G X Yan

Summary

Country: USA

Publications

  1. ncbi request reprint Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall
    G X Yan
    Main Line Health Heart Center, Wynnewood, PA, USA
    Circulation 103:2851-6. 2001
  2. ncbi request reprint Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization
    G X Yan
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 281:H1968-75. 2001
  3. ncbi request reprint Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance
    Gan Xin Yan
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Am Coll Cardiol 42:401-9. 2003
  4. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
  5. pmc Does Tpeak-Tend provide an index of transmural dispersion of repolarization?
    Charles Antzelevitch
    Heart Rhythm 4:1114-6; author reply 1116-9. 2007
  6. pmc Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
    Tengxian Liu
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Heart Rhythm 3:948-56. 2006
  7. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
  8. ncbi request reprint Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes
    Ying Wu
    Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 16:898-904. 2005
  9. ncbi request reprint ECG repolarization waves: their genesis and clinical implications
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Ann Noninvasive Electrocardiol 10:211-23. 2005
  10. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall
    G X Yan
    Main Line Health Heart Center, Wynnewood, PA, USA
    Circulation 103:2851-6. 2001
    ..The contribution of transmural dispersion of repolarization (TDR) to transmural propagation of EAD and the maintenance of TdP was also evaluated...
  2. ncbi request reprint Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization
    G X Yan
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 281:H1968-75. 2001
    ....
  3. ncbi request reprint Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance
    Gan Xin Yan
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Am Coll Cardiol 42:401-9. 2003
    ....
  4. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
    ..Long QT syndrome is associated with early after-depolarization (EAD) that may result in torsade de pointes (TdP). Interestingly, the corrected QT interval seems to be proportional to body mass across species under physiologic conditions...
  5. pmc Does Tpeak-Tend provide an index of transmural dispersion of repolarization?
    Charles Antzelevitch
    Heart Rhythm 4:1114-6; author reply 1116-9. 2007
  6. pmc Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
    Tengxian Liu
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Heart Rhythm 3:948-56. 2006
    ..The present study provides a blinded appraisal of drugs, in an isolated arterially-perfused rabbit ventricular wedge preparation, with and without the potential to produce TdP...
  7. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
    ....
  8. ncbi request reprint Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes
    Ying Wu
    Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 16:898-904. 2005
    ..This study examined the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide...
  9. ncbi request reprint ECG repolarization waves: their genesis and clinical implications
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Ann Noninvasive Electrocardiol 10:211-23. 2005
    ..A physiological U wave is thought to be due to delayed repolarization of the Purkinje system...
  10. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
    ..The present study examined the role of phase 2 reentry in the initiation of VF during early myocardial ischemia...
  11. ncbi request reprint Electrocardiographic T wave: a symbol of transmural dispersion of repolarization in the ventricles
    Gan Xin Yan
    J Cardiovasc Electrophysiol 14:639-40. 2003
  12. ncbi request reprint Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome
    Fadi G Akar
    Heart and Vascular Research Center and Departments of Medicine and Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Circulation 105:1247-53. 2002
    ..However, the mechanisms by which dysfunction at the molecular level translates into functional electrical instability leading to torsade de pointes (TdP) in LQTS are poorly understood...
  13. ncbi request reprint Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?
    Victor A Medina-Ravell
    Centro Medico Guerra Mendez, Valencia, Venezuela
    Circulation 107:740-6. 2003
    ..The present study examined pacing site-dependent changes in QT interval and transmural dispersion of repolarization (TDR) and their potential role in the development of torsade de pointes (TdP)...
  14. ncbi request reprint Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models
    Ajay Joshi
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 37:7-14. 2004
    ..Signals specifically pertinent to the development of TdP, ie, early afterdepolarization (EAD) and an increase in TDR can be detected as well. The preclinical data obtained from the wedge preparation correlate well with clinical outcomes...
  15. ncbi request reprint Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy
    Xiaoping Xu
    Main Line Health Heart Center, Suite 558, Medical Office Building East, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 283:H664-70. 2002
    ..2 Hz. Pharmacological activation of I(Ks) is a promising new strategy to suppress arrhythmias resulting from excessive AP prolongation in patients with certain forms of long QT syndrome or cardiac hypertrophy and failure...
  16. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
    ..AP triangulation has been shown to be an important predictor of drug-induced TdP...
  17. ncbi request reprint Ischemia versus amiodarone induced polymorphic ventricular tachycardia
    Harinder Sharma
    Department of Internal Medicine, Main Line Health Heart Center, Lankenau Hospital and Institute of Medical Research, Wynnewood, Pennsylvania, USA
    Pacing Clin Electrophysiol 25:1382-4. 2002
  18. ncbi request reprint Mechanisms underlying arrhythmogenesis in long QT syndrome
    Ramarao S Lankipalli
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:69-73. 2005
    ..Enhanced TDR is essential not only for the genesis of the first initiating beat of TdP by facilitating the propagation of EAD, but also for the maintenance of TdP by serving as a functional reentrant substrate...
  19. ncbi request reprint ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage
    Juan Shu
    Cardiology Department, The First Hospital of Xi An Jiaotong University, Xi an, Shaanxi 710061, China
    J Electrocardiol 38:26-32. 2005
    ..When Ito is relatively small as in the ERS, partial depression of the dome occurs without the development of phase 2 reentry...
  20. ncbi request reprint Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action
    Xiaoping Xu
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Pharmacol 41:414-21. 2003
    ..These effects are self-limited due to SB-237376-induced I(Ca,L) blockade at high concentrations, which may explain its lower proarrhythmic risk than dl-sotalol...
  21. ncbi request reprint Making a silk purse out of a sow's ear
    Peter R Kowey
    J Am Coll Cardiol 46:688-9. 2005
  22. ncbi request reprint Accurate interpretation of the QT interval: a vital task that remains unaccomplished
    Rong Bai
    Heart Rhythm 2:575-7. 2005
  23. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008
    ..Our data indicate that abnormal intracellular Ca(2+) fluctuation may exert a strong feedback on the membrane I(Cl,Ca), leading to a beat-to-beat change in the net repolarizing current that manifests as T-wave alternans on the ECG...