Research Topics
| T ZhengSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal statusYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
Breast Cancer Res 7:R745-52. 2005..MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The present case-control study investigated associations between two single nucleotide polymorphisms (SNPs) in the MBD2 gene and breast cancer risk...- Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathwaysAaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
BMC Cancer 10:110. 2010..As such, aberrant expression of CRY2 may influence carcinogenic processes and thereby impact cancer susceptibility... - Breast cancer risk associated with congeners of polychlorinated biphenylsT Zheng
Department of Epidemiology, Yale University School of Public Health, New Haven, CT, USA
Am J Epidemiol 152:50-8. 2000..These results suggest that environmental exposure to PCBs may not substantially affect breast cancer risk... - Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancerT Zheng
Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
Eur J Cancer Prev 11:229-35. 2002..Radiation exposure from diagnostic X-rays was not associated with a significantly increased risk of breast cancer in this study... - Occupational risk factors for brain cancer: a population-based case-control study in IowaT Zheng
Yale University School of Public Health, New Haven, USA
J Occup Environ Med 43:317-24. 2001..Workers in industries with a potential for gasoline or motor exhaust exposures experienced a non-significant excess risk of brain glioma... - Occupation and bladder cancer: a population-based, case-control study in IowaTongzhang Zheng
Division of Environmental Health Science, Yale University School of Public Health, New Haven, Connecticut, USA
J Occup Environ Med 44:685-91. 2002..Housekeepers and butlers and workers in laundering and dry cleaning were also at increased risk. In conclusion, these results suggest that occupational exposures may play a significant role in the risk of bladder cancer... - Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphomaT Zheng
Yale University School of Public Health, USA
J Occup Environ Med 43:641-9. 2001..These results suggest an increased risk of NHL associated with carbamate pesticide use, particularly Sevin. Further investigation of the association is warranted... - Childhood asthma in Beijing, China: a population-based case-control studyTongzhang Zheng
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
Am J Epidemiol 156:977-83. 2002..8, 95% CI: 1.0, 3.2). An increased risk was also found for those having both a dog and a cat as pets (OR = 1.5, 95% CI: 1.0, 2.3) or for finding both cockroaches and rats inside their houses (OR = 1.8, 95% CI: 1.2, 2.8)... - Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)Tongzhang Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
Cancer Causes Control 13:637-45. 2002..We sought to determine if there is a gene-environment interaction between GSTM I (GSTM1A and GSTM1B), and GSTT1 genotypes and cigarette smoking in the risk of breast cancer... - Use of hair colouring products and breast cancer risk: a case-control study in ConnecticutT Zheng
Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
Eur J Cancer 38:1647-52. 2002..These data suggest that the use of hair colouring products does not have a major impact on the risk of breast cancer... - Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut womenTongzhang Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Am J Epidemiol 159:454-66. 2004..The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted... - Occupation and risk of pancreatic cancer: a population-based case-control study in iowaYawei Zhang
Yale University School of Public Health, New Haven, Connecticut 06520, USA
J Occup Environ Med 47:392-8. 2005..Previous epidemiological studies have inconsistently linked various occupations and industries to pancreatic cancer risk... - Environmental exposure to hexachlorobenzene (HCB) and risk of female breast cancer in ConnecticutT Zheng
Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Epidemiol Biomarkers Prev 8:407-11. 1999..1 (95% CI, 0.5-8.8) for the third tertile when compared with the lowest based on few subjects. Therefore, our study does not support a positive association between environmental exposure to HCB and risk of breast cancer... - Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2'-bis(p-chlorophenyl)ethyleneT Zheng
Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut 06520, USA
Cancer Epidemiol Biomarkers Prev 9:167-74. 2000..Our study does not support the hypothesis that DDE and PCBs, as encountered through environmental exposure, increase the risk of female breast cancer... - Exposure to electromagnetic fields from use of electric blankets and other in-home electrical appliances and breast cancer riskT Zheng
Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
Am J Epidemiol 151:1103-11. 2000..In conclusion, exposure to EMFs from in-home electrical appliance use was not found to increase breast cancer risk in this study... - Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer riskT Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College, New Haven, CT, USA
Br J Cancer 88:58-62. 2003..In conclusion, alcohol consumption may increase breast cancer risk among those who carry susceptible GST genotypes... - Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphomaYawei Zhang
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA
Am J Epidemiol 167:1321-31. 2008..1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded... - Lactation reduces breast cancer risk in Shandong Province, ChinaT Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
Am J Epidemiol 152:1129-35. 2000..02) and lifetime duration of lactation (p = 0.00). Further stratification by menopausal status resulted in the same conclusion. These data suggest that prolonged lactation reduces breast cancer risk... - Lactation and breast cancer risk: a case-control study in ConnecticutT Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College, New Haven, CT 06520, USA
Br J Cancer 84:1472-6. 2001..These results support an inverse association between breastfeeding and breast cancer risk... - Interferon gamma induction of pulmonary emphysema in the adult murine lungZ Wang
Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
J Exp Med 192:1587-600. 2000..IFN-gamma causes emphysema and alterations in pulmonary protease/antiprotease balance when expressed in pulmonary tissues... - A case-control study of occupation and breast-cancer risk in ConnecticutT Zheng
Yale University School of Medicine, Yale Cancer Center, New Haven, CT, USA
J Cancer Epidemiol Prev 7:3-11. 2002..Considering that teachers and librarians represent one of the largest single occupational groups among employed US women, further investigation of this association is warranted... - Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic miceZ Zhu
Section of Pulmonary and Critical Care Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8057, USA
Am J Respir Crit Care Med 164:S67-70. 2001..This system may be useful in defining the reversibility of transgene-induced airway remodeling responses... - Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol, and alpha-tocopherol in humansS T Mayne
Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06520 8034, USA
Am J Clin Nutr 68:642-7. 1998..Up to 5 y of daily supplementation with beta-carotene increased circulating concentrations of alpha- and beta-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or alpha-tocopherol... - Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among womenL M Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, 129 Church Street, Suite 700, New Haven, CT 06510, USA
Br J Cancer 89:2087-92. 2003..This research highlights the importance of distinguishing between NHL subtypes in future research on the aetiology of NHL... - Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic miceZ Zhu
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8057, USA
J Biol Chem 276:25222-9. 2001..Optimal "off/on" regulation of transgene expression can be accomplished with the combined use of tTS and rtTA... - IL-11: insights in asthma from overexpression transgenic modelingT Zheng
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Allergy Clin Immunol 108:489-96. 2001..Studies using transgenic mice also demonstrated that IL-11 inhibits antigen-induced tissue inflammation. Thus IL-11 might be an important regulator of inflammatory and remodeling responses in the asthmatic airway... - Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registriesG Zhu
Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital, Lanzhou Cancer Institute Hospital, Chinese Academy of Medical Sciences, Beijing Department of Occupational and Environmental Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China School of Public Health, Yale University, New Haven, Connecticut, USA
Dis Esophagus 25:505-11. 2012..Thus, randomized clinical trials to address the association of radiotherapy and the risk of secondary cancer are warranted... - Menarcheal and pubertal development and determining factors among schoolgirls in Kumasi, GhanaP M Opare-Addo
Department of Occupational and Environmental Medicine, Yale University, New Haven, CT, USA
J Obstet Gynaecol 32:159-65. 2012..32 years/decade. The predicting factors provide an important opportunity for intervention through school curricula and targeted education of adolescents... - Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysemaT Zheng
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
