N M Wikonkal
Affiliation: Yale University
- Ultraviolet radiation induced signature mutations in photocarcinogenesisN M Wikonkal
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
J Investig Dermatol Symp Proc 4:6-10. 1999..Thus cancer involves both a single-cell problem and a multi-cell problem; in skin cancer, sunlight appears to drive both...
- The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genesD E Brash
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Conneticut 06520 8040, USA
J Invest Dermatol 117:1234-40. 2001..DNA photoproducts in actively transcribed genes were involved in approximately 89% of the Mdm2 response...
- Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteineM Liu
Department of Therapeutic Radiology and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8040, USA
Carcinogenesis 20:1869-72. 1999..An antioxidant whose action is limited to scavenging radicals, Trolox, does not induce G(1) arrest. Taken together, these results suggest a potential novel molecular basis for chemoprevention by NAC...
- Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutationsW Zhang
Department of Therapeutic Radiology Yale School of Medicine, P.O. Box 208040, New Haven, CT 06520-8040, USA
Proc Natl Acad Sci U S A 98:13948-53. 2001....