Heping Zhang

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium
    Ru Sun
    Department of Surgery, Yale University, New Haven, CT 06520 8062, USA
    Mol Vis 14:2237-62. 2008
  2. pmc Novel tree-based method to generate markers from rare variant data
    Yuan Jiang
    Department of Epidemiology and Public Health, Yale School of Public Health, School of Medicine, Yale University, 60 College Street, PO Box 208034, New Haven, CT 06520 8034, USA
    BMC Proc 5:S102. 2011
  3. pmc A LASSO-based approach to analyzing rare variants in genetic association studies
    Jennifer S Brennan
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Proc 5:S100. 2011
  4. pmc Cell and tumor classification using gene expression data: construction of forests
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Proc Natl Acad Sci U S A 100:4168-72. 2003
  5. pmc Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Hum Reprod 25:2612-21. 2010
  6. pmc Willows: a memory efficient tree and forest construction package
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    BMC Bioinformatics 10:130. 2009
  7. ncbi request reprint Guideline for data analysis of genomewide association studies
    Heping Zhang
    Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Cancer Genomics Proteomics 4:27-34. 2007
  8. ncbi request reprint Mixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve data
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Stat Methods Med Res 13:63-82. 2004
  9. ncbi request reprint DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
  10. pmc Linkage analysis of longitudinal data and design consideration
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    BMC Genet 7:37. 2006

Research Grants

  1. RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGING
    Stanislav Kasl; Fiscal Year: 2007
  2. RESEARCH TRAINING IN MENTAL HEALTH EPIDEMIOLOGY
    Heping Zhang; Fiscal Year: 2007
  3. Data Coordination Center for the RMN
    Heping Zhang; Fiscal Year: 2007
  4. Analysis of Genomic Data for Complex Traits
    Heping Zhang; Fiscal Year: 2009
  5. Data Management, Statistics, and informatics Core
    Heping Zhang; Fiscal Year: 2007
  6. Methodological Research on Substance Use
    Heping Zhang; Fiscal Year: 2007
  7. PATHWAYS TO ALCOHOLISM THROUGH PSYCHOPATHOLOGY
    Heping Zhang; Fiscal Year: 2001
  8. STATISTICAL METHODS FOR CORRELATED SUBSTANCE USE DATA
    Heping Zhang; Fiscal Year: 2003
  9. Statistical Methods in Genetic Studies of Substance Use
    Heping Zhang; Fiscal Year: 2007
  10. Analysis of Genomic Data for Complex Traits
    Heping Zhang; Fiscal Year: 2010

Collaborators

Detail Information

Publications79

  1. pmc Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium
    Ru Sun
    Department of Surgery, Yale University, New Haven, CT 06520 8062, USA
    Mol Vis 14:2237-62. 2008
    ..We examined whether retinal secretions that increase the barrier functions of tight junctions in vitro also make gene expression in general more in vivo-like...
  2. pmc Novel tree-based method to generate markers from rare variant data
    Yuan Jiang
    Department of Epidemiology and Public Health, Yale School of Public Health, School of Medicine, Yale University, 60 College Street, PO Box 208034, New Haven, CT 06520 8034, USA
    BMC Proc 5:S102. 2011
    ..We correctly identify the association between gene FLT1 and phenotype Affect, although there exist other false positives in our results. Our analyses are performed without knowledge of the underlying simulating model...
  3. pmc A LASSO-based approach to analyzing rare variants in genetic association studies
    Jennifer S Brennan
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Proc 5:S100. 2011
    ..Our method identified 38 markers (in 65 genes) that are significantly associated with the phenotype Affected and correctly identified two causal genes, SIRT1 and PDGFD...
  4. pmc Cell and tumor classification using gene expression data: construction of forests
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Proc Natl Acad Sci U S A 100:4168-72. 2003
    ..In addition to numerical improvement, the main advantage of deterministic forests is reproducibility and scientific interpretability of all steps in tree construction...
  5. pmc Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Hum Reprod 25:2612-21. 2010
    ..g. genetic markers), there is still much utility in exploring whether it is possible to estimate treatment efficacy based on demographic and baseline variables...
