Anthony N van den Pol

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Weighing the role of hypothalamic feeding neurotransmitters
    A N Van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuron 40:1059-61. 2003
  2. doi request reprint Neuropeptide transmission in brain circuits
    Anthony N van den Pol
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 76:98-115. 2012
  3. pmc Highly attenuated recombinant vesicular stomatitis virus VSV-12'GFP displays immunogenic and oncolytic activity
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
    J Virol 87:1019-34. 2013
  4. pmc Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 81:332-48. 2007
  5. ncbi request reprint Olfactory ensheathing cells: time lapse imaging of cellular interactions, axonal support, rapid morphologic shifts, and mitosis
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 458:175-94. 2003
  6. pmc Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 83:420-7. 2009
  7. pmc Excitatory neuromodulator reduces dopamine release, enhancing prolactin secretion
    Anthony N van den Pol
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 65:147-9. 2010
  8. pmc Viral infection leading to brain dysfunction: more prevalent than appreciated?
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuron 64:17-20. 2009
  9. ncbi request reprint GABA immunoreactivity in hypothalamic neurons and growth cones in early development in vitro before synapse formation
    A N Van den Pol
    Section of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 383:178-88. 1997
  10. pmc Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 516:456-81. 2009

Research Grants

  1. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2010
  2. Response properties of hypothalamic MCH neurons
    Anthony N van den Pol; Fiscal Year: 2010
  3. Oncolytic Virus Targets Brain Tumors
    Anthony van den Pol; Fiscal Year: 2007
  4. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2007
  5. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2007
  6. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2007
  7. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2007
  8. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2006
  9. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2006
  10. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2006

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Weighing the role of hypothalamic feeding neurotransmitters
    A N Van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuron 40:1059-61. 2003
    ....
  2. doi request reprint Neuropeptide transmission in brain circuits
    Anthony N van den Pol
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 76:98-115. 2012
    ....
  3. pmc Highly attenuated recombinant vesicular stomatitis virus VSV-12'GFP displays immunogenic and oncolytic activity
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
    J Virol 87:1019-34. 2013
    ..Intratumoral injection of tumors with VSV-12'GFP dramatically suppressed tumor growth and enhanced survival. Together these data suggest this recombinant virus merits further study for its oncolytic and vaccine potential...
  4. pmc Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 81:332-48. 2007
    ..These results suggest that coupling IFN administration with current treatments may reduce CMV infections in the developing brain...
  5. ncbi request reprint Olfactory ensheathing cells: time lapse imaging of cellular interactions, axonal support, rapid morphologic shifts, and mitosis
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 458:175-94. 2003
    ....
  6. pmc Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 83:420-7. 2009
    ..These data suggest that brain injury enhances CMV invasion of the brain, but only when the adaptive immune system is compromised, and that the brain's ability to resist viral infection recovers rapidly after injury...
  7. pmc Excitatory neuromodulator reduces dopamine release, enhancing prolactin secretion
    Anthony N van den Pol
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 65:147-9. 2010
    ....
  8. pmc Viral infection leading to brain dysfunction: more prevalent than appreciated?
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuron 64:17-20. 2009
    ..Virus infections of the brain can lead to transient or permanent neurologic or psychiatric dysfunction. Some of the complexities in establishing the causal role of viruses in brain disease are explored here...
  9. ncbi request reprint GABA immunoreactivity in hypothalamic neurons and growth cones in early development in vitro before synapse formation
    A N Van den Pol
    Section of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 383:178-88. 1997
    ..Astrocytes in the same cultures showed no immunolabeling. These results indicate that GABA is present very early in the development of hypothalamic neurons and is in a position to be released...
  10. pmc Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 516:456-81. 2009
    ..DG-VSVs with genes coding for different color reporters allow multicolor visualization of neurons wherever applied...
  11. ncbi request reprint Early synaptogenesis in vitro: role of axon target distance
    A N Van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 399:541-60. 1998
    ..A short intercell distance may increase the concentration of limited amounts of trophic factors available to a nearby cell, and once contact is made, a neuronal membrane provides a superior substrate for neuritic elongation...
