ADAM WISNEWSKI

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Chem Biol Interact 205:38-45. 2013
  2. pmc Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG
    Adam V Wisnewski
    Department of Internal Medicine, Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Ann Occup Hyg 56:901-10. 2012
  3. pmc Hexamethylene diisocyanate (HDI) vapor reactivity with glutathione and subsequent transfer to human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Toxicol In Vitro 27:662-71. 2013
  4. pmc Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, United States
    Mol Immunol 54:233-7. 2013
  5. pmc Developments in laboratory diagnostics for isocyanate asthma
    Adam V Wisnewski
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520 8057, USA
    Curr Opin Allergy Clin Immunol 7:138-45. 2007
  6. pmc Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates
    A V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Clin Exp Allergy 38:957-67. 2008
  7. pmc Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Anal Biochem 400:251-8. 2010
  8. pmc Pro/Con debate: Is occupational asthma induced by isocyanates an immunoglobulin E-mediated disease?
    A V Wisnewski
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Clin Exp Allergy 40:1155-62. 2010
  9. pmc Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
    Adam V Wisnewski
    Department of Internal Medicine Yale University School of Medicine 300 Cedar Street New Haven, CT 06510, USA
    J Occup Med Toxicol 6:6. 2011
  10. pmc Toluene diisocyanate reactivity with glutathione across a vapor/liquid interface and subsequent transcarbamoylation of human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8057, USA
    Chem Res Toxicol 24:1686-93. 2011

