B E Sumpio

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Application of Porter’s Five Forces Model and generic strategies for vascular surgery: should be stuck in the middle?
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Vascular 21:149-56. 2013
  2. doi Clinical implications of the angiosome model in peripheral vascular disease
    Bauer E Sumpio
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Vasc Surg 58:814-26. 2013
  3. ncbi Green tea, the "Asian paradox," and cardiovascular disease
    Bauer E Sumpio
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Am Coll Surg 202:813-25. 2006
  4. ncbi The multidisciplinary approach to limb salvage
    B E Sumpio
    Centers for Vascular Disease and Diabetic Limb Preservation, Yale University School of Medicine, New Haven, CT 96510, USA
    Acta Chir Belg 104:647-53. 2004
  5. ncbi Cells in focus: endothelial cell
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 34:1508-12. 2002
  6. ncbi Vascular evaluation and arterial reconstruction of the diabetic foot
    Bauer E Sumpio
    Yale University School of Medicine, Department of Surgery Vascular, 333 Cedar Street, FMB 137, New Haven, CT 06510, USA
    Clin Podiatr Med Surg 20:689-708. 2003
  7. ncbi Regulation of PDGF-B in endothelial cells exposed to cyclic strain
    B E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Conn 06510, USA
    Arterioscler Thromb Vasc Biol 18:349-55. 1998
  8. ncbi Role of negative pressure wound therapy in treating peripheral vascular graft infections
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Vascular 16:194-200. 2008
  9. doi The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520, USA
    J Vasc Surg 51:1504-6. 2010
  10. ncbi Foot ulcers
    B E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Conn 06510, USA
    N Engl J Med 343:787-93. 2000

Collaborators

Detail Information

Publications80

  1. ncbi Application of Porter’s Five Forces Model and generic strategies for vascular surgery: should be stuck in the middle?
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Vascular 21:149-56. 2013
    ..It brings an initial perspective that is convenient to adapt to vascular surgery in order to reveal opportunities.Vascular surgery is uniquely situated to pursue both a differentiation and high value leadership strategy...
  2. doi Clinical implications of the angiosome model in peripheral vascular disease
    Bauer E Sumpio
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Vasc Surg 58:814-26. 2013
    ....
  3. ncbi Green tea, the "Asian paradox," and cardiovascular disease
    Bauer E Sumpio
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Am Coll Surg 202:813-25. 2006
  4. ncbi The multidisciplinary approach to limb salvage
    B E Sumpio
    Centers for Vascular Disease and Diabetic Limb Preservation, Yale University School of Medicine, New Haven, CT 96510, USA
    Acta Chir Belg 104:647-53. 2004
    ..It also provides for increased academic output through publications, participation in clinical trials and educational venues...
  5. ncbi Cells in focus: endothelial cell
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 34:1508-12. 2002
    ..It is involved in the immune response, coagulation, growth regulation, production of extracellular matrix components, and is a modulator of blood flow and blood vessel tone...
  6. ncbi Vascular evaluation and arterial reconstruction of the diabetic foot
    Bauer E Sumpio
    Yale University School of Medicine, Department of Surgery Vascular, 333 Cedar Street, FMB 137, New Haven, CT 06510, USA
    Clin Podiatr Med Surg 20:689-708. 2003
    ..Peripheral vascular disease is highly treatable if intervention is instituted in a timely and collegial fashion...
  7. ncbi Regulation of PDGF-B in endothelial cells exposed to cyclic strain
    B E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Conn 06510, USA
    Arterioscler Thromb Vasc Biol 18:349-55. 1998
    ....
  8. ncbi Role of negative pressure wound therapy in treating peripheral vascular graft infections
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Vascular 16:194-200. 2008
    ..The results supported by the literature and the clinical practice of the consensus panel suggested that NPWT can be a useful adjunct to the management of vascular groin infections and dehiscences but must be used with caution...
  9. doi The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520, USA
    J Vasc Surg 51:1504-6. 2010
    ....
  10. ncbi Foot ulcers
    B E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Conn 06510, USA
    N Engl J Med 343:787-93. 2000
    ..The multidisciplinary approach will provide a comprehensive treatment protocol that will increase the long-term viability of the foot...
