Yong Zhu

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
    Yingying Mao
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA
    BMC Cancer 13:498. 2013
  2. pmc Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways
    Ran Liu
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China
    BMC Cell Biol 14:1. 2013
  3. pmc Advanced sleep schedules affect circadian gene expression in young adults with delayed sleep schedules
    Yong Zhu
    School of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Sleep Med 14:449-55. 2013
  4. doi request reprint Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis
    Aaron E Hoffman
    Corresponding Author Yong Zhu, Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 22:327-36. 2013
  5. pmc Epigenetic impact of long-term shiftwork: pilot evidence from circadian genes and whole-genome methylation analysis
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Chronobiol Int 28:852-61. 2011
  6. pmc The phylogeny of the social wasp subfamily Polistinae: evidence from microsatellite flanking sequences, mitochondrial COI sequence, and morphological characters
    Elisabeth Arevalo
    Department of Biology, Providence College, Providence, RI 02918 0001, USA
    BMC Evol Biol 4:8. 2004
  7. pmc Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH Room 702, New Haven, CT 06520, USA
    Breast Cancer Res Treat 107:421-5. 2008
  8. pmc Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 120:432-5. 2007
  9. pmc Does "clock" matter in prostate cancer?
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 15:3-5. 2006
  10. ncbi request reprint Period3 structural variation: a circadian biomarker associated with breast cancer in young women
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 14:268-70. 2005

Detail Information

Publications80

  1. ncbi request reprint Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
    Yingying Mao
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA
    BMC Cancer 13:498. 2013
    ..Recent studies have indicated that the circadian and cell cycle regulator, TIMELESS, may serve as a molecular bridge between these two regulatory systems...
  2. pmc Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways
    Ran Liu
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China
    BMC Cell Biol 14:1. 2013
    ..Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis...
  3. pmc Advanced sleep schedules affect circadian gene expression in young adults with delayed sleep schedules
    Yong Zhu
    School of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Sleep Med 14:449-55. 2013
    ..Human circadian rhythms are regulated by the interplay between circadian genes and environmental stimuli. The influence of altered sleep-wake schedules or light on human circadian gene expression patterns is not well characterized...
  4. doi request reprint Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis
    Aaron E Hoffman
    Corresponding Author Yong Zhu, Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 22:327-36. 2013
    ..miRNAs have been implicated in numerous tumorigenic pathways, and previous studies have associated miR-202 dysregulation with various cancer types, including follicular lymphoma...
  5. pmc Epigenetic impact of long-term shiftwork: pilot evidence from circadian genes and whole-genome methylation analysis
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Chronobiol Int 28:852-61. 2011
    ..Considering there are millions of shiftworkers worldwide, understanding the effects of this exposure may lead to novel strategies for cancer prevention and new policies regulating shiftwork...
  6. pmc The phylogeny of the social wasp subfamily Polistinae: evidence from microsatellite flanking sequences, mitochondrial COI sequence, and morphological characters
    Elisabeth Arevalo
    Department of Biology, Providence College, Providence, RI 02918 0001, USA
    BMC Evol Biol 4:8. 2004
    ..We used nuclear DNA microsatellite flanking sequences, mitochondrial COI sequence, and morphological characters to generate a phylogeny for the Polistinae (Hymenoptera) using 69 species...
  7. pmc Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH Room 702, New Haven, CT 06520, USA
    Breast Cancer Res Treat 107:421-5. 2008
    ..46-0.81, P = 0.001). This is the first evidence demonstrating a role of the circadian gene NPAS2 in human breast cancer, suggesting that genetic variations in circadian genes might be a novel panel of biomarkers for breast cancer risk...
  8. pmc Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 120:432-5. 2007
    ....
  9. pmc Does "clock" matter in prostate cancer?
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 15:3-5. 2006
    ..Confirmation of this hypothesis will add to our understanding of the role of the circadian clock in prostate tumorigenesis and further facilitate the development of novel risk and prognostic biomarkers for prostate cancer...
  10. ncbi request reprint Period3 structural variation: a circadian biomarker associated with breast cancer in young women
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 14:268-70. 2005
    ..7; 95% confidence interval, 1.0-3.0). Our finding suggests that the circadian genes might be a novel panel of potential biomarkers for breast cancer and worth further investigation...
  11. pmc Clock-cancer connection in non-Hodgkin's lymphoma
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
    Med Hypotheses 70:788-92. 2008
    ..Confirmation of this hypothesis will further add to our understanding of the role of the circadian clock in lymphomagenesis and facilitate the development of novel risk and prognostic biomarkers for NHL...
