Yong Xiong


Affiliation: Yale University
Country: USA


  1. Wolfe L, Stanley B, Liu C, Eliason W, Xiong Y. Dissection of the HIV Vif interaction with human E3 ubiquitin ligase. J Virol. 2010;84:7135-9 pubmed publisher
    ..Our purified Vif constructs also provide direct biochemical evidence that the Vif cullin box, containing the PPLP region, leads to the dimerization of Vif-EloBC complexes but not Cul5-Vif-EloBC complexes. ..
  2. Zhang Y, Cheng T, Huang G, Lu Q, Surleac M, Mandell J, et al. Transposon molecular domestication and the evolution of the RAG recombinase. Nature. 2019;: pubmed publisher
  3. Wang W, Chen X, Wolin S, Xiong Y. Structural Basis for tRNA Mimicry by a Bacterial Y RNA. Structure. 2018;26:1635-1644.e3 pubmed publisher
    ..Since nucleotides in the D and T stems are conserved among YrlAs, they may be an interaction site for an unknown factor. Our experiments identify YrlA RNAs as a new class of tRNA mimics. ..
  4. Knecht K, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, et al. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc Natl Acad Sci U S A. 2018;115:E10022-E10031 pubmed publisher
  5. Jia X, Zhao Q, Xiong Y. HIV suppression by host restriction factors and viral immune evasion. Curr Opin Struct Biol. 2015;31:106-14 pubmed publisher
    ..Here we review the recent developments towards establishing the structural and biochemical bases of HIV inhibition by, and viral countermeasures of, the restriction factors TRIM5, MxB, APOBEC3, SAMHD1, and BST2/tetherin. ..
  6. Rao T, Longerich S, Zhao W, Aihara H, Sung P, Xiong Y. Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage. DNA Repair (Amst). 2018;64:53-58 pubmed publisher
    ..Our study therefore furnishes biochemical evidence for a role of hFAN1 homodimerization in biological processes that involve 5' DNA Flap cleavage. ..
  7. Ji X, Xiong Y. Two tales (tails) of SAMHD1 destruction by Vpx. Cell Host Microbe. 2015;17:425-7 pubmed publisher
    ..In this issue of Cell Host & Microbe, Schwefel et al. (2015) report the structural basis of SAMHD1 N-terminal targeting by Vpx. ..
  8. Nguyen H, Yang H, Fribourgh J, Wolfe L, Xiong Y. Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex. Structure. 2015;23:441-449 pubmed publisher
    ..Our structure provides a structural basis for the study of the pathogenesis of VHL disease and rationale for the design of novel compounds that may modulate cullin-substrate receptor interactions. ..
  9. Tang C, Ji X, Wu L, Xiong Y. Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592. J Biol Chem. 2015;290:26352-9 pubmed publisher
    ..These results provide a mechanistic understanding of how SAMHD1 phosphorylation at residue Thr-592 may modulate its cellular and antiviral functions. ..

More Information


  1. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, et al. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. elife. 2014;3:e02362 pubmed publisher
    ..The ability of Vpu to hijack AP-dependent trafficking pathways suggests a potential common theme for Vpu-mediated downregulation of host proteins.DOI: http://dx.doi.org/10.7554/eLife.02362.001. ..
  2. Ji X, Tang C, Zhao Q, Wang W, Xiong Y. Structural basis of cellular dNTP regulation by SAMHD1. Proc Natl Acad Sci U S A. 2014;111:E4305-14 pubmed publisher
    ..These results establish a complete framework for a mechanistic understanding of the important functions of SAMHD1 in the regulation of cellular dNTP levels, as well as in HIV restriction and the pathogenesis of CLL and AGS. ..
  3. al Yacoub N, Shaheen R, Awad S, Kunhi M, Dzimiri N, Nguyen H, et al. FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy. Genome Biol. 2016;17:2 pubmed publisher
    ..Our results indicate that abnormal SCF activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of DCM. ..
  4. Nguyen H, Wang W, Xiong Y. Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction. Subcell Biochem. 2017;83:323-347 pubmed publisher
  5. Buzovetsky O, Kwon Y, Pham N, Kim C, Ira G, Sung P, et al. Role of the Pif1-PCNA Complex in Pol ?-Dependent Strand Displacement DNA Synthesis and Break-Induced Replication. Cell Rep. 2017;21:1707-1714 pubmed publisher
    ..These results provide insights into the role of the Pif1-PCNA-PolĀ ? ensemble during DNA break repair by homologous recombination. ..
  6. Buzovetsky O, Tang C, Knecht K, Antonucci J, Wu L, Ji X, et al. The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun. 2018;9:411 pubmed publisher
    ..Our results provide insights into the regulation of SAMHD1 activity, thereby facilitating the improvement of HIV mouse models and the development of new therapies for certain cancers and autoimmune diseases. ..