  11. ncbi The role of interdisciplinary team approach in the management of the diabetic foot: a joint statement from the Society for Vascular Surgery and the American Podiatric Medical Association
    Bauer E Sumpio
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Podiatr Med Assoc 100:309-11. 2010
    ....
  12. ncbi MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells
    Bauer E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:11185-91. 2005
    ....
  13. ncbi Differential responsiveness of early- and late-passage endothelial cells to shear stress
    Fabio A Kudo
    Department of Surgery, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave, New Haven, CT 06519, USA
    Am J Surg 190:763-9. 2005
    ....
  14. ncbi Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway
    Wei Li
    Dept of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Heart Circ Physiol 288:H1591-7. 2005
    ..Cyclic strain also activated 4E-BP1, which could be inhibited by PI3K inhibitors. These data suggest that the PI3K-dependent S6K-mTOR-4E-BP1 signal pathway may be critically involved in strain-induced bovine aortic EC proliferation...
  15. ncbi Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinase
    Quanhai Chen
    Department of Surgery, Yale University School of Medicine and Connecticut VA Health Care System, 333 Cedar Street, New Haven, CT 06520 8062, USA
    J Vasc Surg 37:660-8. 2003
    ..We assessed stretch-induced nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase activation and the redox sensitivity of cyclic strain-stimulated activation of the mitogen-activated protein kinase (MAPK) family...
  16. ncbi Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain
    Taeseung Lee
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Physiol 194:349-55. 2003
    ..Taken together, our result suggests that PP2A plays a regulatory role in p38 MAPK activation in endothelial cells exposed to cyclic strain...
  17. ncbi Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells
    J D Smith
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Endothelium 8:41-8. 2001
    ..CONCLUSION: Exposure of VSMC to physiological levels of stretch induces a biologically significant increase in VEGF secretion and may provide an arterial stimulus for maintenance of steady state levels of VEGF essential for EC survival...
  18. ncbi The cardiovascular protective effect of red wine
    Alfredo C Cordova
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Am Coll Surg 200:428-39. 2005
  19. ncbi The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain
    John D Kakisis
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 37:1396-406. 2005
    ..Serine phosphorylation of STAT-3 is mediated by ERK1/2, while tyrosine phosphorylation is mediated by Src. A negative feedback loop was also found between p38 and ERK1/2...
  20. ncbi Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming
    Wai Ki Yiu
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Vasc Surg 46:557-564. 2007
    ..This study investigated the differential effects of vascular cell survival and proliferation in an in vitro model simulating cryoplasty...
  21. ncbi Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain
    Yuji Hoshino
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine and Veterans Administration Health Care System, New Haven, Connecticut 06520, USA
    J Cell Biochem 100:515-26. 2007
    ..Inhibition of PTEN activity had no effect on CS-mediated cell proliferation but inhibited CS-mediated suppression of apoptosis...
  22. ncbi The integrin-mediated cyclic strain-induced signaling pathway in vascular endothelial cells
    S G Frangos
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Endothelium 8:1-10. 2001
    ..Ultimately, it is the regulation of gene expression through the modulation of transcription factors that allows endothelial cells to respond to changes in local hemodynamics...
  23. ncbi Effects of increased ambient pressure on colon cancer cell adhesion
    M D Basson
    Department of Surgery, Yale University, New Haven, CT 06520 8062, USA
    J Cell Biochem 78:47-61. 2000
    ....
  24. ncbi Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways
    Masae Haga
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Endothelium 10:149-57. 2003
    ..This suggests an additional mechanism by which hemodynamic forces can differentially regulate transcription in ECs, and thereby possibly maintain the viability of normal endothelium...
  25. ncbi Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells
    Wei Li
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cell Physiol 195:202-9. 2003
    ..05). The results suggest that strain-induced SMC alignment is dependent on activation of p38, but not S6 kinase. Strain induced SMC proliferation is S6 kinase, but not p38 activation, dependent...
  26. ncbi Role of AKT in cyclic strain-induced endothelial cell proliferation and survival
    Kengo Nishimura
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, 333 Cedar St, FMB 137, New Haven, CT 06520 8062, USA
    Am J Physiol Cell Physiol 290:C812-21. 2006
    ..We conclude that AKT is important in enhancing the survival of ECs exposed to CS but is not involved in EC proliferation...
