Research Topics
| James B YuSummaryAffiliation: Yale University Country: USA Publications
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Publications
Proton versus intensity-modulated radiotherapy for prostate cancer: patterns of care and early toxicityJames B Yu
Yale University School of Medicine, Department of Therapeutic Radiology, 40 Park St, New Haven, CT 06511, USA
J Natl Cancer Inst 105:25-32. 2013..We therefore compared patterns of PRT use, cost, and early toxicity among Medicare beneficiaries with prostate cancer with those of intensity-modulated radiotherapy (IMRT)...
Patterns of care and outcomes associated with intensity-modulated radiation therapy versus conventional radiation therapy for older patients with head-and-neck cancerJames B Yu
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA
Int J Radiat Oncol Biol Phys 83:e101-7. 2012..We performed a retrospective cohort study of Medicare patients treated with IMRT compared with standard RT to assess outcomes in national practice...
A new formula for prostate cancer lymph node riskJames B Yu
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
Int J Radiat Oncol Biol Phys 80:69-75. 2011..The Roach formula (RF) has been criticized as overestimating LN risk. A modification of the RF has been attempted by other investigators using simplified adjustment ratios: the Nguyen formula (NF)...
Postmastectomy radiation therapy for lymph node-negative, locally advanced breast cancer after modified radical mastectomy: analysis of the NCI Surveillance, Epidemiology, and End Results databaseJames B Yu
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
Cancer 113:38-47. 2008..The role of postmastectomy radiotherapy (PMRT) for lymph node-negative locally advanced breast carcinoma (T3N0M0) after modified radical mastectomy (MRM) with regard to improvement in survival remains an area of controversy...
Validation of the partin nomogram for prostate cancer in a national sampleJames B Yu
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA
J Urol 183:105-11. 2010..The nomogram is based on patients undergoing radical prostatectomy at The Johns Hopkins Medical Institutions. We validated the Partin tables in a large, population based sample...
Assessing the impact of a cooperative group trial on breast cancer care in the medicare populationPamela R Soulos
Yale School of Medicine, Primary Care Center, New Haven, CT 06520, USA
J Clin Oncol 30:1601-7. 2012..Although treatment guidelines were changed to indicate that some women could forego RT, the impact of the C9343 results on clinical practice is unclear...
The adoption of new adjuvant radiation therapy modalities among Medicare beneficiaries with breast cancer: clinical correlates and cost implicationsKenneth B Roberts
Cancer Outcomes, Public Policy, and Effectiveness Research COPPER Center, Yale Comprehensive Cancer Center and Yale University School of Medicine, New Haven, Connecticut, USA
Int J Radiat Oncol Biol Phys 85:1186-92. 2013..New radiation therapy modalities have broadened treatment options for older women with breast cancer, but it is unclear how clinical factors, geographic region, and physician preference affect the choice of radiation therapy modality...
Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinomaAyal A Aizer
Department of Radiation Oncology, Yale School of Medicine, New Haven, CT, USA
Int J Radiat Oncol Biol Phys 75:1344-9. 2009..To determine whether whole pelvic radiotherapy (WPRT) or prostate-only radiotherapy (PORT) yields improved biochemical disease-free survival (BDFS) in patients with advanced or aggressive prostate adenocarcinoma...
Variation in receipt of radiation therapy after breast-conserving surgery: assessing the impact of physicians and geographic regionsAaron J Feinstein
Cancer Outcomes, Public Policy, and Effectiveness Research COPPER Center, Yale Comprehensive Cancer Center, New Haven, CT, USA
Med Care 51:330-8. 2013..Little is known about the impact of physicians and regional factors on the use of RT across LE groups...
The impact of pretreatment prostate volume on severe acute genitourinary toxicity in prostate cancer patients treated with intensity-modulated radiation therapyAyal A Aizer
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA
Int J Radiat Oncol Biol Phys 79:379-84. 2011..To assess the impact of pretreatment prostate volume on the development of severe acute genitourinary toxicity in patients undergoing intensity-modulated radiation therapy (IMRT) for prostate cancer...
A prognostic index for predicting lymph node metastasis in minor salivary gland cancerShane Lloyd
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
Int J Radiat Oncol Biol Phys 76:169-75. 2010..Large studies examining the clinical and pathological factors associated with nodal metastasis in minor salivary gland cancer are lacking in the literature...
Patterns of use and short-term complications of breast brachytherapy in the national medicare population from 2008-2009Carolyn J Presley
Yale University School of Medicine, New Haven, CT 06520, USA
J Clin Oncol 30:4302-7. 2012..Brachytherapy has disseminated into clinical practice as an alternative to whole-breast irradiation (WBI) for early-stage breast cancer; however, current national treatment patterns and associated complications remain unknown...
