Research Topics
Genomes and Genes
Species | Yawei ZhangSummaryAffiliation: Yale University Country: USA Publications
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Publications
Changing patterns of bladder cancer in the USA: evidence of heterogeneous diseaseYawei Zhang
School of Public Health, Yale University, New Haven, CT 06520, USA
BJU Int 109:52-6. 2012..To test the hypothesis that bladder cancer is a heterogeneous disease...- Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in PennsylvaniaBriseis Aschebrook-Kilfoy
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Environ Health 11:6. 2012..Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function... 
Hair dye use and risk of human cancerYawei Zhang
Yale University School of Public Health, New Haven, CT 06520, USA
Front Biosci (Elite Ed) 4:516-28. 2012..Several methodological issues should also be considered in future studies including completed hair dye use information such as on timing, duration, frequency and type of hair dye product use...- A novel COMP mutation in a pseudoachondroplasia family of Chinese originLi Dai
National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, 20 Ren Min Nan Lu Section 3, Chengdu 610041, China
BMC Med Genet 12:72. 2011..Pseudoachondroplasia (PSACH) is caused exclusively by mutations in the gene for cartilage oligomeric matrix protein (COMP). Only a small number of studies have documented the clinical phenotype and genetic basis in Chinese PSACH patients... - Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysisYu Tong
Open laboratory, West China Second University Hospital, Sichuan University, Chengdu, PR China
BMC Med Genet 10:15. 2009.... - A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphomaYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
J Natl Cancer Inst 97:1616-8. 2005..2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation... - Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphomaYawei Zhang
Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, New Haven, CT 06520, USA
Cancer Causes Control 18:351-9. 2007..The relationship between family history of specific hematopoietic and non-hematopoietic malignancies and the risk of NHL and by NHL subtypes are unclear... - Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphomaYawei Zhang
School of Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
Am J Epidemiol 170:1222-30. 2009..A possible role of genetic variation in xenobiotic metabolism in the carcinogenicity of hair dye use needs to be confirmed in larger studies... - Ultraviolet radiation exposure and risk of non-Hodgkin's lymphomaYawei Zhang
Yale University School of Epidemiology and Public Health, New Haven, CT 06520 8034, USA
Am J Epidemiol 165:1255-64. 2007..0051). The risk appears to vary by non-Hodgkin's lymphoma subtypes. Further investigations of the role of ultraviolet radiation on the risk of non-Hodgkin's lymphoma are warranted... - Family history of cancer and risk of lung cancer among nonsmoking Chinese womenYawei Zhang
School of Epidemiology and Public Health, Yale University, 60 College Street, LEPH 440, New Haven, CT 06520, USA
Cancer Epidemiol Biomarkers Prev 16:2432-5. 2007..The associations were stronger when a sibling, rather than a parent, was affected. The apparent link between lung cancer risk and a family history of colorectal, stomach, and pancreas cancers may be worth further investigation... - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancerYawei Zhang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:353-8. 2006..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations... - Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphomaXuesong Han
Yale University School of Public Health, New Haven, CT 06520 8034, USA
Cancer Epidemiol Biomarkers Prev 18:1429-38. 2009..Our results suggest that genetic polymorphisms in oxidative stress pathway genes, especially in the NOS genes, modify the association between vegetable and fruit intake and risk of NHL... - Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survivalXuesong Han
Yale University School of Public Health, 60 College Street, New Haven, CT 06520 8034, USA
Am J Hematol 85:51-6. 2010..Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis... - Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphomaBriseis A Kilfoy
Department of Environmental Health Sciences, School of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
Am J Hematol 84:279-82. 2009..4; 95% CI 1.0-5.7), but a decreased risk for the variant G allele for CYP1B1 (OR = 0.6, 95% CI 0.4-1.0). Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL... - Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)Tongzhang Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
Cancer Causes Control 13:637-45. 2002..We sought to determine if there is a gene-environment interaction between GSTM I (GSTM1A and GSTM1B), and GSTT1 genotypes and cigarette smoking in the risk of breast cancer... - Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphomaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, EPS 8109, Bethesda, MD 20892 7240, USA
Hum Genet 121:161-8. 2007..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL... - Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut womenRong Wang
Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520 8034, USA
