SCOTT STROBEL

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Comparative analysis of hairpin ribozyme structures and interference data
    Sean P Ryder
    Yale University, Department of Molecular Biophysics and Biochemistry, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 30:1287-91. 2002
  2. pmc Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center
    K Mark Parnell
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 99:11658-63. 2002
  3. pmc RNA catalysis: ribozymes, ribosomes, and riboswitches
    Scott A Strobel
    Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520 8114, USA
    Curr Opin Chem Biol 11:636-43. 2007
  4. pmc A two-step chemical mechanism for ribosome-catalysed peptide bond formation
    David A Hiller
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 476:236-9. 2011
  5. pmc Linguistic analysis of project ownership for undergraduate research experiences
    D I Hanauer
    Department of English, Indiana University of Pennsylvania, Indiana, PA 15705, USA
    CBE Life Sci Educ 11:378-85. 2012
  6. ncbi request reprint Crystal structure of a self-splicing group I intron with both exons
    Peter L Adams
    Department of Molecular Biophysics and Biochemistry, 260 Whitney Avenue, Yale University, New Haven, Connecticut 06520 8114, USA
    Nature 430:45-50. 2004
  7. pmc Plasticity of the RNA kink turn structural motif
    Alexandra H Antonioli
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 16:762-8. 2010
  8. ncbi request reprint Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping
    Juliane K Soukup
    Department of Molecular Biophysics, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 41:10426-38. 2002
  9. pmc Bioactive endophytes warrant intensified exploration and conservation
    Stephen A Smith
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 3:e3052. 2008
  10. pmc Crystal structure of a group I intron splicing intermediate
    Peter L Adams
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520 8114, USA
    RNA 10:1867-87. 2004

Research Grants

Collaborators

  • Jimin Wang
  • THOMAS ARTHUR STEITZ
  • Gary Strobel
  • Stephen A Smith
  • Michael J Donoghue
  • Joseph A Piccirilli
  • Kensuke Okuda
  • Peter B Moore
  • RACHEL D GREEN
  • Noriaki Minakawa
  • ROBERT TODD BATEY
  • Ronald Breaker
  • Marina V Rodnina
  • Jesse C Cochrane
  • Mary R Stahley
  • Sarah V Lipchock
  • Joshua S Weinger
  • Minghong Zhong
  • Kevin S Huang
  • T Martin Schmeing
  • David A Hiller
  • Ian T Suydam
  • Peter L Adams
  • K Mark Parnell
  • Kathryn D Smith
  • Anne B Kosek
  • Lara B Weinstein Szewczak
  • Miyun Kwon
  • Michelle L Gill
  • D I Hanauer
  • Jonathan R Russell
  • Vipender Singh
  • Alexandra H Antonioli
  • Lori Ann Boulanger
  • Vladimir I Katunin
  • Carol A Bascom-Slack
  • Juliane K Soukup
  • Rachel M Anderson
  • Ashley Eversole Hesslein
  • Joan A Steitz
  • Suzanne J DeGregorio
  • Jessee C Cochrane
  • Fatima D Jones
  • Sean P Ryder
  • Alexander A Szewczak
  • Amy C Seila
  • Adegboyega K Oyelere
  • B Fotinakes
  • J Frederick
  • Daniel H Marks
  • Michael Vishnevetsky
  • Amanda G Sandoval
  • Mario Percy Núñez Vargas
  • Maria A Townes
  • Carol Bascom-Slack
  • Paul A Mittermiller
  • Marina Santiago
  • Dashawn Hickman
  • Kaury Kucera
  • Justin Jee
  • Kathleen W Dantzler
  • Farrah M Kimovec
  • Salvador Joel Núñez
  • David Koppstein
  • Pria Anand
  • Jeffrey Huang
  • Neely E Williams
  • Stephen D Levandoski
  • Elizabeth G Kelley-Swift
  • Puyao Li
  • Joshua S Greene
  • Kathleen Fenn
  • Vivek Kembaiyan
  • Cong Ma
  • Emily H Lin
  • Percy Núñez Vargas
  • W M Hess
  • David Y Light
  • Sun Jin Lee
  • Beatrice Babbs
  • Bradley D Hann
  • Emily Moore
  • Tyler D Ames
  • Jocelyn Keehner
  • Daniel Vekhter
  • Michelle A Schorn
  • Emmanuel Pfund
  • Nicolas Carrasco
  • J Patrick Loria
  • Ethan B Butler