  6. pmc Willows: a memory efficient tree and forest construction package
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    BMC Bioinformatics 10:130. 2009
    ..However, they cannot deal with the data generated by recent genotyping platforms for single nucleotide polymorphisms due to the massive size of the data and its excessive memory demand...
  7. ncbi request reprint Guideline for data analysis of genomewide association studies
    Heping Zhang
    Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Cancer Genomics Proteomics 4:27-34. 2007
    ..This review is purposely meant to be relatively short and of practical use for the space constraints of typical federal grant proposals...
  8. ncbi request reprint Mixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve data
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Stat Methods Med Res 13:63-82. 2004
    ..The analysis of a real example is also presented to illustrate the application and interpretation of MASAL. Open questions are posed for further investigation...
  9. ncbi request reprint DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
    ..Although the heritability of nicotine dependence (ND) is well documented and many candidate genetic regions have been identified, few of them were confirmed. This may be, in part, due to analytic methods that sacrifice power...
  10. pmc Linkage analysis of longitudinal data and design consideration
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    BMC Genet 7:37. 2006
    ..So far, little attention has been paid to examine the relationship among key factors in genetic longitudinal studies including power, the number of families or sibships, and the number of repeated measures per individual subjects...
  11. pmc Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, CT 06520 8034, USA
    BMC Genet 6:S118. 2005
    ..Our multivariate linkage analysis found linkage evidence on two regions on chromosome 4: around marker GABRB1 at 51.4 cM and marker FABP2 at 116.8 cM (unadjusted p-value = 0.00006)...
  12. pmc Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Am J Hum Genet 59:951-7. 1996
    ..The degree of saving in the required sample sizes varies among different models and allele frequencies. The reduction is most dramatic (a 28-fold reduction) for a rare recessive gene...
  13. pmc Detection of genes for ordinal traits in nuclear families and a unified approach for association studies
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Genetics 172:693-9. 2006
    ..We further demonstrated the advantage of our test by revealing a significant association (P = 0.00067) between alcohol dependence and a SNP in the growth-associated protein 43...
  14. ncbi request reprint A frailty model of segregation analysis: understanding the familial transmission of alcoholism
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Biometrics 56:815-23. 2000
    ..Moreover, females manifest alcoholism at a lower threshold, and there is no sex-specific familial transmission of alcoholism after adjustment for the threshold effect...
  15. ncbi request reprint Use of classification trees for association studies
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Genet Epidemiol 19:323-32. 2000
    ..Our purpose is to demonstrate the great potential of tree-based analyses for genetic studies, and discuss some issues that warrant further investigation...
  16. ncbi request reprint Strategies to identify genes for complex diseases
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Ann Med 29:493-8. 1997
    ....
  17. ncbi request reprint Binary regression for risks in excess of subject-specific thresholds
    H Zhang
    Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
    Biometrics 55:1247-51. 1999
    ..We estimate parameters from both the tolerance distribution and the risk function for a large group of mice exposed to very low levels of a known carcinogen...
  18. ncbi request reprint Analysis of infant growth curves using multivariate adaptive splines
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biometrics 55:452-9. 1999
    ..In addition to the fitting of growth curves, we demonstrate particularly how to explore and estimate the underlying covariance structures for the longitudinal data that were collected from a rather irregular schedule...
  19. pmc Recursive partitioning for tumor classification with gene expression microarray data
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Proc Natl Acad Sci U S A 98:6730-5. 2001
    ..In addition, competing classification trees are displayed, which suggest that different genes may coregulate colon cancers...
  20. pmc Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome
    Heping Zhang
    Department of Epidemiology and Public Health, Yale Child Study Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hum Genet 70:896-904. 2002
    ..000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of.0001 for genomewide scans...
  21. ncbi request reprint Tree-based analysis of microarray data for classifying breast cancer
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Front Biosci 7:c63-7. 2002
    ..1) and has been shown by others to have altered expression levels in breast cancer. Nonetheless, our identified genes warrant further investigation as to whether they play a role in the etiology of breast cancer...
  22. ncbi request reprint Model for the analysis of binary time series of respiratory symptoms
    H Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Am J Epidemiol 151:1206-15. 2000
    ..Sulfate level was not related to the incidence of new episodes but was associated with the duration of the episodes...
  23. pmc Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Alcohol Clin Exp Res 37:730-9. 2013
    ..Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors...
