Graham V Williams

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi A role for inhibition in shaping the temporal flow of information in prefrontal cortex
    Christos Constantinidis
    Department of Neurobiology, Yale University School of Medicine, P.O. Box 208001, 333 Cedar Street, SHM B404, New Haven, Connecticut 06520-8001, USA
    Nat Neurosci 5:175-80. 2002
  2. ncbi The physiological role of 5-HT2A receptors in working memory
    Graham V Williams
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:2843-54. 2002
  3. ncbi Under the curve: critical issues for elucidating D1 receptor function in working memory
    G V Williams
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Neuroscience 139:263-76. 2006
  4. ncbi Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States VA Connecticut Healthcare System, West Haven, CT 06519, United States
    Behav Brain Res 212:41-8. 2010
  5. ncbi Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 210:407-18. 2010
  6. ncbi Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
  7. ncbi Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia
    Stacy A Castner
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 174:111-25. 2004
  8. ncbi Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 67:998-1001. 2010
  9. ncbi Glycine transporter inhibition reverses ketamine-induced working memory deficits
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Neuroreport 21:390-4. 2010
  10. ncbi Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 69:12-8. 2011

Research Grants

  1. Neurophysiology of Receptor Actions in Prefrontal Cortex
    Graham Williams; Fiscal Year: 2006

Collaborators

Detail Information

Publications14

  1. ncbi A role for inhibition in shaping the temporal flow of information in prefrontal cortex
    Christos Constantinidis
    Department of Neurobiology, Yale University School of Medicine, P.O. Box 208001, 333 Cedar Street, SHM B404, New Haven, Connecticut 06520-8001, USA
    Nat Neurosci 5:175-80. 2002
    ..These findings suggest an important role of inhibition in the cerebral cortex-controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information...
  2. ncbi The physiological role of 5-HT2A receptors in working memory
    Graham V Williams
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:2843-54. 2002
    ..We conclude that prefrontal 5-HT2A receptors have a hitherto unrecognized role in the cognitive function of working memory, which involves actions at both excitatory and inhibitory elements within local circuitry...
  3. ncbi Under the curve: critical issues for elucidating D1 receptor function in working memory
    G V Williams
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Neuroscience 139:263-76. 2006
    ..If we look under the bell-shaped curve of prefrontal dopamine function, it is the relationship between neuromodulation and cognitive function that promises to bridge our knowledge between molecule and mind...
  4. ncbi Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States VA Connecticut Healthcare System, West Haven, CT 06519, United States
    Behav Brain Res 212:41-8. 2010
    ..These results support AMPA receptor potentiators as a potential adjunctive treatment for cognitive impairment associated with schizophrenia (CIAS)...
  5. ncbi Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 210:407-18. 2010
    ..Translational studies with ketamine in nonhuman primates promise to extend the neurobiological understanding of this model...
  6. ncbi Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
    ..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience...
  7. ncbi Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia
    Stacy A Castner
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 174:111-25. 2004
    ..Prefrontal dysfunction in schizophrenia has been linked to altered dopaminergic and glutamatergic transmission. However, to date, antipsychotics provide no substantial relief from the debilitating cognitive consequences of this disease...
  8. ncbi Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 67:998-1001. 2010
    ....
  9. ncbi Glycine transporter inhibition reverses ketamine-induced working memory deficits
    Brooke M Roberts
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Neuroreport 21:390-4. 2010
    ..Theses findings build upon those in patients by providing translational support for targeting glycine transporter in adjunctive treatment for cognitive dysfunction in schizophrenia...
  10. ncbi Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 69:12-8. 2011
    ..Here, we sought to establish whether selective stimulation of the neuronal nicotinic α7 receptor could improve spatial working memory in nonhuman primates...
  11. ncbi From vice to virtue: insights from sensitization in the nonhuman primate
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1572-92. 2007
    ..Actively harnessing this same process by repeated, intermittent D1 agonist administration may be the key to improved working memory and decision making in addiction and other dopamine dysfunctional states, such as schizophrenia...
  12. ncbi Tuning the engine of cognition: a focus on NMDA/D1 receptor interactions in prefrontal cortex
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Brain Cogn 63:94-122. 2007
    ....
  13. ncbi Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
    Patricia S Goldman-Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychopharmacology (Berl) 174:3-16. 2004
    ..Moreover, working memory deficits can be ameliorated by treatments that augment D(1) receptor stimulation, indicating that this target presents a unique opportunity for the restoration of cognitive function in schizophrenia...
  14. ncbi Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States
    Drug Discov Today 14:690-7. 2009
    ..In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia...

Research Grants3

  1. Neurophysiology of Receptor Actions in Prefrontal Cortex
    Graham Williams; Fiscal Year: 2006
    ..Findings from this work will help to elucidate the elements of intrinsic circuitry by which dopamine exerts its role in prefrontal function and pinpoint the probable sites of dopamine dysregulation in schizophrenia. ..