Frans J Th Wackers

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 27:1954-61. 2004
  2. ncbi request reprint Diabetes and coronary artery disease: the role of stress myocardial perfusion imaging
    Frans J Th Wackers
    Cardiovascular Nuclear Imaging and Exercise Laboratories Yale University School of Medicine, New Haven, CT 06520 8042, USA
    Cleve Clin J Med 72:21-5, 29-33. 2005
  3. ncbi request reprint Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study
    Frans J Th Wackers
    Yale University School of Medicine, Section of Cardiovascular Medicine, 333 Cedar St Fitkin 3, New Haven, CT 06520, USA
    Diabetes Care 30:2892-8. 2007
  4. ncbi request reprint Third Annual Mario S. Verani, MD, Memorial Lecture: The future of clinical nuclear cardiology
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Cardiovascular Nuclear Imaging Laboratory, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Nucl Cardiol 12:381-91. 2005
  5. pmc Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial
    Lawrence H Young
    Yale University School of Medicine, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT 06520, USA
    JAMA 301:1547-55. 2009
  6. ncbi request reprint The impact of screening for asymptomatic myocardial ischemia in individuals with type 2 diabetes
    Deborah A Chyun
    Yale University School of Nursing, New Haven, Conn 06536 0740, USA
    J Cardiovasc Nurs 21:E1-7. 2006
  7. ncbi request reprint Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
    Brian G Abbott
    Yale University School of Medicine, Section of Cardiovascular Medicine, New Haven, Conn 06520, USA
    J Nucl Cardiol 10:9-16. 2003
  8. doi request reprint 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
    Mohit Jain
    The Section of Cardiovascular Medicine, Department of Internal Medicine and the Cardiovascular Nuclear Imaging and Stress Laboratories, Yale University School of Medicine, New Haven, CT 06510, USA
    J Nucl Cardiol 18:1026-35. 2011
  9. pmc Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis
    Shanti Bansal
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 34:204-9. 2011
  10. ncbi request reprint New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation
    Yi Hwa Liu
    Section of Cardiovascular Medicine, Department of Internal Medicine, Cardiovascular Nuclear Imaging Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA
    J Nucl Cardiol 12:55-65. 2005

Detail Information

Publications36

  1. ncbi request reprint Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 27:1954-61. 2004
    ..To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines...
  2. ncbi request reprint Diabetes and coronary artery disease: the role of stress myocardial perfusion imaging
    Frans J Th Wackers
    Cardiovascular Nuclear Imaging and Exercise Laboratories Yale University School of Medicine, New Haven, CT 06520 8042, USA
    Cleve Clin J Med 72:21-5, 29-33. 2005
    ..Nevertheless, MPI is clearly emerging as a valuable tool for improving management of coronary artery disease in all patients with diabetes mellitus...
  3. ncbi request reprint Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study
    Frans J Th Wackers
    Yale University School of Medicine, Section of Cardiovascular Medicine, 333 Cedar St Fitkin 3, New Haven, CT 06520, USA
    Diabetes Care 30:2892-8. 2007
    ..The purpose of this study was to assess whether the prevalence of inducible myocardial ischemia increases over time in patients with type 2 diabetes...
  4. ncbi request reprint Third Annual Mario S. Verani, MD, Memorial Lecture: The future of clinical nuclear cardiology
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Cardiovascular Nuclear Imaging Laboratory, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Nucl Cardiol 12:381-91. 2005
    ..He was so fragile and, at the same time, so courageous. I felt sad that there was so much that we could have discussed that we did not. Life seems sometimes full of missed opportunities... ...
  5. pmc Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial
    Lawrence H Young
    Yale University School of Medicine, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT 06520, USA
    JAMA 301:1547-55. 2009
    ..Coronary artery disease (CAD) is the major cause of mortality and morbidity in patients with type 2 diabetes. But the utility of screening patients with type 2 diabetes for asymptomatic CAD is controversial...
  6. ncbi request reprint The impact of screening for asymptomatic myocardial ischemia in individuals with type 2 diabetes
    Deborah A Chyun
    Yale University School of Nursing, New Haven, Conn 06536 0740, USA
    J Cardiovasc Nurs 21:E1-7. 2006
    ..Lower levels of diabetes competence and higher levels of controlled motivation for diet were associated with poorer emotional outcomes. Improvements in CAD risk factor behaviors were not observed...
