Stephen Strittmatter

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc The reticulons: a family of proteins with diverse functions
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, CT 06536, USA
    Genome Biol 8:234. 2007
  2. pmc Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse
    Erika Chung
    Department of Neurology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    BMC Neurosci 11:130. 2010
  3. ncbi request reprint The Nogo-66 receptor: focusing myelin inhibition of axon regeneration
    Aaron W McGee
    Departments of Neurology and Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06520, USA
    Trends Neurosci 26:193-8. 2003
  4. ncbi request reprint Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo
    Stephen M Strittmatter
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Mol Neurosci 19:117-21. 2002
  5. ncbi request reprint Regulating axon growth within the postnatal central nervous system
    Fenghua Hu
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Perinatol 28:371-8. 2004
  6. ncbi request reprint Nogo and the Nogo-66 receptor
    Alyson E Fournier
    Department of Neurology, Section of Neurobiology, Yale University School of Medicine, P O Box 208018, New Haven, CT 06510, USA
    Prog Brain Res 137:361-9. 2002
  7. ncbi request reprint Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury
    Ji Eun Kim
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 44:439-51. 2004
  8. pmc Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients
    Noam Y Harel
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Biomarkers 14:414-7. 2009
  9. pmc Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor
    Aaron W McGee
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 309:2222-6. 2005
  10. ncbi request reprint Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact
    Xingxing Wang
    Departments of Neurology and Neurosurgery and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:5505-15. 2002

Research Grants

  1. Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration
    Stephen Strittmatter; Fiscal Year: 2007
  2. AXONAL GROWTH CONE SIGNAL TRANSDUCTION
    Stephen Strittmatter; Fiscal Year: 2007
  3. MOLECULAR DETERMINANTS OF AXONAL REGENERATION
    Stephen Strittmatter; Fiscal Year: 2007
  4. Nogo Receptor Antagonist for Ischemic Stroke Recovery
    Stephen Strittmatter; Fiscal Year: 2007
  5. Nogo Receptor in Axonal Regeneration
    Stephen Strittmatter; Fiscal Year: 2005
  6. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
  7. Nogo Receptor Antagonist for Ischemic Stroke Recovery
    Stephen M Strittmatter; Fiscal Year: 2010
  8. Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration
    Stephen M Strittmatter; Fiscal Year: 2010
  9. Conference on Axonal Connections
    Stephen Strittmatter; Fiscal Year: 2005
  10. CONTROL OF GROWTH CONE FUNCTION BY GTP-BINDING PROTEINS
    Stephen Strittmatter; Fiscal Year: 1993

Collaborators

  • William B J Cafferty
  • Noam Y Harel
  • Juha Lauren
  • Jun Yu
  • Heping Zhang
  • Laura Ment
  • Paul Lombroso
  • Thomas M Wisniewski
  • Helen Treloar
  • Quentin S Fischer
  • N W Daw
  • P D Mehta
  • Daniel H S Lee
  • M E Cudkowicz
  • AMY FT ARNSTEN
  • N Marklund
  • Ji Eun Kim
  • Betty P Liu
  • Stephane Budel
  • James H Park
  • Fenghua Hu
  • Alyson E Fournier
  • Shuxin Li
  • Xingxing Wang
  • Haakon B Nygaard
  • Tadzia GrandPre
  • Aaron W McGee
  • Yvonne S Yang
  • David A Gimbel
  • Erik C Gunther
  • Weiwei Li
  • Andre Schmandke
  • Eric F Schmidt
  • Robert Qing Miao
  • Jung Kil Lee
  • Benxiu Ji
  • Lee Walus
  • Yongfang Zhang
  • Erika Chung
  • Eric A Huebner
  • Katsuhisa Tanabe
  • Philip Duffy
  • Iris E Bonilla
  • Antonio Schmandke
  • Hongyu Zhao
  • Fuki Hisama
  • Zeny Feng
  • Jill S Cameron
  • Ji Liao
  • William C Sessa
  • Mingwei Li
  • Timothy Vartanian
  • Lisette Acevedo
  • Jared Weiss
  • Adrienna Jirik
  • Dinah W Y Sah
  • Blake Pepinsky
  • Rahul C Deo
  • Eugene Choi
  • Dane Worley
  • Alyson Fournier
  • Dike Qiu
  • William A Barton
  • Pradeep Kurup
  • Yanjie Sun
  • Paul Greengard
  • Regina B Kascsak
  • Richard J Kascsak
  • Nikisha Carty
  • Erin E Coffey
  • Stephanie M Fernandez
  • Christopher Pittenger
  • Yong Ji
  • Angus C Nairn
  • Jian Xu
  • Zachary A Gimbel
  • Shuh Narumiya
  • Kang Ho Song
  • Jonathan Sigworth
  • Grahame Gould
  • Kenneth Baughman
  • Joel Gelernter
  • Stefano Sodi
  • Bao zhu Yang
  • Althea Stillman
  • Sang Ohk Shim
  • Sam Johnson
  • Thihan Padukkavidana
  • Joseph Volpe
  • Jacob A Sloane

