Brian L Weiss
Affiliation: Yale University
- The peritrophic matrix mediates differential infection outcomes in the tsetse fly gut following challenge with commensal, pathogenic, and parasitic microbesBrian L Weiss
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520
J Immunol 193:773-82. 2014..Collectively, our findings indicate that effective insect antimicrobial responses depend largely upon the coordination of multiple host and microbe-specific developmental factors. ..
- Trypanosome infection establishment in the tsetse fly gut is influenced by microbiome-regulated host immune barriersBrian L Weiss
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
PLoS Pathog 9:e1003318. 2013..Our results document a novel finding, which is the existence of a positive correlation between tsetse's larval microbiome and the integrity of the emerging adult PM gut immune barrier...
- Obligate symbionts activate immune system development in the tsetse flyBrian L Weiss
Division of Epidemiology of Microbial Diseases, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 188:3395-403. 2012..Our finding that molecular components of Wigglesworthia exhibit immunostimulatory activity within tsetse is representative of a novel evolutionary adaptation that steadfastly links an obligate symbiont with its host...
- Tsetse immune system maturation requires the presence of obligate symbionts in larvaeBrian L Weiss
Department of Epidemiology and Public Health, Division of Epidemiology of Microbial Diseases, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS Biol 9:e1000619. 2011..This phenomenon provides evidence of yet another important physiological adaptation that further anchors the obligate symbiosis between tsetse and Wigglesworthia...
- OmpA-mediated biofilm formation is essential for the commensal bacterium Sodalis glossinidius to colonize the tsetse fly gutMichele A Maltz
Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, Connecticut, USA
Appl Environ Microbiol 78:7760-8. 2012..Acquiring a better understanding of the dynamics that promote Sodalis colonization of the tsetse gut may enhance the development of novel disease control strategies...
- An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein ABrian L Weiss
Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, LEPH 606, 60 College Street, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 105:15088-93. 2008..coli K12. Our results show that polymorphisms in the exposed loop domains of OmpA represent a microbial adaptation that mediates host tolerance of endogenous symbiotic bacteria...
- Tsetse fly microbiota: form and functionJingwen Wang
Department of Epidemiology of Microbial Diseases, Yale School of Public Health New Haven, CT, USA
Front Cell Infect Microbiol 3:69. 2013..This review provides a detailed description of tsetse's microbiome, and describes the physiology underlying host-microbe, and microbe-microbe, interactions that occur in this fly. ..
- Interspecific transfer of bacterial endosymbionts between tsetse fly species: infection establishment and effect on host fitnessBrian L Weiss
Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH 606, 60 College Street, New Haven, CT 06510, USA
Appl Environ Microbiol 72:7013-21. 2006..Our ability to transinfect tsetse flies is indicative of Sodalis ' recent evolutionary history with its tsetse fly host and demonstrates that this procedure may be used as a means of streamlining future paratransgenesis experiments...
- Analysis of multiple tsetse fly populations in Uganda reveals limited diversity and species-specific gut microbiotaEmre Aksoy
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
Appl Environ Microbiol 80:4301-12. 2014..Additionally, we discuss the implications of Wigglesworthia and Sodalis density variations as they relate to trypanosome transmission dynamics and vector competence variations associated with different tsetse species. ..
- Gene expression in commensal tsetse symbiontsBrian Weiss; Fiscal Year: 2007..Recombinant Sodalis will be reintroduced to tsetse. These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..