  12. pmc Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
    Mutat Res 639:80-8. 2008
    ..Our findings suggest that bioinformatic tools are useful in predicting SNP functionality and may facilitate future genetic epidemiological studies...
  13. pmc Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study
    Yong Zhu
    Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 69:9315-22. 2009
    ....
  14. pmc Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Breast Cancer Res 7:R745-52. 2005
    ..MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The present case-control study investigated associations between two single nucleotide polymorphisms (SNPs) in the MBD2 gene and breast cancer risk...
  15. pmc CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 70:1459-68. 2010
    ..Our findings support the hypothesis that circadian genes influence tumorigenesis, and identify a set of circadian gene variants as candidate breast cancer susceptibility biomarkers...
  16. pmc Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 69:3605-13. 2009
    ..75E(-9)) and hematologic disease (B-H P = 8.01E(-8)). In conclusion, both genetic association and functional analyses suggest that the circadian gene CRY2 may play an important role in NHL development...
  17. ncbi request reprint Telomere dysfunction: a potential cancer predisposition factor
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:1211-8. 2003
    ..Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies...
  18. doi request reprint Methylation alterations at imprinted genes detected among long-term shiftworkers
    Daniel I Jacobs
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA
    Environ Mol Mutagen 54:141-6. 2013
    ..We conclude that long-term shiftwork may alter methylation patterns at imprinted genes, which may be an important mechanism by which shiftwork has carcinogenic potential and warrants further investigation...
  19. pmc Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:110. 2010
    ..As such, aberrant expression of CRY2 may influence carcinogenic processes and thereby impact cancer susceptibility...
  20. pmc The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Prev Res (Phila) 3:539-48. 2010
    ..These findings suggest a role for CRY2 in breast tumorigenesis and provide further evidence that the circadian system may be an important modulator of hormone-related cancer susceptibility...
  21. pmc microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 69:5970-7. 2009
    ....
  22. pmc Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 8:15. 2007
    ....
  23. pmc Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma
    Yawei Zhang
    School of Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 170:1222-30. 2009
    ..A possible role of genetic variation in xenobiotic metabolism in the carcinogenicity of hair dye use needs to be confirmed in larger studies...
  24. ncbi request reprint A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 97:1616-8. 2005
    ..2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation...
  25. pmc Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women
    Rong Wang
    Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 169:176-85. 2009
    ..Results suggest an increased risk of NHL associated with occupational exposure to organic solvents for women...
  26. pmc The circadian gene NPAS2 is a novel prognostic biomarker for breast cancer
    Chunhui Yi
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, 06520, USA
    Breast Cancer Res Treat 120:663-9. 2010
    ..96, P = 0.020). These findings provide the first evidence suggesting prognostic significance of the circadian gene NPAS2 in breast cancer...
  27. doi request reprint Aberrant DNA methylation of miR-219 promoter in long-term night shiftworkers
    Fengqin Shi
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA
    Environ Mol Mutagen 54:406-13. 2013
    ....
  28. ncbi request reprint Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma
    Yawei Zhang
    Yale University School of Epidemiology and Public Health, New Haven, CT 06520 8034, USA
    Am J Epidemiol 165:1255-64. 2007
    ..0051). The risk appears to vary by non-Hodgkin's lymphoma subtypes. Further investigations of the role of ultraviolet radiation on the risk of non-Hodgkin's lymphoma are warranted...
  29. doi request reprint Genetic and epigenetic associations of circadian gene TIMELESS and breast cancer risk
    Alan Fu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Mol Carcinog 51:923-9. 2012
    ..Our findings support the hypothesized role of circadian genes in breast tumorigenesis, and identify a set of circadian biomarkers for breast cancer susceptibility...
  30. pmc The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cancer Res 6:1461-8. 2008
    ..Thus, NPAS2 may play a role in tumorigenesis by affecting expression of cancer-related genes and could be considered a novel tumor suppressor...
  31. pmc Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis
    Chun Hui Yi
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
    Cancer Lett 284:149-56. 2009
    ..These results report the first list of direct transcriptional targets of NPAS2 and will shed light on the role of circadian genes in tumorigenesis...
  32. ncbi request reprint An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2251-7. 2004
    ..Using such a molecular evolutionary approach may hold great promise for prioritizing SNPs to be genotyped in future molecular epidemiological studies...