Am J Epidemiol 169:176-85. 2009..Results suggest an increased risk of NHL associated with occupational exposure to organic solvents for women... - Menstrual and reproductive factors and risk of non-Hodgkin's lymphoma among Connecticut womenYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
Am J Epidemiol 160:766-73. 2004..These findings support a reduced risk of non-Hodgkin's lymphoma associated with multiple pregnancies and an increased risk of non-Hodgkin's lymphoma associated with later age at menarche... - Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphomaKathryn Hughes Barry
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Epidemiol 173:404-13. 2011..77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings... - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studiesMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Br J Haematol 151:239-44. 2010..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL... - Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte developmentLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009..Replication of our findings and further study to identify functional SNPs are warranted... - Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphomaBriseis A Kilfoy
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Cancer Causes Control 21:127-33. 2010..We conclude that these findings require replication in larger studies and ultimately in pooled analyses... - Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in ConnecticutKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Hematol 85:560-3. 2010..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy... - Polymorphisms in immune function genes and non-Hodgkin lymphoma survivalBriseis Aschebrook-Kilfoy
School of Public Health, Yale University, New Haven, CT, USA
J Cancer Surviv 6:102-14. 2012..Given these biologic properties, there is reason to hypothesize that cytokine activity influences the pathogenesis of non-Hodgkin lymphoma (NHL)... - Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populationsQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Immunogenetics 59:839-52. 2007..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted... - Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2Aaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Res 69:3605-13. 2009..75E(-9)) and hematologic disease (B-H P = 8.01E(-8)). In conclusion, both genetic association and functional analyses suggest that the circadian gene CRY2 may play an important role in NHL development... - The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signalingAaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Cancer Prev Res (Phila) 3:539-48. 2010..These findings suggest a role for CRY2 in breast tumorigenesis and provide further evidence that the circadian system may be an important modulator of hormone-related cancer susceptibility... - Caspase polymorphisms and genetic susceptibility to multiple myelomaH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Hematol Oncol 26:148-51. 2008..The protective associations observed in two key caspase genes suggest that genetic variation in CASP genes may play an important role in the aetiology of multiple myeloma... - Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph ConsortiumChristine F Skibola
237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
Am J Epidemiol 171:267-76. 2010..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology... - Blood transfusion and risk of non-Hodgkin's lymphoma in Connecticut womenYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
Am J Epidemiol 160:325-30. 2004..In summary, the authors' findings do not support the hypothesis that allogeneic blood transfusion increases the risk of non-Hodgkin's lymphoma... - A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973-2004Cairong Zhu
Yale University School of Public Health, New Haven, Connecticut 06520, USA
Thyroid 19:1061-6. 2009.... - Vegetable and fruit intake and non-Hodgkin lymphoma survival in Connecticut womenXuesong Han
School of Public Health, Yale University, New Haven, CT, USA
Leuk Lymphoma 51:1047-54. 2010..Our study suggests that increasing vegetable and citrus fruit consumption could be a useful strategy to improve survival in NHL patients... - Family history of malignancies and risk of breast cancer: prospective data from the Shanghai women's health studyBriseis A Kilfoy
School of Epidemiology and Public Health, Yale University, New Haven, CT 06520 8034, USA
Cancer Causes Control 19:1139-45. 2008..The link between breast cancer risk and family history of cancers of the lung and esophagus, as well as leukemia, warrants further investigation... - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in ConnecticutMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
Hum Genet 119:659-68. 2006..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies... - Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma riskSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS ONE 4:e5360. 2009..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk... - Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphomaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
Blood 107:4101-8. 2006..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL... - Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Br J Haematol 153:341-50. 2011..This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis... - Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphomaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
Carcinogenesis 28:823-7. 2007..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL... 