  27. ncbi p38 Mitogen-activated protein kinase activation in endothelial cell is implicated in cell alignment and elongation induced by fluid shear stress
    Takayuki Kadohama
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Endothelium 13:43-50. 2006
    ..ECs exposed to shear stress in the presence of the p38 MAPK inhibitor SB-203580 did not orient in any manner and the shape index was similar to the static cells...
  28. ncbi Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells
    A H Chen
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Surgery 130:378-81. 2001
    ..This study examined whether Akt, a serine/threonine protein kinase known to promote cell survival by inhibiting apoptosis, is activated by cyclic strain in bovine aortic SMCs...
  29. ncbi Nicotine: a review of its role in atherosclerosis
    S Kilaru
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Coll Surg 193:538-46. 2001
  30. ncbi Translocation of PKC isoforms in bovine aortic smooth muscle cells exposed to strain
    O Han
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biochem 80:367-72. 2001
    ....
  31. ncbi Intermittent pneumatic compression devices -- physiological mechanisms of action
    A H Chen
    Yale University School of Medicine, Section of Vascular Surgery, 333 Cedar Street, New Haven, FMB 137, CT 06520, USA
    Eur J Vasc Endovasc Surg 21:383-92. 2001
    ..In vitro studies of the effects of mechanical stress such as compressive strain and shear on cultured endothelial cells, and their clinical relevance to IPC will also be reviewed...
  32. ncbi Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols
    Omar Araim
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    J Vasc Surg 35:1226-32. 2002
    ..The goal of this study was to determine the effect of red wine, red wine polyphenol extract, and resveratrol, a polyphenol commonly found in red wine, on the proliferation of vascular SMC in culture...
  33. doi The effect of different frequencies of stretch on human dermal keratinocyte proliferation and survival
    Kengo Nishimura
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    J Surg Res 155:125-31. 2009
    ..After experiencing I stretch for 2 d, keratinocyte proliferation rates were significantly decreased. This decrease was most likely not due to apoptosis as TUNEL-positive cells only increased for cells treated with an AKT inhibitor...
  34. ncbi Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway
    Hidenori Asada
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Vasc Surg 42:772-80. 2005
    ....
  35. ncbi Role of ligand-specific integrins in endothelial cell alignment and elongation induced by cyclic strain
    Yo Hirayama
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endothelium 14:275-83. 2007
    ..Our results indicate that ligand-specific integrins play a crucial role in the morphological changes of ECs induced by CS via the p38 MAPK pathway...
  36. pmc Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells
    Ji Il Kim
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Endothelium 15:33-42. 2008
    ....
  37. ncbi Effects of different types of fluid shear stress on endothelial cell proliferation and survival
    Takayuki Kadohama
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Physiol 212:244-51. 2007
    ..Our results demonstrate that different types of shear stress regimens have different effects on EC and may account for the variable response of EC to hemodynamics in the circulation...
  38. doi Synergistic effect of cool/thaw cycles on vascular cells in an in vitro model of cryoplasty
    Wai Ki Yiu
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, and Veterans Administration Health Care System, West Haven, Connecticut 06520 8062, USA
    J Vasc Interv Radiol 19:925-30. 2008
    ..This study investigates the effects of single and dual supercooling and rewarming cycles on the survival responses of smooth muscle cells (SMCs) and endothelial cells (ECs)...
  39. ncbi Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1alpha
    Alan Dardik
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06519, USA
    J Vasc Surg 41:321-31. 2005
    ..We hypothesized that mechanical forces stimulate endothelial cells to secrete SMC chemoattractants to induce migration via the mitogen-activated protein kinase (MAPK) pathway...
  40. ncbi Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration
    Gabriele Di Luozzo
    Section of Vascular Surgery, Department of Surgery, Yale University School of Medicine and Veterans Administration, 333 Cedar Street FMB 137, New Haven, CT 06520, USA
    Atherosclerosis 178:271-7. 2005
    ..In conclusion, nicotine enhances the chemoatactiveness of VSMC. This migration is mediated via the MAPKs p38 and p44/42. Nicotine causes EC production of a chemoattractant molecule that enhances VSMC migration...
  41. ncbi Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism
    Vijayalakshmi Thamilselvan
    Department of Surgery, Wayne State University, Detroit, Michigan 48202, USA
    In Vitro Cell Dev Biol Anim 38:246-53. 2002
    ..ERK activation by S-1-P is not required for its mitogenic effect...
