Research Topics
Genomes and GenesSpecies | Lawrence YoungSummaryAffiliation: Yale University Country: USA Publications
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Publications
AMP-activated protein kinase: a key stress signaling pathway in the heartLawrence H Young
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Trends Cardiovasc Med 15:110-8. 2005..This review focuses on the molecular mechanisms of activation and cardiovascular actions of AMPK in the heart...- AMP-activated protein kinase conducts the ischemic stress response orchestraLawrence H Young
Department of Internal Medicine (Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
Circulation 117:832-40. 2008 
AMP-activated protein kinase regulation and biological actions in the heartVlad G Zaha
Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Circ Res 111:800-14. 2012....- A crystallized view of AMPK activationLawrence H Young
Section of Cardiovascular Medicine, Departments of Internal Medicine and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Cell Metab 10:5-6. 2009..Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches... - Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartJi Li
Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
Am J Physiol Heart Circ Physiol 291:H1927-34. 2006..Despite the pathophysiological importance of gamma(2)-isoform mutations, gamma(1)-isoform complexes account for most of the AMPK activity in the ischemic heart... - Diagnosis of CAD in patients with diabetes: who to evaluateLawrence H Young
Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3 FMP, New Haven, CT 06520, USA
Curr Diab Rep 3:19-27. 2003..This article reviews recent information that may help guide the clinician in the appropriate use of cardiac testing in diabetic patients... - Insulin resistance and the effects of thiazolidinediones on cardiac metabolismLawrence H Young
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med 115:75S-80S. 2003..This article provides a review of the potential beneficial effects of the TZDs on myocardial metabolism... - Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imagingGeorgios I Papaioannou
Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA
J Nucl Cardiol 13:362-8. 2006.... - Diabetes mellitus and cardiovascular diseaseDeborah A Chyun
Yale University School of Nursing, New Haven, CT 06536 0740, USA
Nurs Clin North Am 41:681-95, viii-ix. 2006..The focus of this article is on the acute and chronic manifestations of coronary heart disease... 
AMP-activated protein kinase regulates the assembly of epithelial tight junctionsLi Zhang
Department of Cell Biology, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 103:17272-7. 2006..These results suggest that AMPK plays a role in the regulation of tight junction assembly...- Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesisRichard M Reznick
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Cell Metab 5:151-6. 2007..These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging... - Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) studyFrans J Th Wackers
Yale University School of Medicine, Section of Cardiovascular Medicine, 333 Cedar St Fitkin 3, New Haven, CT 06520, USA
Diabetes Care 30:2892-8. 2007..The purpose of this study was to assess whether the prevalence of inducible myocardial ischemia increases over time in patients with type 2 diabetes... - Screening for coronary artery disease in patients with diabetesJeroen J Bax
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Diabetes Care 30:2729-36. 2007..Better approaches to identify such individuals based on readily obtained clinical variables are sorely needed... - Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heartEdward J Miller
Cardiovascular Medicine Section of the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 451:578-82. 2008..We anticipate that genetic variation in MIF expression may impact on the response of the human heart to ischaemia by the AMPK pathway, and that diagnostic MIF genotyping might predict risk in patients with coronary artery disease... - Physiological role of AMP-activated protein kinase in the heart: graded activation during exerciseDavid L Coven
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Physiol Endocrinol Metab 285:E629-36. 2003..Thus cardiac AMPK activity increases progressively with exercise intensity, supporting the hypothesis that AMPK has a physiological role in the heart... - AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heartJi Li
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Circ Res 97:872-9. 2005..Thus, AMPK has an important role in promoting p38 MAPK activation in the ischemic heart by inducing p38 MAPK autophosphorylation through interaction with the scaffold protein TAB1... - Dual mechanisms regulating AMPK kinase action in the ischemic heartSuzanne J Baron
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
Circ Res 96:337-45. 2005.... - AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryRaymond R Russell
Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
J Clin Invest 114:495-503. 2004..Thus, AMPK is responsible for activation of glucose uptake and glycolysis during low-flow ischemia and plays an important protective role in limiting damage and apoptotic activity associated with ischemia and reperfusion in the heart... - Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD studyFrans J Th Wackers
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Diabetes Care 27:1954-61. 2004..To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines... - Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administrationBrian F Johnson
Pfizer Research, Groton, Connecticut, USA
Diabetes Care 27:448-54. 2004..There was no change in resting diastolic filling rates in either group. CONCLUSIONS: Diabetic patients with neuropathy have LV abnormalities that can be stabilized and partially reversed by ARI treatment... - Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heartYan Huang
Department of Medicine, Yale University, New Haven, Connecticut, USA
FASEB J 18:1138-40. 2004..Further elucidating these relationships may help clarify the molecular pathology of various cardiovascular disease states, including ischemic cardiomyopathy and myocardial hibernation (5, 6)... - Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscleJi Li
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Physiol Endocrinol Metab 287:E834-41. 2004..05). Taken together, these results indicate that activation of the NO-guanylate cyclase pathway contributes to, but is not the sole mediator of, AMPK stimulation of glucose uptake and GLUT4 translocation in heart muscle... - Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003Richard W Nesto
Circulation 108:2941-8. 2003 - Cardiac outcomes after myocardial infarction in elderly patients with diabetes mellitusDeborah Chyun
Yale University, New Haven, Conn, USA
Am J Crit Care 11:504-19. 2002..Comorbid conditions related to diabetes mellitus and ventricular function at the time of the index myocardial infarction are important contributors to poorer outcomes in patients with diabetes mellitus... - Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics-brachial artery reactivity study)Georgios I Papaioannou
Cardiology Division, Henry Low Heart Center, Hartford Hospital, and University of Connecticut School of Medicine, Farmington, USA
Am J Cardiol 94:294-9. 2004..In addition, microalbuminuria is an independent predictor of endothelial dysfunction in asymptomatic patients with DM, especially in the absence of hormone replacement therapy... - Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heartEdward J Miller
Department of Internal Medicine, Yale University School of Medicine, FMP 3, 333 Cedar St, New Haven, CT 06520, USA
Am J Physiol Endocrinol Metab 292:E1922-8. 2007.... - Diastolic function and type 1 diabetesLawrence H Young
Diabetes Care 27:2081-3. 2004 - Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemiaCindy Q Shi
Experimental Nuclear Cardiology Laboratory, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8017, USA
J Nucl Med 43:421-31. 2002..Retention of IPPA correlated with (18)F-FDG accumulation, supporting the potential of IPPA as a noninvasive marker of ischemic myocardium...
Research Grants
- AMP-activated protein kinase in the ischemic heartLawrence Young; Fiscal Year: 2009..We propose to develop novel strategies, directed at these molecules, that may lead to the development of new treatments for patients with coronary artery disease. ..
- VisualSonics Vevo 770 Imaging SystemLawrence Young; Fiscal Year: 2007..Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children. ..
- REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEARTLawrence Young; Fiscal Year: 2007..Such novel therapies may improve the quality of life and prevent cardiac death and have significant health benefit for the U.S. population. ..
- REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEARTLawrence Young; Fiscal Year: 2003..Interaction of AMPK with other signaling pathways will be explored, as well as the role of specific isoforms of AMPK subunits in the heart. The relative roles of exocytosis vs. endocytosis in the process will be evaluated. ..
- AMP-activated protein kinase in the ischemic heartLawrence H Young; Fiscal Year: 2010..We propose to develop novel strategies, directed at these molecules, that may lead to the development of new treatments for patients with coronary artery disease. ..