Lymphoma survival patterns by WHO subtype in the United States, 1973-2003Xuesong Han
Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, P O Box 208034, New Haven, CT 06520 8034, USA
Cancer Causes Control 19:841-58. 2008..The differences in lymphoma survival patterns suggest that distinct prognostic risk factors impact survival by subtype and that future research and public health interventions should address racial disparities in lymphoma survivorship...- Identification of non-Hodgkin's lymphoma prognosis signatures using the CTGDR methodShuangge Ma
School of Public Health, Yale University, New Haven, CT 06510, USA
Bioinformatics 26:15-21. 2010..We propose using resampling methods to evaluate the predictive power and reproducibility of identified genes and SNPs. Simulation study and data analysis suggest satisfactory performance of the CTGDR method... - Common variants in genes that mediate immunity and risk of multiple myelomaElizabeth E Brown
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Int J Cancer 120:2715-22. 2007..Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM... - CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analysesAaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Res 70:1459-68. 2010..Our findings support the hypothesis that circadian genes influence tumorigenesis, and identify a set of circadian gene variants as candidate breast cancer susceptibility biomarkers... - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Carcinogenesis 30:275-81. 2009..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL... - Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States womenYawei Zhang
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Cancer Causes Control 15:419-28. 2004..CONCLUSION: A relationship between certain prior medical conditions and medication use and risk of NHL was observed in this study. Further studies are warranted to confirm our findings... - Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut womenYawei Zhang
Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, CT 06510, USA
Am J Epidemiol 160:1177-83. 2004..In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk... - Genetic polymorphisms in oxidative stress pathway genes and modification of BMI and risk of non-Hodgkin lymphomaChristopher Kim
Yale University School of Public Health, New Haven, CT 06520, USA
Cancer Epidemiol Biomarkers Prev 21:866-8. 2012.... - Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer riskYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH Room 702, New Haven, CT 06520, USA
Breast Cancer Res Treat 107:421-5. 2008..46-0.81, P = 0.001). This is the first evidence demonstrating a role of the circadian gene NPAS2 in human breast cancer, suggesting that genetic variations in circadian genes might be a novel panel of biomarkers for breast cancer risk... - Alcohol consumption and non-Hodgkin lymphoma survivalXuesong Han
School of Public Health, Yale University, New Haven, CT 06520, USA
J Cancer Surviv 4:101-9. 2010..Alcohol drinking has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption on NHL survival by type of alcohol consumed and NHL subtype... - Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Blood 114:264-7. 2009..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis... - Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States)Lindsay McOmber Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Causes Control 14:687-94. 2003..The reduction in risk of NHL associated with increased duration of wine consumption warrants further investigation in other populations... - Hair-coloring product use and risk of non-Hodgkin's lymphoma: a population-based case-control study in ConnecticutYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
Am J Epidemiol 159:148-54. 2004..Further studies are warranted to show whether the observed association reflects the change in hair dye formula contents during the past two decades or indicates that recent users are still in their induction and latent periods... - Hepatitis C virus and risk of non-Hodgkin lymphoma: a population-based case-control study among Connecticut womenLindsay McOmber Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Cancer Epidemiol Biomarkers Prev 13:425-30. 2004.... - Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphomaYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Int J Cancer 120:432-5. 2007.... - Occupation and risk of pancreatic cancer: a population-based case-control study in iowaYawei Zhang
Yale University School of Public Health, New Haven, Connecticut 06520, USA
J Occup Environ Med 47:392-8. 2005..Previous epidemiological studies have inconsistently linked various occupations and industries to pancreatic cancer risk... - International patterns and trends in thyroid cancer incidence, 1973-2002Briseis A Kilfoy
Yale School of Public Health, Yale University, 60 College Street, LEPH 440, P O Box 208034, New Haven, CT 06520, USA
Cancer Causes Control 20:525-31. 2009.... - Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphomaYawei Zhang
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA
Am J Epidemiol 167:1321-31. 2008..1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded... - Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut womenTongzhang Zheng
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Am J Epidemiol 159:454-66. 2004..The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted... - Risk of non-Hodgkin lymphoma and nitrate and nitrite from the diet in Connecticut womenBriseis A Kilfoy