  24. pmc Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012
    ..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence...
  25. ncbi request reprint Family-based association tests for ordinal traits adjusting for covariates
    XueQin Wang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Genet Epidemiol 30:728-36. 2006
    ..The other three SNPs (rs485874, rs718251, and rs1869907) are identified for the first time using this data set, underscoring the potential power of our proposed test...
  26. pmc Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder
    Haiqun Lin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Child Psychol Psychiatry 48:157-66. 2007
    ....
  27. doi request reprint Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Pharmacogenet Genomics 23:395-402. 2013
    ..In the present study, we comprehensively examined the rare variants [minor allele frequency (MAF)<0.05] in the NKAIN1-SERINC2 region to confirm our previous finding...
  28. pmc Prenatal exposure to nicotine and impaired reading performance
    Kelly Cho
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 162:713-718.e2. 2013
    ..To investigate whether prenatal exposure to nicotine has an impact on several reading skill outcomes in school age children...
  29. pmc The impact of environmental and genetic factors on neonatal late-onset sepsis
    Matthew J Bizzarro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Pediatr 158:234-8.e1. 2011
    ..To assess the genetic contribution to late-onset sepsis in twins in the newborn intensive care unit...
  30. pmc Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive-compulsive symptom severity in children and adolescents with Tourette syndrome and obsessive-compulsive disorder
    Haiqun Lin
    Department of Epidemiology and Public Health, Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    Biol Psychiatry 67:684-91. 2010
    ..We then examined the power of GABHS infections and measures of psychosocial stress to predict future tic, obsessive-compulsive (OC), and depressive symptom severity...
  31. pmc Rare ADH variant constellations are specific for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Alcohol Alcohol 48:9-14. 2013
    ..In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference...
  32. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
    ..We concluded that common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans...
  33. pmc The genetic susceptibility to respiratory distress syndrome
    Orly Levit
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Pediatr Res 66:693-7. 2009
    ..We found 49.7% (p = 0.04) of the variance in liability to RDS was the result of genetic factors alone. We conclude that there is a significant genetic susceptibility to RDS in preterm infants...
  34. ncbi request reprint A randomized controlled trial of a coping group intervention for adults with HIV who are AIDS bereaved: longitudinal effects on grief
    Kathleen J Sikkema
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, CT 06520, USA
    Health Psychol 25:563-70. 2006
    ..The long-term effectiveness of this AIDS-bereavement intervention for psychiatrically distressed people with HIV/AIDS supports the need for tailored interventions among those at risk for complicated grief responses...
  35. pmc NCK2 is significantly associated with opiates addiction in African-origin men
    Zhifa Liu
    Department of Biostatistics, Yale University School of Public Health, New Haven, CT 06520, USA
    ScientificWorldJournal 2013:748979. 2013
    ..In summary, our findings provided the first evidence for the involvement of NCK2 in the susceptibility to opiates addiction and further revealed the racial and gender specificities of its impact...
  36. pmc Genetic association test for multiple traits at gene level
    Xiaobo Guo
    Department of Biostatistics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genet Epidemiol 37:122-9. 2013
    ..Using our proposed tests, we reanalyze the dataset from the Study of Addiction: Genetics and Environment (SAGE). Our result validates previous findings while presenting stronger evidence for consideration of multiple traits...
  37. pmc LOT: a tool for linkage analysis of ordinal traits for pedigree data
    Meizhuo Zhang
    Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Bioinformatics 24:1737-9. 2008
    ..It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage...
  38. pmc Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder
    Yuan Jiang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genet Epidemiol 35:125-32. 2011
    ..Our finding underscores the importance of accommodating and controlling for covariate effects in discovering genetic variants associated with complex disorders...
  39. pmc Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Arch Pediatr Adolesc Med 160:65-9. 2006
    ..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
  40. pmc A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26726. 2011
    ..We conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder...
  41. ncbi request reprint Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Biol Psychiatry 57:667-73. 2005
    ..This study was carried out to investigate whether cytokines associated with the innate immune response or T cell activation were altered under baseline conditions and during periods of symptom exacerbation...
  42. ncbi request reprint Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier
    Lawrence J Rizzolo
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Mol Vis 13:1259-73. 2007
    ..A genomic approach was used to investigate the extent of this remodeling...
