Flora M Vaccarino

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Annual Research Review: The promise of stem cell research for neuropsychiatric disorders
    Flora M Vaccarino
    Child Study Center, Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Child Psychol Psychiatry 52:504-16. 2011
  2. ncbi request reprint Stem cells in neurodevelopment and plasticity
    F M Vaccarino
    Child Study Center and Section of Neurobiology Yale University, New Haven, CT 06520, USA
    Neuropsychopharmacology 25:805-15. 2001
  3. pmc Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism
    Flora M Vaccarino
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    J Autism Dev Disord 39:511-20. 2009
  4. ncbi request reprint Astroglial cells in development, regeneration, and repair
    Flora M Vaccarino
    Child Study Center, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA
    Neuroscientist 13:173-85. 2007
  5. pmc Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders
    Flora M Vaccarino
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    Neuropharmacology 60:1355-63. 2011
  6. pmc FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis
    Brian G Rash
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 31:15604-17. 2011
  7. pmc Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:1202-11. 2009
  8. pmc Environmental enrichment increases the GFAP+ stem cell pool and reverses hypoxia-induced cognitive deficits in juvenile mice
    Natalina Salmaso
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 32:8930-9. 2012
  9. pmc Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits
    Hanna E Stevens
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 30:5590-602. 2010
  10. pmc Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum
    John Silbereis
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Stem Cells 27:1152-63. 2009

Research Grants

  1. Astroglial Cells in Perinatal Brain Injury
    Flora Vaccarino; Fiscal Year: 2009
  2. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2010
  3. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
  4. Astroglial Cells in Perinatal Brain Injury
    Flora M Vaccarino; Fiscal Year: 2010
  5. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
  6. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
  7. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2007
  8. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
  9. Biological correlates of altered brain growth in autism
    SHERMAN MORTON WEISSMAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications34

