JOANNE B contact WEIDHAAS

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208040, New Haven, CT 06520, USA
    Cancer Res 67:11111-6. 2007
  2. ncbi The let-7 microRNA reduces tumor growth in mouse models of lung cancer
    Aurora Esquela-Kerscher
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell Cycle 7:759-64. 2008
  3. ncbi A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
    Lena J Chin
    Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
    Cancer Res 68:8535-40. 2008
  4. ncbi Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 15:4199-206. 2009
  5. ncbi A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death
    J B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9946-51. 2006
  6. ncbi A conserved RAS/mitogen-activated protein kinase pathway regulates DNA damage-induced cell death postirradiation in Radelegans
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Cancer Res 66:10434-8. 2006
  7. ncbi The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
    M Kato
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Oncogene 28:2419-24. 2009
  8. ncbi Postmastectomy radiation therapy for lymph node-negative, locally advanced breast cancer after modified radical mastectomy: analysis of the NCI Surveillance, Epidemiology, and End Results database
    James B Yu
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
    Cancer 113:38-47. 2008
  9. ncbi miRNA modulation of the cellular stress response
    Imran A Babar
    Yale University, Department of Molecular, Cellular and Developmental Biology, PO Box 208103, New Haven, CT 06520, USA
    Future Oncol 4:289-98. 2008
  10. ncbi MicroRNAs as a potential magic bullet in cancer
    Frank J Slack
    Yale University, Department of Molecular, Cellular and Developmental Biology, PO Box 208103, New Haven, CT 06520, USA
    Future Oncol 2:73-82. 2006

Research Grants

  1. Defining the Genetic Basis of the Radioresponse Using a C. elegans Tissue Model
    Joanne Weidhaas; Fiscal Year: 2007
  2. Let-7 microRNAs in Lung Cancer: Altering Growth and Radioresistance
    JOANNE B contact WEIDHAAS; Fiscal Year: 2010

Collaborators

  • DAVID EISENMANN
  • Frank Slack
  • Lynn D Wilson
  • Yong Zhu
  • Steven Belinsky
  • Imran A Babar
  • James B Yu
  • M Kato
  • Lena J Chin
  • Aurora Esquela-Kerscher
  • E Gillespie
  • K Keane
  • R Ullrich
  • S Nallur
  • A Esquela-Kerscher
  • T Paranjape
  • R U Muller
  • Andreas G Bader
  • David C Christiani
  • Elizabeth A Burki
  • Richard E Crowell
  • Kenneth K Kidd
  • Lance Ford
  • David Brown
  • Rajeshvari Patel
  • Elena Ratner
  • Rihong Zhai
  • Roman-Ulrich Muller
  • Shuguang Leng
  • Sunitha Nallur
  • Jason F Wiggins
  • Lubna Patrawala
  • Li Su
  • Roman Ulrich Muller
  • Eva Straka
  • Trupti Kulkarni
  • Robert Homer
  • Angie Cheng
  • Daniel Zelterman
  • Phong Trang

Detail Information

Publications10

  1. ncbi MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208040, New Haven, CT 06520, USA
    Cancer Res 67:11111-6. 2007
    ..These findings are the first direct evidence that miRNAs can suppress resistance to anticancer cytotoxic therapy, a common feature of cancer cells, and suggest that miRNAs may be a viable tool to augment current cancer therapies...
  2. ncbi The let-7 microRNA reduces tumor growth in mouse models of lung cancer
    Aurora Esquela-Kerscher
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell Cycle 7:759-64. 2008
    ..These findings provide direct evidence that let-7 acts as a tumor suppressor gene in the lung and indicate that this miRNA may be useful as a novel therapeutic agent in lung cancer...
  3. ncbi A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
    Lena J Chin
    Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
    Cancer Res 68:8535-40. 2008
    ..The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility...
  4. ncbi Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 15:4199-206. 2009
    ..To evaluate the potential of gene expression signatures to predict response to treatment in locally advanced cervical cancer treated with definitive chemotherapy and radiation...
  5. ncbi A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death
    J B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9946-51. 2006
    ..This genetic tissue model provides a valuable tool for oncology-based research and affords a platform to broaden our insight into responses to cytotoxic therapy in tissues...
  6. ncbi A conserved RAS/mitogen-activated protein kinase pathway regulates DNA damage-induced cell death postirradiation in Radelegans
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Cancer Res 66:10434-8. 2006
    ..Radelegans is a platform to further define the genetic basis of the radiation response in tissues...
  7. ncbi The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
    M Kato
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Oncogene 28:2419-24. 2009
    ....
  8. ncbi Postmastectomy radiation therapy for lymph node-negative, locally advanced breast cancer after modified radical mastectomy: analysis of the NCI Surveillance, Epidemiology, and End Results database
    James B Yu
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
    Cancer 113:38-47. 2008
    ..The role of postmastectomy radiotherapy (PMRT) for lymph node-negative locally advanced breast carcinoma (T3N0M0) after modified radical mastectomy (MRM) with regard to improvement in survival remains an area of controversy...
  9. ncbi miRNA modulation of the cellular stress response
    Imran A Babar
    Yale University, Department of Molecular, Cellular and Developmental Biology, PO Box 208103, New Haven, CT 06520, USA
    Future Oncol 4:289-98. 2008
    ....
  10. ncbi MicroRNAs as a potential magic bullet in cancer
    Frank J Slack
    Yale University, Department of Molecular, Cellular and Developmental Biology, PO Box 208103, New Haven, CT 06520, USA
    Future Oncol 2:73-82. 2006
    ..The let-7 miRNA is one of a number of 'oncomirs', natural miRNA tumor suppressors in lung tissue, which may prove useful in treating lung cancer or enhancing current treatments for lung cancer...

Research Grants4

  1. Defining the Genetic Basis of the Radioresponse Using a C. elegans Tissue Model
    Joanne Weidhaas; Fiscal Year: 2007
    ..This work will use a novel model, Radelegans, to identify single-gene targets as well as test the potential of newly identified gene regulators (microRNAs) to accomplish these goals. ..
  2. Let-7 microRNAs in Lung Cancer: Altering Growth and Radioresistance
    JOANNE B contact WEIDHAAS; Fiscal Year: 2010
    ..In this proposal we plan experiments to learn how to harness these natural genetic growth repressors to work towards their application to cancer therapy. ..