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, EPS, Room 8111, 6120 Executive Boulevard, Rockville, MD, 20852 7244, USA
Cancer Causes Control 21:889-96. 2010..We conclude that these results should be replicated in a larger study with data on drinking water as well as dietary sources of nitrate intake... - Genetic variation in cell cycle and apoptosis related genes and multiple myeloma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
Leuk Res 33:1609-14. 2009..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies... - Quality of life among testicular cancer survivors: a case-control study in the United StatesChristopher Kim
Yale School of Public Health, Yale University, 60 College Street, LEPH 440, New Haven, CT 06520, USA
Qual Life Res 20:1629-37. 2011..Evidence from previous studies has suggested there may be physical and mental changes in health among testicular cancer survivors. No studies have been conducted in the United States, however... - Fertility among testicular cancer survivors: a case-control study in the U.SChristopher Kim
Yale University, New Haven, CT 06520, USA
J Cancer Surviv 4:266-73. 2010..Although TGCT treatment directly affects gonadal tissues, it remains unclear whether there are long-term effects on fertility... - Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal statusYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
Breast Cancer Res 7:R745-52. 2005..MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The present case-control study investigated associations between two single nucleotide polymorphisms (SNPs) in the MBD2 gene and breast cancer risk... - Occupational and leisure-time physical activity and risk of colon cancer by subsiteYawei Zhang
Yale University School of Public Health, New Haven, Connecticut, USA
J Occup Environ Med 48:236-43. 2006..5; 95% confidence interval, 0.3-0.8). CONCLUSIONS: Increased physical activity was inversely associated with colon cancer risk. The inverse associations were stronger for the right than for the left colon... - Variation in innate immunity genes and risk of multiple myelomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD, USA
Hematol Oncol 29:42-6. 2011..0 × 10(-5) , P(permutation) = 0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies... - A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Br J Haematol 152:721-6. 2011.... - Sexual functioning among testicular cancer survivors: a case-control study in the U.SChristopher Kim
Yale School of Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
J Psychosom Res 73:68-73. 2012..We conducted a case-control study among United States military men to examine whether testicular cancer survivors experienced impaired sexual function... - Polymorphisms in complement system genes and risk of non-Hodgkin lymphomaBryan A Bassig
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
Environ Mol Mutagen 53:145-51. 2012..Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings... - Polymorphisms in integrin genes and lymphoma riskMin Shen
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7240, USA
Leuk Res 35:968-70. 2011..01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations... - Maternal smoking and testicular germ cell tumorsKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 15:1820-4. 2006..Other early life exposures, however, may explain the familial clustering of lung cancer in mothers and TGCT in sons... - A population-based case-control study of occupation and renal cell carcinoma risk in IowaYawei Zhang
Yale University School of Public Health, New Haven, Connecticut, USA
J Occup Environ Med 46:235-40. 2004..1-11.3); colleges and universities (OR 7.6-95% CI = 2.3-25.6); and retail, including those in grocery stores (OR 2.2, 95% CI = 1.0-4.7). Our results indicate that occupational exposures may increase the risk of renal cell carcinoma... - Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypesStella Koutros
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 20852, USA
Am J Epidemiol 167:287-94. 2008..lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL... - Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic toolsYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
Mutat Res 639:80-8. 2008..Our findings suggest that bioinformatic tools are useful in predicting SNP functionality and may facilitate future genetic epidemiological studies... - Occupation and risk of non-Hodgkin's lymphoma and chronic lymphocytic leukemiaTongzhang Zheng
Division of Environmental Health Science, Yale University School of Public Health, New Haven, CT, USA
J Occup Environ Med 44:469-74. 2002..These data suggest that the workers employed in these industries or occupations experienced an increased risk of NHL and CLL, and the risks associated with these industries or occupations may vary by histological type of NHL... - Occupation and bladder cancer: a population-based, case-control study in IowaTongzhang Zheng
Division of Environmental Health Science, Yale University School of Public Health, New Haven, Connecticut, USA
J Occup Environ Med 44:685-91. 2002..Housekeepers and butlers and workers in laundering and dry cleaning were also at increased risk. In conclusion, these results suggest that occupational exposures may play a significant role in the risk of bladder cancer... - Childhood asthma in Beijing, China: a population-based case-control studyTongzhang Zheng
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