Research Grants

Detail Information

Publications23

  1. pmc Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Chem Biol Interact 205:38-45. 2013
    ..Together, the data define a non-enzymatic, thiol-mediated transcarbamoylating mechanism by which GSH may promote immune responses to MDI exposure, and identify specific factors that might further modulate this process. ..
  2. pmc Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG
    Adam V Wisnewski
    Department of Internal Medicine, Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Ann Occup Hyg 56:901-10. 2012
    ..Hexamethylene diisocyanate (HDI)-specific serum immunoglobulin G (IgG) was evaluated as an exposure biomarker among workers at a US Air Force Air Logistics Center, which includes a large aircraft maintenance facility...
  3. pmc Hexamethylene diisocyanate (HDI) vapor reactivity with glutathione and subsequent transfer to human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Toxicol In Vitro 27:662-71. 2013
    ..Airway fluid glutathione (GSH) reactivity with inhaled vapors of diisocyanate, a common occupational allergen, is postulated to be a key step in exposure-induced asthma pathogenesis...
  4. pmc Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, United States
    Mol Immunol 54:233-7. 2013
    ..Together, the data provide new insight into the molecular determinants of humoral MDI specificity, and characterize anti-MDI IgG1 mAbs that may be developed into useful diagnostic reagents...
  5. pmc Developments in laboratory diagnostics for isocyanate asthma
    Adam V Wisnewski
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520 8057, USA
    Curr Opin Allergy Clin Immunol 7:138-45. 2007
    ..With the increasing use of isocyanates, efficient laboratory tests for isocyanate asthma and exposure are urgently needed...
  6. pmc Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates
    A V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Clin Exp Allergy 38:957-67. 2008
    ..Isocyanates, a leading cause of occupational asthma, are known to induce adaptive immune responses; however, innate immune responses, which generally precede and regulate adaptive immunity, remain largely uncharacterized...
  7. pmc Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Anal Biochem 400:251-8. 2010
    ..The study also describes new applications of contemporary proteomic methodology for characterizing and standardizing MDI-albumin conjugates destined for use in clinical research...
  8. pmc Pro/Con debate: Is occupational asthma induced by isocyanates an immunoglobulin E-mediated disease?
    A V Wisnewski
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Clin Exp Allergy 40:1155-62. 2010
    ..The present Pro/Con Debate, addresses contemporary, controversial issues regarding IgE in isocyanate asthma...
  9. pmc Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
    Adam V Wisnewski
    Department of Internal Medicine Yale University School of Medicine 300 Cedar Street New Haven, CT 06510, USA
    J Occup Med Toxicol 6:6. 2011
    ..abstract:..
  10. pmc Toluene diisocyanate reactivity with glutathione across a vapor/liquid interface and subsequent transcarbamoylation of human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8057, USA
    Chem Res Toxicol 24:1686-93. 2011
    ..Together, the data extend the proof-of-principle for GSH to act as a "shuttle" for a reactive form of TDI, which could contribute to clinical responses to exposure...
  11. ncbi request reprint Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo
    A V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Crit Care Med 162:2330-6. 2000
    ..The data from this study identify keratin and other proteins as potential "carriers" for diisocyanates in vivo, and suggest that HDI conjugation of these proteins may play a role in the pathogenesis of diisocyanate-induced asthma...
  12. ncbi request reprint Isocyanate vapor-induced antigenicity of human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520, USA
    J Allergy Clin Immunol 113:1178-84. 2004
    ..The bioreactivity of isocyanate, a leading cause of occupational asthma, has led to uncertainty regarding the chemical's antigenicity and mechanisms that elicit immunopathology...
  13. ncbi request reprint Human gamma/delta T-cell lines derived from airway biopsies
    A V Wisnewski
    Pulmonary and Critical Care Section, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Cell Mol Biol 24:332-8. 2001
    ..The data suggest that gamma/delta T cells may be functionally enriched in human airways relative to peripheral blood...
  14. ncbi request reprint Recent developments in diisocyanate asthma
    A V Wisnewski
    Occupational and Environmental Medicine Pulmonary and Critical Care Section, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Allergy Clin Immunol 1:169-75. 2001
    ..A better understanding of the pathogenesis of diisocyanate asthma should facilitate the development of better diagnostic tests and strategies for disease surveillance and intervention...
  15. pmc Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Environ Health Perspect 110:901-7. 2002
    ..Together, the data describe a novel approach for investigating the effects of HDI binding and uptake by human airway epithelial cells and begin to identify genes that may be involved in the acute response to exposure...
  16. ncbi request reprint Recent developments in diisocyanate asthma
    Qing Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann Allergy Asthma Immunol 90:35-41. 2003
    ..To summarize the latest experimental findings on diisocyanate asthma and discuss the impact of these data on our understanding of disease pathogenesis and diagnosis...
  17. ncbi request reprint Suburban leptospirosis: atypical lymphocytosis and gamma-delta T cell response
    Michele Barry
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Clin Infect Dis 43:1304-7. 2006
    ..Atypical lymphocytosis corresponded to an expansion of gamma-delta T cells in peripheral blood...
  18. ncbi request reprint Mouse models of diisocyanate asthma
    Carrie A Redlich
    Occupational Medical Program and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Am J Respir Cell Mol Biol 27:385-90. 2002
  19. ncbi request reprint Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Immunobiology and Dermatology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Allergy Clin Immunol 112:538-46. 2003
    ..The human immune response to isocyanate, a leading cause of occupational asthma, remains incompletely characterized, including the cell types involved and the form of the chemical that acts as an antigen...
  20. ncbi request reprint A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge
    Christina A Herrick
    Departments of Dermatology, Immunobiology, and Internal Medicine, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    J Allergy Clin Immunol 109:873-8. 2002
    ..In contrast to mouse models of atopic asthma, previous mouse models of diisocyanate-induced asthma have failed to show lung inflammation with characteristics of human disease...
  21. ncbi request reprint Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation
    Christina A Herrick
    Departments of Dermatology, Immunobiology, and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Allergy Clin Immunol 111:1087-94. 2003
    ....
  22. pmc Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates
    Anjoeka Pronk
    Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Am J Respir Crit Care Med 176:1090-7. 2007
    ..Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers...
  23. ncbi request reprint Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma
    Young Min Ye
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Allergy Clin Immunol 118:885-91. 2006
    ..Structural elucidation of TDI-albumin conjugates is crucial to understanding the human immune response to TDI exposure...

Research Grants12

  1. Isocyanate Antigens and T-cells that Cause Asthma
    ADAM WISNEWSKI; Fiscal Year: 2005
    ..Together the results should provide significant insights into the pathogenesis of diisocyanate asthma. ..
  2. Human Lung gamma/delta T cells, Antigens and Functions
    ADAM WISNEWSKI; Fiscal Year: 2004
    ..The results of these experiments should provide important insights into the role of airway mucosal gamma/delta T cells in maintaining human pulmonary immune homeostasis. ..
  3. ISOCYANATE ANTIGENS AND T CELLS THAT CAUSE ASTHMA
    ADAM WISNEWSKI; Fiscal Year: 2001
    ..Characterization of isocyanate antigens and isocyanate-responsive T-cells will identify targets for the diagnosis, prevention and treatment of isocyanate asthma. ..