Bruce Wexler

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1694-7. 2000
  2. ncbi request reprint Word and tone working memory deficits in schizophrenia
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 55:1093-6. 1998
  3. ncbi request reprint Functional magnetic resonance imaging of cocaine craving
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Am J Psychiatry 158:86-95. 2001
  4. ncbi request reprint Deficits in language-mediated mental operations in patients with schizophrenia
    Bruce E Wexler
    Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, 34, Park Street, New Haven, CT 06519, USA
    Schizophr Res 53:171-9. 2002
  5. ncbi request reprint Cognitive remediation and vocational rehabilitation for schizophrenia
    Bruce E Wexler
    Department of Psychiatry, Yale University, USA
    Schizophr Bull 31:931-41. 2005
  6. doi request reprint Neuropsychological near normality and brain structure abnormality in schizophrenia
    Bruce E Wexler
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park St, New Haven, CT 06519, USA
    Am J Psychiatry 166:189-95. 2009
  7. ncbi request reprint Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Arch Gen Psychiatry 62:649-59. 2005
  8. doi request reprint Neurocognitive enhancement therapy with vocational services: work outcomes at two-year follow-up
    Morris D Bell
    VA Connecticut Healthcare System, Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Schizophr Res 105:18-29. 2008
  9. ncbi request reprint Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
    Joanna M Fiszdon
    Department of Psychiatry, Yale University School of Medicine, 25 Park Street, New Haven, CT 06519, USA
    Psychiatry Res 125:1-7. 2004
  10. ncbi request reprint Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
    Sara L Dolan
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, Rm S 109, Substance Abuse Center, New Haven, CT 06519, USA
    Schizophr Res 70:263-75. 2004