  12. ncbi request reprint Mouse cytomegalovirus in developing brain tissue: analysis of 11 species with GFP-expressing recombinant virus
    A N Van den Pol
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06520, USA
    J Comp Neurol 427:559-80. 2000
    ..Cytomegaloviruses thus have potential as useful vectors for gene transfer and labeling central nervous system cells, with the actions of CMV being dependent on a number of factors...
  13. ncbi request reprint GABA, not glutamate, a primary transmitter driving action potentials in developing hypothalamic neurons
    X B Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurophysiol 85:425-34. 2001
    ..Thus a number of factors related to spike-dependent stabilization of neuronal connections, including Hebbian mechanisms, that are generally applied to glutamate transmission may also participate in stabilization of GABA circuits...
  14. pmc Relative neurotropism of a recombinant rhabdovirus expressing a green fluorescent envelope glycoprotein
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 76:1309-27. 2002
    ..Together, these data suggest a relative affinity of rVSV for some neuronal types in the CNS, adding to our understanding of the long-lasting changes in rodent behavior found after transient VSV infection...
  15. ncbi request reprint Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 42:635-52. 2004
    ..Together, these data support the view that MCH neurons may integrate information within the arousal system in favor of energy conservation...
  16. pmc Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 541:169-85. 2002
    ..Together these data suggest that the hypothalamus, via hypocretin projections, may therefore be in a position to enhance arousal and modulate plasticity in higher brain centres through the developing LC...
  17. pmc Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Neurosci 29:4622-39. 2009
    ....
  18. ncbi request reprint Viral infections in the developing and mature brain
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Trends Neurosci 29:398-406. 2006
    ..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).]..
  19. ncbi request reprint Group III metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:3013-22. 2004
    ..Together, these data suggest that tonically active inhibitory mGluRs are expressed on local hypocretin-sensitive glutamate neurons within the lateral hypothalamus that modulate the output of the hypocretin arousal system...
  20. ncbi request reprint Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
    Rong Jian Liu
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:9453-64. 2002
    ..The greater potency of hcrts in direct excitation compared with indirect inhibition suggests a negative feedback function for the latter at higher levels of hcrt activity...
  21. pmc Cannabinoids excite circadian clock neurons
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Neurosci 30:10061-6. 2010
    ..These data raise the possibility that the time dissociation described by cannabinoid users may result in part from altered circadian clock function and/or entrainment to environmental time cues...
  22. pmc Enhanced excitatory input to melanin concentrating hormone neurons during developmental period of high food intake is mediated by GABA
    Ying Li
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 29:15195-204. 2009
    ..Thus during the early developmental period when food consumption is high, MCH neurons are more depolarized than in the adult, and an increased level of excitatory synaptic input to these orexigenic cells is mediated by GABA...
  23. pmc Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism
    Li ying Fu
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Neurosci 30:10205-19. 2010
    ..POMC cells may hypothetically serve as a conditional relay station downstream of kisspeptin and GnIH to signal the availability of energy resources relevant to reproduction...
  24. ncbi request reprint Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system
    Li ying Fu
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:8741-51. 2004
    ....
  25. ncbi request reprint Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    J Neurophysiol 94:2195-206. 2005
    ..Together, these results show a depolarizing response to extracellular ATP that would lead to an increased activity of the hypocretin arousal system...
  26. ncbi request reprint Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system
    Ying Li
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 36:1169-81. 2002
    ..Norepinephrine and serotonin, transmitters of other arousal systems, decreased spike frequency and evoked outward currents, whereas acetylcholine and histamine had little effect...
  27. ncbi request reprint Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons
    Min Wu
    Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 24:3527-36. 2004
    ..Thus Hcrt effects within the septum should increase hippocampal acetylcholine release and thereby promote hippocampal arousal...
  28. pmc Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons
    Li ying Fu
    Department of Neurosurgery, Yale University, School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:5433-49. 2008
    ..Together, our data suggest that the mechanism of AgRP actions on these excitatory VMH cells appears to be independent of the actions of melanocortins on MC receptors...
