Anthony N van den Pol

Summary

Affiliation: Yale University
Country: USA

Publications

  1. van den Pol A. Neuropeptide transmission in brain circuits. Neuron. 2012;76:98-115 pubmed publisher
  2. van den Pol A, Robek M, Ghosh P, Ozduman K, Bandi P, Whim M, et al. Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain. J Virol. 2007;81:332-48 pubmed
    ..These results suggest that coupling IFN administration with current treatments may reduce CMV infections in the developing brain. ..
  3. Zhang X, Mao G, van den Pol A. Chikungunya-vesicular stomatitis chimeric virus targets and eliminates brain tumors. Virology. 2018;522:244-259 pubmed publisher
    ..These data suggest VSV?G-CHIKV can target and destroy brain tumors in multiple animal models without the neurotropism associated with the wild type VSV glycoprotein. ..
  4. van den Pol A, Ozduman K, Wollmann G, Ho W, Simon I, Yao Y, et al. Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression. J Comp Neurol. 2009;516:456-81 pubmed publisher
    ..DG-VSVs with genes coding for different color reporters allow multicolor visualization of neurons wherever applied. ..
  5. van den Pol A. Viral infection leading to brain dysfunction: more prevalent than appreciated?. Neuron. 2009;64:17-20 pubmed publisher
    ..Virus infections of the brain can lead to transient or permanent neurologic or psychiatric dysfunction. Some of the complexities in establishing the causal role of viruses in brain disease are explored here. ..
  6. Wollmann G, Paglino J, Maloney P, Ahmadi S, van den Pol A. Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector. Virology. 2015;475:1-14 pubmed publisher
    ..Together, these data suggest that AAV-IFN or IFN with ribavirin and chloroquine provide an optimal anti-virus combination against VSV in the brain. ..
  7. Wollmann G, DROKHLYANSKY E, Davis J, Cepko C, van den Pol A. Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors. J Virol. 2015;89:6711-24 pubmed publisher
    ..Lassa-VSV was particularly effective, showed no adverse side effects even when injected directly into the brain, and targeted and destroyed two different types of deadly brain cancer, including glioblastoma and melanoma. ..
  8. van den Pol A, Dalton K, Rose J. Relative neurotropism of a recombinant rhabdovirus expressing a green fluorescent envelope glycoprotein. J Virol. 2002;76:1309-27 pubmed
    ..Together, these data suggest a relative affinity of rVSV for some neuronal types in the CNS, adding to our understanding of the long-lasting changes in rodent behavior found after transient VSV infection. ..
  9. van den Pol A. Excitatory neuromodulator reduces dopamine release, enhancing prolactin secretion. Neuron. 2010;65:147-9 pubmed publisher

More Information

Publications19

  1. van den Pol A, Mao G, Chattopadhyay A, Rose J, Davis J. Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain. J Virol. 2017;91: pubmed publisher
    ..These results suggest that while chimeric VSVs show promise, each must be tested with both intranasal and intracranial administration to ensure the absence of lethal neurotropism. ..
  2. van den Pol A, Mao G, Yang Y, Ornaghi S, Davis J. Zika Virus Targeting in the Developing Brain. J Neurosci. 2017;37:2161-2175 pubmed publisher
    ..These data suggest that ZIKV infects multiple cell types within the brain and that astrocyte infection may play a more important role in initial infection than previously appreciated. ..
  3. Zhang X, van den Pol A. Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation. Science. 2017;356:853-859 pubmed publisher
    ..These data suggest an unexpected robust orexigenic potential for the ZI GABA neurons. ..
  4. request reprint
    van den Pol A, Acuna Goycolea C, Clark K, Ghosh P. Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron. 2004;42:635-52 pubmed
    ..Together, these data support the view that MCH neurons may integrate information within the arousal system in favor of energy conservation. ..
  5. van den Pol A, Yao Y, Fu L, Foo K, Huang H, Coppari R, et al. Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci. 2009;29:4622-39 pubmed publisher
  6. Zhang X, van den Pol A. Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin. J Neurosci. 2015;35:14966-82 pubmed publisher
    ..TH-containing neurons appeared to release synaptic GABA within the ARC onto dopamine neurons and unidentified neurons, suggesting that the cells not only control pituitary hormones but also may modulate nearby neurons. ..
  7. Ornaghi S, Davis J, Gorres K, Miller G, Paidas M, van den Pol A. Mood stabilizers inhibit cytomegalovirus infection. Virology. 2016;499:121-135 pubmed publisher
    ..Our work provides a novel potential direction for CMV therapeutics through repositioning of agents already approved for use in psychiatric disorders. ..
  8. van den Pol A. Viral infections in the developing and mature brain. Trends Neurosci. 2006;29:398-406 pubmed publisher
    ..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).]..
  9. request reprint
    Gao X, Van den Pol A. GABA, not glutamate, a primary transmitter driving action potentials in developing hypothalamic neurons. J Neurophysiol. 2001;85:425-34 pubmed
    ..Thus a number of factors related to spike-dependent stabilization of neuronal connections, including Hebbian mechanisms, that are generally applied to glutamate transmission may also participate in stabilization of GABA circuits...
  10. Ornaghi S, Hsieh L, Bordey A, Vergani P, Paidas M, van den Pol A. Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities. J Neurosci. 2017;37:6877-6893 pubmed publisher
    ..Treatment of uninfected control animals exerts no detectable adverse effects. VCD also blocks CMV replication in human fetal brain cells. ..