  33. ncbi request reprint Benzo[a]pyrene diol epoxide-induced 9p21 aberrations associated with genetic predisposition to bladder cancer
    Aditi Hazra
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Genes Chromosomes Cancer 41:330-8. 2004
    ..04, 5.69), 5.14 (1.12, 23.59), and 21.51 (4.75, 97.34), respectively, providing increasing dose-response evidence of the locus-specific alterations. Thus, 9p21 may be a molecular target for BPDE-induced damage in bladder cancer cases...
  34. ncbi request reprint Methyl-CpG-binding domain 2: a protective role in bladder carcinoma
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1853-8. 2004
    ..In the current case-control study, the authors investigated the association between MBD2 expression and bladder carcinoma risk...
  35. ncbi request reprint Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes
    Stella Koutros
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 20852, USA
    Am J Epidemiol 167:287-94. 2008
    ..lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL...
  36. ncbi request reprint Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma
    Yawei Zhang
    Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, New Haven, CT 06520, USA
    Cancer Causes Control 18:351-9. 2007
    ..The relationship between family history of specific hematopoietic and non-hematopoietic malignancies and the risk of NHL and by NHL subtypes are unclear...
  37. pmc Dysregulated methylation at imprinted genes in prostate tumor tissue detected by methylation microarray
    Daniel I Jacobs
    Yale School of Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Urol 13:37. 2013
    ..While loss of imprinting (LOI) has been reported for two genes in prostate cancer (IGF2 and TFPI2), disease-related changes in methylation across all imprinted gene regions has not been investigated...
  38. pmc A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973-2004
    Cairong Zhu
    Yale University School of Public Health, New Haven, Connecticut 06520, USA
    Thyroid 19:1061-6. 2009
    ....
  39. ncbi request reprint Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women
    Yawei Zhang
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, CT 06510, USA
    Am J Epidemiol 160:1177-83. 2004
    ..In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk...
  40. ncbi request reprint Occupational and leisure-time physical activity and risk of colon cancer by subsite
    Yawei Zhang
    Yale University School of Public Health, New Haven, Connecticut, USA
    J Occup Environ Med 48:236-43. 2006
    ..Studies of physical activity and colon cancer risk by anatomic site have provided inconsistent results...
  41. doi request reprint Lymphoma survival patterns by WHO subtype in the United States, 1973-2003
    Xuesong Han
    Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Causes Control 19:841-58. 2008
    ..The differences in lymphoma survival patterns suggest that distinct prognostic risk factors impact survival by subtype and that future research and public health interventions should address racial disparities in lymphoma survivorship...
  42. ncbi request reprint Role of one-carbon metabolizing pathway genes and gene-nutrient interaction in the risk of non-Hodgkin lymphoma
    Qian Li
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06510, USA
    Cancer Causes Control 24:1875-84. 2013
    ..However, the results have been inconsistent. The objectives of this study were to examine the potential relationship between gene-nutrient interactions and the risk of non-Hodgkin lymphoma (NHL)...
  43. ncbi request reprint From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..To our knowledge, this is the largest study conducted evaluating the functional relevance of these polymorphisms...
  44. ncbi request reprint Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:1408-15. 2005
    ..Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome of bladder cancer treatment...
  45. ncbi request reprint A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 102:536-40. 2002
    ..67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer...
  46. doi request reprint Genome-wide methylation analysis identifies involvement of TNF-α mediated cancer pathways in prostate cancer
    Sun Jung Kim
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Cancer Lett 302:47-53. 2011
    ..These findings may lend credence to the possibility of using tumor-specific alterations in methylation patterns as biomarkers in estimating prognosis and assessing treatment options for prostate cancer...
  47. pmc A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
    Lena J Chin
    Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
    Cancer Res 68:8535-40. 2008
    ..The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility...
  48. pmc Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 7:68. 2006
    ....
  49. ncbi request reprint Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation
    Jinliang Xing
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1304, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:606-9. 2007
    ..Our findings provide the first evidence linking the mutagen-induced telomerase activity in peripheral blood lymphocytes to the risk of bladder cancer, which warrants further investigation in large-sized studies and other cancer types...
  50. doi request reprint Let-7a regulation of insulin-like growth factors in breast cancer
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 126:687-94. 2011
    ..Let-7a may up-regulate the expression of IGFs in cancer cells, which is different from its inhibitory effects on other oncogenes...
  51. ncbi request reprint Death receptor 4 and bladder cancer risk
    Aditi Hazra
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:1157-9. 2003
    ....