  42. ncbi Thrombospondin-1-induced vascular smooth muscle cell chemotaxis: the role of the type 3 repeat and carboxyl terminal domains
    Taeseung Lee
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biochem 89:500-6. 2003
    ..The T2 domain had no effect on VSMC chemotaxis. These results suggest activation of the p38 pathway may be more specific than ERK for COOH- and T3-induced VSMC chemotaxis...
  43. ncbi Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation
    Masae Haga
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, 333 Cedar St, FMB 137, New Haven, CT 06520 8062, USA
    J Vasc Surg 37:1277-84. 2003
    ..However, the effects of oscillatory shear stress (SS) on SMC proliferation and signal transduction pathways that control survival are not well described...
  44. ncbi Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells
    Jianhu Zhang
    Department of Surgery, John D Dingell Veterans Administration Hospital Chief VAMC, Surgical Service 112, 4646 John R Street, Detroit, MI 48201 1932, USA
    Biochem Biophys Res Commun 306:746-9. 2003
    ..Since tissue and plasma fibronectin levels vary in acute or chronic inflammatory or infectious conditions, these results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation...
  45. ncbi Differential effects of orbital and laminar shear stress on endothelial cells
    Alan Dardik
    Section of Vascular Surery, Yale University School of Medicine, New Haven, CT 06519, USA
    J Vasc Surg 41:869-80. 2005
    ..The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared...
  46. ncbi The differential effect of contrast agents on endothelial cell and smooth muscle cell growth in vitro
    C J Sawmiller
    Department of Surgery, St Mary s Hospital, Waterbury, Conn, USA
    J Vasc Surg 27:1128-40. 1998
    ..This study was designed to evaluate the effects of ionic and nonionic contrast agents on endothelial cell (EC) and smooth muscle cell (SMC) proliferation, and to determine the role of osmolality as the etiology of these effects...
  47. ncbi Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1
    Hirokazu Ueno
    Department of Surgery, Yale University School of Medicine, New Haven, and the Veterans Affairs Connecticut Health Care System, West Haven, CT, USA
    Cardiovasc Toxicol 6:39-50. 2006
    ....
  48. ncbi Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases
    Taeseung Lee
    Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, PO Box 208062, FMB 137, New Haven, CT 06520, USA
    Biotechnol Appl Biochem 39:129-39. 2004
    ..This Review will focus on the significance of several of these phosphatases and present information on the role of protein phosphatase type 2a in endothelial cells exposed to haemodynamic forces...
  49. ncbi Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis
    Bertrand Poussier
    Department of Vascular Surgery, Yale University School of Medicine, VA Connecticut, New Haven, Connecticut, USA
    J Vasc Surg 42:1190-7. 2005
    ..The aim of this study was to determine the effects of resveratrol, a major polyphenol component of red wine, on vascular smooth muscle cell (SMC) proliferation in vitro...
  50. doi Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase
    Xiu Jie Wang
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT, USA
    Vasc Endovascular Surg 42:256-62. 2008
    ..Further, geldanamycin also inhibited migration. These results suggest focal adhesion kinase is involved in thrombospondin-1-induced vascular smooth muscle cell migration...
  51. ncbi Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
    Kazumi Akasaka
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Vasc Surg 41:517-22. 2005
    ..The purpose of this study was to examine the effects of homocysteine on smooth muscle cell (SMC) migration and to determine whether p38 was involved in this process...
  52. ncbi The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis
    S M Nesselroth
    Yale University School of Medicine, Section of Vascular Surgery and the Harvard Medical School, New Haven, CT 06520, USA
    J Vasc Surg 33:595-600. 2001
    ..This experiment suggests that future strategies in the prevention of VSMC migration, an initial step in the development of vascular lesions, may involve selective inhibition of the COOH domain of TSP-1...
  53. ncbi Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling
    Akimasa Yamashita
    Section of Vascular Surgery, Yale University School of Medicine, New Haven and VA Connecticut Healthcare Systems, West Haven, CT, USA
    J Vasc Surg 37:866-73. 2003
    ..We examined the effect of ASbFGF on NIH and the time course of MAPK, extracellular signal-regulated kinase (ERK) 1/2, c-Jun N-terminal protein kinase (JNK), and p38 kinase activation in arterialized vein grafts...
