Patrick Sung

Summary

Affiliation: Yale University
Country: USA

Publications

  1. Wang W, Daley J, Kwon Y, Xue X, Krasner D, Miller A, et al. A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection. J Biol Chem. 2018;293:17061-17069 pubmed publisher
    ..These biochemical systems and results will be valuable for guiding future endeavors directed at delineating the mechanistic intricacy of DNA end resection in eukaryotes. ..
  2. Sung P. Introduction to the Thematic Minireview Series: DNA double-strand break repair and pathway choice. J Biol Chem. 2018;293:10500-10501 pubmed publisher
  3. Krasner D, Daley J, Sung P, Niu H. Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection. J Biol Chem. 2015;290:18806-16 pubmed publisher
    ..We discuss a model in which the dynamic equilibrium between Ku and RPA binding to a partially resected DNA end influences the timing and efficiency of the resection process. ..
  4. Zhao W, Sung P. Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis. Nucleic Acids Res. 2015;43:4055-66 pubmed publisher
    ..Our findings help delineate the intricate manner in which Hop2-Mnd1 engages and functions with RAD51 and DMC1 in mammalian cells and speak to the possible cause of XX ovarian dysgenesis. ..
  5. Zhao W, Vaithiyalingam S, San Filippo J, Maranon D, Jiménez Sáinz J, Fontenay G, et al. Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell. 2015;59:176-87 pubmed publisher
    ..Our findings may provide a paradigm for understanding the roles of DSS1 in other biological processes. ..
  6. Rao T, Longerich S, Zhao W, Aihara H, Sung P, Xiong Y. Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage. DNA Repair (Amst). 2018;64:53-58 pubmed publisher
    ..Our study therefore furnishes biochemical evidence for a role of hFAN1 homodimerization in biological processes that involve 5' DNA Flap cleavage. ..
  7. Chen X, Niu H, Yu Y, Wang J, Zhu S, Zhou J, et al. Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection. Nucleic Acids Res. 2016;44:2742-53 pubmed publisher
    ..We propose that the enrichment of Cdk1-cyclin complexes at DSBs serves as a mechanism for enhanced targeting and modulating of the activity of DNA damage response proteins. ..
  8. Kwon Y, Daley J, Sung P. Reconstituted System for the Examination of Repair DNA Synthesis in Homologous Recombination. Methods Enzymol. 2017;591:307-325 pubmed publisher
    ..These reconstituted systems are particularly valuable for understanding the conserved mechanism of repair DNA synthesis dependent on DNA polymerase δ and its cognate helicase in eukaryotic organisms. ..
  9. Buzovetsky O, Kwon Y, Pham N, Kim C, Ira G, Sung P, et al. Role of the Pif1-PCNA Complex in Pol ?-Dependent Strand Displacement DNA Synthesis and Break-Induced Replication. Cell Rep. 2017;21:1707-1714 pubmed publisher
    ..These results provide insights into the role of the Pif1-PCNA-Pol ? ensemble during DNA break repair by homologous recombination. ..

More Information

Publications15

  1. Longerich S, Kwon Y, Tsai M, Hlaing A, Kupfer G, Sung P. Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA. Nucleic Acids Res. 2014;42:5657-70 pubmed publisher
    ..These results implicate the role of a proper DNA ligand in FANCD2 and FANCI monoubiquitination, and reveal regulatory mechanisms that are dependent on protein-protein and protein-DNA interactions. ..
  2. Daley J, Chiba T, Xue X, Niu H, Sung P. Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection. Nucleic Acids Res. 2014;42:11083-91 pubmed publisher
    ..Moreover, we show that DNA2 stimulates the helicase activity of BLM. Our results thus uncover a multifaceted role of the Topo IIIα-RMI1-RMI2 ensemble and of DNA2 in the DNA resection reaction. ..
  3. Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, et al. Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell. 2014;56:436-45 pubmed publisher
    ..Our findings provide molecular insights into replication fork repair regulation and uncover a role of Smc5-Smc6 in directing Mph1 activity toward a specific biochemical outcome. ..
  4. Liang F, Longerich S, Miller A, Tang C, Buzovetsky O, Xiong Y, et al. Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Rep. 2016;15:2118-2126 pubmed publisher
    ..Our findings provide insights into an apparently USP1-independent role of UAF1 in genome maintenance. ..
  5. Pires E, Sung P, Wiese C. Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis. DNA Repair (Amst). 2017;59:76-81 pubmed publisher
    ..We also discuss how RAD51AP1 may help to promote cancer development and why it could potentially represent a promising new target for therapeutic intervention. ..
  6. Daley J, Jiménez Sáinz J, Wang W, Miller A, Xue X, Nguyen K, et al. Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP. Cell Rep. 2017;21:324-332 pubmed publisher
    ..Specifically, CtIP interacts with BLM and enhances its helicase activity, and it enhances DNA cleavage by DNA2. Thus, CtIP influences multiple aspects of end resection beyond MRE11 regulation. ..