Fei Wang

..This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD...

..The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder...

..In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD...

..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence...

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..We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response...

..Future treatment may be optimized for this BD subgroup by targeting the serotonergic system and the vACC...

..The cerebellar vermis is increasingly implicated in bipolar disorder (BD). In this study, we investigated vermis morphology in BD using a quantitative volumetric analysis...

..TNN is involved in neurite outgrowth and cell migration in hippocampal explants, and TNR is an extracellular matrix protein expressed primarily in the central nervous system...

..Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum...

..These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits...

..This suggests LVV is a morphologic feature associated with psychosis in BD, present by adolescence...

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..While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD...

..In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference...

..Here, regional brain responses to positive, negative, and neutral emotional stimuli were assessed in individuals with BD during elevated, depressed, and euthymic mood states...

..Since a normalized tract can be delineated interactively in a just few seconds using the proposed method, accurate high volume tract comparisons become feasible...

..We investigated the relationship between cortisol response to a laboratory-based social stressor and regional brain responses to emotional face stimuli in adolescents...

..Here we use a within-subject longitudinal design to investigate whether amygdala volume abnormalities persist in adolescents and young adults with BD over a time interval of approximately 2 years...

..Cross-subject statistics of tract data can be compared easily based on these parameters. Our implementation demonstrated interactive speed and is available to the public in a packaged application...

..Recovery may also be associated with compensatory increases in right DLPFC functioning...

..In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD...

..Our output can also serve as the input for subsequent boundary finding or shape analysis...

..Here, an integrated genetic and neuroimaging approach was used to investigate whether VEGF variation influences hippocampus morphology in humans...

..To study the relationship between self-reported exposure to childhood maltreatment (CM) and cerebral gray matter (GM) morphology in adolescents without psychiatric diagnoses...

..This suggests that amygdala-anterior paralimbic connectivity abnormalities are early features of BD that emerge at least by adolescence in the disorder...

..We conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder...

..There were no significant differences between patients and controls in any other regions. This study supports the hypothesis that schizophrenia is associated with abnormal white matter integrity of the anterior cingulum...

..CONCLUSIONS: The findings suggest structural disconnections in the anterior cingulum in patients with schizophrenia...

..More interestingly, a significant left-greater-than-right asymmetry pattern was obtained in most segments of cingulum bundle (-50-25 degrees), except in the most posterior portion of cingulum (25-50 degrees)...

..No structural abnormalities were detected in the white matter of the superior and middle cerebellar peduncles...

..We present examples of performance of our algorithm on synthetic and real data sets along with quantitative accuracy estimates of the registration...

..Our findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population...

..To investigate characteristic features of three-dimensional dynamic contrast-enhanced MR angiography (3D DCE-MRA) and validate its clinical significance for the diagnosis of cavernous transformation of the portal vein (CTPV)...

..These results suggest that volume reductions in vACC and amygdala in females with MDD are present at illness onset...

..Our results demonstrate the power of direct observation in investigating how individual cell behaviors, such as polarization, movement, and division are coordinated in the very complex process of producing multicellular structures...