W V Tamborlane

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Insulin pump therapy in childhood diabetes mellitus: guidelines for use
    William V Tamborlane
    Department of Pediatrics and the Children s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Treat Endocrinol 2:11-21. 2003
  2. ncbi request reprint Disease management in the young diabetic patient: glucose monitoring, coping skills, and treatment strategies
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Pediatr (Phila) 44:393-403. 2005
  3. ncbi request reprint Diabetes in overweight pediatric patients
    William V Tamborlane
    Department of Pediatrics and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Clin Cornerstone 7:S25-9. 2005
  4. ncbi request reprint Insulin pump therapy in children and adolescents
    W V Tamborlane
    Department of Pediatrics, Yale School of Medicine, 333 Cedar Street, New Haven, CT, USA
    Diabetes Nutr Metab 15:422-5. 2002
  5. ncbi request reprint The renaissance of insulin pump treatment in childhood type 1 diabetes
    William V Tamborlane
    General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Rev Endocr Metab Disord 7:205-13. 2006
  6. ncbi request reprint Short-term effects of coping skills training as adjunct to intensive therapy in adolescents
    M Grey
    Department of Pediatrics, School of Medicine, Yale University School of Nursing, New Haven, Connecticut 06536 0740, USA
    Diabetes Care 21:902-8. 1998
  7. ncbi request reprint Personal and family factors associated with quality of life in adolescents with diabetes
    M Grey
    Department of Pediatrics, School of Medicine, Yale University School of Nursing, New Haven, Connecticut 06536 0740, USA
    Diabetes Care 21:909-14. 1998
  8. ncbi request reprint Oral glucose augments the counterregulatory hormone response during insulin-induced hypoglycemia in humans
    R A Heptulla
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 86:645-8. 2001
  9. ncbi request reprint Continuous subcutaneous insulin infusion. A new way to lower risk of severe hypoglycemia, improve metabolic control, and enhance coping in adolescents with type 1 diabetes
    E A Boland
    Yale Children s Clinical Research Center, Yale University School of Nursing, New Haven, Connecticut, USA
    Diabetes Care 22:1779-84. 1999
  10. ncbi request reprint The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance
    Catherine W Yeckel
    Yale University School of Medicine, Department of Pediatrics, P O Box 802064, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 90:747-54. 2005

Research Grants

  1. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    William Tamborlane; Fiscal Year: 2002
  2. Pediatric Endocrine/Diabetes Physician Scientists
    William Tamborlane; Fiscal Year: 2005
  3. Training in Pediatric Endocrinology/Diabetes Research
    William Tamborlane; Fiscal Year: 2006

Detail Information

Publications84

  1. ncbi request reprint Insulin pump therapy in childhood diabetes mellitus: guidelines for use
    William V Tamborlane
    Department of Pediatrics and the Children s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Treat Endocrinol 2:11-21. 2003
    ..The recent introduction of methods for continuous glucose monitoring provides a new means to optimize the basal and bolus capabilities of CSII and offers hope for the development of a feedback-controlled artificial pancreas...
  2. ncbi request reprint Disease management in the young diabetic patient: glucose monitoring, coping skills, and treatment strategies
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Pediatr (Phila) 44:393-403. 2005
    ..Overall, careful management, monitoring, and education can improve glycemic control and yield positive treatment outcomes in the child or adolescent with diabetes...
  3. ncbi request reprint Diabetes in overweight pediatric patients
    William V Tamborlane
    Department of Pediatrics and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Clin Cornerstone 7:S25-9. 2005
    ..Insulin pumps and insulin analogues represent promising new avenues that have enhanced convenience, cost-effectiveness, patient satisfaction, and metabolic control of childhood DM...
  4. ncbi request reprint Insulin pump therapy in children and adolescents
    W V Tamborlane
    Department of Pediatrics, Yale School of Medicine, 333 Cedar Street, New Haven, CT, USA
    Diabetes Nutr Metab 15:422-5. 2002
  5. ncbi request reprint The renaissance of insulin pump treatment in childhood type 1 diabetes
    William V Tamborlane
    General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Rev Endocr Metab Disord 7:205-13. 2006
    ..Clinical studies of safety and efficacy of CSII in children are reviewed, as well as criteria for patient selection and practical considerations using pump therapy in youth with T1DM...