Detail Information

Publications35

  1. ncbi request reprint Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1694-7. 2000
    ..The authors' goal was to evaluate the possibility of treating brain and behavioral aspects of verbal memory dysfunction in patients with schizophrenia through cognitive exercises...
  2. ncbi request reprint Word and tone working memory deficits in schizophrenia
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 55:1093-6. 1998
    ..Verbal memory deficits have been reported in many studies of patients with schizophrenia. We evaluated the specificity of these deficits by comparing patients and control subjects on several verbal and nonverbal auditory memory tests...
  3. ncbi request reprint Functional magnetic resonance imaging of cocaine craving
    B E Wexler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Am J Psychiatry 158:86-95. 2001
    ..Identification of brain activity associated with craving is important for understanding the neurobiology of addiction...
  4. ncbi request reprint Deficits in language-mediated mental operations in patients with schizophrenia
    Bruce E Wexler
    Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, 34, Park Street, New Haven, CT 06519, USA
    Schizophr Res 53:171-9. 2002
    ..The verbal memory tests were easier than the non-verbal memory tests for controls, thus deconfounding task difficulty and deficit specificity...
  5. ncbi request reprint Cognitive remediation and vocational rehabilitation for schizophrenia
    Bruce E Wexler
    Department of Psychiatry, Yale University, USA
    Schizophr Bull 31:931-41. 2005
    ..Instead, the goal is to provide the rationale for the progression of our studies, describe the methods, and summarize the results, so that readers may understand, critique, and improve upon what we have done...
  6. doi request reprint Neuropsychological near normality and brain structure abnormality in schizophrenia
    Bruce E Wexler
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park St, New Haven, CT 06519, USA
    Am J Psychiatry 166:189-95. 2009
    ....
  7. ncbi request reprint Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Arch Gen Psychiatry 62:649-59. 2005
    ..Cigarette smoking rates in schizophrenia are higher than in the general population...
  8. doi request reprint Neurocognitive enhancement therapy with vocational services: work outcomes at two-year follow-up
    Morris D Bell
    VA Connecticut Healthcare System, Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Schizophr Res 105:18-29. 2008
    ..The present study aimed to determine whether NET could enhance functional outcomes among schizophrenia and schizoaffective patients in a community mental health center receiving community-based vocational services...
  9. ncbi request reprint Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
    Joanna M Fiszdon
    Department of Psychiatry, Yale University School of Medicine, 25 Park Street, New Haven, CT 06519, USA
    Psychiatry Res 125:1-7. 2004
    ..There were no significant group differences on the word serial position task at any time point. Results indicate that computerized training can lead to sustained improvements on some, but not all, training tasks...
  10. ncbi request reprint Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
    Sara L Dolan
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, Rm S 109, Substance Abuse Center, New Haven, CT 06519, USA
    Schizophr Res 70:263-75. 2004
    ..These preliminary data suggest that in schizophrenics, neuropsychological deficits are associated with smoking cessation treatment failure...
  11. pmc Predictors of on-site vocational support for people with schizophrenia in supported employment
    Wayne Zito
    Yale University School of Medicine, Department of Psychiatry, 34 Park St, New Haven, CT 06519, United States
    Schizophr Res 94:81-8. 2007
    ..Results suggest that these clients require more specialist contact because of failure to adequately engage natural supports at work...
  12. ncbi request reprint Neurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups
    Morris D Bell
    Department of Veterans Affairs VA Connecticut Healthcare System, West Haven, CT, USA
    J Rehabil Res Dev 42:829-38. 2005
    ..Results indicate that work outcomes were enhanced by NET training. Effects were greatest for NET responders. Findings support the efficacy of cognitive training when it is integrated into broader rehabilitation programs...
  13. pmc Improved cognitive function in schizophrenia after one year of cognitive training and vocational services
    Tamasine C Greig
    Yale University School of Medicine, Department of Psychiatry, Connecticut, USA
    Schizophr Res 96:156-61. 2007
    ..Augmenting vocational services with a multifaceted cognitive remediation program may improve cognition in participants with schizophrenia or schizoaffective disorder...
  14. ncbi request reprint Neuropsychological deficits in nonsmokers with schizophrenia: effects of a nicotinic antagonist
    Kristi A Sacco
    Program for Research in Smokers with Mental Illness PRISM, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 85:213-21. 2006
    ....
  15. ncbi request reprint Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 183:171-80. 2005
    ..Identifying neural activity associated with stress and stress-induced cocaine craving is important in understanding the neurobiology of cocaine craving and relapse...
  16. ncbi request reprint Cue-induced brain activity changes and relapse in cocaine-dependent patients
    Thomas R Kosten
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:644-50. 2006
    ..This physiological activation was a better predictor of relapse than subjective reports of craving, and may be a useful target for treatment development...
  17. pmc Memory profiles in schizophrenia: categorization validity and stability
    Morris D Bell
    VA Connecticut Healthcare System, Psychology Service, West Haven CT 06516, United States
    Schizophr Res 118:26-33. 2010
    ....
  18. doi request reprint Teaching an interdisciplinary approach to the treatment of chronic mental illness: challenges and rewards
    Jeanne L Steiner
    Connecticut Mental Health Center, New Haven, CT, USA
    Acad Psychiatry 32:255-8. 2008
    ....
  19. pmc Social attribution test--multiple choice (SAT-MC) in schizophrenia: comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures
    Morris D Bell
    VA Connecticut Healthcare System, Rehabilitation Research and Development Service, West Haven, CT 06517, USA
    Schizophr Res 122:164-71. 2010
    ..Logistic regression using SAT-MC scores correctly classified 75% of both samples. Results suggest that this measure may have promise, but alternative versions will be needed before it can be used in pre-post or longitudinal designs...
  20. ncbi request reprint Gambling urges in pathological gambling: a functional magnetic resonance imaging study
