Research Topics
Species | Guido WollmannSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potentialGuido Wollmann
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Virol 79:6005-22. 2005..Together, these data suggest that four (VSV, Sindbis virus, MVMi, and MVMp) of the nine viruses studied merit further analysis for potential therapeutic actions on glioblastoma...
Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptorsGuido Wollmann
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
J Neurophysiol 94:2195-206. 2005..Together, these results show a depolarizing response to extracellular ATP that would lead to an increased activity of the hypocretin arousal system...- Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease miceGuido Wollmann
Institut fuer Klinische Physiologie, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
Vision Res 46:688-98. 2006..Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models... - Variable deficiencies in the interferon response enhance susceptibility to vesicular stomatitis virus oncolytic actions in glioblastoma cells but not in normal human glial cellsGuido Wollmann
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Virol 81:1479-91. 2007..Together, our results demonstrate that activation of the interferon pathway protects normal human brain cells from VSV infection while maintaining the vulnerability of human glioblastoma cells to viral destruction... 
Oncolytic virus therapy for glioblastoma multiforme: concepts and candidatesGuido Wollmann
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
Cancer J 18:69-81. 2012....- Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cellsGuido Wollmann
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Virol 84:1563-73. 2010..We concluded that some, but not all, attenuated VSV mutants display a favorable oncolytic profile and merit further investigation... - Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brainAnthony N van den Pol
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Virol 81:332-48. 2007..These results suggest that coupling IFN administration with current treatments may reduce CMV infections in the developing brain... - Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expressionAnthony N van den Pol
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Comp Neurol 516:456-81. 2009..DG-VSVs with genes coding for different color reporters allow multicolor visualization of neurons wherever applied... - Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brainKoray Ozduman
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 28:1882-93. 2008..Quantitative PCR analysis of how VSVrp30a selectively infected tumor cells suggested multiple mechanisms, including cell surface binding and internalization... - Peripheral immunization blocks lethal actions of vesicular stomatitis virus within the brainKoray Ozduman
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
J Virol 83:11540-9. 2009..These results indicate that attenuated recombinant viruses show reduced neurovirulence and that peripheral immunization blocks the lethal actions of all VSVs tested... - Rostral midbrain infarction producing isolated lateropulsionJoachim M Baehring
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA
Neurology 70:655-6. 2008 - Effects of protein kinase C on delayed rectifier K+ channel regulation by tyrosine kinase in rat retinal pigment epithelial cellsOlaf Strauss
Institute for Clinical Physiology, Benjamin Franklin University Clinic, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
Invest Ophthalmol Vis Sci 43:1645-54. 2002..Investigation of the regulation of delayed rectifier potassium channels by protein kinases in retinal pigment epithelial (RPE) cells... - Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processingJavier Ortego
Yale University School of Medicine, Department of Ophthalmology and Visual Science, 330 Cedar Street, New Haven, CT 06510, USA
Neurosci Lett 333:49-53. 2002..PC1 and PC2 mRNA expression was induced in a cell-specific manner by the same agents that enhanced pro-NT/NN biosynthesis. These results demonstrate cell-specific processing of pro-NT/NN by the ciliary epithelium...