Zhinan Yin

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults
    Zhinan Yin
    Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    Hum Immunol 71:1187-90. 2010
  2. ncbi Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, Room 517, 300 Cedar Street, 208031, New Haven, CT 06520-8031, USA
    Cancer Immunol Immunother 55:1258-66. 2006
  3. ncbi c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:308-16. 2008
  4. ncbi JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response
    Jian Tao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8031, USA
    Eur J Immunol 37:818-29. 2007
  5. ncbi Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells
    Liang Chen
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 178:2730-6. 2007
  6. ncbi JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:5783-9. 2005
  7. ncbi IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection
    Tian Wang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 171:2524-31. 2003
  8. ncbi IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis
    Joao H F Pedra
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    FEMS Immunol Med Microbiol 50:401-10. 2007
  9. ncbi Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response
    Meng Pan
    Section of Rheumatology, Yale School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Clin Immunol 24:481-91. 2004
  10. ncbi Gamma delta T cells provide an early source of interferon gamma in tumor immunity
    Yunfei Gao
    Section of Rheumatology, Yale School of Medicine, 300 Cedar Street, CAB Building Room S517, New Haven, CT 06520, USA
    J Exp Med 198:433-42. 2003

Research Grants

  1. Regulation/function of Gamma DELTA T cell differentiatio
    Zhinan Yin; Fiscal Year: 2005
  2. Mechanism and function of T cell differentiation
    Zhinan Yin; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. ncbi Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults
    Zhinan Yin
    Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    Hum Immunol 71:1187-90. 2010
    ....
  2. ncbi Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, Room 517, 300 Cedar Street, 208031, New Haven, CT 06520-8031, USA
    Cancer Immunol Immunother 55:1258-66. 2006
    ..In summary, our results demonstrate that AHCC can enhance tumor immune surveillance through regulating both innate and adaptive immune responses...
  3. ncbi c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:308-16. 2008
    ..Collectively, these findings provide strong evidence that JNK2 is an important regulatory protein for IFN-gamma secretion upon challenge with A. phagocytophilum...
  4. ncbi JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response
    Jian Tao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8031, USA
    Eur J Immunol 37:818-29. 2007
    ..In summary, our results demonstrate that JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response...
  5. ncbi Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells
    Liang Chen
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 178:2730-6. 2007
    ..Our results demonstrate that both epigenetic and transcriptional programs contribute to the early vigorous IFN-gamma production by gammadelta T cells...
  6. ncbi JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:5783-9. 2005
    ..Taken together, our results demonstrate that JNK1 plays an important role in tumor immune surveillance through regulating the effector functions of CD8+ T cells...
  7. ncbi IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection
    Tian Wang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 171:2524-31. 2003
    ..These data demonstrate a distinct role for gammadelta T cells in the control of and prevention of mortality from murine WN virus infection...
  8. ncbi IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis
    Joao H F Pedra
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    FEMS Immunol Med Microbiol 50:401-10. 2007
    ..The IL-12/23p40 subunit drives the CD4(+) Th1 immune response in the early phase of infection and IL-12/23p40-independent mechanisms ultimately contribute to pathogen elimination from the host...
  9. ncbi Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response
    Meng Pan
    Section of Rheumatology, Yale School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Clin Immunol 24:481-91. 2004
    ..Our results define for the first time that a defective secondary immune responses in B6 mice leads to the resistance of CIA...
  10. ncbi Gamma delta T cells provide an early source of interferon gamma in tumor immunity
    Yunfei Gao
    Section of Rheumatology, Yale School of Medicine, 300 Cedar Street, CAB Building Room S517, New Haven, CT 06520, USA
    J Exp Med 198:433-42. 2003
    ..These results demonstrate that gammadelta T cells can play a necessary role in tumor immunity through provision of an early source of IFN-gamma that in turn may regulate the function of tumor-triggered alphabeta T cells...
  11. ncbi Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response
    Xin You
    Yale University, New Haven, Connecticut 06520-8031, USA
    Arthritis Rheum 54:877-86. 2006
    ..CONCLUSION: Because of its ability to specifically suppress innate immune responses, DCB 3503 may be a novel therapeutic agent for inflammatory arthritis in humans...
  12. ncbi IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
    Jian Tao
    Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520 8031, USA
    Arthritis Res Ther 13:R212. 2011
    ..However, the role of this cytokine in T cells in the pathogenesis of collagen-induced arthritis is unclear. The purpose of this study was to define the role of IL-10 signaling in T cells in the pathogenesis of collagen-induced arthritis...
  13. ncbi Regulation of pulmonary fibrosis by chemokine receptor CXCR3
    Dianhua Jiang
    Department of Medicine, Section of Pulmonary and Critical Care, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 114:291-9. 2004
    ..These data demonstrate a nonredundant role for CXCR3 in limiting tissue fibroproliferation and suggest that this effect may be mediated, in part, by the innate production of IFN-gamma following lung injury...
  14. ncbi IL-10 regulates murine lupus
    Zhinan Yin
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 169:2148-55. 2002
    ..In summary, our results provide evidence that IL-10 can down-modulate murine lupus through inhibition of pathogenic Th1 cytokine responses. Modulation of the level of IL-10 may be of potential therapeutic benefit for human lupus...
  15. ncbi A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice
    Lin Leng
    Department of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 186:527-38. 2011
    ..These data highlight the feasibility of targeting the MIF-MIF receptor interaction by small-molecule antagonism and support the therapeutic value of downregulating MIF-dependent pathways of tissue damage in systemic lupus erythematosus...
  16. ncbi STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
    Thomas Welte
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:1879-84. 2003
    ....
  17. ncbi T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells
    Zhinan Yin
    Sections of Rheumatology and Pulmonary and Critical Care Medicine, Department of Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:1566-71. 2002
    ....

Research Grants4

  1. Regulation/function of Gamma DELTA T cell differentiatio
    Zhinan Yin; Fiscal Year: 2005
    ..Study of the mechanisms of gamma-delta T cell differentiation in vitro and their functions in vivo is critical for understanding the function of gamma-delta T cells in immune responses. ..
  2. Mechanism and function of T cell differentiation
    Zhinan Yin; Fiscal Year: 2006
    ..abstract_text> ..