Detail Information

Publications51

  1. pmc Comparative analysis of hairpin ribozyme structures and interference data
    Sean P Ryder
    Yale University, Department of Molecular Biophysics and Biochemistry, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 30:1287-91. 2002
    ..These local differences may suggest a role for these atoms in the transition state, either directly in chemistry or via a local structural rearrangement...
  2. pmc Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center
    K Mark Parnell
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 99:11658-63. 2002
    ..0 and 8.5. These data argue against a mechanism for peptidyl transfer in which a residue with near neutral pKa stabilizes the transition-state oxyanion, at least to the extent that CCdApPmn accurately mimics the transition state...
  3. pmc RNA catalysis: ribozymes, ribosomes, and riboswitches
    Scott A Strobel
    Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520 8114, USA
    Curr Opin Chem Biol 11:636-43. 2007
    ..This catalytic breadth raises intriguing evolutionary questions about how RNA lost its biological role in some cases, but not in others, and what catalytic roles RNA might still be playing in biology...
  4. pmc A two-step chemical mechanism for ribosome-catalysed peptide bond formation
    David A Hiller
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 476:236-9. 2011
    ..This suggests that in addition to substrate positioning, the ribosome is contributing to chemical catalysis by changing the rate-limiting transition state...
  5. pmc Linguistic analysis of project ownership for undergraduate research experiences
    D I Hanauer
    Department of English, Indiana University of Pennsylvania, Indiana, PA 15705, USA
    CBE Life Sci Educ 11:378-85. 2012
    ..These elements suggest several features that could be incorporated into an undergraduate research experience to foster a student's sense of project ownership...
  6. ncbi request reprint Crystal structure of a self-splicing group I intron with both exons
    Peter L Adams
    Department of Molecular Biophysics and Biochemistry, 260 Whitney Avenue, Yale University, New Haven, Connecticut 06520 8114, USA
    Nature 430:45-50. 2004
    ..This structure represents the first splicing complex to include a complete intron, both exons and an organized active site occupied with metal ions...
  7. pmc Plasticity of the RNA kink turn structural motif
    Alexandra H Antonioli
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 16:762-8. 2010
    ..Such plasticity suggests that the K-turn is not a primary element in RNA folding, but instead is shaped by other structural elements within the RNA or ribonucleoprotein assembly...
  8. ncbi request reprint Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping
    Juliane K Soukup
    Department of Molecular Biophysics, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 41:10426-38. 2002
    ..Biochemical identification of these interactions may provide valuable constraints for RNA structure prediction...
  9. pmc Bioactive endophytes warrant intensified exploration and conservation
    Stephen A Smith
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 3:e3052. 2008
    ..Here we provide direct evidence from bioassays of endophytes isolated from tropical plants and bioinformatic analyses that novel biology will indeed yield novel chemistry of potential value...
  10. pmc Crystal structure of a group I intron splicing intermediate
    Peter L Adams
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520 8114, USA
    RNA 10:1867-87. 2004
    ..Models of the pre-first and pre-second steps of intron splicing are proposed with full-sized tRNA exons. They suggest that the tRNA undergoes substantial angular motion relative to the intron between the two steps of splicing...
  11. pmc RNA kink turns to the left and to the right
    Scott A Strobel
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520 8114, USA
    RNA 10:1852-4. 2004
    ..The final structure may be specified by external factors, such as protein binding or the tertiary structural context, rather than the intrinsic conformation of the RNA...
  12. ncbi request reprint Plant endophytes as a platform for discovery-based undergraduate science education
    Scott A Strobel
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, Connecticut 06520 8114, USA
    Nat Chem Biol 3:356-9. 2007
    ..We have embarked on an experiment in undergraduate education that targets isolation of microbes from rainforest plants and characterization of natural products as objectives for discovery-based undergraduate research...
  13. pmc Structural metals in the group I intron: a ribozyme with a multiple metal ion core
    Mary R Stahley
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520 8114, USA
    J Mol Biol 372:89-102. 2007
    ..The structural data are correlated to the biochemical results to further understand the role of metal ions in group I intron structure and function...
  14. pmc Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme
    Jesse C Cochrane
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 48:3239-46. 2009
    ....
  15. doi request reprint Multiple, novel biologically active endophytic actinomycetes isolated from upper Amazonian rainforests
    Carol A Bascom-Slack
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Microb Ecol 58:374-83. 2009
    ..Our results provide evidence of the untapped biodiversity in the form of biologically active microbes present within the tissues of higher plants...
  16. ncbi request reprint RNA splicing: group I intron crystal structures reveal the basis of splice site selection and metal ion catalysis
    Mary R Stahley
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Curr Opin Struct Biol 16:319-26. 2006
    ..The structures support a two-metal-ion mechanism for group I intron splicing that might have corollaries to group II intron and pre-mRNA splicing by the spliceosome...