  6. ncbi request reprint Short-term effects of coping skills training as adjunct to intensive therapy in adolescents
    M Grey
    Department of Pediatrics, School of Medicine, Yale University School of Nursing, New Haven, Connecticut 06536 0740, USA
    Diabetes Care 21:902-8. 1998
    ....
  7. ncbi request reprint Personal and family factors associated with quality of life in adolescents with diabetes
    M Grey
    Department of Pediatrics, School of Medicine, Yale University School of Nursing, New Haven, Connecticut 06536 0740, USA
    Diabetes Care 21:909-14. 1998
    ..The purpose of this study was to evaluate the factors that influence quality of life in adolescents with IDDM...
  8. ncbi request reprint Oral glucose augments the counterregulatory hormone response during insulin-induced hypoglycemia in humans
    R A Heptulla
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 86:645-8. 2001
    ..Thus, ingestion of glucose may reverse hypoglycemia directly by provision of substrate, as well as indirectly by stimulating counteregulatory mechanisms...
  9. ncbi request reprint Continuous subcutaneous insulin infusion. A new way to lower risk of severe hypoglycemia, improve metabolic control, and enhance coping in adolescents with type 1 diabetes
    E A Boland
    Yale Children s Clinical Research Center, Yale University School of Nursing, New Haven, Connecticut, USA
    Diabetes Care 22:1779-84. 1999
    ....
  10. ncbi request reprint The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance
    Catherine W Yeckel
    Yale University School of Medicine, Department of Pediatrics, P O Box 802064, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 90:747-54. 2005
    ..005). Increased 2-h plasma glucose within the range of normal glucose tolerance in obese youth is associated with a specific impairment of beta-cell responsiveness distinct from the deterioration of insulin sensitivity...
  11. ncbi request reprint Use of lispro insulin and quality of life in adolescents on intensive therapy
    M Grey
    Yale School of Nursing, New Haven, CT 06536 0740, USA
    Diabetes Educ 25:934-41. 1999
    ..This study examined the metabolic and quality-of-life effects of using lispro insulin in teenagers...
  12. ncbi request reprint Epipen as an alternative to glucagon in the treatment of hypoglycemia in children with diabetes
    T P Monsod
    Department of Pediatrics, Yale University, New Haven, Connecticut 06520, USA
    Diabetes Care 24:701-4. 2001
    ..Epinephrine is available as a premixed injection (Epipen) that may be used by all care providers. Using Epipen to treat hypoglycemia may be an effective, safe, and easy-to-use alternative to glucagon...
  13. ncbi request reprint The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P O Box 208064, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 90:3731-7. 2005
    ..Obese insulin-sensitive adolescents are characterized by lower lipid deposition in the intramyocellular and visceral compartments and greater levels of adiponectin, despite similar degree of adiposity...
  14. ncbi request reprint Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
    Ranjana Sinha
    Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 346:802-10. 2002
    ..We determined the prevalence of impaired glucose tolerance in a multiethnic cohort of 167 obese children and adolescents...
  15. ncbi request reprint Limitations of conventional methods of self-monitoring of blood glucose: lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes
    E Boland
    Yale University School of Medicine, Yale University, New Haven, Connecticut 06519, USA
    Diabetes Care 24:1858-62. 2001
    ..The MiniMed Continuous Glucose Monitoring System (CGMS) has provided a new method to obtain continuous glucose profiles and opportunities to examine limitations of conventional monitoring...
  16. ncbi request reprint In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study
    Rubina A Heptulla
    Department of Pediatrics, Baylor College of Medicine, Clinical Care Center, Houston, TX 77030 2399, USA
    Pediatr Res 53:830-5. 2003
    ..63, p < 0.01). Our data suggest that failure of insulin to inhibit lipolysis in muscle and adipose tissue contributes to the severe peripheral insulin resistance that characterizes poorly controlled T1DM during adolescence...