  1. pmc Annual Research Review: The promise of stem cell research for neuropsychiatric disorders
    Flora M Vaccarino
    Child Study Center, Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Child Psychol Psychiatry 52:504-16. 2011
    ....
  2. ncbi request reprint Stem cells in neurodevelopment and plasticity
    F M Vaccarino
    Child Study Center and Section of Neurobiology Yale University, New Haven, CT 06520, USA
    Neuropsychopharmacology 25:805-15. 2001
    ..These programs are likely to be similar to gene cascades that control proliferation, differentiation and migration of progenitor cells at earlier stages of development...
  3. pmc Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism
    Flora M Vaccarino
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    J Autism Dev Disord 39:511-20. 2009
    ..Thus, many risk factors may converge upon FGF-regulated pathogenetic pathways, which alter excitatory/inhibitory balance and cortical modular architecture, and predispose to autism spectrum disorders...
  4. ncbi request reprint Astroglial cells in development, regeneration, and repair
    Flora M Vaccarino
    Child Study Center, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA
    Neuroscientist 13:173-85. 2007
    ....
  5. pmc Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders
    Flora M Vaccarino
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    Neuropharmacology 60:1355-63. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  6. pmc FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis
    Brian G Rash
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 31:15604-17. 2011
    ....
  7. pmc Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:1202-11. 2009
    ..In contrast, there is incomplete recovery of inhibitory neurons after injury, which may account for persistent behavioral deficits...
  8. pmc Environmental enrichment increases the GFAP+ stem cell pool and reverses hypoxia-induced cognitive deficits in juvenile mice
    Natalina Salmaso
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 32:8930-9. 2012
    ....
  9. pmc Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits
    Hanna E Stevens
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 30:5590-602. 2010
    ..These data demonstrate that FGFR2 signaling expands the number of excitatory neurons in the mPFC and secondarily influences target neurons in subcortical stations of the limbic system...
  10. pmc Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum
    John Silbereis
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Stem Cells 27:1152-63. 2009
    ..This restricted critical period implies that powerful inhibitory factors may restrict their fate potential in vivo at later stages of development...
  11. ncbi request reprint Midline radial glia translocation and corpus callosum formation require FGF signaling
    KAREN MULLER SMITH
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 9:787-97. 2006
    ..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells...
  12. ncbi request reprint Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo
    Yosif M Ganat
    Child Study Center, Yale University Medical School, New Haven, Connecticut 06520, USA
    J Neurosci 26:8609-21. 2006
    ....
  13. ncbi request reprint Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    Wei Zheng
    Yale University, Child Study Center, New Haven, CT 06520, USA
    Dev Neurosci 26:181-96. 2004
    ..Thus, FGF2 regulates the number of proliferative cells and olfactory bulb neurogenesis by maintaining a slow-dividing stem cell pool within the SVZa...
  14. pmc Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
    Karen Müller Smith
    Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, USA
    Brain Res 1460:12-24. 2012
    ..The disrupted cerebellar size and laminar architecture resulting from loss of FGFR signaling impair motor learning and coordination in FGFR DKO mice...
  15. pmc Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
    Yuko Kataoka
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:277-91. 2010
    ..The selective deficit of PV+ and cholinergic striatal interneurons in TS subjects may result in an impaired cortico/thalamic control of striatal neuron firing in TS...
  16. pmc Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene
    Kesi Chen
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    BMC Neurosci 9:94. 2008
    ..However, the description of putative alternative exons located downstream from the canonical exon 1 raised the possibility that alternatively spliced transcripts may compensate for the lack of the canonical exon 1 in the Fgf2 -/- mice...
  17. ncbi request reprint Cortical neurogenesis enhanced by chronic perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University Medical School, 230 South Frontage Road, New Haven, CT 06520, USA
    Exp Neurol 199:77-91. 2006
    ..We suggest that cortical neurogenesis may play a significant role in repairing neuronal losses after neonatal injury...
  18. pmc Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain
    Brian G Rash
    Child Study Center, Department of Neurobiology, and Kavli Institute for Neuroscience, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 33:10802-14. 2013
    ..Our findings demonstrate that individual members of the diverse Fgf gene family differentially regulate global as well as regional cortical growth rates while maintaining cortical layer structure. ..
  19. ncbi request reprint Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    ..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
  20. ncbi request reprint Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice
    Karen Müller Smith
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    Biol Psychiatry 63:953-62. 2008
    ..Motor hyperactivity due to hyper-dopaminergic neurotransmission in the basal ganglia is well characterized; much less is known about the role of the neocortex in controlling motor behavior...
  21. pmc Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
    Joshua J Breunig
    Department of Neurobiology, Kavli Institute for Neuroscience, and Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20558-63. 2007
    ..These results provide evidence for the expansive prevalence of Notch signaling in hippocampal morphogenesis and plasticity, suggesting that Notch1 could be a target of diverse traumatic and environmental modulators of adult neurogenesis...
  22. pmc Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain
    Mila Komitova
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 33:13375-87. 2013
    ....
  23. ncbi request reprint Annotation: Tourette syndrome: a relentless drumbeat--driven by misguided brain oscillations
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Child Psychol Psychiatry 47:537-50. 2006
    ..This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS)...
  24. pmc Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration
    Ying Zhang
    Program in Neurodevelopment and Regeneration, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 110:12361-6. 2013
    ....
  25. pmc Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
    Alexej Abyzov
    Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA
    Nature 492:438-42. 2012
    ..Our study paves the way to understanding the fundamental question of the extent to which cells of the human body normally acquire structural alterations in their DNA post-zygotically...
  26. pmc Modeling human cortical development in vitro using induced pluripotent stem cells
    Jessica Mariani
    Program in Neurodevelopment and Regeneration, Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:12770-5. 2012
    ..Thus, hiPSC are capable of enacting a transcriptional program specifying human telencephalic (pallial) development. This model will allow the study of human brain development as well as disorders of the human cerebral cortex...
  27. pmc Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury
    Baoyuan Bi
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:9205-21. 2011
    ..Our data support the conclusion that hypoxia promotes pluripotency in GFAP(+) cells in the cortical parenchyma. Such plasticity possibly explains the cognitive recovery found in some preterm children...
  28. pmc Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
    Paul S A Kalanithi
    Child Study Center and Department of Neurobiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 102:13307-12. 2005
    ..The imbalance in striatal and GPi inhibitory neuron distribution suggests that the functional dynamics of cortico-striato-thalamic circuitry are fundamentally altered in severe, persistent TS...
  29. pmc Neurobiology meets genomic science: the promise of human-induced pluripotent stem cells
    Hanna E Stevens
    Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Dev Psychopathol 24:1443-51. 2012
    ....
  30. pmc Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus
    Hanna E Stevens
    Child Study Center, Yale University, New Haven, CT 06520, USA
    Biol Psychiatry 71:1090-8. 2012
    ..FGF receptor 2 (FGFR2) has a significant role in the production of cortical neurons during embryogenesis, but its role in the hippocampus during development and in adulthood has not been described...
  31. pmc Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment
    Halima Chahboune
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06510, USA
    Cereb Cortex 19:2891-901. 2009
    ..Thus, CSH mice revealed developmental and behavioral deficits that are similar to those observed in low birth weight preterm infants...
  32. ncbi request reprint Fibroblast growth factor 2 is necessary for the growth of glutamate projection neurons in the anterior neocortex
    Sailaja Korada
    Child Study Center and Department of Neurobiology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 22:863-75. 2002
    ..Thus, Fgf2 signaling may contribute to the regional specification of the cerebral cortex and may play a role in increasing the size of anterior cortical regions during vertebrate evolution...
  33. doi request reprint Neurobiology of premature brain injury
    Natalina Salmaso
    Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut, USA
    Nat Neurosci 17:341-6. 2014
    ..Together, these findings suggest that the global mechanism by which perinatal hypoxia alters development is through a delay in maturation of affected cell types, including astroglia, oligodendroglia and neurons. ..
  34. pmc Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex
    Hanna E Stevens
    Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States
    Psychoneuroendocrinology 38:509-21. 2013
    ..These results demonstrate that early disruption in GABAergic progenitor migration caused by prenatal stress may be responsible for neuronal defects in disorders with GABAergic abnormalities like schizophrenia...

