Huiping Zhang

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e65648. 2013
  2. pmc Array-based profiling of DNA methylation changes associated with alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 37:E108-15. 2013
  3. pmc Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 57:670-5. 2012
  4. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
  5. pmc Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 55:278-84. 2010
  6. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
  7. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
  8. pmc Identification of POMC exonic variants associated with substance dependence and body mass index
    Fan Wang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e45300. 2012
  9. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
  10. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008

Collaborators

Detail Information

Publications24

  1. pmc Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e65648. 2013
    ..Our findings suggest that CA could induce population-specific methylation alterations in the promoter regions of specific genes, thus leading to changes in gene transcription and an increased risk for AD and other disorders...
  2. pmc Array-based profiling of DNA methylation changes associated with alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 37:E108-15. 2013
    ..Epigenetic regulation through DNA methylation may influence vulnerability to numerous disorders, including alcohol dependence (AD)...
  3. pmc Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 57:670-5. 2012
    ..6%) (P=0.049). Sex and CA did not significantly influence OPRM1 promoter methylation levels. Our findings suggest that OPRM1 promoter hypermethylation may increase the risk for AD and other substance dependence disorders...
  4. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
    ..Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence...
  5. pmc Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 55:278-84. 2010
    ..These results suggest that the minor G-allele of SNP rs569356 may enhance transcription factor binding and increase OPRD1 expression...
  6. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  7. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis...
  8. pmc Identification of POMC exonic variants associated with substance dependence and body mass index
    Fan Wang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e45300. 2012
    ..Risk of substance dependence (SD) and obesity has been linked to the function of melanocortin peptides encoded by the proopiomelanocortin gene (POMC)...
  9. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  10. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
    ..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared...
  11. doi request reprint BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study
    Kristina F Zdanys
    Alzheimer s Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    J Alzheimers Dis 17:887-98. 2009
    ..The effect of the Val66Met polymorphism on premorbid educational attainment is intriguing and should be verified in a larger sample...
  12. pmc Variation in NGFB is associated with primary affective disorders in women
    Donghong Cui
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 156:401-12. 2011
    ..07, P = 4.2E-05). No SNPs or haplotypes were associated with PAFDs in men or with CAFDs in either sex. We conclude that variation in NGFB is a risk factor for PAFDs in women, but not for CAFD...
  13. pmc Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2508-16. 2009
    ..We conclude that variation in KIBRA influences cognitive flexibility in a population-specific way, and that current smoking status moderates this effect...
  14. pmc Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 35:2211-24. 2010
    ..These findings could account in part for differences in ND risk associated with these variants in AAs and EAs...
  15. pmc Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:669-76. 2012
    ..80, 95% CI=1.18-2.73, P=0.0044; FTND: OR=1.79, 95% CI=1.11-2.88, P=0.012). No interaction was found in women. This study provides evidence of a sex-specific gene × environment effect of CHRNA5 and childhood adversity on the risk for ND...
  16. pmc Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 141:387-93. 2006
    ..The negative results for AFDs, PTSD, and schizophrenia could be due to the low statistical power. Further study with larger samples is warranted...
  17. ncbi request reprint Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Pharmacogenet Genomics 17:1031-8. 2007
    ....
  18. ncbi request reprint CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:1557-68. 2007
    ..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD...
  19. pmc A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence
    Fan Wang
    Department of Psychiatry, Yale University School of Medicine, VA Medical Center 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
    Hum Genet 132:347-58. 2013
    ..In summary, this large-scale meta-analysis confirmed the association between the Taq1A polymorphism and AD. Future studies are required to investigate the functional significance of the ANKK1/DRD2 Taq1A polymorphism in AD...
  20. ncbi request reprint Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study
    Joel Gelernter
    VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 31:555-63. 2007
    ..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)...
  21. pmc Child abuse and epigenetic mechanisms of disease risk
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Prev Med 44:101-7. 2013
    ..Little is currently known about the mechanism by which early adversity confers risk for health problems later in life...
  22. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  23. pmc Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain
    Jacqueline M Barker
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 37:E101-7. 2013
    ..It is unclear whether DNA methylation changes in alcoholics result directly from alcohol consumption or predated the occurrence of alcohol abuse or dependence and whether altered DNA methylation influences gene expression...
  24. pmc Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis
    Hexin Chen
    The Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Cancer Res 68:3637-44. 2008
    ..Our data show, for the first time, that deregulated expression of Hoxb7 in mammary tumor cells can significantly modulate HER-2/neu-oncogene induced tumorigenesis in vivo...

Research Grants2

  1. Association and Function of Opioid Receptor Gene Variants to Substance Dependence
    Huiping Zhang; Fiscal Year: 2007
    ..Joel Gelernter (primary) and Dr. Jeffrey Gruen (co-mentor), who are both excellent supervisors with substantial experience in genetic studies of complex disorders and who have both mentored numerous previous trainees. ..