Lawrence Young

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint AMP-activated protein kinase: a key stress signaling pathway in the heart
    Lawrence H Young
    Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Cardiovasc Med 15:110-8. 2005
  2. doi request reprint AMP-activated protein kinase conducts the ischemic stress response orchestra
    Lawrence H Young
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 117:832-40. 2008
  3. doi request reprint AMP-activated protein kinase regulation and biological actions in the heart
    Vlad G Zaha
    Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Circ Res 111:800-14. 2012
  4. doi request reprint A crystallized view of AMPK activation
    Lawrence H Young
    Section of Cardiovascular Medicine, Departments of Internal Medicine and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 10:5-6. 2009
  5. ncbi request reprint Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart
    Ji Li
    Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
    Am J Physiol Heart Circ Physiol 291:H1927-34. 2006
  6. ncbi request reprint Diagnosis of CAD in patients with diabetes: who to evaluate
    Lawrence H Young
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3 FMP, New Haven, CT 06520, USA
    Curr Diab Rep 3:19-27. 2003
  7. ncbi request reprint Insulin resistance and the effects of thiazolidinediones on cardiac metabolism
    Lawrence H Young
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med 115:75S-80S. 2003
  8. ncbi request reprint Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
    Georgios I Papaioannou
    Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA
    J Nucl Cardiol 13:362-8. 2006
  9. ncbi request reprint Diabetes mellitus and cardiovascular disease
    Deborah A Chyun
    Yale University School of Nursing, New Haven, CT 06536 0740, USA
    Nurs Clin North Am 41:681-95, viii-ix. 2006
  10. pmc AMP-activated protein kinase regulates the assembly of epithelial tight junctions
    Li Zhang
    Department of Cell Biology, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:17272-7. 2006

