex neuroendocrinology of PTSD than has previously been described...
  21. ncbi request reprint Cortisol levels in adult offspring of Holocaust survivors: relation to PTSD symptom severity in the parent and child
    Rachel Yehuda
    Bronx Veteran Affairs Medical Center, Psychiatry OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 27:171-80. 2002
    ....
  22. ncbi request reprint Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion
    R Yehuda
    Mount Sinai School of Medicine, Bronx, New York, USA
    Dev Psychopathol 13:733-53. 2001
    ..We conclude that the experience of childhood trauma may be an important factor in the transmission of PTSD from parent to child...
  23. ncbi request reprint Biology of posttraumatic stress disorder
    R Yehuda
    Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY, USA
    J Clin Psychiatry 62:41-6. 2001
    ..Sensitization of the HPA axis is consistent with the clinical picture of hyperreactivity and hyperresponsiveness in PTSD...
  24. ncbi request reprint Relationship between cortisol and age-related memory impairments in Holocaust survivors with PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Department of Psychiatry OOMH, Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Psychoneuroendocrinology 30:678-87. 2005
    ..To investigate the implications of age-related HPA axis alterations on cognition, we examined correlations between parameters reflecting circadian cortisol release and implicit and explicit memory performance...
  25. ncbi request reprint Circadian rhythm of salivary cortisol in Holocaust survivors with and without PTSD
    Rachel Yehuda
    Mount Sinai School of Medicine, USA
    Am J Psychiatry 162:998-1000. 2005
    ..The authors' goal was to determine whether cortisol circadian rhythm alterations observed in younger subjects with posttraumatic stress disorder (PTSD) are also present in geriatric trauma survivors with PTSD...
  26. ncbi request reprint Longitudinal assessment of cognitive performance in Holocaust survivors with and without PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York 10468, USA
    Biol Psychiatry 60:714-21. 2006
    ..It is therefore unclear whether relationships between memory and symptoms differ over time among older persons with and without PTSD...
  27. ncbi request reprint Low cortisol and risk for PTSD in adult offspring of holocaust survivors
    R Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 157:1252-9. 2000
    ..The study examined the association between cortisol and putative risk factors for posttraumatic stress disorder (PTSD) in a sample of subjects at increased risk for the development of PTSD...
  28. ncbi request reprint Biology of posttraumatic stress disorder
    R Yehuda
    Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, NY, USA
    J Clin Psychiatry 61:14-21. 2000
    ..This article examines some of the biological alterations in PTSD and develops a framework for understanding the development progression of the neurobiology of this disorder...
  29. doi request reprint Status of glucocorticoid alterations in post-traumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1179:56-69. 2009
    ..Results of these studies have provided an important rationale for using glucocorticoid strategies in the treatment of PTSD...
  30. ncbi request reprint Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring
    R Yehuda
    The Traumatic Stress Studies Program of the Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY 10468, USA
    J Psychiatr Res 35:261-70. 2001
    ..The identification of parental PTSD as a risk factor for PTSD in offspring of Holocaust survivors defines a sample in which the biological and psychological correlates of risk for PTSD can be further examined...
  31. ncbi request reprint Clinical relevance of biologic findings in PTSD
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, NY, USA
    Psychiatr Q 73:123-33. 2002
    ..This review will discuss these new findings and their treatment implications...
  32. ncbi request reprint Enhanced effects of cortisol administration on episodic and working memory in aging veterans with PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 32:2581-91. 2007
    ..The findings suggest that there may be opportunities for developing therapeutic strategies using glucocorticoids in the treatment of aging combat veterans...
  33. ncbi request reprint Understanding heterogeneous effects of trauma exposure: relevance to postmortem studies of PTSD
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, New York, USA
    Psychiatry 67:391-7. 2004
  34. ncbi request reprint Post-traumatic stress disorder
    Rachel Yehuda
    Division of Traumatic Stress Studies and Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    N Engl J Med 346:108-14. 2002
  35. ncbi request reprint Ten-year follow-up study of cortisol levels in aging holocaust survivors with and without PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Department of Psychiatry, Mount Sinai School of Medicine, Bronx NY, USA
    J Trauma Stress 20:757-61. 2007
    ..The authors conclude that cortisol levels are affected by change in PTSD status and age...
  36. ncbi request reprint Response variation following trauma: a translational neuroscience approach to understanding PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Mount Sinai School of Medicine, James J Peters Veteran Affairs, New York, NY 10468, USA
    Neuron 56:19-32. 2007
    ..We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD...