  17. ncbi request reprint Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction
    T Martin Schmeing
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell 20:437-48. 2005
    ....
  18. pmc A relaxed active site after exon ligation by the group I intron
    Sarah V Lipchock
    Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520
    Proc Natl Acad Sci U S A 105:5699-704. 2008
    ..Together, these data suggest that release of the ligated exons from the intron is preceded by a change in substrate-metal coordination before tertiary hydrogen bonding contacts to the exons are broken...
  19. doi request reprint Probing RNA structure and function by nucleotide analog interference mapping
    Jesse C Cochrane
    Yale University, New Haven, Connecticut, USA
    Curr Protoc Nucleic Acid Chem . 2004
    ..The analogs, techniques, and data analysis used in NAIM are described here...
  20. ncbi request reprint Toward ribosomal RNA catalytic activity in the absence of protein
    Rachel M Anderson
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Mol Evol 64:472-83. 2007
    ..This study represents a step on the path toward isolating that native activity...
  21. pmc Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor
    Jesse C Cochrane
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520, USA
    Chem Biol 14:97-105. 2007
    ..This demonstrates that RNA, like protein enzymes, can employ the chemical diversity of small molecules to promote catalytic activity...
  22. pmc Structural basis of ligand binding by a c-di-GMP riboswitch
    Kathryn D Smith
    Department of Chemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 16:1218-23. 2009
    ....
  23. ncbi request reprint Substrate-assisted catalysis of peptide bond formation by the ribosome
    Joshua S Weinger
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Nat Struct Mol Biol 11:1101-6. 2004
    ..These results suggest that substrate assistance has been retained as a catalytic strategy during the evolution of the prebiotic peptidyl transferase center into the modern ribosome...
  24. ncbi request reprint pK(a) perturbation in genomic Hepatitis Delta Virus ribozyme catalysis evidenced by nucleotide analogue interference mapping
    Adegboyega K Oyelere
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 41:3667-75. 2002
    ....
  25. ncbi request reprint Identification of an active site ligand for a group I ribozyme catalytic metal ion
    Alexander A Szewczak
    Department of Molecular Biophysics, Yale University, New Haven, Connecticut 06520 8114, USA
    Biochemistry 41:2516-25. 2002
    ....
  26. pmc Catalytic importance of a protonated adenosine in the hairpin ribozyme active site
    Ian T Suydam
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 49:3723-32. 2010
    ..All pK(a) reduced analogues, including those of the previous study, produce selective interference at A38 when substrates are stably bound and docked, consistent with the importance of base ionization at this site...
  27. ncbi request reprint A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits
    T Martin Schmeing
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Nat Struct Biol 9:225-30. 2002
    ..Thus, this structure represents a state that occurs after peptide bond formation but before the hybrid state of protein synthesis...
  28. pmc Riboswitch effectors as protein enzyme cofactors
    Jesse C Cochrane
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    RNA 14:993-1002. 2008
    ..Here we review the chemistry of AdoCbl, SAM, FMN, and TPP in protein enzymology and speculate on how these cofactors might have been used by ribozymes in the prebiotic RNA World or may still find application in modern biology...
  29. pmc Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping
    Jessee C Cochrane
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 9:1282-9. 2003
    ..These experiments on a model system demonstrate that QNAIM is an efficient method to establish a chemically detailed free energy profile for a wide variety of RNA-ligand interactions...
  30. ncbi request reprint HIS & HERS, magic magnesium and the ballet of protein synthesis
    K Mark Parnell
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520 8114, USA
    Curr Opin Chem Biol 7:528-33. 2003
    ..This review focuses on how this RNA enzyme orients its substrates and promotes the chemical reaction that is center stage in protein synthesis...
  31. doi request reprint Catalytic strategies of self-cleaving ribozymes
    Jesse C Cochrane
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Acc Chem Res 41:1027-35. 2008
    ..This diversity is in contrast to the relatively small number of functional groups that serve as a general base, where at least three of the nucleolytic ribozymes may use the N1 of a G...
  32. ncbi request reprint Structural evidence for a two-metal-ion mechanism of group I intron splicing
    Mary R Stahley
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Science 309:1587-90. 2005
    ..The evolutionary convergence of RNA and protein active sites on the same inorganic architecture highlights the intrinsic chemical capacity of the two-metal-ion catalytic mechanism for phosphoryl transfer...
  33. pmc Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex
    Michelle L Gill
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 34:4506-14. 2006
    ..The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale...
  34. pmc Participation of the tRNA A76 hydroxyl groups throughout translation
    Joshua S Weinger
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 45:5939-48. 2006
    ..In this review, we follow the 2'- and 3'-OHs through the steps of translation and examine the involvement of these critical functional groups...
  35. pmc Biodegradation of polyester polyurethane by endophytic fungi
    Jonathan R Russell
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Appl Environ Microbiol 77:6076-84. 2011