Detail Information

Publications62

  1. pmc The reticulons: a family of proteins with diverse functions
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, CT 06536, USA
    Genome Biol 8:234. 2007
    ..The diversity of structure, topology, localization and expression patterns of reticulons is reflected in their multiple, diverse functions in the cell...
  2. pmc Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse
    Erika Chung
    Department of Neurology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    BMC Neurosci 11:130. 2010
    ..At the conclusion of behavioral testing, animals were sacrificed and brain tissue was analyzed biochemically or immunohistochemically for the levels of amyloid plaques, PrPC, synaptophysin, Aβ40/42 and Aβ oligomers...
  3. ncbi request reprint The Nogo-66 receptor: focusing myelin inhibition of axon regeneration
    Aaron W McGee
    Departments of Neurology and Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06520, USA
    Trends Neurosci 26:193-8. 2003
    ..Although these findings expand our understanding of the molecular determinants of adult CNS axonal regrowth, the physiological roles of myelin-associated inhibitors in the intact adult CNS remain ill-defined...
  4. ncbi request reprint Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo
    Stephen M Strittmatter
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Mol Neurosci 19:117-21. 2002
    ..The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer's Disease is considered...
  5. ncbi request reprint Regulating axon growth within the postnatal central nervous system
    Fenghua Hu
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Perinatol 28:371-8. 2004
    ..The regulation of axonal growth, sprouting and connections in the postnatal brain by myelin proteins is an area of important investigation and potential therapeutic intervention...
  6. ncbi request reprint Nogo and the Nogo-66 receptor
    Alyson E Fournier
    Department of Neurology, Section of Neurobiology, Yale University School of Medicine, P O Box 208018, New Haven, CT 06510, USA
    Prog Brain Res 137:361-9. 2002
    ..Blockade of Nogo-66 interaction with its receptor provides one potential avenue to promote axonal regeneration after adult mammalian CNS injury...
  7. ncbi request reprint Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury
    Ji Eun Kim
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 44:439-51. 2004
    ..Thus, NgR is partially responsible for limiting the regeneration of certain fiber systems in the adult CNS...
  8. pmc Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients
    Noam Y Harel
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Biomarkers 14:414-7. 2009
    ..0% vs 4.7%) displayed markedly elevated levels of Nogo-A. Additional study is required to determine the factors that lead to elevated Nogo-A levels in a subset of both ALS patients and healthy controls...
  9. pmc Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor
    Aaron W McGee
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 309:2222-6. 2005
    ..After pathological trauma, similar NgR signaling limits functional recovery and axonal regeneration...
  10. ncbi request reprint Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact
    Xingxing Wang
    Departments of Neurology and Neurosurgery and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:5505-15. 2002
    ..Taken together, these data confirm the apposition of Nogo ligand and NgR receptor in situations of limited axonal regeneration and support the hypothesis that this system regulates CNS axonal plasticity and recovery from injury...
  11. ncbi request reprint Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
    Betty P Liu
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 297:1190-3. 2002
    ..MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury...
  12. ncbi request reprint Nogo-66 receptor antagonist peptide promotes axonal regeneration
    Tadzia GrandPre
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nature 417:547-51. 2002
    ..Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent...
  13. pmc Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Neurotrauma 27:2055-66. 2010
    ..In this lesion model, the effects of NgR deletion and training were not synergistic for the tasks assessed. Further work is required to optimize the interaction between pharmacological and physical interventions for SCI...
  14. ncbi request reprint Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity
    Jared Weiss
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Neurol 189:141-9. 2004
    ..Thus, hypoxia-induced reduction in myelin-derived axon outgrowth inhibitors appears to contribute axonal misconnection to the pathology of very low birth weight infants...
  15. pmc Axonal growth therapeutics: regeneration or sprouting or plasticity?
    William B J Cafferty
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Neurosci 31:215-20. 2008
    ..The phenotypes produced by molecular interventions that overcome astroglial scar or myelin-associated inhibitors are reframed and discussed in this context...
  16. pmc Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury
    Shuxin Li
    Department of Neurology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06510, USA
    Mol Cell Neurosci 29:26-39. 2005
    ..These data indicate that the NgR ligands, Nogo-66, MAG, and OMgp, play a role in limiting axonal growth in the injured adult CNS and that NgR(310)ecto might provide a therapeutic means to promote recovery from SCI...
