Research Topics
Species | Jane TaylorSummaryAffiliation: Yale University Country: USA Publications
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Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaineJane R Taylor
Department of Psychiatry, Division of Molecular Psychiatry and Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
Proc Natl Acad Sci U S A 104:4147-52. 2007....- Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addictionJane R Taylor
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, S307 Connecticut Mental Health Center, Ribicoff Research Laboratories, 34 Park Street, New Haven, CT 06508, USA
Neuropharmacology 56:186-95. 2009.... - Reconsolidation of a cocaine-associated stimulus requires amygdalar protein kinase AHayde Sanchez
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 30:4401-7. 2010..These data show that memory reconsolidation for a cocaine-paired stimulus is retrieval dependent and time limited and critically depends upon amygdalar PKA... - Blockade of melanocortin transmission inhibits cocaine rewardRichard Hsu
Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
Eur J Neurosci 21:2233-42. 2005..Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction... - Dissociation of genetic and hormonal influences on sex differences in alcoholism-related behaviorsJacqueline M Barker
Department of Psychiatry, Yale University, Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
J Neurosci 30:9140-4. 2010..Conversely, alcohol drinking was predicted by gonadal phenotype independent of sex chromosome complement. These results indicate that different alcoholism-related behaviors are determined independently by gonadal and chromosomal sex... - Prior chronic cocaine exposure in mice induces persistent alterations in cognitive functionDilja D Krueger
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, New Haven, Connecticut, USA
Behav Pharmacol 20:695-704. 2009..These results indicate that prior chronic cocaine exposure in mice induces long-lasting alterations in cognitive functions associated with the prefrontal cortex... 
Repeated nicotine exposure enhances reward-related learning in the ratPeter Olausson
Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, New Haven, CT, USA
Neuropsychopharmacology 28:1264-71. 2003..In this study, all nicotine treatment schedules increased Pavlovian discriminative approach behavior and, thus, prior repeated exposure to nicotine, repeated postsession nicotine injections, or both, facilitated reward-related learning...- Neuronal correlates of instrumental learning in the dorsal striatumEyal Y Kimchi
Interdepartmental Neuroscience Program, Yale University, Connecticut Mental Health Center, Abraham Ribicoff Research Facilities, John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, USA
J Neurophysiol 102:475-89. 2009..Together, these data suggest that representations of task-relevant stimuli and movements develop in the dorsal striatum during instrumental learning... - Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learningJ David Jentsch
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 52:111-8. 2002.... - Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female ratsWendy J Lynch
Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 191:263-71. 2007..Chronic cocaine produces changes in the dopamine (DA)/D1/cAMP/protein kinase A (PKA)-regulated signaling pathway that may underlie the development of addiction... - Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in ratEvelyn K Lambe
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 25:5225-9. 2005..We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex... - Bidirectional modulation of goal-directed actions by prefrontal cortical dopaminePaul K Hitchcott
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
Cereb Cortex 17:2820-7. 2007..Reinforcer consumption data indicated that this was not a consequence of altered sensitivity to the reinforcer itself. We suggest that vmPFC dopamine reengages attentional processes underlying goal-directed behavior... - D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbensMary M Torregrossa
Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
J Neurosci 30:10526-33. 2010..A pharmacological method that can render extinction context independent may provide an innovative method to reduce cue-induced relapse in addicts and to study the neurobiology of addiction... - Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult ratMounira Banasr
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 62:496-504. 2007..However, little is known about the mechanisms that contribute to this decrease in cell number... - Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primatePeter Olausson
Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06508, USA
Ann N Y Acad Sci 1121:610-38. 2007.... - Protein kinase A as a therapeutic target for memory disorders: rationale and challengesAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Trends Mol Med 11:121-8. 2005..PKA might be most practical as a therapeutic target in disorders with global alterations in cAMP-PKA activity due to genetic or environmental factors... - Decreased motivation following cocaine self-administration under extended access conditions: effects of sex and ovarian hormonesWendy J Lynch
Department of Psychiatry, Yale University, New Haven, CT, USA