  54. ncbi Single-stage surgical treatment of noninfected diabetic foot ulcers
    Peter A Blume
    Department of Orthopaedics and Rehabilitation, Section of Podiatric Surgery, Yale University School of Medicine, New Haven, CT, USA
    Plast Reconstr Surg 109:601-9. 2002
    ..Most importantly, by addressing the underlying bony pathologic findings, the recurrence rates were also drastically reduced...
  55. ncbi Photochemotherapy of vascular cells with 8-methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells
    David M Lee
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, CT 06510, USA
    Photodermatol Photoimmunol Photomed 18:244-52. 2002
    ..The long-term efficacy of percutaneous transluminal coronary angioplasty is limited by the restenosis which occurs in approximately 40% of patients, usually within 6 months of the procedure...
  56. ncbi The role of thrombospondin-1 in human disease
    Nowokere Esemuede
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Surg Res 122:135-42. 2004
    ..Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease...
  57. ncbi Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells
    Taeseung Lee
    Section of Vascular Surgery, Yale University School of Medicine and the VA Connecticut Healthcare System, New Haven, CT 06520, USA
    J Vasc Surg 38:147-54. 2003
    ..Matrix metalloproteinase-2 (MMP2) is associated with basement membrane and ECM degradation, important processes for cell migration. We hypothesized that TSP-1 modulates MMP2 activity in VSMCs and is critical for VSMC migration...
  58. ncbi Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival
    Kengo Nishimura
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Wound Repair Regen 15:646-56. 2007
    ..The inhibitors of p38 MAPK and MAPK/ERK kinase as well as dominant-negative AKT reduced cell number after both HF and I stretch but these pathways were not critical for the stretch-induced decrease in cell number...
  59. ncbi Review of prevalence and outcome of vascular disease in patients with diabetes mellitus
    J S Weiss
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Eur J Vasc Endovasc Surg 31:143-50. 2006
    ..Review the literature to determine the prevalence and outcome in patients with diabetes that undergo surgery to correct carotid artery stenosis, lower extremity arterial disease, and abdominal aortic aneurysm (AAA)...
  60. ncbi Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals
    O Han
    Department of Surgery, Yale University School of Medicine, New Haven 06520-8062, USA
    Am J Physiol 275:G534-41. 1998
    ..These results suggest that cyclic deformation may modulate intestinal epithelial proliferation and brush-border enzyme activity by regulating PKC and tyrosine kinase signals...
  61. doi The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration
    Shoichi Fuse
    Yale University School of Medicine, Section of Vascular Surgery, New Haven, CT, USA
    Surgery 144:86-92. 2008
    ....
  62. pmc The effects of freezing versus supercooling on vascular cells: implications for balloon cryoplasty
    Maria Theresa G Basco
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8062, USA
    J Vasc Interv Radiol 21:910-5. 2010
    ..To investigate the effects of supercooling, a phase whereby cells are below 0 degrees C but still in a liquid state, and freezing, the phase when cells become solid, of vascular cells in culture...
  63. ncbi Predictors for the healing of transmetatarsal amputations: retrospective study of 91 amputations
    Peter Blume
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06515, USA
    Vascular 15:126-33. 2007
    ..0001). In group 1, 20 of 27 (74%) limbs that were revascularized healed (p = .0336). Nonhealing amputations were associated with end-stage renal disease (13 of 19; 68%) (p = .0209) and leukocytosis (13 of 19; 68%) (p = .0052)...
  64. ncbi Vascular smooth muscle cell apoptosis induced by "supercooling" and rewarming
    Wai Ki Yiu
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8062, USA, and Department of Vascular Surgery, Queen Mary Hospital, Hong Kong
    J Vasc Interv Radiol 17:1971-7. 2006
    ..Because vascular smooth muscle cells (SMCs) are known to play a critical role in restenosis and neointimal hyperplasia, the aim of this study was to determine SMC survival under conditions of "supercooling" and/or rewarming...
  65. doi The critical role of hemodynamics in the development of cerebral vascular disease
    Alexander M Nixon
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosurg 112:1240-53. 2010
    ..The recognition of WSS as an important factor in cerebral vascular disease may help to identify individuals at risk and guide treatment options...