  43. ncbi request reprint Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 128:94-101. 2004
    ..Interestingly, one of our most promising linkage regions, includes a region previously identified as linked to PD...
  44. pmc A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
    Yuanqing Ye
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    BMC Genet 6:S135. 2005
    ..Our analysis also identified genes that were reported in other studies of alcoholism and identified new genes or single-nucleotide polymorphisms that can be useful candidates for future studies...
  45. pmc Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
    Xiaoyun Zhong
    Yale University School of Medicine, New Haven, Connecticut, USA
    BMC Genet 6:S31. 2005
    ..We also compare the methods with mean identity-by-descent tests and transmission/disequilibrium tests that do not use age of onset information...
  46. pmc A forest-based approach to identifying gene and gene gene interactions
    Xiang Chen
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Proc Natl Acad Sci U S A 104:19199-203. 2007
    ..Thus, the importance of this work is twofold: it proposes a powerful and flexible method to identify high-risk haplotypes and their interactions and reveals a potentially protective variant for AMD...
  47. ncbi request reprint Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity
    Jared Weiss
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Neurol 189:141-9. 2004
    ..Thus, hypoxia-induced reduction in myelin-derived axon outgrowth inhibitors appears to contribute axonal misconnection to the pathology of very low birth weight infants...
  48. ncbi request reprint Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003
    ..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...
  49. ncbi request reprint Development of the Yale Children's Global Stress Index (YCGSI) and its application in children and adolescents ith Tourette's syndrome and obsessive-compulsive disorder
    Diane B Findley
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 42:450-7. 2003
    ..This study was designed to evaluate the psychometric properties of the YCGSI...
  50. doi request reprint Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence
    Lingjun Zuo
    Departments of aPsychiatry and bGenetics, Yale University School of Medicine cDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine dDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut eDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee fMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Psychiatr Genet 23:233-8. 2013
    ..In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence...
  51. pmc Multiscale adaptive marginal analysis of longitudinal neuroimaging data with time-varying covariates
    Martha Skup
    Division of Biostatistics, Yale University, New Haven, CT, USA
    Biometrics 68:1083-92. 2012
    ..Martha Skup, Hongtu Zhu, and Heping Zhang for the Alzheimer's Disease Neuroimaging Initiative.
  52. pmc Large scale association analysis for drug addiction: results from SNP to gene
    Xiaobo Guo
    Department of Biostatistics, Yale University School of Public Health, New Haven, CT 06520, USA
    ScientificWorldJournal 2012:939584. 2012
    ..In terms of gene findings, our results validate many genes that were either reported from the analysis of the same dataset or based on animal studies for substance dependence...
  53. pmc Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility
    Hao Huang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 97:959-67. 2012
    ..To identify risk factors for pregnancy outcomes in couples treated with intracervical or intrauterine insemination, with or without superovulation for unexplained or male-factor infertility...
  54. pmc Substance-abusing mothers and disruptions in child custody: an attachment perspective
    Nancy E Suchman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Subst Abuse Treat 30:197-204. 2006
    ..g., children nested within families). Findings are consistent with an attachment perspective on parenting suggesting that the internal psychological processes of a parent play a critical role in the continuity of parenting...
  55. ncbi request reprint Cortical neurogenesis enhanced by chronic perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University Medical School, 230 South Frontage Road, New Haven, CT 06520, USA
    Exp Neurol 199:77-91. 2006
    ..We suggest that cortical neurogenesis may play a significant role in repairing neuronal losses after neonatal injury...
  56. pmc The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women
    Xiang Chen
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e16002. 2011
    ..Our findings underscore the importance of considering multiple addiction types and the importance of considering population and gender stratification when analyzing data with heterogeneous population...
  57. ncbi request reprint Familial and genetic susceptibility to major neonatal morbidities in preterm twins
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 117:1901-6. 2006
    ..Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity and mortality in preterm newborns...
  58. ncbi request reprint Genetic susceptibility to retinopathy of prematurity
    Matthew J Bizzarro
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8064, USA
    Pediatrics 118:1858-63. 2006
    ..The goals were to isolate and to estimate the genetic susceptibility to retinopathy of prematurity...