  17. ncbi request reprint Predictors of changes in glucose tolerance status in obese youth
    Ram Weiss
    Yale University School of Medicine, Department of Pediatrics, P O Box 802064, New Haven, CT 06520, USA
    Diabetes Care 28:902-9. 2005
    ..Type 2 diabetes in obese youth is an emerging problem. The metabolic and anthropometric predictors of change in glucose tolerance status in obese youth are unknown...
  18. ncbi request reprint The influence of insulin on circulating ghrelin
    Daniel E Flanagan
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 284:E313-6. 2003
    ..Our data suggest that insulin may suppress circulating ghrelin independently of glucose, although glucose may have an additional effect. We conclude that the GH response seen during hypoglycemia is not regulated by circulating ghrelin...
  19. ncbi request reprint A summer vacation from diabetes: evidence from a clinical trial
    E A Boland
    Yale University School of Nursing, New Haven, CT 06536 0740, USA
    Diabetes Educ 25:31-40. 1999
    ..This study examined the metabolic trend and factors associated with an unexpected rise in HbA1c levels during the summer, with a return to baseline when school resumed, in 40 intensively treated adolescents with type 1 diabetes...
  20. ncbi request reprint Using a primary nurse manager to implement DCCT recommendations in a large pediatric program
    J A Ahern
    Department of Pediatrics, Children s Clinical Research Center, Yale University School of Medicine and Yale New Haven Hospital, New Haven, Connecticut, USA
    Diabetes Educ 26:990-4. 2000
    ....
  21. ncbi request reprint Metabolic impact of obesity in childhood
    S Caprio
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Endocrinol Metab Clin North Am 28:731-47. 1999
    ..These observations underscore the need for research efforts directed at the development of effective interventions to stem the tide of the childhood obesity epidemic...
  22. ncbi request reprint Optimal control of type 1 diabetes mellitus in youth receiving intensive treatment
    Dena Springer
    Department of Pediatrics and the General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Pediatr 149:227-32. 2006
    ....
  23. ncbi request reprint Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents
    Catherine W Yeckel
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 89:1096-101. 2004
    ..74 and -0.71; P < 0.0001), a tissue marker for insulin resistance. Insulin sensitivity can be estimated using plasma glucose and insulin responses derived from the OGTT in obese youth with normal and impaired glucose tolerance...
  24. ncbi request reprint Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
    R Weiss
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, P O Box 208064, CT 06520, USA
    Diabetologia 49:571-9. 2006
    ..The aim of this study was to evaluate the early insulin response and insulin clearance in response to an oral glucose load in obese children and adolescents...
  25. pmc Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth
    Melissa Shaw
    Department of Pediatrics, Yale University, New Haven, Connecticut, USA
    Diabetes Care 32:45-7. 2009
    ..To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children...
  26. pmc Practical aspects of real-time continuous glucose monitors: the experience of the Yale Children's Diabetes Program
    Brett Ives
    APYale Children s Diabetes Program, 2 Church Street South, Suite 404, New Haven, CT 06519, USA
    Diabetes Educ 36:53-62. 2010
    ..Careful training and troubleshooting strategies will ensure the most positive experience possible for a family using RT-CGM...
  27. ncbi request reprint Fulfilling the promise of insulin pump therapy in childhood diabetes
    William V Tamborlane
    Department of Pediatrics and the General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Diabetes 7:4-10. 2006
    ....
  28. pmc Early pharmacokinetic and pharmacodynamic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes
    Eda Cengiz
    Division of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 33:1009-12. 2010
    ....
  29. pmc Is an automatic pump suspension feature safe for children with type 1 diabetes? An exploratory analysis with a closed-loop system
    Eda Cengiz
    Department of Pediatrics, Section of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Technol Ther 11:207-10. 2009
    ..It has been proposed that the first step towards a closed-loop artificial pancreas might be to use a continuous glucose sensor to automatically suspend the basal insulin delivery based on projected low sensor glucose values...
  30. doi request reprint Perception of the impact of type 1 diabetes on low-income families
    Sadiqa Edmonds-Myles
    Sadiqa Edmonds Myles, 3415 Bainbridge Avenue, Bronx, NY 10467, USA
    Diabetes Educ 36:318-25. 2010
    ..The purpose of this study was to explore the psychosocial impact of type 1 diabetes (T1DM) on low-income families of various racial/ethnic backgrounds...