  37. ncbi request reprint Assessing dissociation as a risk factor for posttraumatic stress disorder: a study of adult offspring of holocaust survivors
    Sarah L Halligan
    The Division of Traumatic Stress Studies, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Nerv Ment Dis 190:429-36. 2002
    ..The results suggest that dissociative symptoms are related to current psychiatric symptomatology, including PTSD, rather than representing an enduring trait or preexisting risk factor for the development of PTSD...
  38. ncbi request reprint The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder
    Rachel Yehuda
    The Traumatic Stress Program and the Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Biol Psychiatry 52:393-403. 2002
    ....
  39. ncbi request reprint Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1071:410-21. 2006
    ....
  40. ncbi request reprint Biological factors associated with susceptibility to posttraumatic stress disorder
    R Yehuda
    Mount Sinai School of Medicine, USA
    Can J Psychiatry 44:34-9. 1999
    ..Thus, even the most biological of explanations for vulnerability must at some point deal with the fact that a traumatic event has occurred...
  41. ncbi request reprint Vulnerability to posttraumatic stress disorder in adult offspring of Holocaust survivors
    R Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx VA Medical Center, NY 10468, USA
    Am J Psychiatry 155:1163-71. 1998
    ....
  42. ncbi request reprint Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression
    Robert Grossman
    Department of Psychatry Bronx VeteransAffairs medical Center, Bronx, NY, USA
    Am J Psychiatry 160:1291-8. 2003
    ..To investigate the effect of PTSD, the authors conducted a 0.5-mg DST, which is more sensitive than the 1.0-mg DST for detection of increased cortisol suppression, in a group of subjects with personality disorders...
  43. ncbi request reprint Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Biol Psychiatry 55:1110-6. 2004
    ..The aim of this study was to determine whether there is increased responsiveness to corticosteroids in posttraumatic stress disorder (PTSD) by examining the differential effects of dexamethasone (DEX) on the inhibition of lysozyme activity...
  44. ncbi request reprint Variability and severity of depression and anxiety in post traumatic stress disorder and major depressive disorder
    J A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx VA Medical Center, 00MH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Depress Anxiety 13:97-100. 2001
    ..These findings suggest there are phenomenologic differences in the affective symptoms experienced by patients with PTSD and with MDD and that mood variability may distinguish between them...
  45. ncbi request reprint Psychological dimensions of depression in borderline personality disorder
    S M Southwick
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 152:789-91. 1995
    ..The authors' goal was to test empirically a commonly held assumption that the depression in borderline personality disorder is primarily anaclitic...
  46. ncbi request reprint Association between childhood trauma and catecholamine response to psychological stress in police academy recruits
    Christian Otte
    Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biol Psychiatry 57:27-32. 2005
    ..Childhood trauma is a risk factor for anxiety disorders in adulthood. One possible mechanism for this association is an increased neuroendocrine response to stress in adults with a history of childhood trauma...
  47. pmc Ten-year follow-up study of PTSD diagnosis, symptom severity and psychosocial indices in aging holocaust survivors
    R Yehuda
    Division of Traumatic Stress Studies, Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Acta Psychiatr Scand 119:25-34. 2009
    ..We performed a longitudinal study of holocaust survivors with and without post-traumatic stress disorder (PTSD) by assessing symptoms and other measures at two intervals, approximately 10 years apart...
  48. ncbi request reprint Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, California, USA
    Biol Psychiatry 61:952-6. 2007
    ..We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with post-traumatic stress disorder (PTSD). In this study, we aimed to extend these findings to women...
  49. doi request reprint Dissociation versus posttraumatic stress: cortisol and physiological correlates in adults highly exposed to the World Trade Center attack on 9/11
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 161:325-9. 2008
    ..This small study emphasizes the importance of dissecting the neurobiology of posttraumatic stress versus dissociative traumatic responses...
  50. ncbi request reprint Learning and memory in Holocaust survivors with posttraumatic stress disorder
    Rachel Yehuda
    Traumatic Stress Studies Program, Psychiatry Department, Bronx Veterans Affairs, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Biol Psychiatry 55:291-5. 2004
    ..Impairments in explicit memory have been observed in Holocaust survivors with posttraumatic stress disorder...
  51. ncbi request reprint Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program
    John W Mason
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychosom Med 64:238-46. 2002
    ....
  52. ncbi request reprint Salivary cortisol levels and the cortisol response to dexamethasone before and after EMDR: a case report
    Ruth Heber
    Mount Sinai School of Medicine, USA
    J Clin Psychol 58:1521-30. 2002
    ..These results suggest the potential utility of including neuroendocrine measures in the assessment of treatment outcome in PTSD...