  29. pmc Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons
    Ying Li
    Dept of Neurosurgery, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Neurophysiol 109:1571-8. 2013
    ....
  30. ncbi request reprint Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons
    Ying Li
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:173-83. 2005
    ..These data suggest that catecholamines evoke strong inhibitory actions on hypocretin neurons and suggest negative feedback from catecholamine cells that may be excited by hypocretin...
  31. pmc Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons
    Yang Yao
    Dept of Neurosurgery, Yale Univ School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 302:R815-24. 2012
    ..Thus, some of the central actions of vasopressin and oxytocin may be mediated through MCH cells...
  32. ncbi request reprint Neurons synthesizing melanin-concentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses
    Xiao Bing Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurophysiol 90:3978-85. 2003
    ....
  33. ncbi request reprint Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 25:7406-19. 2005
    ..Together, these results show that the family of neuropeptide Y modulators reduces the activity of inhibitory GABA neurons in the ARC by multiple presynaptic and postsynaptic mechanisms...
  34. ncbi request reprint Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:10510-9. 2005
    ..Dual PYY(3-36) inhibition of both NPY and POMC cells may temporarily reduce the contribution of arcuate cells to feeding circuits, enhancing the role of other CNS loci...
  35. ncbi request reprint Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal
    Hao Huang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:4870-81. 2007
    ..Together, these results show that cannabinoids have opposite effects on MCH and hypocretin neurons. These opposing actions could help explain the increase in feeding and reduction in arousal induced by cannabinoids...
  36. pmc Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism
    Min Wu
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    J Physiol 587:1401-11. 2009
    ..This in turn could suppress gonadotropin release, influence reproductive development and alter sex behaviour...
  37. pmc GABA excitation in mouse hilar neuropeptide Y neurons
    Li ying Fu
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 579:445-64. 2007
    ..Depolarizing actions of GABA and GABA-dependent burst-firing may synchronize a rapid release of GABA, NPY, and SST, leading to pre- and postsynaptic inhibition of excitatory hippocampal circuits...
  38. ncbi request reprint Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition
    Min Wu
    Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 22:7754-65. 2002
    ....
  39. pmc Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions
    Xiaobing Zhang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 32:3032-43. 2012
    ..Together, our data suggest that TRH inhibits MCH neurons by increasing synaptic inhibition from local GABA neurons. Inhibition of MCH neurons may contribute to the TRH-mediated reduction in food intake and sleep...
  40. pmc Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 84:1563-73. 2010
    ..We concluded that some, but not all, attenuated VSV mutants display a favorable oncolytic profile and merit further investigation...
  41. pmc Systemic immune deficiency necessary for cytomegalovirus invasion of the mature brain
    Jon D Reuter
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Virol 78:1473-87. 2004
    ....
  42. pmc Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale Medical School, New Haven, Connecticut 06520, USA
    J Neurosci 29:1503-13. 2009
    ..Thus, in contrast to previous suggestions that hypocretin inhibited POMC cells, our results demonstrate robust direct excitation of POMC neurons by hypocretin...
  43. ncbi request reprint Rapid direct excitation and long-lasting enhancement of NMDA response by group I metabotropic glutamate receptor activation of hypothalamic melanin-concentrating hormone neurons
    Hao Huang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:11560-72. 2007
    ....
  44. ncbi request reprint Long-distance interferon signaling within the brain blocks virus spread
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 88:3695-704. 2014
    ..Most signaling within the brain occurs across the 20-nm synaptic cleft. The unique long-distance IFN signaling described here occurs across many millimeters within the brain and is critical for survival and normal brain function...
  45. ncbi request reprint Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin/orexin neuropeptides
    Ying Li
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 26:13037-47. 2006
    ..These results suggest that hypocretin neurons may be able to exercise a high degree of modulatory control over postsynaptic targets using multiple neuropeptides with target-dependent actions...