The prognostic importance of midline involvement in oral tongue cancerShane Lloyd
Division of Otolaryngology, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA
Am J Clin Oncol 35:468-73. 2012..To examine the importance of midline involvement and other clinicopathologic factors in predicting the rate of contralateral lymph node metastasis and survival in oral tongue squamous cell carcinoma...
The population level prevalence and correlates of appropriate and inappropriate imaging to stage incident prostate cancer in the medicare populationDanil V Makarov
Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, United States
J Urol 187:97-102. 2012..According to guidelines most men with incident prostate cancer do not require staging imaging. We determined the population level prevalence and correlates of appropriate and inappropriate imaging in this cohort...
Immortal time bias: a frequently unrecognized threat to validity in the evaluation of postoperative radiotherapyHenry S Park
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
Int J Radiat Oncol Biol Phys 83:1365-73. 2012..To evaluate the influence of immortal time bias on observational cohort studies of postoperative radiotherapy (PORT) and the effectiveness of sequential landmark analysis to account for this bias...
Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapyShane Lloyd
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520 8040, USA
Am J Clin Oncol 34:76-81. 2011..The effect of adjuvant radiation therapy (RT) on survival in patients with adenoid cystic carcinoma (ACC) is much debated. Studies with large numbers of patients and long follow-up are lacking in the literature...
Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skinJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Clin Oncol 33:125-7. 2010..Microcystic adnexal carcinoma (MAC) is a very rare cancer of the skin. It has only been described previously in case reports and small retrospective series...
Testicular doses in image-guided radiotherapy of prostate cancerJun Deng
Department of Therapeutic Radiology, Yale University, New Haven, CT 06510 3221, USA
Int J Radiat Oncol Biol Phys 82:e39-47. 2012..To investigate testicular doses contributed by kilovoltage cone-beam computed tomography (kVCBCT) during image-guided radiotherapy (IGRT) of prostate cancer...
The association between diffusion of the surgical robot and radical prostatectomy ratesDanil V Makarov
Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, CT, USA
Med Care 49:333-9. 2011..Despite its expense and controversy surrounding its benefit, the surgical robot has been widely adopted for the treatment of prostate cancer...
Surveillance epidemiology and end results evaluation of the role of surgery for stage I small cell lung cancerJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
J Thorac Oncol 5:215-9. 2010..This study was performed to evaluate the clinical outcomes of surgery for stage I small cell lung cancer (SCLC)...
Radical prostatectomy vs. intensity-modulated radiation therapy in the management of localized prostate adenocarcinomaAyal A Aizer
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA
Radiother Oncol 93:185-91. 2009....
Geographic analysis of the radiation oncology workforceSanjay Aneja
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
Int J Radiat Oncol Biol Phys 82:1723-9. 2012..To evaluate trends in the geographic distribution of the radiation oncology (RO) workforce...
A significant decrease in rectal volume and diameter during prostate IMRTNicole S Anderson
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
Radiother Oncol 98:187-91. 2011..To record changes in rectal volume (RV) and diameter (RD) of patients with prostate adenocarcinoma prior to and at an interim period during radiotherapy, which could potentially affect treatment toxicity and tumor control...
Patient perspectives regarding the value of total skin electron beam therapy for cutaneous T-cell lymphoma/mycosis fungoides: a pilot studyJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
Am J Clin Oncol 32:142-4. 2009..This prospective study was initiated to evaluate perceptions of total skin electron beam therapy (TSEBT) by patients with mycosis fungoides who had failed at least 3 prior therapies...
Historical trends in the use of radiation therapy for pediatric cancers: 1973-2008Vikram Jairam
Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut, USA
Int J Radiat Oncol Biol Phys 85:e151-5. 2013..This study was undertaken to assess historical trends in the use of radiation therapy (RT) for pediatric cancers over the past 4 decades...
Hypofractionated radiation therapy for prostate cancer: risks and potential benefits in a fiscally conservative health care systemSanjay Aneja
Yale School of Medicine, New Haven, Connecticut, USA
Oncology (Williston Park) 26:512-8. 2012....
A retrospective review of 1349 cases of sebaceous carcinomaTina Dasgupta
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer 115:158-65. 2009..The objective of the current study was to analyze demographic characteristics and outcomes for patients with this malignancy from a large United States-based population registry...
Salvage external beam radiotherapy for prostate cancer after radical prostatectomy: current status and controversyAnn Raldow
Therapeutic Radiology, Yale University School of Medicine New Haven, Connecticut 06520 8040, USA
Oncology (Williston Park) 24:692-700, 702. 2010..We discuss the known side effects from SRT, weigh the cost and benefit of SRT, and discuss possible tools that may improve the cost/benefit ratio for SRT by helping to select patients whom SRT may be more likely to benefit...
Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results databaseJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Clin Oncol 26:1483-8. 2008..The primary intention of the analysis of the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database was to report epidemiologic information and overall survival of patients with PCLPD...
Radiosurgical dose selection for brain metastasisJames B Yu
Yale University School of Medicine, Department of Therapeutic Radiology, Smilow Cancer Hospital, New Haven, CT, USA
Prog Neurol Surg 25:139-47. 2012..Physician knowledge and careful judgment, together with careful treatment planning and delivery can minimize the risks associated with brain metastasis radiosurgery...
Adjuvant radiotherapy after radical prostatectomy: evidence and analysisAnn Raldow
Yale School of Medicine, New Haven, CT, United States
Cancer Treat Rev 37:89-96. 2011..Finally, we discuss the cost-effectiveness of ART, in the context of other medical interventions...
The role of postoperative radiation therapy (PORT) in the treatment of extrahepatic bile duct cancer: a surveillance, epidemiology, and end results (SEER) population-based investigationJames B Yu
Department of Therapeutic Radiology, Yale School of Medicine, HRT 133, 333 Cedar St, New Haven, CT 06520, USA
J Gastrointest Cancer 39:11-21. 2008..Extrahepatic bile duct cancers (EBDC) are aggressive cancers for which the importance of the use of postoperative radiation therapy (PORT) in potentially curative cases remains the subject of clinical investigation...
Role of neurosurgery and radiation therapy in the management of brain tumorsToral R Patel
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
Hematol Oncol Clin North Am 26:757-77. 2012..This article reviews the current role of neurosurgery and radiation therapy in the management of primary brain tumors...
Geographical information systems: applications and limitations in oncology researchSanjay Aneja
Yale School of Medicine, New Haven, Connecticut, USA
Oncology (Williston Park) 25:1221-5. 2011..Our aims are to help clinicians and policy makers interpret studies generated using GIS, and to help clinical investigators implement GIS in future research...
The influence of regional health system characteristics on the surgical management and receipt of post operative radiation therapy for glioblastoma multiformeSanjay Aneja
Yale School of Medicine, New Haven, CT, USA
J Neurooncol 112:393-401. 2013..Policies aimed at narrowing disparities in treatment may need to focus on addressing regional variations in oncology resources...
Complications of brain tumors and their treatmentJill Lacy
Section of Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
Hematol Oncol Clin North Am 26:779-96. 2012..Recognition of the acute, early delayed, and late complications of brain irradiation is essential to optimize management and mitigate their clinical impact...
How radiation oncologists would disclose errors: results of a survey of radiation oncologists and traineesSuzanne B Evans
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8040, USA
Int J Radiat Oncol Biol Phys 84:e131-7. 2012..To analyze error disclosure attitudes of radiation oncologists and to correlate error disclosure beliefs with survey-assessed disclosure behavior...
Age, race, sex, stage, and incidence of cutaneous lymphomaLynn D Wilson
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
Clin Lymphoma Myeloma Leuk 12:291-6. 2012..These findings have significant implications regarding need for earlier diagnosis and understanding the reasons for racial disparity in age and stage of presentation...
Stereotactic radiosurgery with or without whole-brain radiotherapy for brain metastases: an updateHenry S Park
Yale University School of Medicine, New Haven, CT, USA
Expert Rev Anticancer Ther 11:1731-8. 2011..We also discuss recent nonrandomized evidence for the use of SRS alone for oligometastatic disease...
Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningiomaRobert L Lesser
40 Temple Street Suite 5 B, New Haven, CT 06510, USA
Br J Ophthalmol 94:559-63. 2010..No major side effects from radiation were seen. CONCLUSIONS Vision, MRI and complication outcomes are favourable for using fractionated conformal radiotherapy for ONSM...
Treatment of primary cutaneous CD30+ anaplastic large-cell lymphoma with radiation therapyJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
Int J Radiat Oncol Biol Phys 70:1542-5. 2008..Primary cutaneous CD30+ anaplastic large-cell lymphoma (CALCL) is a relatively rare and indolent variant of cutaneous T-cell lymphoma (CTCL). This report examines the response of localized disease to radiation alone...
A dosimetric evaluation of conventional helmet field irradiation versus two-field intensity-modulated radiotherapy techniqueJames B Yu
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
Int J Radiat Oncol Biol Phys 68:621-31. 2007..To compare dosimetric differences between conventional two-beam helmet field irradiation (external beam radiotherapy, EBRT) of the brain and a two-field intensity-modulated radiotherapy (IMRT) technique...
Impact of immediate postoperative death on the estimation of a survival benefit from postoperative radiation therapy for cancer of the gallbladderJames B Yu
J Clin Oncol 26:4523; author reply 4524-6. 2008