Research Grants21

  1. Astroglial Cells in Perinatal Brain Injury
    Flora Vaccarino; Fiscal Year: 2009
    ..We will focus on specific growth factor that affect the degree to which neural stem cells naturally present in the brain generate neurons and glia that survive long-term in the injured brain. ..
  2. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2010
    ..Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. ..
  3. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..If confirmed, this hypothesis may represent a catalyst for further investigations on the developmental mechanisms of TS and a step forward in devising future treatment for this disabling condition. ..
  4. Astroglial Cells in Perinatal Brain Injury
    Flora M Vaccarino; Fiscal Year: 2010
    ..We will focus on specific growth factor that affect the degree to which neural stem cells naturally present in the brain generate neurons and glia that survive long-term in the injured brain. ..
  5. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    ..If confirmed, this hypothesis may represent a catalyst for further investigations on the developmental mechanisms of TS and a step forward in devising future treatment for this disabling condition. ..
  6. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Morphometric and immunocytochemical analyses will include areas where FGF1 and FGF2 are jointly expressed during development. ..
  7. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2007
    ..We further predict that the degree of these impairments will be predicted by the degree of neuronal hypoactivity (as assessed by c-fos immunostaining) within regions of the frontal cortex. ..
  8. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
    ..If confirmed, this hypothesis may represent a catalyst for further investigations on the developmental mechanisms of TS and a step forward in devising future treatment for this disabling condition. ..
  9. Biological correlates of altered brain growth in autism
    SHERMAN MORTON WEISSMAN; Fiscal Year: 2010
    ..The aim is create a resource and analytical tool, which will allow us to examine neuronal differentiation in autism spectrum disorders. ..