  46. ncbi request reprint Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal
    Hao Huang
    Dept of Neurosurgery, Yale Univ, School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Neurophysiol 95:1656-68. 2006
    ....
  47. pmc Bystander attenuation of neuronal and astrocyte intercellular communication by murine cytomegalovirus infection of glia
    Winson S C Ho
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 81:7286-92. 2007
    ..These bystander effects would tend to cause further deterioration of cellular communication in the brain in addition to the problems caused by the loss of directly infected cells...
  48. pmc Direct inhibition of arcuate proopiomelanocortin neurons: a potential mechanism for the orexigenic actions of dynorphin
    Xiaobing Zhang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 591:1731-47. 2013
    ..A number of orexigenic hypothalamic neurons release dynorphin along with other neuropeptides. The inhibition of anorexigenic POMC neurons may be one mechanism underlying the orexigenic actions of dynorphin...
  49. pmc Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
    Hao Huang
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St New Haven, CT 06520, USA
    J Neurophysiol 106:1191-202. 2011
    ..Together, these results indicate that nicotine has a number of similar actions, but also a few different actions, on POMC and NPY neurons that could contribute to the weight loss associated with smoking...
  50. doi request reprint Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain
    Koray Ozduman
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:1882-93. 2008
    ..Quantitative PCR analysis of how VSVrp30a selectively infected tumor cells suggested multiple mechanisms, including cell surface binding and internalization...
  51. pmc Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons
    Xiao Bing Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 542:273-86. 2002
    ..The attenuation of calcium currents is consistent with an inhibitory action for the peptide in neurons...
  52. pmc Variable deficiencies in the interferon response enhance susceptibility to vesicular stomatitis virus oncolytic actions in glioblastoma cells but not in normal human glial cells
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 81:1479-91. 2007
    ..Together, our results demonstrate that activation of the interferon pathway protects normal human brain cells from VSV infection while maintaining the vulnerability of human glioblastoma cells to viral destruction...
  53. doi request reprint Mu-opioid receptor-mediated depression of the hypothalamic hypocretin/orexin arousal system
    Ying Li
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:2814-9. 2008
    ..Together, these data are consistent with the view that the hypocretin system may be an important direct target for drugs of abuse, including opiates, that induce sedation and mental lethargy...
  54. pmc LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells
    Justin C Paglino
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 86:7280-91. 2012
    ..Intravenous or intracranial LuIII caused no adverse effects. Intracranial LuIII caused no infection of mature mouse neurons or glia in vivo but showed a modest infection of developing neurons...
  55. pmc CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain
    Jon D Reuter
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Virol 79:9527-39. 2005
    ..Systemic adoptive transfer may be a rapid and effective approach to preventing CMV entrance into the brain and for reducing neurotropic infection...
  56. ncbi request reprint Autonomous parvoviruses neither stimulate nor are inhibited by the type I interferon response in human normal or cancer cells
    Justin C Paglino
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 88:4932-42. 2014
    ..Parvoviral resistance to the effects of IFN in cancer cells may constitute an advantage in the virotherapy of some tumors...
  57. pmc Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 87:6644-59. 2013
    ..Similar to human melanocytes, mouse melanocytes resisted VSV-rp30 infection. This study confirms the general susceptibility of the majority of human melanoma types for VSV-mediated oncolysis...
  58. pmc Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer J 18:69-81. 2012
    ....
  59. pmc Enhanced cytomegalovirus infection of developing brain independent of the adaptive immune system
    Anthony N van den Pol
    Departments of Neurosurgery Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 76:8842-54. 2002
    ....
  60. pmc Peripheral immunization blocks lethal actions of vesicular stomatitis virus within the brain
    Koray Ozduman
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Virol 83:11540-9. 2009
    ..These results indicate that attenuated recombinant viruses show reduced neurovirulence and that peripheral immunization blocks the lethal actions of all VSVs tested...
  61. pmc Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential
    Guido Wollmann
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 79:6005-22. 2005
    ..Together, these data suggest that four (VSV, Sindbis virus, MVMi, and MVMp) of the nine viruses studied merit further analysis for potential therapeutic actions on glioblastoma...