  52. ncbi request reprint BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 95:563-8. 2002
    ..Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens...
  53. pmc Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma
    Aaron E Hoffman
    Department of Epidemiology, Tulane School of Public Health and Tropical Medicine and Tulane Cancer Center, New Orleans, LA, USA
    Cancer Epidemiol Biomarkers Prev 22:736-44. 2013
    ....
  54. ncbi request reprint Occupation and risk of pancreatic cancer: a population-based case-control study in iowa
    Yawei Zhang
    Yale University School of Public Health, New Haven, Connecticut 06520, USA
    J Occup Environ Med 47:392-8. 2005
    ..Previous epidemiological studies have inconsistently linked various occupations and industries to pancreatic cancer risk...
  55. pmc A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis
    Trupti Paranjape
    Department of Therapeutic Radiology, Yale University, New Haven, CT 06880, USA
    Lancet Oncol 12:377-86. 2011
    ..We aimed to investigate the association of this KRAS variant with breast cancer and tumour biology...
  56. ncbi request reprint Genetic instability of specific chromosomes associated with a family history of cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Genet Cytogenet 136:73-7. 2002
    ..These findings suggested that chromosome 4 mutagen sensitivity might be a predictor of familial susceptibility to cancer...
  57. ncbi request reprint Prenatal exposure to organochlorine pesticides and infant birth weight in China
    Huan Guo
    Yale School of Public Health, New Haven, CT 06510, USA School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
    Chemosphere 110:1-7. 2014
    ..Prenatal exposure to DDT, β-BHC, HCB, and mirex were associated with a decrease in birth weight, but these results need validation in larger sample-sized studies. ..
  58. ncbi request reprint Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 62:2813-8. 2002
    ..This is the first study to examine mutagen sensitivity in a premalignant condition. The next step is to correlate these findings in surrogate (lymphocyte) tissue with molecular events in the target tissue...
  59. ncbi request reprint Soup consumption is associated with a lower dietary energy density and a better diet quality in US adults
    Yong Zhu
    Department of Epidemiology, The University of Iowa, Iowa City, IA, USA
    Br J Nutr 111:1474-80. 2014
    ..001). The relationship between soup consumption and body weight could be due to a reduced dietary ED and an improved diet quality. Consumers need to pay attention to their Na intake and choose low-Na products for a healthier diet...
  60. doi request reprint Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors
    Yong Zhu
    Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China
    Arch Pharm Res 35:1723-32. 2012
    ..The structures of these new hydroxamic acids derivatives were confirmed by IR, (1)H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines...
  61. pmc Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  62. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  63. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  64. pmc Caspase polymorphisms and genetic susceptibility to multiple myeloma
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hematol Oncol 26:148-51. 2008
    ..The protective associations observed in two key caspase genes suggest that genetic variation in CASP genes may play an important role in the aetiology of multiple myeloma...
  65. ncbi request reprint Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma
    Deng Fu Yao
    Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China
    Hepatobiliary Pancreat Dis Int 4:220-6. 2005
    ....
  66. doi request reprint Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer
    Hushan Yang
    Department of Epidemiology and Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:2530-7. 2008
    ..92-fold (1.36-2.71) increased risk (P(trend) < 0.0001). Overall, this is the first epidemiologic study showing that miRNA-related genetic variants may affect bladder cancer risk individually and jointly...
  67. ncbi request reprint The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain
    Fei Liu
    Department of Immunology, 4th Military Medical University, Xi an City, Shannxi Province, PR China
    Mol Cell Biochem 232:163-7. 2002
    ..The interaction between gp130 and TLE1 indicated that molecules of TLE family might play a role in gp 130 signaling...
  68. ncbi request reprint A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    ..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
  69. ncbi request reprint [Denaturant gradient gel electrophoresis in the genetic diagnosis of hereditary multiple exostoses]
    Hong Bo He
    Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:323-7. 2007
    ..To detect the mutations of EXT2 gene in hereditary multiple exostoses (HME) families and to investigate the sensitivity of denaturant gradient gel electrophoresis (DGGE) in screening the mutations in EXT2 gene...
  70. ncbi request reprint Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis
    Yong Zhu
    Department of Biochemistry, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
    Cell Res 15:133-40. 2005
    ..This helps to explain why the drm1 exhibits a much more severe late-flowering phenotype than most late-flowering mutants reported. It also implies that the DRM1 might act upstream of these repressors...