  59. ncbi request reprint Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors
    Zeev N Kain
    Department of Anesthesiology, Yale University School of Medicine 333 Cedar Street, New Haven, CT 06510, USA
    Anesth Analg 99:1648-54, table of contents. 2004
    ....
  60. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
    ..We aimed to identify novel, functional, replicable and genome-wide significant risk regions specific for alcohol dependence using genome-wide association studies (GWASs)...
  61. pmc Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests
    Minghui Wang
    Department of Epidemiology and Public Health, 60 College Street, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    BMC Proc 3:S69. 2009
    ..Further analysis of this region indicates a strong association to the rheumatoid arthritis status...
  62. pmc Memory management in genome-wide association studies
    Xiang Chen
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    BMC Proc 3:S54. 2009
    ..We conclude that our memory management approach is simple, efficient, and effective for genome-wide association studies...
  63. pmc Genetic contribution to patent ductus arteriosus in the premature newborn
    Vineet Bhandari
    Yale University School of Medicine, Department of Pediatrics, 333 Cedar St, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 123:669-73. 2009
    ..In addition to prematurity and environmental factors, we hypothesized that genetic factors play a significant role in this condition...
  64. pmc Maximal conditional chi-square importance in random forests
    Minghui Wang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Bioinformatics 26:831-7. 2010
    ..Random forests represent a very useful approach for this purpose, using a variable importance score. This importance score has several shortcomings. We propose an alternative importance measure to overcome those shortcomings...
  65. ncbi request reprint Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment
    Denis G Sukhodolsky
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 42:98-105. 2003
    ..To examine the association of disruptive behavior with social, adaptive, and family functioning in Tourette's syndrome (TS) with and without comorbid attention-deficit/hyperactivity disorder (ADHD)...
  66. pmc Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
    Mutat Res 639:80-8. 2008
    ..Our findings suggest that bioinformatic tools are useful in predicting SNP functionality and may facilitate future genetic epidemiological studies...
  67. pmc Modelling gene regulation networks via multivariate adaptive splines
    Xiang Chen
    Department of Epidemiology and Public Health and Collaborative Center for Statistics in Science, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Cancer Genomics Proteomics 5:55-62. 2008
    ..Our findings reveal the potential of multivariate adaptive splines in deciphering complex and important transcriptional regulatory networks in eukaryotes...
  68. ncbi request reprint Assessing sex differences on treatment effectiveness from the drug abuse treatment outcome study (DATOS)
    Suddhasatta Acharyya
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Am J Drug Alcohol Abuse 29:415-44. 2003
    ..Cumulative logit models were used in our analysis. The choice of treatment modality is sex specific, although sex did not appear to be a significant factor for treatment effectiveness when we controlled for other explanatory variables...
  69. ncbi request reprint Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights
    Fenghai Duan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Bioinformatics 20:1766-71. 2004
    ..g. k-means), which group open reading frames (ORFs) based on similar expression levels, are deficient unless the temporal pattern of the expression levels of the ORFs is taken into account...
  70. pmc Impaired consciousness in temporal lobe seizures: role of cortical slow activity
    Dario J Englot
    Department of Neurosurgery, University of California, San Francisco, CA 94122, USA
    Brain 133:3764-77. 2010
    ..Further investigations will be needed to fully determine the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments to prevent this important negative consequence of temporal lobe epilepsy...
  71. pmc A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
    Wensheng Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, Connecticut 06520, USA
    BMC Proc 3:S119. 2009
    ..We conducted a permutation test to assess the associations between MASAL selected markers and triglycerides trait and report significant gene-gene and gene-environment interaction effects on the trait of interest...
  72. pmc Linkage analysis of ordinal traits for pedigree data
    Rui Feng
    Department of Epidemiology and Public Health and Yale Child Study Center, Yale University of School of Medicine, New Haven, CT 06250 8034, USA
    Proc Natl Acad Sci U S A 101:16739-44. 2004
    ..However, our method identified three markers at 4q34-35 (P = 0.0009), 5q35.2-35.3 (P = 0.0001), and 17q25 (P = 0.0005) that manifest significant allele sharing...
  73. ncbi request reprint Tree-based disease classification using protein data
    Hongtu Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Proteomics 3:1673-7. 2003
    ..This method has been successfully applied to protein data, provided by the Department of Radiology and Chemistry at Duke University...
