Alexander O Vortmeyer

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease
    Sharon B Shively
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Mod Pathol 24:1023-30. 2011
  2. ncbi request reprint Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms
    Alexander O Vortmeyer
    Department of Pathology, Yale University School of Medicine, 416A Lauder Hall 310 Cedar Street, New Haven, CT 06520, USA
    Acta Neuropathol 125:333-50. 2013
  3. ncbi request reprint Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D 37, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 90:3747-51. 2005
  4. ncbi request reprint Coexpression of erythropoietin and its receptor in endolymphatic sac tumors
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 103:284-8. 2005
  5. ncbi request reprint Metastases to hemangioblastomas in von Hippel-Lindau disease
    S Taylor Jarrell
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 105:256-63. 2006
  6. ncbi request reprint Somatic mutations in VHL germline deletion kindred correlate with mild phenotype
    Scott D Wait
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20982, USA
    Ann Neurol 55:236-40. 2004
  7. ncbi request reprint Tumor Young Investigator Award: induction of glioblastoma multiforme in primates after fractionated whole-brain irradiation in the therapeutic dose range
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Clin Neurosurg 50:350-73. 2003
  8. ncbi request reprint Interspecies comparative genomic hybridization (I-CGH): a new twist to study animal tumor models
    Sivakumar Jaikumar
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 6:836-42. 2007
  9. pmc Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas
    Jie Li
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Neuro Oncol 10:45-51. 2008
  10. ncbi request reprint Effects of VHL deficiency on endolymphatic duct and sac
    Sven Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 65:10847-53. 2005

Collaborators

Detail Information

Publications62

  1. pmc Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease
    Sharon B Shively
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Mod Pathol 24:1023-30. 2011
    ..We provide evidence that developmentally arrested structural elements in the cerebellum are composed of developmentally arrested hemangioblast progenitor cells in the molecular layer of the dorsum cerebelli...
  2. ncbi request reprint Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms
    Alexander O Vortmeyer
    Department of Pathology, Yale University School of Medicine, 416A Lauder Hall 310 Cedar Street, New Haven, CT 06520, USA
    Acta Neuropathol 125:333-50. 2013
    ..Finally, metastasis to brain may not only be caused by renal carcinoma, but may derive from VHL disease-associated pheochromocytoma/paraganglioma, or pancreatic neuroendocrine tumor...
  3. ncbi request reprint Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D 37, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 90:3747-51. 2005
    ..These findings suggest an alternative process of tumorigenesis in VHL- and MEN 2-associated pheochromocytomas and implicate Epo as a clinical biomarker to differentiate these tumors...
  4. ncbi request reprint Coexpression of erythropoietin and its receptor in endolymphatic sac tumors
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 103:284-8. 2005
    ....
  5. ncbi request reprint Metastases to hemangioblastomas in von Hippel-Lindau disease
    S Taylor Jarrell
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 105:256-63. 2006
    ....
  6. ncbi request reprint Somatic mutations in VHL germline deletion kindred correlate with mild phenotype
    Scott D Wait
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20982, USA
    Ann Neurol 55:236-40. 2004
    ..This unique genetic mechanism correlates with and may help to understand the mild clinical phenotype seen in these patients...
  7. ncbi request reprint Tumor Young Investigator Award: induction of glioblastoma multiforme in primates after fractionated whole-brain irradiation in the therapeutic dose range
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Clin Neurosurg 50:350-73. 2003
  8. ncbi request reprint Interspecies comparative genomic hybridization (I-CGH): a new twist to study animal tumor models
    Sivakumar Jaikumar
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 6:836-42. 2007
    ....
  9. pmc Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas
    Jie Li
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Neuro Oncol 10:45-51. 2008
    ..RNA interference could suppress glioma cell growth by blocking WHSC1 expression. Our novel findings encourage the application of proteomic techniques in cancer research...
  10. ncbi request reprint Effects of VHL deficiency on endolymphatic duct and sac
    Sven Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 65:10847-53. 2005
    ..Therefore, inactivation of the VHL wild-type allele seems necessary but not sufficient for the formation of tumor...
  11. ncbi request reprint Proteomic comparison of oligodendrogliomas with and without 1pLOH
    Hiroaki Okamoto
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 1414, USA
    Cancer Biol Ther 6:391-6. 2007
    ..Despite a high morphological similarity, tumors with allelic loss on the short arm of chromosome 1 (1pLOH) are more chemosensitive than those without 1pLOH...
  12. ncbi request reprint Proteomic profiling: a novel method for differential diagnosis?