  7. ncbi request reprint Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
    Brian G Abbott
    Yale University School of Medicine, Section of Cardiovascular Medicine, New Haven, Conn 06520, USA
    J Nucl Cardiol 10:9-16. 2003
    ..However, the prognostic significance of ST-segment depression with adenosine in patients with normal MPI is not known...
  8. doi request reprint 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
    Mohit Jain
    The Section of Cardiovascular Medicine, Department of Internal Medicine and the Cardiovascular Nuclear Imaging and Stress Laboratories, Yale University School of Medicine, New Haven, CT 06510, USA
    J Nucl Cardiol 18:1026-35. 2011
    ..We hypothesized that this approach importantly may underestimate exercise capacity and inducible ischemia...
  9. pmc Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis
    Shanti Bansal
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 34:204-9. 2011
    ..To estimate baseline cardiovascular risk of 1,123 participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study and to assess cardiac event rates and the effect of screening on outcomes in these higher-risk participants...
  10. ncbi request reprint New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation
    Yi Hwa Liu
    Section of Cardiovascular Medicine, Department of Internal Medicine, Cardiovascular Nuclear Imaging Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA
    J Nucl Cardiol 12:55-65. 2005
    ..The aims of this study were to present the methodology, to validate the gated SPECT cardiac quantification (GSCQ) method in phantoms and patients, and to determine normal values of LVEF...
  11. ncbi request reprint Clinical validation of SPECT attenuation correction using x-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation
    Yasmin Masood
    Cardiovascular Nuclear Imaging Laboratory, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Cardiol 12:676-86. 2005
    ....
  12. ncbi request reprint The association of psychological factors, physical activity, neuropathy, and quality of life in type 2 diabetes
    Deborah A Chyun
    Yale University School of Nursing, New Haven, CT 06536 0740, USA
    Biol Res Nurs 7:279-88. 2006
    ..In addition, potentially important correlations were demonstrated between psychological factors, neuropathy, body mass index, and physical inactivity...
  13. ncbi request reprint Differential effect of 180 degrees and 360 degrees acquisition orbits on the accuracy of SPECT imaging: quantitative evaluation in phantoms
    Yi Hwa Liu
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Nucl Med 43:1115-24. 2002
    ..The differential effect of 180 degrees and 360 degrees acquisition orbits on image accuracy (homogeneity and defect size) was assessed quantitatively in phantom studies...
  14. ncbi request reprint Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia
    Cindy Q Shi
    Experimental Nuclear Cardiology Laboratory, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Nucl Med 43:421-31. 2002
    ..This study evaluated the potential of dynamic SPECT imaging of a FFA analog, p-(123)I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with (18)F-FDG accumulation...
  15. ncbi request reprint Acute rest myocardial perfusion imaging for chest pain
    Michael C Kontos
    Department of Internal Medicine, Medical College of Virginia, Richmond, USA
    J Nucl Cardiol 11:470-81. 2004
  16. ncbi request reprint Highlights of the 2007 scientific sessions of the American Society of Nuclear Cardiology San Diego, California, September 6-9, 2007
    Raymond R Russell
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Coll Cardiol 50:2336-43. 2007
  17. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 155:113.e1-8. 2008
    ....
  18. ncbi request reprint Pharmacologic stress perfusion imaging with adenosine: role of simultaneous low-level treadmill exercise
    Habib Samady
    Division of Cardiovascular Medicine, University of Virginia Health Systems, Charlottesville, VA, USA
    J Nucl Cardiol 9:188-96. 2002
    ..Our aim was to determine the feasibility of combining low-level treadmill exercise with adenosine MPI and its impact on adverse effects, image quality, and myocardial ischemia...
  19. ncbi request reprint Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
    Georgios I Papaioannou
    Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA
    J Nucl Cardiol 13:362-8. 2006
    ..Myocardial perfusion imaging (MPI) is an effective method of detection of coronary artery disease (CAD); however, the relationship between endothelial function and MPI in asymptomatic patients with T2DM has not been examined...