  66. ncbi Do estrogen effects on blood vessels translate into clinically significant atheroprotection?
    Sanjeev Pradhan
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Coll Surg 198:462-74. 2004
  67. ncbi Effects of cyclic strain on vascular cells
    John D Kakisis
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Endothelium 11:17-28. 2004
    ..Understanding of these responses has provided new insights in the pathogenesis and treatment of vascular diseases, such as atherosclerosis and intimal hyperplasia...
  68. ncbi Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium
    Sangseob Yun
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:34808-14. 2002
    ....
  69. pmc Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow
    Ryuzo Abe
    Departments of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Heart Circ Physiol 300:H1345-51. 2011
    ..These results provide added insight into the mechanism of atherosclerosis in areas of disturbed flow...
  70. ncbi Utility of the aortic fenestration technique in the management of acute aortic dissections
    Sanjeev Pradhan
    Department of Vascular and Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann Thorac Cardiovasc Surg 13:296-300. 2007
    ..We believe that these two techniques can be safe and effective alternatives to medical management and aortic replacement surgery in properly selected patients...
  71. ncbi Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium
    Seiichi Yamaguchi
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Lab Invest 82:949-56. 2002
    ..These results suggest that cyclic strain up-regulates the Egr-1-mediated expression of MT1-MMP in rat microvascular EC, emphasizing the importance of hemodynamic forces in the regulation of MT1-MMP in vivo...
  72. ncbi Efficacy of dextran solutions in vascular surgery
    Farshad Abir
    Yale University School of Medicine, Section of Vascular Surgery, New Haven, CT 06520 5062, USA
    Vasc Endovascular Surg 38:483-91. 2004
    ..Dextran has numerous important implications in vascular surgery, in particular with CEA patients or "difficult'' infragenicular bypasses. Its effectiveness with endovascular stents remains unknown...
  73. doi The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy
    Yuzhe Feng
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Vasc Surg 50:675-82, 682.e1. 2009
    ..The purpose of this systematic review is to evaluate current evidence in the literature on the efficacy of Semmes Weinstein monofilament examination (SWME) in diagnosing diabetic peripheral neuropathy (DPN)...
  74. doi Role of integrins and focal adhesion kinase in the orientation of dermal fibroblasts exposed to cyclic strain
    Huang Wen
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Int Wound J 6:149-58. 2009
    ..Fibroblast orientation in response to cyclic stretch is mediated at least in part by integrin beta1 through phosphorylation of FAK, p38 and activation of Rho...
  75. ncbi Effect of gender on outcome following infrainguinal bypass graft surgery: a systematic review
    Spiros G Frangos
    Department of Surgery, Yale University School of Medicine, New Haven, USA
    Conn Med 66:137-44. 2002
  76. doi Olive oil, the mediterranean diet, and cardiovascular health
    Christina L Huang
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Coll Surg 207:407-16. 2008
  77. ncbi Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins
    Jianhu Zhang
    Departments of Surgery, Wayne State University, USA
    FASEB J 17:926-8. 2003
    ..Tissue or plasma fibronectin may regulate the intestinal epithelial response to strain via integrins containing alpha5 or alpha(v)...
  78. ncbi Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1
    Shu Q Liu
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208 3107, USA
    J Biol Chem 280:39294-301. 2005
    ..These observations suggest that SIRP alpha and SHP-1 potentially mediate the inhibitory effect of elastic laminae on monocyte adhesion...
  79. ncbi Digital image analysis: a reliable tool in the quantitative evaluation of cutaneous lesions and beyond
    Zakiya M Pressley
    Department of Dermatology, Emory University School of Medicine, 101 Woodruff Cir, Atlanta, GA 30322, USA
    Arch Dermatol 143:1331-3. 2007

Research Grants14

  1. MECHANISMS BY WHICH EC SENSE CHANGES IN HEMODYNAMICS
    Bauer Sumpio; Fiscal Year: 2002
    ..The clinical relevance of this proposal is the potential to understand the mechanism by which a hemodynamic force alters EC function. ..
  2. MECHANISMS BY WHICH EC SENSE CHANGES IN HEMODYNAMICS
    Bauer Sumpio; Fiscal Year: 1993
    ..Such information might provide a rationale approach to modulating the in vivo responses of EC by altering the generation of these second messengers...
  3. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..