Research Topics
Genomes and Genes
Species | Ning WeiSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
The COP9 signalosomeNing Wei
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
Annu Rev Cell Dev Biol 19:261-86. 2003..The involvement of CSN in a number of cellular and developmental processes has been attributed to its control over ubiquitin-proteasome-mediated protein degradation...- The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower developmentXiping Wang
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Plant Cell 15:1071-82. 2003..We conclude that CSN is an essential regulator of Arabidopsis flower development and suggest that CSN regulates Arabidopsis flower development in part by modulating SCF(UFO)-mediated AP3 activation... - Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complexGiovanna Serino
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
Plant Cell 15:719-31. 2003..Comparative analyses of the subunit interaction of CSN revealed a set of conserved subunit contacts and resulted in a model of CSN subunit topology, some aspects of which were substantiated by in vivo cross-link tests... - Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosomeSuchithra Menon
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
BMC Biochem 9:1. 2008..The level of Nedd8 modification is critically dependent on the COP9 signalosome (CSN), an eight-subunit protein complex containing Nedd8 isopeptidase activity... - The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responsesSuhua Feng
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
Plant Cell 15:1083-94. 2003..Furthermore, we showed that both COI1 and CSN are essential for modulating the expression of genes in most cellular pathways responsive to JA. Thus, CSN and SCF(COI1) work together to control genome expression and promote JA responses... - Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymesElah Pick
Department of Molecualr, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Mol Cell Biol 27:4708-19. 2007..Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism... - Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic deathKarin Lykke-Andersen
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
Mol Cell Biol 23:6790-7. 2003..Furthermore, Csn2(-/-) embryos contained elevated levels of p53 and p21, which may contribute to premature cell cycle arrest of the mutant... - Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plantsSuchithra Menon
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA
Methods Enzymol 398:468-81. 2005..It also describes in vitro deneddylation assays using the HeLa cell extract or the Arabidopsis cell extract, which we have used to test and compare the activity of purified CSN complexes... - CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complexJianyu Zheng
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, Yale University, New Haven, CT 06520, USA
Mol Cell 10:1519-26. 2002..Our data suggest that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F box proteins into the SCF complex, causing their destabilization... - The COP9 signalosome: more than a proteaseNing Wei
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
Trends Biochem Sci 33:592-600. 2008..The independent functions of CSN5 (also known as JAB1) add to the complexity of the CSN machinery. Here, we provide an updated view of the structure, functions and regulation of this protein complex... - Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cellsChunling Yi
Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208104, 165 Prospect Street, OML 352A, New Haven, CT 06520 8104, USA
Int J Biochem Cell Biol 38:1076-83. 2006..The association of WD40 protein COP1 with TRiC/Hsp70 in mammalian cells suggests that facilitating the folding of WD40 proteins may be a conserved function for TRiC/Hsp70 from yeast to mammals... - Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8)Karin Lykke-Andersen
Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208104, New Haven, CT 06520 8104, USA
Gene 321:65-72. 2003..Immunostaining studies revealed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely expressed in E9.5-day embryos... - An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1Chunling Yi
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
BMC Cell Biol 3:30. 2002..Although COP1 mammalian homologue has been previously reported, its function and distribution in animal kingdom are not known... - CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1Tomohiko Tsuge
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA
Protein Cell 2:423-32. 2011..Thus, in contrast to CSN5/Jab1, which promotes AP-1 activity, CSN1 displays a negative effect on the AP-1 pathway. Finally, we discuss about the dynamic equilibrium of the CSN complexes in regulation of the AP-1 pathway... - COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescenceSuchithra Menon
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA
Nat Immunol 8:1236-45. 2007..Our data define a CSN-dependent pathway of transcriptional control that is essential for antigen-induced initiation of T cell proliferation... - CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosomeXiping Wang
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520
Mol Biol Cell 13:646-55. 2002..We conclude that CSN1 N-terminal domain is not required for the Rub1/Nedd8 deconjugation activity of cullins, but contributes to a significant aspect of CSN functions that are essential for plant development... - Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cellsChunling Yi
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8104, USA
Cancer Res 65:5835-40. 2005..Taken together, we propose that MVP, most likely through its interaction with COP1, suppresses c-Jun-mediated AP-1 transcription under unstressed conditions, thereby preventing cells from undergoing stress response... - The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1Xiaoming Yang
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Curr Biol 12:667-72. 2002..We conclude that CSN inhibits SCF ubiquitin ligase activity in targeting p27 proteolysis and negatively regulates cell cycle at the G1 phase by promoting deneddylation of Cul1... - Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type IILin Wang
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06510, USA
Hepatology 48:1558-69. 2008..Furthermore, we present evidence that G982R weakly associates with various components of the ER quality control system. These data together demonstrate that the PFIC II mutants except R1153C and DeltaGly are degraded by the ERAD pathway... - Phosphorylation of FAR-RED ELONGATED HYPOCOTYL1 is a key mechanism defining signaling dynamics of phytochrome A under red and far-red light in ArabidopsisFang Chen
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Conecticut 06520, USA
Plant Cell 24:1907-20. 2012..Collectively, our results reveal FHY1 phosphorylation as a key mechanism for FR/R spectrum-specific responses in plants and an essential event for plant adaption to changing light conditions in nature... - COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblastJiong Yan
Department of Molecular and Human Genetics, Texas Children s Hospital, Houston, Texas 77030, USA
Mol Cell Biol 23:6798-808. 2003..Therefore, Csn3 is important for maintaining the integrity of the COP9 signalosome and is crucial to maintain the survival of epiblast cells and thus the development of the postimplantation embryo in mice... - Light regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory components, COP1 and HY5, in ArabidopsisVandana Yadav
National Center for Plant Genome Research, JNU Campus, New Delhi 110067, India
Plant J 31:741-53. 2002..DNA-protein interaction studies reveal the presence of a DNA-binding activity that is specific to Z-box. These results provide insights into the regulation of the Z-box LRE mediated by various light signaling components... - DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1Kenneth Wu
Derald H Ruttenberg Cancer Center and Department of Human Genetics, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Biol Chem 278:28882-91. 2003..These results suggest a unique role for DEN1 in regulating the modification of cullins by Nedd8... - A simple and reliable assay for detecting specific nucleotide sequences in plants using optical thin-film biosensor chipsSu Lan Bai
Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, and The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
Plant J 49:354-66. 2007..This technology can be customized for any nucleotide sequence-based identification assay and widely applied in crop breeding, trait mapping, and other work requiring positive detection of specific nucleotide sequences... - A draft sequence for the genome of the domesticated silkworm (Bombyx mori)Qingyou Xia
Southwest Agricultural University, Chongqing Beibei, 400716, China
Science 306:1937-40. 2004..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
Research Grants
- STRUCTURE AND FUNCTION OF THE COP9 SIGNALOSOMENing Wei; Fiscal Year: 2005....