Hugh S Taylor


Affiliation: Yale University
Country: USA


  1. Agarwal S, Chapron C, Giudice L, Laufer M, Leyland N, Missmer S, et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;: pubmed publisher
    ..The time has come to bridge disparities and minimize delays in endometriosis diagnosis and treatment for the benefit of women worldwide. ..
  2. Naqvi H, Ilagan Y, Krikun G, Taylor H. Altered genome-wide methylation in endometriosis. Reprod Sci. 2014;21:1237-43 pubmed publisher
    ..Aberrant DNA methylation and gene expression of these genes may contribute to abnormal regulation of endometrial cell proliferation and function in women. ..
  3. Snegovskikh V, Mutlu L, Massasa E, Taylor H. Identification of putative fallopian tube stem cells. Reprod Sci. 2014;21:1460-4 pubmed publisher
    ..Defective or insufficient stem cell reserve may underlie common tubal diseases, including hydrosalpinx and ectopic pregnancy. ..
  4. Doherty L, Taylor H. Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity. Fertil Steril. 2015;103:845-52 pubmed publisher
    ..Blockade of TGF signaling is a potential strategy to improve infertility and pregnancy loss associated with uterine leiomyoma. ..
  5. Flores V, Taylor H. The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk. Endocrinol Metab Clin North Am. 2015;44:587-602 pubmed publisher
    ..Caution over this hypothesized benefit is warranted until it is substantiated by data on the incidence of breast cancer in tissue selective estrogen complex users. ..
  6. Mutlu L, Hufnagel D, Taylor H. The endometrium as a source of mesenchymal stem cells for regenerative medicine. Biol Reprod. 2015;92:138 pubmed publisher
    ..In this review, we summarize our current understanding of endometrial stem cells and their therapeutic potential in regenerative medicine. ..
  7. Cho S, Mutlu L, Grechukhina O, Taylor H. Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril. 2015;103:1252-60.e1 pubmed publisher
    ..The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis. ..
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    Taylor H, Igarashi P, Olive D, Arici A. Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium. J Clin Endocrinol Metab. 1999;84:1129-35 pubmed
    ..Steroids are novel regulators HOX gene expression. The spatial and temporal pattern of HOXA11 expression in the human endometrium suggests a role in endometrial development, implantation, and maintenance of pregnancy. ..
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    Taylor H, Fei X. Emx2 regulates mammalian reproduction by altering endometrial cell proliferation. Mol Endocrinol. 2005;19:2839-46 pubmed
    ..Emx2 controls mammalian reproduction by adjusting endometrial cell proliferation without effecting differentiation. Regulated uterine Emx2 expression is necessary during reproduction for maximal implantation and litter size. ..

More Information


  1. Taylor H. Endocrine disruptors affect developmental programming of HOX gene expression. Fertil Steril. 2008;89:e57-8 pubmed publisher
    ..Diethylstilbestrol and several environmental xenoestrogens disrupt the development of the female reproductive tract by altering HOX gene expression, leading to structural and functional defects. ..
  2. Taylor H, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101:1379-84 pubmed
    ..HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human. ..
  3. Cho S, Mutlu L, Zhou Y, Taylor H. Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis. Fertil Steril. 2016;106:673-80 pubmed publisher
    ..Modulation of microRNAs involved in the pathogenesis of endometriosis may have therapeutic potential for endometriosis. ..
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    Taylor H, Vanden Heuvel G, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod. 1997;57:1338-45 pubmed
    ..The late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity...
  5. Jorgensen E, Alderman M, Taylor H. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure. FASEB J. 2016;30:3194-201 pubmed publisher
    ..Jorgensen, E. M., Alderman, M. H., III, Taylor, H. S. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure. ..
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    Pluchino N, Taylor H. Endometriosis and Stem Cell Trafficking. Reprod Sci. 2016;23:1616-1619 pubmed
    ..Stem cell trafficking is a central feature of endometriosis. Understanding molecular mechanisms regulating cell mobility and engraftment in endometriosis may reveal new targets for treatment. ..