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 6:343-5. 2007
    ..Proteomics may complement pathological evaluation and characterization of tumors in the future. Furthermore, these results show that metastasis of malignant RCC is not necessarily equivalent to aggressive growth patterns...
  13. ncbi request reprint Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage. Case report
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:421-5. 2007
    ..These findings support tumor-associated hemorrhage as a mechanism underlying the audiovestibular dysfunction associated with ELSTs...
  14. ncbi request reprint Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR
    Svetlana D Pack
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 4:1758-60. 2005
    ..The fact that neuronal stem cells can be identified in adult humans and that somatic mosaicism may be found in neuronal precursor cells deserves further investigation before using adult neural stem cells to treat human disease...
  15. ncbi request reprint Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme
    Timothy W Vogel
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 11:3624-32. 2005
    ..We compared protein expression patterns between solid primary GBMs and GBM cell lines to identify proteins whose expression may be altered in cell culture...
  16. doi request reprint Proteomic characterization of primary diffuse large B-cell lymphomas in the central nervous system
    Jie Li
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosurg 109:536-46. 2008
    ....
  17. ncbi request reprint Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
    Youn Soo Lee
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:1059-64. 2005
    ..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
  18. ncbi request reprint From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue
    Zhengping Zhuang
    Surgical Neurology Branch, NINDS NIH, Bethesda, MD 20892, USA
    Int J Oncol 28:103-10. 2006
    ..This new combination of techniques allows not only for sensitive identification of specific protein patterns that correspond to a histological tumor phenotype, but also for identification of specific disease-associated protein targets...
  19. ncbi request reprint Comparative proteomic profiles of meningioma subtypes
    Hiroaki Okamoto
    Surgical Neurology Branch and Protein Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10199-204. 2006
    ..The proteins and proteomic profiles enhance understanding of the pathogenesis of meningiomas and have implications for diagnosis, prognosis, and treatment...
  20. pmc von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells
    Deric M Park
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Med 4:e60. 2007
    ....
  21. ncbi request reprint Second hit deletion size in von Hippel-Lindau disease
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Rm 5D37, Bethesda, MD 20892, USA
    Ann Neurol 59:105-10. 2006
    ....
  22. ncbi request reprint Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:4167-72. 2006
    ..Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS...
  23. pmc Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease
    Gautam U Mehta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neoplasia 10:1146-53. 2008
    ..We conclude epididymal tumorigenesis in VHL disease to occur in two distinct sequential steps: maldevelopment of VHL-deficient mesonephric cells, followed by neoplastic papillary proliferation...
  24. ncbi request reprint Amplification and overexpression of mutant RET in multiple endocrine neoplasia type 2-associated medullary thyroid carcinoma
    Steve C Huang
    Molecular Pathogenesis Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:459-63. 2003
    ..These findings provide evidence for a third second hit mechanism resulting in overrepresentation and overexpression of mutant RET in MEN 2-associated tumors...
  25. ncbi request reprint Proteomic profiling of von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 pheochromocytomas reveals different expression of chromogranin B
    Frederieke M Brouwers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 14:463-71. 2007
    ..In light of these new findings, as well as existing evidence for differences between both types of pheochromocytomas, we propose that these tumors may have different developmental origins...
  26. ncbi request reprint Protein patterns and proteins that identify subtypes of glioblastoma multiforme
    Makoto Furuta
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD 20892 1414, USA
    Oncogene 23:6806-14. 2004
    ..Proteins that are expressed distinctively may have important implications for the diagnosis, prognosis, and treatment of patients with GBM...
  27. ncbi request reprint Cochlear implantation for hearing loss associated with bilateral endolymphatic sac tumors in von Hippel-Lindau disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Otol Neurotol 28:927-30. 2007
    ..Bilateral endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and often underlie significant audiovestibular morbidity, including hearing loss...
  28. pmc Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Neurosurg 111:531-9. 2009
    ..In this study the authors examined the results of using the pseudocapsule as a surgical capsule in the resection of adenomas in patients with Cushing disease...
  29. pmc Hereditary pituitary hyperplasia with infantile gigantism
    Sven Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E2078-87. 2011
    ..We report hereditary pituitary hyperplasia...
  30. pmc Somatic GNAS mutation causes widespread and diffuse pituitary disease in acromegalic patients with McCune-Albright syndrome
    Alexander O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:2404-13. 2012
    ..Patients exhibit features of acromegaly. In most patients, GH-secreting pituitary adenomas have been held responsible for this presentation. However, surgical adenomectomy rarely eliminates excess GH production...