  20. ncbi request reprint Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics-brachial artery reactivity study)
    Georgios I Papaioannou
    Cardiology Division, Henry Low Heart Center, Hartford Hospital, and University of Connecticut School of Medicine, Farmington, USA
    Am J Cardiol 94:294-9. 2004
    ..In addition, microalbuminuria is an independent predictor of endothelial dysfunction in asymptomatic patients with DM, especially in the absence of hormone replacement therapy...
  21. ncbi request reprint Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy
    Habib Samady
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville 22908 0158, USA
    Am J Cardiol 91:807-11. 2003
    ..We conclude that in patients with severe ischemic cardiomyopathy, unipolar voltage can identify viable from nonviable myocardium and reversible from fixed viable defects as defined by dipyridamole technetium-99m sestamibi SPECT imaging...
  22. ncbi request reprint Assessment of flow-mediated vasodilation
    Rajesh Venkataraman
    J Nucl Cardiol 13:300; author reply 300-1. 2006
  23. ncbi request reprint Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration
    Brian F Johnson
    Pfizer Research, Groton, Connecticut, USA
    Diabetes Care 27:448-54. 2004
    ..The goal of this study was to determine whether treatment with an aldose reductase inhibitor (ARI) has beneficial effects on asymptomatic cardiac abnormalities in diabetic patients with neuropathy...
  24. ncbi request reprint Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: combined use of stress myocardial perfusion imaging and coronary calcium scoring
    Arthur J H A Scholte
    J Nucl Cardiol 13:11-8. 2006
    ..A screening algorithm involving sequential use of coronary calcium scoring and subsequent stress radionuclide myocardial perfusion imaging is proposed...
  25. ncbi request reprint Randomized, controlled dose-ranging study of the selective adenosine A2A receptor agonist binodenoson for pharmacological stress as an adjunct to myocardial perfusion imaging
    James E Udelson
    Division of Cardiology, Tufts New England Medical Center, 750 Washington St, Boston, Mass 02111, USA
    Circulation 109:457-64. 2004
    ..Selective agonism of the adenosine A2A receptor should result in a similar degree of coronary vasodilation (and thus similar perfusion images) with fewer side effects...
  26. ncbi request reprint Highlights of the 2005 scientific sessions of the American Society of Nuclear Cardiology: Seattle, Washington, September 29-October 2, 2005
    Jeroen J Bax
    Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 47:1478-84. 2006
  27. doi request reprint Task force 5: training in nuclear cardiology endorsed by the American Society of Nuclear Cardiology
    Manuel D Cerqueira
    J Am Coll Cardiol 51:368-74. 2008
  28. ncbi request reprint On the bright right side
    Frans J Th Wackers
    J Nucl Cardiol 12:378-80. 2005
  29. ncbi request reprint American society of nuclear cardiology consensus statement: reporting of radionuclide myocardial perfusion imaging studies
    Robert C Hendel
    American Society of Nuclear Cardiology, Bethesda, MD 20814 1699, USA
    J Nucl Cardiol 10:705-8. 2003
  30. ncbi request reprint American Society of Nuclear Cardiology position statement on radionuclide imaging in patients with suspected acute ischemic syndromes in the emergency department or chest pain center
    Frans J Th Wackers
    J Nucl Cardiol 9:246-50. 2002
  31. ncbi request reprint Myocardial perfusion planar imaging
    Peter L Tilkemeier
    J Nucl Cardiol 13:e91-6. 2006
  32. ncbi request reprint American Society of Nuclear Cardiology consensus statement: Reporting of radionuclide myocardial perfusion imaging studies
    Robert C Hendel
    J Nucl Cardiol 13:e152-6. 2006
  33. ncbi request reprint Asymptomatic patients with diabetes mellitus should be screened for coronary artery disease
    Frans J Th Wackers
    J Nucl Cardiol 13:609-15. 2006
  34. ncbi request reprint Accreditation of nuclear cardiology laboratories: an educational process
    Frans J Th Wackers
    J Nucl Cardiol 10:205-7. 2003
  35. ncbi request reprint Task Force 5: training in nuclear cardiology: endorsed by the American Society of Nuclear Cardiology
    Manuel D Cerqueira
    J Am Coll Cardiol 47:898-904. 2006
  36. ncbi request reprint Detection of myocardial ischemia in patients with diabetes mellitus
    Frans J Th Wackers
    Circulation 105:5-7. 2002