  53. ncbi request reprint Neuroendocrine activity and memory-related impairments in posttraumatic stress disorder
    J Golier
    Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, NY 10468, USA
    Dev Psychopathol 10:857-69. 1998
    ..The mechanisms by which these neuroendocrine alterations may influence the formation and processing of traumatic memories are discussed...
  54. ncbi request reprint Clinical correlates of 24-h cortisol and norepinephrine excretion among subjects seeking treatment following the world trade center attacks on 9/11
    Linda M Bierer
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1071:514-20. 2006
    ....
  55. ncbi request reprint The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD
    Lisa Tischler
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:405-9. 2006
    ....
  56. ncbi request reprint Delta sleep response to metyrapone in post-traumatic stress disorder
    Thomas C Neylan
    Department of Psychiatry, University of California, USA
    Neuropsychopharmacology 28:1666-76. 2003
    ..The results suggest that the delta sleep response to metyrapone is a measure of the brain response to increases in hypothalamic CRF. These data also suggest that the ACTH and sleep EEG response to hypothalamic CRF is decreased in PTSD...
  57. pmc Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 61:966-73. 2007
    ..This study investigated basal and stress-induced hypothalamic-pituitary-adrenal (HPA)-axis alterations in dissociative disorders (DDs)...
  58. ncbi request reprint Psychogenic lowering of urinary cortisol levels linked to increased emotional numbing and a shame-depressive syndrome in combat-related posttraumatic stress disorder
    J W Mason
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Psychosom Med 63:387-401. 2001
    ..The purpose of the study was to search for the intrapsychic correlates of individual differences in cortisol levels in male Vietnam combat veterans with posttraumatic stress disorder...
  59. ncbi request reprint CSF norepinephrine concentrations in posttraumatic stress disorder
    T D Geracioti
    Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St, Cincinnati, OH 45220, USA
    Am J Psychiatry 158:1227-30. 2001
    ..The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD...
  60. ncbi request reprint Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 31:1181-9. 2006
    ..To examine whether PTSD or post-deployment health symptoms in veterans of the first Gulf War (Operation Desert Shield/Storm) are associated with enhanced suppression of the pituitary-adrenal axis to low-dose dexamethasone (DEX)...
  61. doi request reprint Using biological markers to inform a clinically meaningful treatment response
    Rachel Yehuda
    Department of Psychiatry, James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
    Ann N Y Acad Sci 1208:158-63. 2010
    ..We propose that future studies consider the unique consequences of combat trauma and develop treatments that incorporate the complex nature of the exposure and response characteristic of a veteran population...
  62. ncbi request reprint Neuropsychological processes in post-traumatic stress disorder
    Julia Golier
    Bronx VA Medical Center, 130 West Kingsbridge Road 116A, Bronx, NY 10468, USA
    Psychiatr Clin North Am 25:295-315, vi. 2002
    ..The implications of these findings for the course and pathophysiology of PTSD are also discussed...
  63. ncbi request reprint Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 62:1175-8. 2007
    ....
  64. ncbi request reprint Differentiating biological correlates of risk, PTSD, and resilience following trauma exposure
    Rachel Yehuda
    Department of Psychiatry, Mount Sinai School of Medicine, New York, and Department of Psychiatry, Bronx VAMC, Bronx, NY 10468, USA
    J Trauma Stress 20:435-47. 2007
    ....
  65. ncbi request reprint Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Bronx, NY, USA
    Arch Gen Psychiatry 64:1040-8. 2007
    ....
  66. pmc Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, United States
    J Psychiatr Res 42:1104-11. 2008
    ..Two recent reports linking maternal PTSD and low offspring cortisol prompted us to examine the relative contributions of maternal vs. paternal PTSD in the prediction of PTSD and other psychiatric diagnoses in offspring...
  67. doi request reprint Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks
    Rachel Yehuda
    Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Bronx, New York 10458, USA
    Biol Psychiatry 66:708-11. 2009
    ....
  68. doi request reprint Pituitary response to metyrapone in Gulf War veterans: relationship to deployment, PTSD and unexplained health symptoms
    Julia A Golier
    Departments of Psychiatry, James J Peters VA Medical Center, Bronx, NY 10468, United States of America
    Psychoneuroendocrinology 34:1338-45. 2009
    ..The metyrapone stimulation test was performed to further characterize hypothalamic-pituitary activity in Gulf War veterans (GWV) and its relationship to unexplained medical symptoms and post-traumatic stress disorder (PTSD)...
  69. doi request reprint Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD
    Rachel Yehuda
    Department of Psychiatry, James J Peters Veterans Affairs Medical Center, 526 OOMH, 130 W Kingsbridge Rd, Bronx, NY, USA
    Psychopharmacology (Berl) 212:405-17. 2010
    ..Given similarities between neuroendocrine aspects of PTSD and ELS, such as in reduced cortisol signaling and glucocorticoid receptor (GR) responsiveness, some aspects of the biology of PTSD may reflect biological correlates of risk...
