Lingjun Zuo

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Alcohol Clin Exp Res 37:730-9. 2013
  2. pmc Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Stud Alcohol Drugs 74:622-5. 2013
  3. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
  4. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
  5. pmc Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:557-66. 2012
  6. pmc Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012
  7. pmc A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26726. 2011
  8. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
  9. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
  10. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006

Detail Information

Publications30

  1. pmc Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Alcohol Clin Exp Res 37:730-9. 2013
    ..Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors...
  2. pmc Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Stud Alcohol Drugs 74:622-5. 2013
    ..In the present study, we scanned the whole exome in three independent samples to search for replicable risk nonsynonymous (ns) variants (ns single-nucleotide polymorphisms [nsSNPs]) for alcohol dependence...
  3. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
    ..We concluded that common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans...
  4. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
    ..We aimed to identify novel, functional, replicable and genome-wide significant risk regions specific for alcohol dependence using genome-wide association studies (GWASs)...
  5. pmc Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:557-66. 2012
    ..TNN is involved in neurite outgrowth and cell migration in hippocampal explants, and TNR is an extracellular matrix protein expressed primarily in the central nervous system...
  6. pmc Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012
    ..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence...
  7. pmc A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26726. 2011
    ..We conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder...
  8. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  9. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
    ..These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD...
  10. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes...
  11. ncbi request reprint ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...
  12. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  13. pmc Association study of DTNBP1 with schizophrenia in a US sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Psychiatr Genet 19:292-304. 2009
    ..This study aimed to test the association in two common US populations by using powerful analytic methods...
  14. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  15. pmc Rare ADH variant constellations are specific for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Alcohol Alcohol 48:9-14. 2013
    ..In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference...
  16. ncbi request reprint CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:1557-68. 2007
    ..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD...
  17. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  18. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
    ..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared...
  19. ncbi request reprint ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    ..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence...
  20. doi request reprint Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Pharmacogenet Genomics 23:395-402. 2013
    ..In the present study, we comprehensively examined the rare variants [minor allele frequency (MAF)<0.05] in the NKAIN1-SERINC2 region to confirm our previous finding...
  21. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study...
  22. ncbi request reprint CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 14:2421-34. 2005
    ..In addition, a specific diplotype might inversely affect risk for AD and DD and risk for affective disorders...
  23. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis...
  24. ncbi request reprint Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence
    Lingjun Zuo
    Departments of aPsychiatry and bGenetics, Yale University School of Medicine cDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine dDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut eDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee fMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Psychiatr Genet 23:233-8. 2013
    ..In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence...
  25. pmc The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation
    Lingjun Zuo
    Departments of Psychiatry, West Haven Campus, Connecticut, USA
    Pharmacogenet Genomics 19:437-46. 2009
    ..We hypothesized that DTNBP1 might also influence the response to antipsychotic treatments. This study aimed to investigate the relationship between the DTNBP1 and the effects of clozapine and haloperidol on refractory schizophrenia...
  26. ncbi request reprint Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Am J Addict 23:411-4. 2014
    ..In the present study, we significantly increased the marker density within this region and examined the specificity of the associations of common variants for alcohol dependence...
  27. pmc Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 4:42. 2008
    ..abstract:..
  28. ncbi request reprint CALCYON gene variation, schizophrenia, and cocaine dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 125:25-30. 2004
    ..Furthermore, these findings begin to establish a haplotype map for this gene in the AA and EA populations...
  29. ncbi request reprint Intestinal microbiome and digoxin inactivation: meal plan for digoxin users?
    Lingeng Lu
    Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, 60 College Street, New Haven, CT, 06520 8034, USA
    World J Microbiol Biotechnol 30:791-9. 2014
    ..We also discuss several issues yet to be addressed in the future, making better strategies in the application of dietary arginine supplements for digoxin users. ..