J Clin Invest 106:1081-93. 2000..They also demonstrate that IL-13 causes emphysema via a MMP- and cathepsin-dependent mechanism(s) and highlight common mechanisms that may underlie COPD and asthma... - Randomized trial of supplemental beta-carotene to prevent second head and neck cancerS T Mayne
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
Cancer Res 61:1457-63. 2001..If our results are replicated by other ongoing/completed trials, this suggests a critical need for mechanistic studies addressing differential responses in one epithelial site (head and neck) versus another (lung)... - Two-sample comparison based on prediction error, with applications to candidate gene association studiesK Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Ann Hum Genet 71:107-18. 2007..To illustrate the application of the proposed method in population-based association studies, we use the procedure to study the association between non-Hodgkin lymphoma and the IL10 gene... - Complete sequence and genome properties of Chinese wheat mosaic virus, a new furovirus from ChinaA Diao
Crop and Disease Management Department, IACR Rothamsted, Harpenden, Herts, UK
J Gen Virol 80:1141-5. 1999..A Cys-Gly ... Cys-Gly-X-X-His amino acid pattern was identified in the cysteine-rich protein of CWMV and those of several other plant virus genera, which seems likely to have some functional significance... - Ethanol-induced contractions in cerebral arteries: role of tyrosine and mitogen-activated protein kinasesZ W Yang
Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
Stroke 32:249-57. 2001..The results could be used to suggest that selective antagonists of protein tyrosine kinases and MAPK may be useful both prophylactically and therapeutically in alcohol-induced strokes... - Sex steroid hormones exert biphasic effects on cytosolic magnesium ions in cerebral vascular smooth muscle cells: possible relationships to migraine frequency in premenstrual syndromes and stroke incidenceW Li
Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
Brain Res Bull 54:83-9. 2001..In addition, our results demonstrate that female sex steroids but not testosterone (in physiologic concentrations) can exert direct effects on [Mg2+]i in cerebral vascular cells... - Antioxidants prevent ethanol-induced contractions of canine cerebral vascular smooth muscle: relation to alcohol-induced brain injuryW Li
Department of Physiology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Neurosci Lett 301:91-4. 2001..The present results, when viewed in light of other recently published data, suggest that antioxidants may prove useful in the amelioration and treatment of alcohol-induced brain damage and strokes... - Evaluation of the toxicity of concentrated barley beta-glucan in a 28-day feeding study in Wistar ratsB Delaney
Cargill Health and Food Technologies, 15407 McGinty Road West, MS110, Wayzata, MN 55391, USA
Food Chem Toxicol 41:477-87. 2003..Results of this study demonstrated that consumption of concentrated barley beta-glucan was not associated with any obvious signs of toxicity in Wistar rats even following consumption of large quantities... - Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscleZ W Yang
Department of Physiology and Pharmacology, Health Science Center at Brooklyn, State University of New York, Brooklyn, New York 11203, USA
Am J Physiol Heart Circ Physiol 280:H2144-52. 2001..This study suggests that activation of PKC isoforms and PI3Ks appears to be an important signaling pathway in ethanol-induced vasoconstriction of cerebral blood vessels... - Antioxidants prevent depletion of [Mg2+]i induced by alcohol in cultured canine cerebral vascular smooth muscle cells: possible relationship to alcohol-induced strokeW Li
Department of Physiology and Pharmacology, State University of New York, Health Science Centre at Brooklyn, Brooklyn, NY 11203, USA
Brain Res Bull 55:475-8. 2001.... - Importance of extracellular Ca2+ and intracellular Ca2+ release in ethanol-induced contraction of cerebral arterial smooth muscleZ Yang
Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Alcohol 24:145-53. 2001.... - Importance of magnesium ions in development of tolerance to ethanol: studies on cultured cerebral vascular smooth muscle cells, type-2 astrocytes and intact rat brainW Li
Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11023, USA
Brain Res Bull 56:153-8. 2001..The results suggest that [Mg(2+)](i) might play a major role in alcohol-induced tolerance in the brain... - Relationship between the renin-angiotensin system genes and diabetic nephropathy in the ChineseS Wu
Department of Endocrinology and Metabolism, Diabetes Research Laboratory and Medical Genetics Research Laboratory, Shanghai Sixth People s Hospital, Shanghai Second Medical University, Shanghai 200233, China
Chin Med J (Engl) 113:437-41. 2000..To clarify whether genetic variants of the renin-angiotensin system (RAS) contribute to the development of diabetic nephropathy (DN) in the Chinese...