C J Zeiss

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Mutant mouse pathology: an exercise in integration
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, LSOG 126, New Haven, CT 06520, USA
    Lab Anim (NY) 31:34-9. 2002
  2. doi request reprint Fungal polymerase chain reaction testing in equine ulcerative keratitis
    Caroline Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Vet Ophthalmol 16:341-51. 2013
  3. doi request reprint Translational models of ocular disease
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06520, USA
    Vet Ophthalmol 16:15-33. 2013
  4. ncbi request reprint Designing phenotyping studies for genetically engineered mice
    C J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, TAC N230, New Haven, CT 06520, USA
    Vet Pathol 49:24-31. 2012
  5. doi request reprint Comparative retinal morphology of the platypus
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Morphol 272:949-57. 2011
  6. doi request reprint Animals as models of age-related macular degeneration: an imperfect measure of the truth
    C J Zeiss
    Yale University School of Medicine, Section of Comparative Medicine, 375 Congress Avenue, New Haven, CT 06520, USA
    Vet Pathol 47:396-413. 2010
  7. doi request reprint Ocular anomalies and holoprosencephaly in a lamb
    Caroline J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06437, USA
    Vet Ophthalmol 11:30-3. 2008
  8. ncbi request reprint Lentoid bodies in the avian retina
    C J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06437, USA
    J Comp Pathol 135:243-8. 2006
  9. ncbi request reprint Neuroanatomical phenotyping in the mouse: the dopaminergic system
    C J Zeiss
    Comparative Medicine, Yale University School of Medicine, 375 Congress Avenue, New Haven, CT 06437, USA
    Vet Pathol 42:753-73. 2005
  10. ncbi request reprint CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06510, USA
    Exp Eye Res 82:395-404. 2006