  31. ncbi request reprint Proteomic analysis of hemangioblastoma cyst fluid
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 5:549-53. 2006
    ..Hemangioblastoma cyst formation is a major cause of morbidity and mortality with these tumors. While peritumoral cysts have been suggested to result from vascular leakage, the mechanism of intratumoral cyst formation is not understood...
  32. pmc Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization
    Daniel P Fitzgerald
    Women s Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37, Room 1126, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Metastasis 25:799-810. 2008
    ..001), suggesting that brain tissue secretes factors conducive to tumor cell growth. Molecules used to signal between tumor cells and the surrounding glia could provide a new avenue of therapeutic targets for brain metastases...
  33. ncbi request reprint Real-time in vivo imaging of the convective distribution of a low-molecular-weight tracer
    David Croteau
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 102:90-7. 2005
    ..The authors examined the safety and utility of an iodine-based low-molecular-weight surrogate tracer for computerized tomography (CT) scanning during CED...
  34. ncbi request reprint Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme
    Irina A Lubensky
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 5:452-6. 2006
    ..The findings provide insight into the tumorigenesis of de novo GBMs and suggest a new strategy for treatment of these lethal tumors by targeting both inactivation of N-CoR and inhibition of EGFR...
  35. doi request reprint Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1414, USA
    Neurosurgery 64:4-14; discussion 14. 2009
    ..The study of proteins, or proteomics, is a relatively new but rapidly expanding field with increasing relevance to neurosurgery...
  36. ncbi request reprint Pheochromocytoma in von hippel-lindau disease: distinct histopathologic phenotype compared to pheochromocytoma in multiple endocrine neoplasia type 2
    Christian A Koch
    Pediatric and Reporoductive ENdocinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Endocr Pathol 13:17-27. 2002
    ..Our findings of a distinct histologic phenotype of VHL pheochromocytoma may further help in subdividing patients who clinically present with multiple, bilateral pheochromocytomas...
  37. ncbi request reprint von Hippel-Lindau disease: epididymal cystadenoma targeted by metastatic events
    Gautam U Mehta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Urology 69:1209.e9-12. 2007
    ..The multiplicity of these metastatic events suggests the epididymal cystadenoma as a preferential site of metastasis for von Hippel-Lindau disease-associated renal clear cell carcinoma...
  38. ncbi request reprint Tumors of the endolymphatic sac in patients with von Hippel-Lindau disease: implications for their natural history, diagnosis, and treatment
    H Jeffrey Kim
    Neuro Otology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 102:503-12. 2005
    ..To clarify the uncertainties associated with the pathophysiology and treatment of ELSTs, the authors describe a series of patients with VHL disease in whom serial examinations recorded the development of ELSTs...
  39. ncbi request reprint Edema is a precursor to central nervous system peritumoral cyst formation
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 58:392-9. 2005
    ..When the delivery of plasma from the tumor exceeds the capacity of the surrounding tissue to absorb the extravasated fluid, edema (with its associated increased interstitial pressure) and subsequent cyst formation occur...
  40. ncbi request reprint Sacral hemangioblastoma in a patient with von Hippel-Lindau disease. Case report and review of the literature
    Ryszard M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurg Focus 15:E11. 2003
    ..Because they originate from the nerve root, the nerve root from which the hemangioblastoma originates must be sacrificed to achieve complete resection...
  41. ncbi request reprint New insights into the genetics of familial chromaffin cell tumors
    Christian A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:11-28. 2002
    ..Many genetic alterations have been found in sporadic chromaffin cell tumors. However, at present such genetic changes are difficult to place into context with regard to tumor formation and progression...
  42. ncbi request reprint Developmental effects of von Hippel-Lindau gene deficiency
    Alexander O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, NIH, Bethesda, MD 20892, USA
    Ann Neurol 55:721-8. 2004
    ..Therefore, in VHL disease, inactivation of the VHL wild-type allele appears necessary, but not sufficient, for the formation of tumor that produces symptoms and neurological disability...
  43. ncbi request reprint Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats
    Jeffrey W Degen
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 99:893-8. 2003
    ....
  44. ncbi request reprint Surgical management of lumbosacral nerve root hemangioblastomas in von Hippel-Lindau syndrome
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 99:64-9. 2003
    ....
  45. ncbi request reprint Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. Report of four cases
    Robert J Weil
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 96:775-87. 2002
    ....