  70. doi request reprint Hydrocortisone responsiveness in Gulf War veterans with PTSD: effects on ACTH, declarative memory hippocampal [(18)F]FDG uptake on PET
    Rachel Yehuda
    James J Peters Veterans Affairs Medical Center, Bronx, NY, USA
    Psychiatry Res 184:117-27. 2010
    ..Differences in brain metabolic responses between GW veterans with and without PTSD may reflect differences in peripheral and central GR responsiveness...
  71. ncbi request reprint Predictors of posttraumatic stress in police and other first responders
    Charles R Marmar
    San Francisco Veterans Affairs Medical Center, 4150 Clement St 116 P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:1-18. 2006
    ..Next steps in this line of research will be to test this model prospectively in a sample of 400 police academy recruits assessed during training and currently being followed for the first 2 years of police service...
  72. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  73. ncbi request reprint Memory performance in older trauma survivors: implications for the longitudinal course of PTSD
    Julia A Golier
    James J Peters VA Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:54-66. 2006
    ..PTSD is associated with considerable cognitive burden with age. Longitudinal studies of older subjects are warranted to examine whether PTSD is associated with accelerated aging or progressive memory loss...
  74. ncbi request reprint Assessment of depression in medically ill children presenting to pediatric specialty clinics
    Eyal Shemesh
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, NY 10029, USA
    J Am Acad Child Adolesc Psychiatry 44:1249-57. 2005
    ..This approach has not been validated. We evaluated the diagnostic accuracy of the Children's Depression Inventory (CDI) in medically ill children who were referred for evaluation by their pediatricians...
  75. ncbi request reprint PTSD symptoms predict waking salivary cortisol levels in police officers
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 30:373-81. 2005
    ....
  76. ncbi request reprint Association between alexithymia and neuroendocrine response to psychological stress in police academy recruits
    Shannon E McCaslin
    PTSD Research Program, University of California, San Francisco, VAMC 4150 Clement Street 116P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:425-7. 2006
    ..Alexithymia scores were negatively associated with catecholamine response to the video challenge but no association was found between alexithymia scores and cortisol reactivity...
  77. doi request reprint Trauma and violence: are women the weaker sex?
    Laura C Pratchett
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatr Clin North Am 33:465-74. 2010
    ..Risk and resilience can perhaps more appropriately be considered specific to symptom picture rather than merely development of pathology...
  78. ncbi request reprint Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: relation to risk and resilience factors
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, New York, NY, United States
    J Psychiatr Res 41:435-45. 2007
    ....
  79. pmc Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Bronx Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    J Psychiatr Res 43:877-83. 2009
    ....
  80. ncbi request reprint Cognitive-behavioral psychology: implications for disaster and terrorism response
    Josefi Ruzek
    National Center for Post Traumatic Stress Disorder, Veterans Administration Palo Alto Health Care System, Menlo Park, California 94025, USA
    Prehosp Disaster Med 23:397-410. 2008
    ....
  81. ncbi request reprint Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatry Res 139:53-64. 2005
    ..Larger temporal lobe volumes may be associated with early traumatization and survival or may reflect some other characteristic of Holocaust survivors...
  82. pmc Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001
    Rachel Yehuda
    Traumatic Stress Studies Division, Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, Psychiatry 116 A OOMH, Bronx, NY 10468 3904, USA
    Psychoneuroendocrinology 34:1304-13. 2009
    ....
  83. doi request reprint Is trauma a causal agent of psychopathologic symptoms in posttraumatic stress disorder? Findings from identical twins discordant for combat exposure
    Mark W Gilbertson
    Department of Research Service, Manchester VA Medical Center, 718 Smyth Rd, Manchester, NH 03104, USA
    J Clin Psychiatry 71:1324-30. 2010
    ..The current study tests this hypothesis...
  84. ncbi request reprint Memory for trauma-related information in Holocaust survivors with PTSD
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 121:133-43. 2003
    ..This trauma-related facilitation of explicit memory, together with generally poorer explicit memory, may help to explain the bi-directional nature of the memory impairments in PTSD...
  85. doi request reprint Changes in relative glucose metabolic rate following cortisol administration in aging veterans with posttraumatic stress disorder: an FDG-PET neuroimaging study
    Rachel Yehuda
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    J Neuropsychiatry Clin Neurosci 21:132-43. 2009
    ..The restorative effects of HCORT on metabolism and working memory provide a rationale for examining the therapeutic benefits of glucocorticoid manipulation in aging PTSD patients...
