Research Topics
Genomes and Genes
Species | Lingjun ZuoSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descentLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA VA Alcohol Research Center, VA Connecticut Healthcare System, West Haven, CT, USA Electronic address
Drug Alcohol Depend 129:254-64. 2013..We aimed to identify novel, functional, replicable and genome-wide significant risk regions specific for alcohol dependence using genome-wide association studies (GWASs)...- Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1qLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 37:557-66. 2012..TNN is involved in neurite outgrowth and cell migration in hippocampal explants, and TNR is an extracellular matrix protein expressed primarily in the central nervous system... - Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence... - A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association studyLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 6:e26726. 2011..We conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder... - Population admixture modulates risk for alcohol dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
Hum Genet 125:605-13. 2009..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study... - Multiple ADH genes modulate risk for drug dependence in both African- and European-AmericansXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Hum Mol Genet 16:380-90. 2007..These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD... 
ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studiesXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 31:1085-95. 2006..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...- ADH1A variation predisposes to personality traits and substance dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD... - Association study of DTNBP1 with schizophrenia in a US sampleLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Psychiatr Genet 19:292-304. 2009..This study aimed to test the association in two common US populations by using powerful analytic methods... - Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sampleLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neuropsychopharmacology 34:1504-13. 2009..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs... - CHRM2 variation predisposes to personality traits of agreeableness and conscientiousnessXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Hum Mol Genet 16:1557-68. 2007..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD... - ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjectsXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared... - CNR1 variation modulates risk for drug and alcohol dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
Biol Psychiatry 62:616-26. 2007..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample... - Personality traits of agreeableness and extraversion are associated with ADH4 variationXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:599-608. 2007..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study... - ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studiesXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Pharmacogenet Genomics 15:755-68. 2005..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence... - CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association studyXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Hum Mol Genet 14:2421-34. 2005..In addition, a specific diplotype might inversely affect risk for AD and DD and risk for affective disorders... - Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populationsXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis... - Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependenceXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Am J Hum Genet 78:973-87. 2006..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes... - The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variationLingjun Zuo
Departments of Psychiatry, West Haven Campus, Connecticut, USA
Pharmacogenet Genomics 19:437-46. 2009..We hypothesized that DTNBP1 might also influence the response to antipsychotic treatments. This study aimed to investigate the relationship between the DTNBP1 and the effects of clozapine and haloperidol on refractory schizophrenia... - Rare ADH variant constellations are specific for alcohol dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Alcohol Alcohol 48:9-14. 2013..In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference... - Genome-Wide Significant Association Signals in IPO11-HTR1A Region Specific for Alcohol and Nicotine CodependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
Alcohol Clin Exp Res 37:730-9. 2013..Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors... - Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD testXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Behav Brain Funct 4:42. 2008..abstract:.. - CALCYON gene variation, schizophrenia, and cocaine dependenceXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 125:25-30. 2004..Furthermore, these findings begin to establish a haplotype map for this gene in the AA and EA populations...