  74. ncbi request reprint Developmental trajectories of cocaine-and-other-drug-exposed and non-cocaine-exposed children
    Linda C Mayes
    Yale Child Study Center, New Haven, CT 06520, USA
    J Dev Behav Pediatr 24:323-35. 2003
    ..Results suggest that prenatally cocaine-exposed children show delayed developmental indices, particularly in their mental performance, but their trajectories across time are similar to those from impoverished, non-cocaine-exposed groups...
  75. pmc Sex differences in grey matter atrophy patterns among AD and aMCI patients: results from ADNI
    Martha Skup
    Biostatistics Division, Yale University School of Public Health, New Haven, CT 06520, USA
    Neuroimage 56:890-906. 2011
    ..As one of the first investigation to model more than two time points of structural MRI data over time, our findings add insight into how AD and aMCI males and females differ from controls and from each other over time...
  76. ncbi request reprint Longitudinal effects of coping on outcome in a randomized controlled trial of a group intervention for HIV-positive adults with AIDS-related bereavement
    Nathan B Hansen
    The Consultation Center, Department of Psychiatry, Yale University School of Medicine, 389 Whitney Avenue, New Haven, CT 06511, USA
    Death Stud 30:609-36. 2006
    ....
  77. pmc Disrupted synaptic development in the hypoxic newborn brain
    Sheila M Curristin
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15729-34. 2002
    ..These patterns reveal a global dysynchrony in the maturation programs of the hypoxic developing brain, and offer insights into the vulnerabilities of processes that guide early postnatal cerebral maturation...
  78. pmc A high productivity/low maintenance approach to high-performance computation for biomedicine: four case studies
    Nicholas Carriero
    Department of Computer Science, Yale University, New Haven, CT 06520 8285, USA
    J Am Med Inform Assoc 12:90-8. 2005
    ....
  79. ncbi request reprint The spectrum of social phobia in the Zurich cohort study of young adults
    Kathleen Ries Merikangas
    Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 51:81-91. 2002
    ....

Research Grants22

  1. RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGING
    Stanislav Kasl; Fiscal Year: 2007
    ..In addition, Ph.D. candidates in biostatistics who will work with our biostatistics faculty on developing new techniques for the analysis of longitudinal data on older persons will also be eligible for support. ..
  2. RESEARCH TRAINING IN MENTAL HEALTH EPIDEMIOLOGY
    Heping Zhang; Fiscal Year: 2007
    ..Dr. Stan Kasl has been the Principal Investigator since 1975; however, Dr. Heping Zhang has taken over as Program Director and Dr. Kasl has become Co-Director since 2002...
  3. Data Coordination Center for the RMN
    Heping Zhang; Fiscal Year: 2007
    ..We are committed to the role and responsibilities of the DCC as stated in the RFA and have full institutional support in this endeavor. ..
  4. Analysis of Genomic Data for Complex Traits
    Heping Zhang; Fiscal Year: 2009
    ..That in turn leads to better prevention and treatment strategies. ..
  5. Data Management, Statistics, and informatics Core
    Heping Zhang; Fiscal Year: 2007
    ....
  6. Methodological Research on Substance Use
    Heping Zhang; Fiscal Year: 2007
    ..This award enables the PI to invest a major effort in a relatively long term to develop some of the critically needed, timely statistical methods and software, which help us advance our understanding of substance use disorders. ..
  7. PATHWAYS TO ALCOHOLISM THROUGH PSYCHOPATHOLOGY
    Heping Zhang; Fiscal Year: 2001
    ..They further state that identifying these pathways will ultimately assist in the development of an empirical basis for the primary prevention of secondary alcoholism. ..
  8. STATISTICAL METHODS FOR CORRELATED SUBSTANCE USE DATA
    Heping Zhang; Fiscal Year: 2003
    ....
  9. Statistical Methods in Genetic Studies of Substance Use
    Heping Zhang; Fiscal Year: 2007
    ..Although the focus of application is on genetic epidemiology of SUBs, our methodologies will be useful for understanding complex ordinal traits in general. ..
  10. Analysis of Genomic Data for Complex Traits
    Heping Zhang; Fiscal Year: 2010
    ..That in turn leads to better prevention and treatment strategies. ..