Research Grants

Detail Information

Publications23

  1. ncbi request reprint Mutant mouse pathology: an exercise in integration
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, LSOG 126, New Haven, CT 06520, USA
    Lab Anim (NY) 31:34-9. 2002
  2. doi request reprint Fungal polymerase chain reaction testing in equine ulcerative keratitis
    Caroline Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Vet Ophthalmol 16:341-51. 2013
    ..To assess the diagnostic utility of fungal polymerase chain reaction (PCR) in forty-three horses with naturally acquired corneal ulcers presenting to a private practice...
  3. doi request reprint Translational models of ocular disease
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06520, USA
    Vet Ophthalmol 16:15-33. 2013
    ..Emphasis is placed on those conditions shared by humans and domestic animals, with the intent of exploring how the study of comparable conditions in humans, domestic animals, and laboratory animals informs one another. ..
  4. ncbi request reprint Designing phenotyping studies for genetically engineered mice
    C J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, TAC N230, New Haven, CT 06520, USA
    Vet Pathol 49:24-31. 2012
    ..As poor design is the most common reason why studies fail to yield enduring results, emphasis is placed on reduction of bias, sampling, controlled study design, and appropriate statistical analysis...
  5. doi request reprint Comparative retinal morphology of the platypus
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Morphol 272:949-57. 2011
    ..These include scleral cartilage, double cones and cone droplets. In the platypus, as in other mammals, rod rhodopsin is the predominant photoreceptor pigment, at expense of the cone system...
  6. doi request reprint Animals as models of age-related macular degeneration: an imperfect measure of the truth
    C J Zeiss
    Yale University School of Medicine, Section of Comparative Medicine, 375 Congress Avenue, New Haven, CT 06520, USA
    Vet Pathol 47:396-413. 2010
    ..Finally, the article gives an overview of spontaneous and induced nonhuman primate models and describes relevant mouse models in the context of each pathogenetic mechanism...
  7. doi request reprint Ocular anomalies and holoprosencephaly in a lamb
    Caroline J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06437, USA
    Vet Ophthalmol 11:30-3. 2008
    ..These lesions are consistent with signaling defects in the sonic hedgehog signaling pathway. Genetic and toxic causes of sonic hedgehog signaling defects are discussed...
  8. ncbi request reprint Lentoid bodies in the avian retina
    C J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06437, USA
    J Comp Pathol 135:243-8. 2006
    ..The immunohistochemical data suggest that they arise from Müller cells. Association of lentoids with retinal damage supports the assertion that they arise following disruption of normal cell-cell communication...
  9. ncbi request reprint Neuroanatomical phenotyping in the mouse: the dopaminergic system
    C J Zeiss
    Comparative Medicine, Yale University School of Medicine, 375 Congress Avenue, New Haven, CT 06437, USA
    Vet Pathol 42:753-73. 2005
    ..Finally, we review mouse models of Parkinson's and Huntington's diseases, as well as those genetically altered mice that elucidate aspects of dopamine metabolism and receptor function...
  10. ncbi request reprint CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06510, USA
    Exp Eye Res 82:395-404. 2006
    ..These changes were more marked in rcd-1 retinas than in wild-type retinas. This implies that the consequences of CNTF treatment may be substantially influenced by the cellular context into which it is introduced...
  11. ncbi request reprint A morphologic study of intravitreal membranes associated with intraocular hemorrhage in the dog
    Caroline J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06437, USA
    Vet Ophthalmol 7:239-43. 2004
    ..This in turn, may arise from new vessels associated with epiretinal or preiridial membranes, or hemorrhage associated with optic disc cupping or retinal neovascularization. All of these phenomena may accompany glaucoma...
  12. ncbi request reprint Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse
    Caroline J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Invest Ophthalmol Vis Sci 45:971-6. 2004
    ..Studies of cell cycle proteins in other models of neuronal death provide consistent evidence that a repertoire of proliferative markers accompanies apoptosis...
  13. ncbi request reprint Caspase-3 in postnatal retinal development and degeneration
    Caroline J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Invest Ophthalmol Vis Sci 45:964-70. 2004
    ..Its activation has been demonstrated in rodent models of photoreceptor degeneration and its ablation results in exencephaly and neonatal death...
  14. ncbi request reprint Feline intraocular tumors may arise from transformation of lens epithelium
    C J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, 375 Congress Avenue, LSOG 126, New Haven, CT 06437, USA
    Vet Pathol 40:355-62. 2003
    ..The history and morphologic features of feline ocular sarcomas are reminiscent of feline vaccine-induced sarcomas. These tumors may share pathophysiologic similarities unique to this species...
  15. ncbi request reprint The apoptosis-necrosis continuum: insights from genetically altered mice
    C J Zeiss
    Section of Comparative Medicine, Yale School of Medicine, 375 Congress Avenue, 126 LSOG, New Haven, CT 06520, USA
    Vet Pathol 40:481-95. 2003
    ..An understanding of the physiologic conditions that influence these decisions is required to adequately prevent, or induce, cell death...
  16. ncbi request reprint Hypotensive infarction of the spinal cord in a rhesus macaque (Macaca mulatta)
    C J Zeiss
    Section of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA
    Vet Pathol 38:105-8. 2001
    ..Possible factors contributing to the hypotensive episode in this case included the addition of xylazine to ketamine and atropine in the preanesthetic medication, positioning during anesthesia, and decreased blood pressure during surgery...
  17. ncbi request reprint Anisocoria and middle cerebral artery saccular (berry) aneurysm in a rhesus macaque (Macaca mulatta)
    S Ovadia
    Section of Comparative Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520-8016, USA
    Comp Med 51:562-6. 2001
    ..To our knowledge, this report represents the first documented case of a naturally occurring intracranial aneurysm in nonhuman primates...
  18. ncbi request reprint The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice
    D R Johnson
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center and Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 61:1469-76. 2001
    ....
  19. ncbi request reprint Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus
    Susan R Compton
    Section of Comparative Medicine, Yale University School of Medicine, PO Box 208016, New Haven, Connecticut 06520 8016, USA
    Comp Med 53:197-206. 2003
    ..In addition, co-infection of these mice with H. hepaticus results in alterations in the pathogenesis of MHV-G infection...
  20. ncbi request reprint Motor deficits and altered striatal gene expression in aphakia (ak) mice
    Bhupinder Singh
    Section of Comparative Medicine, Yale University, 375 Congress Ave, New Haven, CT 06519, USA
    Brain Res 1185:283-92. 2007
    ..Their striatal gene expression patterns are consistent with dopaminergic denervation, and change over time, despite relatively unaltered motor performance...
  21. pmc Analysis of six candidate genes as potential modifiers of disease expression in canine XLPRA1, a model for human X-linked retinitis pigmentosa 3
    Richard Guyon
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Vis 13:1094-105. 2007
    ....
  22. ncbi request reprint Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis
    Samuel G Jacobson
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Gene Ther 17:845-58. 2006
    ..RPE65. The potential value of foveal treatment for LCA and other retinal degenerations warrants further research into how to achieve gene transfer without retinal injury from surgical detachment of the retina...
  23. ncbi request reprint Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection
    Samuel G Jacobson
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 13:1074-84. 2006
    ..5-log unit range of vector doses proved efficacious. The efficacy and toxicity limits defined in this study lead to suggestions for the design of a subretinal AAV-2/2.RPE65 human trial of RPE65-associated LCA...

Research Grants5

  1. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2003
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  2. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2004
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  3. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2005
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  4. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2006
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  5. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..