  31. doi request reprint From pumps to prevention: recent advances in the treatment of type 1 diabetes
    Jennifer Sherr
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States
    Drug Discov Today 14:973-81. 2009
    ..Another area of exploration is the autoimmune process that causes beta-cell destruction. Immunomodulators used for T1DM prevention and secondary intervention will be reviewed...
  32. ncbi request reprint Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes
    William V Tamborlane
    Department of Pediatrics and General Clinical Research Center, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Res Clin Pract 74:S112-5. 2006
    ..Clinical studies of safety and efficacy of CSII in children are reviewed...
  33. pmc Effect of age of infusion site and type of rapid-acting analog on pharmacodynamic parameters of insulin boluses in youth with type 1 diabetes receiving insulin pump therapy
    Karena L Swan
    Department of Pediatrics, Section of Pediatric Endocrinology, Yale University, New Haven, Connecticut, USA
    Diabetes Care 32:240-4. 2009
    ..The purpose of this study was to examine the effect of type of insulin analog and age of insertion site on the pharmacodynamic characteristics of a standard insulin bolus in youth with type 1 diabetes receiving insulin pump therapy...
  34. doi request reprint Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance
    Tania S Burgert
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Diabetes 9:567-76. 2008
    ....
  35. pmc Past, present, and future of insulin pump therapy: better shot at diabetes control
    Jennifer Sherr
    Department of Pediatrics and Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, CT, USA
    Mt Sinai J Med 75:352-61. 2008
    ..Finally, newer findings on continuous glucose sensors are discussed as the next era of pump therapy continues to focus on the goal of developing an artificial pancreas...
  36. pmc A tale of two compartments: interstitial versus blood glucose monitoring
    Eda Cengiz
    Section of Pediatric Endocrinology and Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Technol Ther 11:S11-6. 2009
    ..This article will review the differences between interstitial and blood glucose and some of the challenges in measuring interstitial glucose levels accurately...
  37. doi request reprint Sensor-augmented pump therapy in type 1 diabetes
    Stuart A Weinzimer
    Department of Pediatrics, Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Endocrinol Diabetes Obes 15:118-22. 2008
    ..The purpose of this review is to familiarize the reader with the new glucose sensors and discuss the literature evaluating their accuracy and effectiveness...
  38. doi request reprint Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Diabetes Care 31:934-9. 2008
    ..However, delays in insulin absorption associated with the subcutaneous route of delivery inevitably lead to large postprandial glucose excursions...
  39. ncbi request reprint Decompensated hyperglycemic hyperosmolarity without significant ketoacidosis in the adolescent and young adult population
    Michael F Canarie
    Section of Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA
    J Pediatr Endocrinol Metab 20:1115-24. 2007
    ..To identify patients aged 10-30 years with probable hyperglycemic hyperosmolar syndrome (HHS), to describe demographic and clinical profiles, and to attempt to assess risk factors for poor outcomes...
  40. ncbi request reprint Effect of puberty on the pharmacodynamic and pharmacokinetic properties of insulin pump therapy in youth with type 1 diabetes
    Karena L Swan
    Section of Pediatric Endocrinology, Yale University, New Haven, Connecticut 06520, USA
    Diabetes Care 31:44-6. 2008
  41. ncbi request reprint Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial
    Mary Savoye
    Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, CT 06520, USA
    JAMA 297:2697-704. 2007
    ..Since most overweight children become overweight adults, this chronic condition results in serious metabolic complications by early adulthood. To curtail this major health issue, effective pediatric interventions are essential...
  42. ncbi request reprint Insulin pump treatment of childhood type 1 diabetes
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatr Clin North Am 52:1677-88. 2005
    ..Clinical studies of safety and efficacy of CSII in children are reviewed...
  43. pmc Long-term results of an obesity program in an ethnically diverse pediatric population
    Mary Savoye
    Yale University School of Medicine, Pediatric Endocrinology, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 127:402-10. 2011
    ..To determine if beneficial effects of a weight-management program could be sustained for up to 24 months in a randomized trial in an ethnically diverse obese population...