Am J Epidemiol 156:977-83. 2002..8, 95% CI: 1.0, 3.2). An increased risk was also found for those having both a dog and a cat as pets (OR = 1.5, 95% CI: 1.0, 2.3) or for finding both cockroaches and rats inside their houses (OR = 1.8, 95% CI: 1.2, 2.8)... - Period3 structural variation: a circadian biomarker associated with breast cancer in young womenYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Cancer Epidemiol Biomarkers Prev 14:268-70. 2005..7; 95% confidence interval, 1.0-3.0). Our finding suggests that the circadian genes might be a novel panel of potential biomarkers for breast cancer and worth further investigation... - Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)... - Does "clock" matter in prostate cancer?Yong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Cancer Epidemiol Biomarkers Prev 15:3-5. 2006..Confirmation of this hypothesis will add to our understanding of the role of the circadian clock in prostate tumorigenesis and further facilitate the development of novel risk and prognostic biomarkers for prostate cancer... - Risk of multiple myeloma following medication use and medical conditions: a case-control study in Connecticut womenOla Landgren
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
Cancer Epidemiol Biomarkers Prev 15:2342-7. 2006..We conducted a population-based case-control study to investigate the role of medical history in the etiology of multiple myeloma among Connecticut women... - microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysisAaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Res 69:5970-7. 2009.... - Through the looking glass at early-life exposures and breast cancer riskMichele R Forman
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Invest 23:609-24. 2005..Events and secular trends influencing birth cohorts may not be adequately addressed, thereby limiting the interpretation and implications of the findings. Research in nonhuman primates may help uncover underlying mechanisms... - Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)Sophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Blood 109:3479-88. 2007..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology... - Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology ConsortiumSilvia de Sanjose
Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d Investigacio Biomedica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain
Clin Gastroenterol Hepatol 6:451-8. 2008..We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection... - Regular use of hair dyes and risk of lymphoma in SpainYolanda Benavente
Servei d'Epidemiologia and Registre del Cancer, IDIBELL, Institut Catala d'Oncologia, Barcelona, Spain
Int J Epidemiol 34:1118-22. 2005..3, 95% CI 1.1-4.7). The risk of CLL increased with lifetime doses received. CONCLUSIONS: Ever use of hair dye products is unlikely to substantially modify the risk of lymphoma. The observed association with CLL needs to be replicated... - Older age predicts a decline in adjuvant chemotherapy recommendations for patients with breast carcinoma: evidence from a tertiary care cohort of chemotherapy-eligible patientsAngela DeMichele
Division of Hematology Oncology, Department of Medicine, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 97:2150-9. 2003.... - A time-to-prescription-refill measure of antiretroviral adherence predicted changes in viral load in HIVRobert Grossberg
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 57:1107-10. 2004..The goal of this study was to determine the validity and utility of a pharmacy-based time-to-refill measure of antiretroviral therapy adherence... - Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNAZhongxing Liang
Department of Radiology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Biochem Biophys Res Commun 363:542-6. 2007..These data support the conclusion that miRNA against CXCR4 can serve as an alterative means of therapy to lower CXCR4 expression and to block the invasion and metastasis of breast cancer cells... - Facility-level variation in antibiotic prescriptions for veterans with upper respiratory infectionsSherrie L Aspinall
Center for Health Equity Research and Promotion, Veterans Affairs Healthcare System, Pittsburgh, USA
Clin Ther 27:258-62. 2005..Organizational factors, such as time pressure, may be important targets for future interventions designed to reduce inappropriate antibiotic use in ambulatory care settings... - Re: No increased risk of non-Hodgkin's lymphoma with steroids, estrogens and psychotropics (Netherlands)Tongzhang Zheng
Cancer Causes Control 15:433-4. 2004 - Pattern of lymph node metastases in patients with squamous cell carcinoma of the thoracic esophagus who underwent three-field lymphadenectomyHecheng Li
Department of Thoracic Surgery, Cancer Hospital of Fudan University, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Eur Surg Res 39:1-6. 2007..The purpose of the present study was to explore the pattern of lymph node metastasis and factors that are correlated with lymph node metastasis in patients with esophageal cancer who underwent three-field lymphadenectomy... - Changing incidence of thyroid cancerYawei Zhang
JAMA 296:1350; author reply 1350. 2006
Research Grants
- Quality of Life of Testicular Cancer SurvivorsYawei Zhang; Fiscal Year: 2007..The increasing incidence of TC in young men, and the high survival rate, makes understanding the morbidity associated with TC survival a public health priority. ..