  62. pmc Viral mutagenesis as a means for generating novel proteins
    John N Davis
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 84:1625-30. 2010
    ..Similar methods may be useful in the development of physiologically sensitive fluorescent reporter proteins and directed evolution or mutagenesis of proteins in general...
  63. pmc Vesicular stomatitis virus has extensive oncolytic activity against human sarcomas: rare resistance is overcome by blocking interferon pathways
    Justin C Paglino
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 85:9346-58. 2011
    ..Overall, we find that the potential efficacy of VSV as an oncolytic agent extends to nonhematologic mesodermal tumors and that unusually strong resistance to VSV oncolysis can be overcome with interferon attenuators...
  64. pmc Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat
    Timothy J Grudt
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Physiol 538:517-25. 2002
    ....
  65. doi request reprint Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis
    Tomomi Tsunematsu
    Department of Molecular Pharmacology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 28:228-38. 2008
    ..This system appears to play a key role in water deprivation-induced hyperlocomotor activity, a response to dehydration that increases the chance of locating water in nature...
  66. ncbi request reprint Differential distribution of hypocretin (orexin) and melanin-concentrating hormone in the goldfish brain
    Gema Huesa
    Department of Cell and Developmental Biology, University of Colorado at Denver, Health Sciences Center, Aurora, Colorado 80045, USA
    J Comp Neurol 488:476-91. 2005
    ....
  67. ncbi request reprint Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons
    Karl Obrietan
    Department of Neuroscience, The Ohio State University, Columbus 43210, USA
    J Neurophysiol 88:1005-15. 2002
    ..Signaling via the MAPK cascade and the transcription factor CREB appear to play a substantial role in this process...
  68. ncbi request reprint Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression
    Adam W Hantman
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:836-42. 2004
    ....
  69. ncbi request reprint Developing neurons make the switch
    Anthony N van den Pol
    Nat Neurosci 7:7-8. 2004

Research Grants52

  1. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2010
    ..Similar to other neurons of the arcuate nucleus that serve multiple homeostatic functions, the function of the excitatory arcuate glutamate neuron may include other roles in addition to that of energy homeostasis. ..
  2. Response properties of hypothalamic MCH neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ....
  3. Oncolytic Virus Targets Brain Tumors
    Anthony van den Pol; Fiscal Year: 2007
    ..The primary goal of these studies is to test the efficacy and safety of variant oncolytic VSVs as the first step as a potential treatment for currently incurable human brain tumors. ..
  4. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2007
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  5. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2007
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  6. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2007
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  7. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2007
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  8. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2006
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  9. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2006
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  10. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2006
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  11. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2006
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  12. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  13. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2009
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  14. Oncolytic Virus Targets Brain Tumors
    Anthony N van den Pol; Fiscal Year: 2010
    ..The primary goal of these studies is to test the efficacy and safety of variant oncolytic VSVs as the first step as a potential treatment for currently incurable human brain tumors. ..
  15. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  16. Oncolytic Virus Targets Brain Tumors
    Anthony van den Pol; Fiscal Year: 2009
    ..The primary goal of these studies is to test the efficacy and safety of variant oncolytic VSVs as the first step as a potential treatment for currently incurable human brain tumors. ..
  17. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2009
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  18. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2009
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  19. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2009
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  20. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2005
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  21. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2005
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  22. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2001
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  23. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2001
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  24. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2001
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  25. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2000
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  26. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2000
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  27. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2000
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  28. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 1999
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  29. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 1999
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  30. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2002
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  31. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2002
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  32. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2005
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  33. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2005
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  34. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2004
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  35. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2004
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  36. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2003
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  37. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2004
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  38. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2003
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  39. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2003
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  40. DETERMINANTS OF AXON LENGTH FOLLOWING INJURY
    Anthony van den Pol; Fiscal Year: 2002
    ..We will use their transgenic mouse to study the attributes of olfactory ensheathing cells in enhancing axonal recovery after cord injury. ..
  41. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  42. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2002
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..