  44. ncbi request reprint Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: a follow-up report
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, Connecticut 06520, USA
    Pediatrics 114:1601-5. 2004
    ..The objective of this study was to analyze the CSII efficacy and safety data in very young children with type 1 diabetes from our Diabetes Clinic database...
  45. ncbi request reprint Analysis of continuous glucose monitoring data from non-diabetic and diabetic children: a tale of two algorithms
    Stuart A Weinzimer
    Department of Pediatrics and Children s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Technol Ther 5:375-80. 2003
    ..Solutions 3.0 may be a more useful algorithm for preventing over-reading of low and high SG readings in non-diabetic children, whereas both algorithms give similar results in children with diabetes...
  46. ncbi request reprint A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine
    Elizabeth A Doyle
    Department of Pediatrics and Children s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 27:1554-8. 2004
    ..Our principal aim in this short-term study was to compare the efficacy of CSII to MDI with glargine in lowering HbA(1c) levels in children and adolescents with type 1 diabetes...
  47. ncbi request reprint Do sensor glucose levels accurately predict plasma glucose concentrations during hypoglycemia and hyperinsulinemia?
    Teresa P Monsod
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 25:889-93. 2002
    ....
  48. ncbi request reprint Beta-cell function across the spectrum of glucose tolerance in obese youth
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, P O Box 208064, New Haven, CT 06520, USA
    Diabetes 54:1735-43. 2005
    ..Obese youth with IGT have a significant defect in first-phase insulin secretion, while a defect in second-phase secretion and proinsulin processing is specific for type 2 diabetes in this age-group...
  49. ncbi request reprint Quality of life in school-aged children with type 1 diabetes on intensive treatment and their parents
    Robin Whittemore
    Yale School of Nursing, 100 Church Street South, New Haven, CT 06536 0740, USA
    Diabetes Educ 29:847-54. 2003
    ..The purpose of this study was to examine the child, parent, and family factors associated with quality of life and metabolic control in school-aged children with type 1 diabetes on intensive treatment...
  50. ncbi request reprint Case study: contrasting challenges of insulin pump therapy in a toddler and adolescent with type 1 diabetes
    Elizabeth A Doyle Boland
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Educ 31:584-90. 2005
    ..To describe the challenges and outcomes of continuous subcutaneous insulin infusion (CSII) pump therapy in a toddler and adolescent with type 1 diabetes. Insight into patient-family aspects motivating pump use is provided...
  51. ncbi request reprint Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation
    Monica A Borg
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Diabetes 52:663-6. 2003
    ..05). In conclusion, the glucose-sensing mechanism in the VMH responds to lactate and, thus, is not specific for glucose. This implies that the VMH may act as a fuel sensor rather than as a glucose sensor...
  52. ncbi request reprint Continuous glucose monitoring in type 1 diabetes
    Stuart A Weinzimer
    Yale University School of Medicine, Department of Pediatrics, PO Box 208064, 333 Cedar Street, New Haven, CT 06520, USA
    Curr Diab Rep 4:95-100. 2004
    ..The current "state of the art" of this technology, including accuracy, performance in clinical trials, limitations, and recommendations for use, is discussed for the two currently approved continuous glucose monitoring devices...
  53. ncbi request reprint Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia
    Staffan Enoksson
    Department of Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 88:1503-11. 2003
    ..This defect within peripheral tissues may lead to a delayed increase in glucose disposal that could contribute to the severity of hypoglycemia when it is prolonged...
  54. ncbi request reprint Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
    R R Russell
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 281:E1029-36. 2001
    ..Although diabetic subjects have a more pronounced cardiac response to hyperinsulinemia per se than nondiabetic subjects, their response to hypoglycemia is blunted...
  55. ncbi request reprint Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT)
    N H White
    Yale University School of Medicine, New Haven, CT, USA
    J Pediatr 139:804-12. 2001
    ....
  56. ncbi request reprint Recent advances in treatment of youth with Type 1 diabetes: better care through technology
    W V Tamborlane
    Department of Paediatrics and the Children s Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Diabet Med 18:864-70. 2001
    ..Even more important, we may finally be at the threshold of development of a practically applicable artificial pancreas...