  86. ncbi request reprint Transgenerational transmission of cortisol and PTSD risk
    Rachel Yehuda
    The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, James J Peters VAMC, 116 A, OOMH PTSD, Bronx, NY 10468, USA
    Prog Brain Res 167:121-35. 2008
    ..Since low cortisol levels are particularly associated with the presence of maternal PTSD the findings suggest the involvement of epigenetic mechanisms...
  87. ncbi request reprint The ACTH response to dexamethasone in Persian Gulf War veterans
    Julia A Golier
    Bronx VA Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:448-53. 2006
    ....
  88. ncbi request reprint History of past sexual abuse in married observant Jewish women
    Rachel Yehuda
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 164:1700-6. 2007
    ..The authors examined instances of past sexual abuse and related demographic characteristics in the self-reports of a select group of married observant Jewish women...
  89. ncbi request reprint Memory performance in Holocaust survivors with posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:1682-8. 2002
    ..The authors evaluated memory performance in Holocaust survivors and its association with posttraumatic stress disorder (PTSD) and age...
  90. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  91. ncbi request reprint Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder
    Omer Bonne
    The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
    Psychiatry Res 119:171-5. 2003
    ..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects...
  92. pmc Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors
    Michael G Griffin
    University of Missouri St Louis, Center for Trauma Recovery, St Louis, MO 63121, USA
    Am J Psychiatry 162:1192-9. 2005
    ..The authors compared responses of female domestic violence survivors and a matched group of nontraumatized participants to a low-dose (0.5 mg) dexamethasone suppression test (DST)...
  93. ncbi request reprint Salivary cortisol responses to dexamethasone in adolescents with posttraumatic stress disorder
    Deborah S Lipschitz
    Yale University School of Medicine, 100 York Street, New Haven, CT 06511, USA
    J Am Acad Child Adolesc Psychiatry 42:1310-7. 2003
    ..The purpose of the present study was to investigate salivary cortisol responses to low-dose dexamethasone in adolescents with PTSD...
  94. pmc Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure
    Roger K Pitman
    Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1071:242-54. 2006
    ..These results support the conclusion that the latter abnormalities represent antecedent, familial vulnerability factors for developing chronic PTSD upon exposure to a traumatic event...
  95. ncbi request reprint Electrophysiological responses to affective stimuli in American Indians experiencing trauma with and without PTSD
    Cindy L Ehlers
    The Scripps Research Institute, 10550 N Torrey Pines Road, CVN 14, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1071:125-36. 2006
    ..They also partially confirm ERP data reported in combat victims with PTSD suggesting that PTSD may induce neurobiological consequences that transcend type of eliciting trauma as well as ethnic and cultural factors...
  96. ncbi request reprint Longitudinal course of salivary cortisol in post-traumatic stress disorder
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany
    Acta Psychiatr Scand 105:153-5; discussion 155-6. 2002
    ..However, so far no longitudinal data on the natural course or on the effect of therapy are available...
  97. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part II: the adrenergic response
    Elizabeth J Videlock
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:373-80. 2008
    ..Peripheral levels of NE, shortly after traumatic events, are poor risk indicators of subsequent PTSD among civilian trauma victims. Simplified biological models may not properly capture the complex aetiology of PTSD...
  98. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responses
    Arieh Y Shalev
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:365-72. 2008
    ..Female subjects had lower ACTH levels than males. PTSD in females was associated with higher levels of ACTH. In unselected cohorts of trauma survivors, PTSD is not preceded by a detectable abnormality of peripheral HPA axis hormones...
  99. pmc Cortisol levels are positively correlated with hippocampal N-acetylaspartate
    Thomas C Neylan
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 54:1118-21. 2003
    ..This study examined the relationship of hypothalamic-pituitary-adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects...
  100. ncbi request reprint Twenty-four-hour urine cortisol in combat veterans with PTSD and comorbid borderline personality disorder
    Steven M Southwick
    Clinical Neurosciences Division, National Center for PTSD 116 A, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, Connecticut 06516, USA
    J Nerv Ment Dis 191:261-2. 2003

Research Grants13

  1. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2006
    ..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
  2. Psychobiology of PTSD: A Decade of Progress
    Rachel Yehuda; Fiscal Year: 2005
    ..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
  3. Relationship between Bio and Psych Correlates of PTSD
    Rachel Yehuda; Fiscal Year: 2005
    ..abstract_text> ..
  4. Genetics, Endocrinology and PTSD Risk in the Population
    Rachel Yehuda; Fiscal Year: 2006
    ..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..