Research Grants

  1. AMP-activated protein kinase in the ischemic heart
    Lawrence Young; Fiscal Year: 2009
  2. VisualSonics Vevo 770 Imaging System
    Lawrence Young; Fiscal Year: 2007
  3. REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEART
    Lawrence Young; Fiscal Year: 2007
  4. REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEART
    Lawrence Young; Fiscal Year: 2003
  5. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint AMP-activated protein kinase: a key stress signaling pathway in the heart
    Lawrence H Young
    Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Cardiovasc Med 15:110-8. 2005
    ..This review focuses on the molecular mechanisms of activation and cardiovascular actions of AMPK in the heart...
  2. doi request reprint AMP-activated protein kinase conducts the ischemic stress response orchestra
    Lawrence H Young
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 117:832-40. 2008
  3. doi request reprint AMP-activated protein kinase regulation and biological actions in the heart
    Vlad G Zaha
    Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Circ Res 111:800-14. 2012
    ....
  4. doi request reprint A crystallized view of AMPK activation
    Lawrence H Young
    Section of Cardiovascular Medicine, Departments of Internal Medicine and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 10:5-6. 2009
    ..Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches...
  5. ncbi request reprint Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart
    Ji Li
    Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
    Am J Physiol Heart Circ Physiol 291:H1927-34. 2006
    ..Despite the pathophysiological importance of gamma(2)-isoform mutations, gamma(1)-isoform complexes account for most of the AMPK activity in the ischemic heart...
  6. ncbi request reprint Diagnosis of CAD in patients with diabetes: who to evaluate
    Lawrence H Young
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3 FMP, New Haven, CT 06520, USA
    Curr Diab Rep 3:19-27. 2003
    ..This article reviews recent information that may help guide the clinician in the appropriate use of cardiac testing in diabetic patients...
  7. ncbi request reprint Insulin resistance and the effects of thiazolidinediones on cardiac metabolism
    Lawrence H Young
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med 115:75S-80S. 2003
    ..This article provides a review of the potential beneficial effects of the TZDs on myocardial metabolism...
  8. ncbi request reprint Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
    Georgios I Papaioannou
    Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA
    J Nucl Cardiol 13:362-8. 2006
    ..Myocardial perfusion imaging (MPI) is an effective method of detection of coronary artery disease (CAD); however, the relationship between endothelial function and MPI in asymptomatic patients with T2DM has not been examined...
  9. ncbi request reprint Diabetes mellitus and cardiovascular disease
    Deborah A Chyun
    Yale University School of Nursing, New Haven, CT 06536 0740, USA
    Nurs Clin North Am 41:681-95, viii-ix. 2006
    ..The focus of this article is on the acute and chronic manifestations of coronary heart disease...
  10. pmc AMP-activated protein kinase regulates the assembly of epithelial tight junctions
    Li Zhang
    Department of Cell Biology, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:17272-7. 2006
    ..These results suggest that AMPK plays a role in the regulation of tight junction assembly...
  11. pmc Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    Richard M Reznick
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 5:151-6. 2007
    ..These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging...
  12. ncbi request reprint Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study
    Frans J Th Wackers
    Yale University School of Medicine, Section of Cardiovascular Medicine, 333 Cedar St Fitkin 3, New Haven, CT 06520, USA
    Diabetes Care 30:2892-8. 2007
    ..The purpose of this study was to assess whether the prevalence of inducible myocardial ischemia increases over time in patients with type 2 diabetes...
  13. ncbi request reprint Screening for coronary artery disease in patients with diabetes
    Jeroen J Bax
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 30:2729-36. 2007
    ..Better approaches to identify such individuals based on readily obtained clinical variables are sorely needed...
  14. doi request reprint Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
    Edward J Miller
    Cardiovascular Medicine Section of the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 451:578-82. 2008
    ..We anticipate that genetic variation in MIF expression may impact on the response of the human heart to ischaemia by the AMPK pathway, and that diagnostic MIF genotyping might predict risk in patients with coronary artery disease...
  15. ncbi request reprint Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise
    David L Coven
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Physiol Endocrinol Metab 285:E629-36. 2003
    ..Thus cardiac AMPK activity increases progressively with exercise intensity, supporting the hypothesis that AMPK has a physiological role in the heart...
  16. ncbi request reprint AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
    Ji Li
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Circ Res 97:872-9. 2005
    ..Thus, AMPK has an important role in promoting p38 MAPK activation in the ischemic heart by inducing p38 MAPK autophosphorylation through interaction with the scaffold protein TAB1...
  17. ncbi request reprint Dual mechanisms regulating AMPK kinase action in the ischemic heart
    Suzanne J Baron
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circ Res 96:337-45. 2005
    ....
  18. pmc AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    Raymond R Russell
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Invest 114:495-503. 2004
    ..Thus, AMPK is responsible for activation of glucose uptake and glycolysis during low-flow ischemia and plays an important protective role in limiting damage and apoptotic activity associated with ischemia and reperfusion in the heart...
  19. ncbi request reprint Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 27:1954-61. 2004
    ..To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines...
  20. ncbi request reprint Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration
    Brian F Johnson
    Pfizer Research, Groton, Connecticut, USA
    Diabetes Care 27:448-54. 2004
    ..The goal of this study was to determine whether treatment with an aldose reductase inhibitor (ARI) has beneficial effects on asymptomatic cardiac abnormalities in diabetic patients with neuropathy...
  21. ncbi request reprint Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart
    Yan Huang
    Department of Medicine, Yale University, New Haven, Connecticut, USA
    FASEB J 18:1138-40. 2004
    ..Further elucidating these relationships may help clarify the molecular pathology of various cardiovascular disease states, including ischemic cardiomyopathy and myocardial hibernation (5, 6)...
  22. ncbi request reprint Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
    Ji Li
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Endocrinol Metab 287:E834-41. 2004
    ..05). Taken together, these results indicate that activation of the NO-guanylate cyclase pathway contributes to, but is not the sole mediator of, AMPK stimulation of glucose uptake and GLUT4 translocation in heart muscle...
  23. ncbi request reprint Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003
    Richard W Nesto
    Circulation 108:2941-8. 2003
  24. ncbi request reprint Cardiac outcomes after myocardial infarction in elderly patients with diabetes mellitus
    Deborah Chyun
    Yale University, New Haven, Conn, USA
    Am J Crit Care 11:504-19. 2002
    ....
  25. ncbi request reprint Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics-brachial artery reactivity study)
    Georgios I Papaioannou
    Cardiology Division, Henry Low Heart Center, Hartford Hospital, and University of Connecticut School of Medicine, Farmington, USA
    Am J Cardiol 94:294-9. 2004
    ..In addition, microalbuminuria is an independent predictor of endothelial dysfunction in asymptomatic patients with DM, especially in the absence of hormone replacement therapy...
  26. ncbi request reprint Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart
    Edward J Miller
    Department of Internal Medicine, Yale University School of Medicine, FMP 3, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Endocrinol Metab 292:E1922-8. 2007
    ....
  27. ncbi request reprint Diastolic function and type 1 diabetes
    Lawrence H Young
    Diabetes Care 27:2081-3. 2004
  28. ncbi request reprint Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia
    Cindy Q Shi
    Experimental Nuclear Cardiology Laboratory, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Nucl Med 43:421-31. 2002
    ..This study evaluated the potential of dynamic SPECT imaging of a FFA analog, p-(123)I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with (18)F-FDG accumulation...

Research Grants10

  1. AMP-activated protein kinase in the ischemic heart
    Lawrence Young; Fiscal Year: 2009
    ..We propose to develop novel strategies, directed at these molecules, that may lead to the development of new treatments for patients with coronary artery disease. ..
  2. VisualSonics Vevo 770 Imaging System
    Lawrence Young; Fiscal Year: 2007
    ..Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children. ..
  3. REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEART
    Lawrence Young; Fiscal Year: 2007
    ..Such novel therapies may improve the quality of life and prevent cardiac death and have significant health benefit for the U.S. population. ..
  4. REGULATION OF GLUCOSE TRANSPORT IN THE ISCHEMIC HEART
    Lawrence Young; Fiscal Year: 2003
    ..Interaction of AMPK with other signaling pathways will be explored, as well as the role of specific isoforms of AMPK subunits in the heart. The relative roles of exocytosis vs. endocytosis in the process will be evaluated. ..
  5. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2010
    ..We propose to develop novel strategies, directed at these molecules, that may lead to the development of new treatments for patients with coronary artery disease. ..