  57. ncbi request reprint Clinical and psychosocial factors associated with achievement of treatment goals in adolescents with diabetes mellitus
    M Grey
    Office of Research Affairs, Yale School of Nursing, New Haven, Connecticut 06536 0740, USA
    J Adolesc Health 28:377-85. 2001
    ..and psychosocial factors are associated with achievement of metabolic control treatment goals after 1 year? and (b) What baseline clinical and psychosocial factors are associated with improvement in the quality of life after 12 months?..
  58. pmc Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Lancet 362:951-7. 2003
    ..We investigated whether altered partitioning of myocellular and abdominal fat relates to abnormalities in glucose homoeostasis in obese adolescents with prediabetes...
  59. ncbi request reprint Clinical outcomes and cost-effectiveness of retinopathy screening in youth with type 1 diabetes
    Betty Huo
    Department of Pediatric Endocrinology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Diabetes Care 30:362-3. 2007
  60. ncbi request reprint Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth
    Ram Weiss
    Department of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 30:1845-50. 2007
    ..quot; We examined whether glucose allostasis can be demonstrated using oral glucose tolerance tests (OGTTs) and the effects of the dynamics of beta-cell demand on longitudinal changes of glucose tolerance in obese youth...
  61. ncbi request reprint Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat
    Tania S Burgert
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:4287-94. 2006
    ..Nevertheless, the complete metabolic phenotype associated with abnormalities in biomarkers of liver injury and intrahepatic fat accumulation remains to be established...
  62. ncbi request reprint Temporal patterns of circulating leptin levels in lean and obese adolescents: relationships to insulin, growth hormone, and free fatty acids rhythmicity
    R Heptulla
    Department of Pediatrics and the Yale Children's Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 86:90-6. 2001
    ..The nocturnal rise in leptin was paralleled by a nocturnal rise in GH and FFA levels. Additional studies are needed to test the potential link between the adipose-derived peptide and GH axis in humans...
  63. ncbi request reprint Importance of plasma leptin in predicting future weight gain in obese children: a two-and-a-half-year longitudinal study
    M Savoye
    Department of Pediatrics and The Children s General Clinical Research Center and the Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Int J Obes Relat Metab Disord 26:942-6. 2002
    ..To determine whether relatively low leptin levels predict changes in adiposity in prepubertal and pubertal obese children...
  64. ncbi request reprint Obesity and the metabolic syndrome in children and adolescents
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 350:2362-74. 2004
    ....
  65. ncbi request reprint Insulin pump therapy in the 21st century. Strategies for successful use in adults, adolescents, and children with diabetes
    Bruce W Bode
    Diabetes Resource Center, Atlanta Diabetes Associates, 77 Collier Rd NW, Suite 2080, Atlanta, GA 30309, USA
    Postgrad Med 111:69-77; quiz 27. 2002
    ..Careful adjustment of basal and bolus doses and close follow-up, including patient education, are vital to the success of CSII...
  66. ncbi request reprint Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes
    Michael L Christensen
    University of Tennessee, 50 North Dunlap, Room 306, Memphis, TN 38103, USA
    J Clin Pharmacol 45:1137-44. 2005
    ..5- to 3.0-fold for M-III and M-IV. The sustained total serum concentration of active compounds during multiple dosing provides the basis for once-daily dose administration of pioglitazone in adolescents...
  67. ncbi request reprint Triple jeopardy: nocturnal hypoglycemia after exercise in the young with diabetes
    William V Tamborlane
    J Clin Endocrinol Metab 92:815-6. 2007
  68. pmc The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes
    Michael J Tansey
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Care 29:20-5. 2006
    ..To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes...
  69. pmc Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study
    Stuart A Weinzimer
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Technol Ther 7:675-80; discussion 681-3. 2005
    ..The objective of this study was to assess how the accuracy of the FreeStyle Flash (Abbott Diabetes Care, Alameda, CA) meter compares with that of the One Touch Ultra (Lifescan, Milpitas, CA) home glucose meter (HGM)...