  46. pmc The vestibular aqueduct: site of origin of endolymphatic sac tumors
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 108:751-6. 2008
    ..To determine the precise topographic origin of ELSTs, the authors analyzed the imaging, operative, and pathological findings in patients with von Hippel-Lindau disease (VHL) and ELSTs...
  47. ncbi request reprint Proteomic analysis of inclusion body myositis
    Jie Li
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Neuropathol Exp Neurol 65:826-33. 2006
    ..We further applied Western blot and immunohistochemistry to verify the proteomic findings. This study validates proteomics as a powerful tool in the study of muscle disease and indicates a unique pattern of protein expression in IBM...
  48. ncbi request reprint Proteomic applications for differential diagnosis of histologically identical tumors
    Alexander O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1414, USA
    Neurology 61:1626-7. 2003
  49. ncbi request reprint Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 57:542-8. 2005
    ..Patients with neuronopathic Gaucher's disease and similar central nervous system disorders may benefit from this treatment...
  50. doi request reprint Intrinsic indicators for specimen degradation
    Jie Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Lab Invest 93:242-53. 2013
    ..Implementing these indicators may yield a potentially transformative platform dedicated to quality control in clinical specimen analyses...
  51. ncbi request reprint Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004
  52. ncbi request reprint Surgical remission of pituitary adenomas confined to the neurohypophysis in Cushing's disease
    Robert J Weil
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D37, MSC 1414, 9000 Rockville Pike, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 91:2656-64. 2006
    ..Many patients who fail complete or partial hypophysectomy are cured by sellar and parasellar irradiation...
  53. pmc Brainstem pathology in spasmodic dysphonia
    Kristina Simonyan
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20814 1416, USA
    Laryngoscope 120:121-4. 2010
    ..No abnormal protein accumulations and no demyelination or axonal degeneration were found. These neuropathological findings may provide insights into the pathophysiology of SD...
  54. ncbi request reprint Induction of glioblastoma multiforme in nonhuman primates after therapeutic doses of fractionated whole-brain radiation therapy
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 97:1378-89. 2002
    ....
  55. ncbi request reprint Premeiotic origin of teratomas: is meiosis required for differentiation into mature tissues?
    Zhengping Zhuang
    National Institute for Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Cell Cycle 4:1683-7. 2005
    ..The findings suggest that immature teratomas and at least a subset of mature teratomas may originate from premeiotic cells, and implicate that meiosis may be required for differentiation into mature tissues...
  56. doi request reprint Prospective evaluation of the characteristics and incidence of adenoma-associated dural invasion in Cushing disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 116:272-9. 2012
    ..To characterize the incidence and anatomical distribution of dural invasion by ACTH-secreting adenomas, the authors prospectively and systematically analyzed features of dural invasion in patients with CD...
  57. ncbi request reprint Non-islet origin of pancreatic islet cell tumors
    Alexander O Vortmeyer
    Molecular Pathogenesis Laboratory, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:1934-8. 2004
    ..The findings suggest presence of multiple developmental aberrations in MEN1 pancreas that potentially serve as precursor material for neuroendocrine tumors...
  58. ncbi request reprint Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease
    Alexander O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Cancer Res 63:7051-5. 2003
    ..Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts simultaneously coexpress Epo, which may represent a crucial pathogenetic step in tumor formation...
  59. pmc Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pathol 198:14-20. 2002
    ..Merlin was not expressed in the retina, optic nerve, or iris lesions. These results suggest that inactivation of the NF2 gene is associated with the formation of a variety of retinal and optic nerve lesions in NF2 patients...
  60. doi request reprint Two-level thoracic pedicle subtraction osteotomy for progressive post-laminectomy kyphotic deformity following resection of an unusual thoracolumbar intradural extramedullary tumor
    Brian J Kelley
    Yale Spine Institute, Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neurosurg Pediatr 10:334-9. 2012
    ..The authors' experience supports the use of multilevel PSO with fusion as a potential treatment option for significant pediatric thoracolumbar kyphotic deformity requiring surgical correction...
  61. doi request reprint Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage
    Bawarjan Schatlo
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurgery 67:721-8; discussion 728-9. 2010
    ..Thus far, no animal model of SAH is known to produce this peculiar infarct pattern, and its pathogenesis remains enigmatic...
  62. ncbi request reprint Significance of histology in determining management of lesions regrowing after radiosurgery
    Sameer K Nath
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Neurooncol 117:303-10. 2014
    ..In summary, our findings underscore the importance of surgically obtaining tissue in a method that facilitates complete lesional interpretive histology in order to accurately guide ongoing patient management. ..