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 60:828-36. 2003
    ..An improved understanding of the neural correlates of gambling urges in PG would advance our understanding of the brain mechanisms underlying PG and would help direct research into effective treatments...
  21. ncbi request reprint Replication of a premenstrual decrease in right-ear advantage on language-related dichotic listening tests of cerebral laterality
    Gerianne M Alexander
    Yale University Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    Neuropsychologia 40:1293-9. 2002
    ..Future research manipulating task demands (e.g. memory load) or the affective valence of the stimuli may be useful in understanding the observed changes in hemispheric advantage...
  22. ncbi request reprint Effects of smoking abstinence on visuospatial working memory function in schizophrenia
    Tony P George
    Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 26:75-85. 2002
    ..These results suggest that smoking abstinence differentially alters VSWM in schizophrenic vs. control smokers, and that cigarette smoking has beneficial effects on VSWM in schizophrenic, but not control, smokers...
  23. ncbi request reprint Test-retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients
    Tamsine Conway Greig
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Room 527, 34 Park Street, New Haven, CT 06915, USA
    Psychiatry Res 129:241-7. 2004
    ....
  24. ncbi request reprint Neural circuits underlying emotional distress in humans
    Rajita Sinha
    Program of Research on Stress, Addiction and Psychopathology, Departmetn of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Ann N Y Acad Sci 1032:254-7. 2004
    ..The study also provides a feasible method to study brain correlates of emotional stress processing in healthy individuals and clinical samples...
  25. ncbi request reprint Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
    Nelson H Donegan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8098, USA
    Biol Psychiatry 54:1284-93. 2003
    ..We hypothesized that amygdala hyperreactivity contributes to hypervigilance, emotional dysregulation, and disturbed interpersonal relations in BPD...
  26. ncbi request reprint Functional MRI changes before and after onset of reported emotions
    Isak Prohovnik
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 132:239-50. 2004
    ..The neural correlates of the evoked emotion are multiple, widely distributed, and inclusive of areas important in many cognitive tasks. Positive and negative emotional responses include activation of common and distinctive brain regions...
  27. ncbi request reprint A pilot study of a weight management program with food provision in schizophrenia
    Michel Jean-Baptiste
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Res 96:198-205. 2007
    ....
  28. pmc Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation
    Matthew M Kurtz
    Department of Psychology, Wesleyan University, Middletown, CT 06459, USA
    Schizophr Res 102:303-11. 2008
    ..These findings emphasize the importance of verbal learning for benefiting from psychosocial and cognitive rehabilitation interventions, and suggest the development of alternative rehabilitation strategies for those who do not benefit...
  29. ncbi request reprint The Penn Conditional Exclusion Test (PCET): relationship to the Wisconsin Card Sorting Test and work function in patients with schizophrenia
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program and Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 68:95-102. 2004
    ..These results provide the first evidence of criterion-related validity for the PCET and are part of a growing literature suggesting a relationship between performance on measures of executive function and work skills...
  30. pmc Computer-assisted cognitive remediation in schizophrenia: what is the active ingredient?
    Matthew M Kurtz
    Schizophrenia Rehabilitation and Resource Center, Institute of Living, Hartford, CT, United States
    Schizophr Res 89:251-60. 2007
    ....
  31. ncbi request reprint Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
    Gerard E Bruder
    New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA USA
    Schizophr Res 68:137-47. 2004
    ..The findings add to growing evidence for the existence of a subgroup of schizophrenia having a specific verbal memory deficit that is not limited to working memory, but extends to learning and recall of verbal material...
  32. ncbi request reprint Instability of cognitive processing systems in schizophrenia
    Bruce E Wexler
    Schizophr Res 71:513-4. 2004
  33. ncbi request reprint Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: do they reflect distinct neurocognitive subtypes with distinct functional profiles?
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program and Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Res 81:167-71. 2006
    ..The intact WCST subgroup had greater functional capacity than either "strong" or "poor" learners. These subtypes may have implications for response to behavioral treatment interventions...
  34. ncbi request reprint Atypical depression: enhanced right hemispheric dominance for perceiving emotional chimeric faces
    Gerard E Bruder
    Department of Biopsychology, New York State Psychiatric Institute, New York 10032, USA
    J Abnorm Psychol 111:446-54. 2002
    ..This is further evidence that atypical depression is a biologically distinct subtype and underscores the importance of this diagnostic distinction for neurophysiologic studies...
  35. ncbi request reprint Neurocognitive function in schizophrenia at a 10-year follow-up: a preliminary investigation
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    CNS Spectr 10:277-80. 2005
    ..The goal of the study was to evaluate changes in full-scale intelligence quotient and neurocognitive test performance over a 10-year interval in patients with schizophrenia...

Research Grants11

  1. SUBTYPING SCHIZOPHRENIA WITH MEMORY TESTS, MRI AND FMRI
    Bruce Wexler; Fiscal Year: 1999
    ..Identification of such subgroups is essential for future studies of etiology and treatment. ..
  2. Research Education in Chronic Mental Illness
    Bruce Wexler; Fiscal Year: 2007
    ....
  3. fRMI Studies of Emotion and Cognition
    Bruce Wexler; Fiscal Year: 2007
    ..Both projects provide opportunities to develop and apply skills in measurement of inter-regional brain connectivity and in use of new analytic software. ..
  4. fMRI of Cognitive Remediation Therapy in Schizophrenia
    Bruce Wexler; Fiscal Year: 2005
    ....
  5. fMRI During Simulated Social Interactions in Schizophrenia: Emotion and Cognition
    Bruce E Wexler; Fiscal Year: 2010
    ..In this project we will use new knowledge from social neuroscience research and newly developed brain imaging procedures to study brain aspects of the patient problems in social-emotional function. ..