Neuropsychopharmacology 30:927-35. 2005..The mechanisms that may underlie these observed sex differences, including the role of estrogen, are discussed... - Sex differences in the behavioral effects of 24-h/day access to cocaine under a discrete trial procedureWendy J Lynch
Department of Psychiatry, Yale University, New Haven, CT 06516, USA
Neuropsychopharmacology 29:943-51. 2004.... - Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeysJ David Jentsch
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
Neuropsychopharmacology 26:183-90. 2002..These findings suggest that long-term cocaine administration may disrupt orbitofrontal efferents to the striatum, resulting in impaired inhibition of established conditioned responses... - Neonatal isolation stress potentiates cocaine seeking behavior in adult male and female ratsWendy J Lynch
Department of Psychiatry, Yale University, New Haven, CT 06513, USA
Neuropsychopharmacology 30:322-9. 2005..These findings demonstrate robust and enduring effects of neonatal isolation stress on cocaine seeking behavior in adult male and female rats... - Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerabilityR Andrew Chambers
Connecticut Mental Health Center, the Problem Grambling Clinic, Yale University School of Medicine, New Haven, CT 06508, USA
Am J Psychiatry 160:1041-52. 2003..The authors describe basic and clinical data supporting adolescent neurodevelopment as a biologically critical period of greater vulnerability for experimentation with substances and acquisition of substance use disorders... - Cdk5 modulates cocaine reward, motivation, and striatal neuron excitabilityDavid R Benavides
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:12967-76. 2007..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement... - Repeated nicotine exposure enhances responding with conditioned reinforcementPeter Olausson
Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 173:98-104. 2004.... - Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitizationRuth Sharf
Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, 34 Park St CMHC, New Haven, CT 06519, USA
Brain Res 1317:24-32. 2010..These data suggest that orexin action is not required for locomotor responses to acute and chronic morphine, but Ox1r signaling can influence morphine-seeking in WT animals... - Molecular and behavioral interactions between central melanocortins and cocaineJohn D Alvaro
Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
J Pharmacol Exp Ther 304:391-9. 2003..These data further support a role for the melanocortin-MC4-R neuropeptide system in the biochemical and behavioral effects of cocaine... - Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcementRuth Sharf
Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 67:753-60. 2010..Orexin (hypocretin) signaling is implicated in drug addiction and reward, but its role in feeding and food-motivated behavior remains unclear... - beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 miceDarlene H Brunzell
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 184:328-38. 2006.... - Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaineShannon L Gourley
Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 106:16859-64. 2009..These findings provide evidence that stabilization of dendritic structure beginning in adolescence is critical for the development of adaptive and flexible behavior after cocaine exposure... - Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosteroneShannon L Gourley
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
Biol Psychiatry 64:884-90. 2008.... - Assessment of cognitive function in the heterozygous reeler mouseDilja D Krueger
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 189:95-104. 2006..However, the effect of reelin haploinsufficiency on one of the cardinal symptoms of schizophrenia, the impairment of prefrontal-cortex-dependent cognitive function, has yet to be determined... - Sex-related differences in spatial divided attention and motor impulsivity in ratsJ David Jentsch
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Behav Neurosci 117:76-83. 2003..These results demonstrate a double dissociation between components of impulse control and divided attention in male and female rats and may have implications for sex differences in disorders of attention and cognition... - DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivationPeter Olausson
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 26:9196-204. 2006.... - Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behaviorMindan K Sfakianos
Department of Molecular Biophysics and Biochemistry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 27:10982-92. 2007..Together, these data indicate that signaling through Arg and p190RhoGAP acts late during synaptic refinement to promote dendritic spine maturation and synapse/dendrite stability by attenuating synaptic Rho activity... - Prelimbic cortex bdnf knock-down reduces instrumental responding in extinctionShannon L Gourley
Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
Learn Mem 16:756-60. 2009.... - Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in ratsNii A Addy
Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, 06508, USA
Psychopharmacology (Berl) 200:129-39. 2008..The serine/ threonine phosphatase, calcineurin, is known to modulate several signaling proteins that can influence behavioral responses to cocaine... 