    ....
  36. ncbi request reprint Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative
    Kensuke Okuda
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Biochemistry 44:6675-84. 2005
    ....
  37. pmc Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes
    Ashley Eversole Hesslein
    Yale University, Department of Molecular Biophysics and Biochemistry, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 32:3760-70. 2004
    ....
  38. ncbi request reprint Regiospecificity of the peptidyl tRNA ester within the ribosomal P site
    Kevin S Huang
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    J Am Chem Soc 128:3108-9. 2006
    ..Strong preferential binding to the O3' regioisomer indicates that the peptidyl transferase proceeds through a transition state with an O3'-linked peptide in the P-site...
  39. pmc Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects
    David A Hiller
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA
    Biochemistry 49:3868-78. 2010
    ..These uncatalyzed reactions serve as a basis for determining what aspects of the transition states are stabilized by the ribosome to achieve a rate enhancement...
  40. ncbi request reprint Synthesis of the ribosomal P-site substrate CCA-pcb
    Minghong Zhong
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Org Lett 8:55-8. 2006
    ..Both 3'-esterification and nucleotide coupling were accomplished by in situ activation with imidazolium ions...
  41. pmc Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs
    Ian T Suydam
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    J Am Chem Soc 130:13639-48. 2008
    ..The structural similarity of these analogues, combined with their even incorporation and selective interference, provides an improved method for identifying sites of adenosine protonation in a variety of systems...
  42. pmc Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction
    Kevin S Huang
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Biochemistry 47:8822-7. 2008
    ..Both of these observations are consistent with a proton shuttle mechanism for the peptidyl transferase reaction...
  43. pmc Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein
    Lara B Weinstein Szewczak
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536, USA
    RNA 11:1407-19. 2005
    ..An intramolecular RNA-RNA contact via a 2'-hydroxyl may supercede a putative Type I A-minor interaction in stabilizing the RNA-protein complex...
  44. pmc Chemical basis of glycine riboswitch cooperativity
    Miyun Kwon
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 14:25-34. 2008
    ..These data have direct analogy to well-characterized mutations in hemoglobin, which provides a framework for considering cooperativity in this RNA-based system...
  45. pmc Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction
    Minghong Zhong
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Org Chem 73:603-11. 2008
    ....
  46. ncbi request reprint Ionization of a critical adenosine residue in the neurospora Varkud Satellite ribozyme active site
    Fatima D Jones
    Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 42:4265-76. 2003
    ..These include residues in helix II, helix VI (730 loop), the II-III-VI and III-IV-V helix junctions, and loop V...
  47. ncbi request reprint Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP
    Lara B Weinstein Szewczak
    Department of Molecular Biophysics and Biochemistry, New Haven, CT 06536, USA
    Chem Biol 9:1095-107. 2002
    ..Our results argue that the 15.5 kD protein interacts asymmetrically with the two sets of conserved box C/D elements and that its binding is primarily responsible for the stability of box C/D snoRNAs in vivo...
  48. ncbi request reprint An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
    T Martin Schmeing
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 438:520-4. 2005
    ..Protein release factors may also function, in part, by inducing an active-site rearrangement similar to that produced by the A-site aminoacyl-tRNA, allowing the carbonyl group and water to be positioned for hydrolysis...
  49. ncbi request reprint Ribonucleic general acid
    Scott A Strobel
    Nat Chem Biol 1:5-6. 2005
  50. pmc Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics
    Joshua S Weinger
    Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, NY 10021, USA
    Blood Cells Mol Dis 38:110-6. 2007
    ....
  51. ncbi request reprint Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome
    Vladimir I Katunin
    Sankt Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Russia
    Mol Cell 10:339-46. 2002
    ..These results suggest a contribution to overall catalysis of general acid-base and/or conformational catalysis involving an ionizing group at the active site...

Research Grants19

  1. Mechanism of ribosome catalyzed peptide bond formation
    SCOTT STROBEL; Fiscal Year: 2007
    ..It is a primary drug target for the treatment of bacterial infection. The information gained in this research program will lead to improved antibiotics for combating disease. ..
  2. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2004
    ....
  3. Catalytic Mechanisms of Large Ribozymes
    SCOTT STROBEL; Fiscal Year: 2004
    ..This will lead to improved mechanistic understanding of how RNA can catalyze reactions involved in RNA processing. ..
  4. NONCANONICAL BASE PAIRS IN RNA FOLDING AND CATALYSIS
    SCOTT STROBEL; Fiscal Year: 2000
    ..Synthetic organic chemistry will be used to prepare nucleotide analogs that systematically alter the functional groups of the bases, but retain the pairing conformation. ..
  5. Mechanism of ribosome catalyzed peptide bond formation
    SCOTT STROBEL; Fiscal Year: 2009
    ..It is a primary drug target for the treatment of bacterial infection. The information gained in this research program will lead to improved antibiotics for combating disease. ..