  71. ncbi request reprint Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells
    Abhik Bandyopadhyay
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, TX 78229, USA
    Oncogene 21:3541-51. 2002
    ..These results for the first time indicate that the sRIII-induced tumor suppression appears to be in part due to the inhibition of angiogenesis...
  72. ncbi request reprint Distribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilage and growth plate
    Sherri R Davies
    Washington University School of Medicine at Barnes Jewish Hospital, Department of Orthopaedic Surgery, St Louis, Missouri 63110, USA
    J Histochem Cytochem 50:1059-65. 2002
    ..These immunohistochemical results are the first to localize both [delta]EF1 and AP-2 to adult articular, meniscal, and growth plate cartilages and provide in vivo correlation of previous molecular biological studies...
  73. ncbi request reprint Inhibition of proliferation and transforming growth factor beta3 protein expression by peroxisome proliferators-activated receptor gamma ligands in human uterine leiomyoma cells
    Chun hua Zhang
    Department of Obstetric and Gynecology, Shandong University Shandong Provincial Hospital, Jinan, Shandong 250021, China
    Chin Med J (Engl) 121:166-71. 2008
    ..However, it is not clear whether rosiglitazone affects the protein expression of transforming growth factor beta3 (TGF-beta3) and the cell proliferation in human uterine leiomyoma cells in vitro...
  74. pmc Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii
    Yong Zhu
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    BMC Microbiol 5:11. 2005
    ..Then, we selected a representative of each MLST genotype and used multi-spacer typing (MST) and mouse serotyping to estimate their degree of taxonomic relatedness...
  75. ncbi request reprint Re: No increased risk of non-Hodgkin's lymphoma with steroids, estrogens and psychotropics (Netherlands)
    Tongzhang Zheng
    Cancer Causes Control 15:433-4. 2004
  76. pmc Genotyping Rickettsia prowazekii isolates
    Yong Zhu
    University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 14:1300-2. 2008
    ..This method can be used to type and trace the origin of R. prowazekii isolated from samples collected during epidemics after a bioterrorism attack...
  77. ncbi request reprint Proposal to create subspecies of Rickettsia sibirica and an emended description of Rickettsia sibirica
    Pierre Edouard Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 1078:597-606. 2006
    ..sibirica subsp. nov. (type strain = 2-4-6, ATCC VR-541(T)), and R. sibirica subsp. mongolitimonae subsp. nov. (type strain = HA-91, ATCC VR-1526(T)). The description of R. sibirica is emended to accommodate the two subspecies...
  78. pmc Measurement of DNA mismatch repair activity in live cells
    Xiufen Lei
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Nucleic Acids Res 32:e100. 2004
    ..This method is potentially useful in comparing and monitoring MMR activity in live cells under various growth conditions...
  79. ncbi request reprint The effect of cyclooxygenase-2 inhibitors on spinal fusion
    John Long
    Department of Othopaedic Surgery, Barnes Jewish Hospital at Washington University St Louis, Missouri 63110, USA
    J Bone Joint Surg Am 84:1763-8. 2002
    ..We undertook this study to determine the effects of these more selective nonsteroidal anti-inflammatory drugs on spinal fusion in a rabbit model...
  80. pmc Use of highly variable intergenic spacer sequences for multispacer typing of Rickettsia conorii strains
    Pierre Edouard Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
    J Clin Microbiol 42:5757-66. 2004
    ..conorii isolates. Our study supports the usefulness of MST for strain genotyping. This tool may be useful for tracing a strain and identifying its source during outbreaks, including those resulting from bioterrorism...

Research Grants5

  1. Methylation Related Genes and Breast Cancer Risk
    Yong Zhu; Fiscal Year: 2004
    ..Given the availability of DNA samples and exposure data, this proposal is both time and cost effective in terms of practical feasibility. ..
  2. Circadian Genes and Breast Cancer
    Yong Zhu; Fiscal Year: 2004
    ..Given the availability of DNA samples and exposure data, this proposal is both time and cost effective in terms of practical feasibility. ..
  3. Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes
    Yong Zhu; Fiscal Year: 2009
    ..Findings from this study will enhance the use of SNPs in future phenotypic studies and molecular epidemiologic approaches to address questions related to gene-environment interaction in disease risk estimate. ..
  4. Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes
    Yong Zhu; Fiscal Year: 2007
    ..Findings from this study will enhance the use of SNPs in future phenotypic studies and molecular epidemiologic approaches to address questions related to gene-environment interaction in disease risk estimate. ..