Corticosterone regulates pERK1/2 map kinase in a chronic depression modelShannon L Gourley
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
Ann N Y Acad Sci 1148:509-14. 2008..Notably, prefrontal cortical targets were also regulated. Our data suggest ADTs restore hippocampal pERK1/2 after stress-related insult, and potentially reveal a novel role for prefrontal neurotrophins in depressive-like symptomology...- Sex chromosome complement regulates habit formationJennifer J Quinn
Division of Molecular Psychiatry, Yale University, Connecticut Mental Health Center Abraham Ribicoff Research Facilities, 34 Park Street, New Haven, Connecticut 06508, USA
Nat Neurosci 10:1398-400. 2007.... - Nicotine enhances responding with conditioned reinforcementPeter Olausson
Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 171:173-8. 2004..CONCLUSIONS: These findings demonstrate that acute exposure to nicotine augments the control over behavior by a conditioned reinforcer, suggesting that nicotine may enhance motivational processes... - The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdalaSurojit Paul
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Biol Psychiatry 61:1049-61. 2007..Activation of the ERK pathway by the sequential recruitment of mitogen-activated protein kinases is well understood. In contrast, the proteins that inactivate this pathway are not as well characterized... - Loss of glutamatergic pyramidal neurons in frontal and temporal cortex resulting from attenuation of FGFR1 signaling is associated with spontaneous hyperactivity in miceDana M Shin
Child Study Center, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 24:2247-58. 2004.... - Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase ANatalie C Tronson
Department of Psychiatry, Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06508, USA
Nat Neurosci 9:167-9. 2006..This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA... - Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attentionChristopher D Verrico
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
Neuropsychopharmacology 29:522-9. 2004..Finally, amphetamine's ability to reverse the attentional impairments provides indirect evidence that monoaminergic deficits may be linked to the cognitive dysfunction... - The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of ratsRachael W Sirianni
Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
Brain Res 1321:40-50. 2010..It is evident from this work that both duration and magnitude of BDNF dosing are of critical importance in achieving functional outcome... - Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depressionShannon L Gourley
Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
Biol Psychiatry 63:353-9. 2008..The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate... - Role of calcineurin in nicotine-mediated locomotor sensitizationNii A Addy
Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 27:8571-80. 2007..Together, the data suggest that activation of calcineurin, particularly in the VTA, is a novel signaling event important for nicotine-mediated behavior and intracellular signaling... - A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNFShannon L Gourley
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
Neuropsychopharmacology 34:707-16. 2009.... - Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisitedMary M Torregrossa
Department of Psychiatry, Yale University School of Medicine, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut, USA
Biol Psychiatry 63:253-5. 2008 - Recapitulation and reversal of a persistent depression-like syndrome in rodentsShannon L Gourley
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
Curr Protoc Neurosci . 2009.... - Molecular mechanisms of memory reconsolidationNatalie C Tronson
Department of Psychiatry, Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06508, USA
Nat Rev Neurosci 8:262-75. 2007.... - Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genesWendy J Lynch
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
Brain Res 1213:166-77. 2008..These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity... - Stress and disease: is being female a predisposing factor?Jill B Becker
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 27:11851-5. 2007 - Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cuesElin Löf
Inst Neuroscience and Physiology, Sect Psychiatry and Neurochemistry, Sahlgrenska Academy, Göteborg University and Beroendekliniken, Sahlgrenska University Hospital, Gothenburg, Sweden
Psychopharmacology (Berl) 195:333-43. 2007..Cues associated with alcohol can elicit craving, support drug-seeking and precipitate relapse... - Animal modeling dual diagnosis schizophrenia: sensitization to cocaine in rats with neonatal ventral hippocampal lesionsR Andrew Chambers
Laboratory for Translational Neuroscience of Dual Diagnosis Disorders RAC, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
Biol Psychiatry 56:308-16. 2004..Increased substance disorder comorbidity in schizophrenia may reflect greater vulnerability to addictive processes because of inherent neurocircuit dysfunction in the schizophrenic brain... - Natural reward-related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposureR Andrew Chambers
Laboratory for Translational Neuroscience of Dual Diagnosis Disorders, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA
Psychopharmacology (Berl) 179:470-8. 2005..These effects may represent a persistent impact of drugs on neurocircuits that interface cognitive and motivational processes, which may be further altered in neuropsychiatric conditions that entail increased addiction vulnerability... - Locomotor sensitization to cocaine in rats with olfactory bulbectomyR Andrew Chambers
Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Synapse 52:167-75. 2004.... - Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
Research Grants
- COGNITIVE DYSFUNCTION AFTER CHRONIC PCP, THC AND COCAINEJane Taylor; Fiscal Year: 2007..abstract_text> ..
- Incentive Motivation in Addiction: PKA MechanismsJane Taylor; Fiscal Year: 2007..Persistent alterations in PKA/CREB signaling in limbic-striatal regions produced by cocaine are hypothesized to contribute to compulsive reward seeking in addiction. ..
- Incentive Motivation and Addiction: PKA MechanismsJane Taylor; Fiscal Year: 2009....
- Cognitive Dysfunction after Chronic CocaineJane R Taylor; Fiscal Year: 2010....
- COGNITIVE DYSFUNCTION AFTER CHRONIC PCP, THC AND COCAINEJane Taylor; Fiscal Year: 2002..Novel therapeutic agents that target DA dysfunction in the prelimbic cortex may provide new avenues for the development of therapies to ameliorate impulsivity associated with drug craving. ..
- Incentive Motivation and Addiction: PKA MechanismsJane R Taylor; Fiscal Year: 2010....