Genomes and Genes
Affiliation: Yale University
- Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interactionZ Zhao
Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
Mech Dev 97:201-4. 2000..These data identify that RalA and RalB as inducible GTPases in the developing embryo...
- Expression of Dlx genes during the development of the murine dentitionZ Zhao
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Dev Genes Evol 210:270-5. 2000..The relationship of Dlx gene expression to their genomic organization suggests coordinate regulation of linked genes at early stages but regulatory differences at later stages...
- Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferationZhiyong Zhao
Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Dev Dyn 226:24-32. 2003..These observations show that ROCK kinases play a role in cardiac development and that ROCK kinases regulate cardiac cell proliferation and cell cycle protein expression...
- Rho-associated kinases play a role in endocardial cell differentiation and migrationZhiyong Zhao
Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
Dev Biol 275:183-91. 2004..Collectively, these data show that ROCKs play an essential role in endothelial cell differentiation and migration during endocardial cushion development...
- Involvement of c-Jun N-terminal kinases activation in diabetic embryopathyPeixin Yang
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
Biochem Biophys Res Commun 357:749-54. 2007..JNK activation itself is sufficient to induce embryonic anomalies, and thus mimics the teratogenic effect of hyperglycemia...
- Dietary vitamin and lipid therapy rescues aberrant signaling and apoptosis and prevents hyperglycemia-induced diabetic embryopathy in ratsE Albert Reece
Department of Obstetrics and Gynecology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Am J Obstet Gynecol 194:580-5. 2006....
- Nicotine-induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stressZhiyong Zhao
Department of Obstetrics and Gynecology, The Arkansas Center for Birth Defects Research and Prevention, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Birth Defects Res B Dev Reprod Toxicol 74:383-91. 2005..However, the role of nicotine in embryonic malformations has not been addressed, and the mechanisms by which nicotine affects embryonic development remain to be delineated...
- Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathwaysE Albert Reece
Department of Obstetrics and Gynecology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Am J Obstet Gynecol 192:967-72. 2005..The objective was to test the hypothesis that hyperglycemia-induced injury of yolk sac cell membranes is associated with disruption of cellular apoptotic signaling pathways...
- Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicingPhilippe Gascard
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 74-157, Berkeley CA 94720, USA
Biochim Biophys Acta 1680:71-82. 2004..We propose that first exon specification is coupled to downstream splicing events, generating 4.1B isoforms with diverse roles in kidney and brain physiology, and potentially unique functions in cell proliferation and tumor suppression...
- Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathyPeixin Yang
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Obstet Gynecol 198:130.e1-7. 2008..To establish a link between oxidative stress signaling and diabetic embryopathy, levels of phosphorylated-p66Shc (which is a key signaling molecule that mediates oxidative stress-induced apoptosis) were evaluated...