  70. pmc Limitations of statistical measures of error in assessing the accuracy of continuous glucose sensors
    Craig Kollman
    The Jaeb Center for Health Research, Tampa, Florida 33647, USA
    Diabetes Technol Ther 7:665-72; discussion 673-4. 2005
    ..Various statistical methods are commonly used to assess the accuracy of near-continuous glucose sensors. The performance and reliability of these methods have not been well described...
  71. ncbi request reprint Insulin pumps in pediatrics: we have the technology. We have the evidence. Why are still so few kids using it?
    Thomas Danne
    Pediatr Diabetes 7:2-3. 2006
  72. doi request reprint Continuous glucose monitoring and intensive treatment of type 1 diabetes
    William V Tamborlane
    N Engl J Med 359:1464-76. 2008
    ..The value of continuous glucose monitoring in the management of type 1 diabetes mellitus has not been determined...
  73. pmc Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study
    Michael J Tansey
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Technol Ther 7:109-14. 2005
    ..19%; P < 0.001]. Baseline data from a subsequent outpatient study provide an opportunity to further assess the accuracy of the modified sensor in a much larger sample of children with type 1 diabetes...
  74. pmc Continuous glucose monitoring in children with type 1 diabetes
    Bruce Buckingham
    J Pediatr 151:388-93, 393.e1-2. 2007
    ..To examine the feasibility of daily use of a continuous glucose monitor, the FreeStyle Navigator Continuous Glucose Monitoring System ("Navigator"), in children with type 1 diabetes (T1D)...
  75. pmc The accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes
    Darrell M Wilson
    DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Dr, Suite 350, Tampa, FL 33647, USA
    Diabetes Care 30:59-64. 2007
    ..To evaluate the accuracy and precision of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes...
  76. pmc Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator)
    Bruce Buckingham
    Pediatr Diabetes 9:142-7. 2008
    ..The DATA provides algorithms for making diabetes management decisions using glucose values: (i) in real time which include the direction and rate of change of glucose levels, and (ii) retrospectively based on downloaded sensor data...
  77. pmc Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus
    Eva Tsalikian
    DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA
    J Pediatr 147:528-34. 2005
    ..To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM)...
  78. doi request reprint Insulin glargine versus intermediate-acting insulin as the basal component of multiple daily injection regimens for adolescents with type 1 diabetes mellitus
    H Peter Chase
    Barbara Davis Center, University of Colorado, Aurora, CO 80045 6511, USA
    J Pediatr 153:547-53. 2008
    ....
  79. pmc Evaluation of factors affecting CGMS calibration
    Bruce A Buckingham
    DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Diabetes Technol Ther 8:318-25. 2006
    ..The optimal number/timing of calibrations entered into the CGMS (Medtronic MiniMed, Northridge, CA) continuous glucose monitoring system have not been previously described...
  80. ncbi request reprint Comparison of fingerstick hemoglobin A1c levels assayed by DCA 2000 with the DCCT/EDIC central laboratory assay: results of a Diabetes Research in Children Network (DirecNet) Study
    William V Tamborlane
    Jaeb Center for Health Research, Tampa, FL 33647, USA
    Pediatr Diabetes 6:13-6. 2005
    ..The DCA 2000 + Analyzer (Bayer Inc., Tarrytown, NY, USA), which uses an immunoassay, is a very popular device for measuring HbA1c levels in pediatric diabetes practices...
  81. pmc Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study
    Nelly Mauras
    DirecNet Coordinating Center, Tampa, Florida, USA
    J Pediatr 144:770-5. 2004
    ..Study design Fifteen healthy children (aged 9-17 years, 11 boys) wore a GW2B and a CGMS during a 24-hour period, and reference serum glucose was measured hourly during the day and half-hourly overnight...

Research Grants4

  1. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    William Tamborlane; Fiscal Year: 2002
    ..abstract_text> ..
  2. Pediatric Endocrine/Diabetes Physician Scientists
    William Tamborlane; Fiscal Year: 2005
    ..Dr. James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees. ..
  3. Training in Pediatric Endocrinology/Diabetes Research
    William Tamborlane; Fiscal Year: 2006
    ..James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees. ..