  17. ncbi request reprint Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin
    Alyson E Fournier
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:8876-83. 2002
    ..These data suggest that NgR mediates a significant fraction of myelin inhibition of axon outgrowth...
  18. ncbi request reprint Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity
    Jung Kil Lee
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:6209-17. 2004
    ..Behavioral improvement occurs when therapy is initiated 1 week after arterial occlusion. Thus, delayed pharmacological blockade of the NgR promotes subacute stroke recovery by facilitating axonal plasticity...
  19. pmc The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism
    Fenghua Hu
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 28:1262-9. 2008
    ..Both alpha(v) and alpha5 integrins have widespread expression in adult brain and are found in axonal growth cones. Thus, inhibition of integrin signaling by Amino-Nogo contributes to the failure of CNS axon regeneration...
  20. ncbi request reprint Axon regeneration in young adult mice lacking Nogo-A/B
    Ji Eun Kim
    Department of Neurology, Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 38:187-99. 2003
    ..Numerous fibers regenerate into distal cord segments of nogo-A/B(-/-) mice. Recovery of locomotor function is improved in these mice. Thus, Nogo-A plays a role in restricting axonal sprouting in the young adult CNS after injury...
  21. ncbi request reprint Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury
    Shuxin Li
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 23:4219-27. 2003
    ..Systemic Nogo-66 receptor antagonists have therapeutic potential for subacute CNS axonal injuries such as spinal cord trauma...
  22. pmc Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth
    Stephane Budel
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 28:13161-72. 2008
    ..For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk...
  23. pmc Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition
    James H Park
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:1386-95. 2006
    ..The NgR provides a novel site for modifying the course of AD and highlights the role of axonal dysfunction in the disease...
  24. pmc MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma
    William B J Cafferty
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 30:6825-37. 2010
    ..These data support the hypothesis that targeting all three myelin ligands, as with NgR1 decoy receptor, provides the optimal chance for overcoming myelin inhibition and improving neurological function...
  25. pmc Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice
    James H Park
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:13279-86. 2006
    ..The benefits of peripheral NgR administration are evident when therapy is initiated after disease onset. Thus, the peripheral association of NgR(310)ecto-Fc with central Abeta residues provides an effective therapeutic approach for AD...
  26. pmc Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members
    Juha Lauren
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:5715-25. 2007
    ..This detailed knowledge of the molecular interactions between NgR1 and its ligands is imperative when assessing options for development of NgR1-based therapeutics for central nervous system injuries...
  27. pmc Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    Juha Lauren
    Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 457:1128-32. 2009
    ..Thus, PrP(C) is a mediator of amyloid-beta-oligomer-induced synaptic dysfunction, and PrP(C)-specific pharmaceuticals may have therapeutic potential for Alzheimer's disease...
  28. pmc Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
    Noam Y Harel
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 7:603-16. 2006
    ..In addition to focusing on methods to stimulate growth in the adult, we also expand on approaches to recapitulate development itself...
  29. ncbi request reprint Rho kinase inhibition enhances axonal regeneration in the injured CNS
    Alyson E Fournier
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:1416-23. 2003
    ..Furthermore, Y-27632 enhances sprouting of CST fibers in vivo and accelerates locomotor recovery after CST lesions in adult rats...
  30. pmc Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord
    Philip Duffy
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 29:15266-76. 2009
    ..Together, these findings demonstrate that the ROCKII gene product limits axonal growth after CNS trauma...
  31. ncbi request reprint Nogo-C is sufficient to delay nerve regeneration
    Ji Eun Kim
    Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 23:451-9. 2003
    ..Thus, expression of the Nogo-66 domain by otherwise permissive myelinating cells is sufficient to hinder axonal reextension after trauma...
  32. ncbi request reprint Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury
    Shuxin Li
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:10511-20. 2004
    ..The ability of soluble NgR(310)ecto to promote axon growth and locomotor recovery demonstrates a therapeutic potential for NgR antagonism in traumatic spinal cord injury...
  33. pmc Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist
    Fenghua Hu
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:5298-304. 2005
    ..Thus, NgR activation by Nogo-A involves multiple sites of interaction between Nogo-A and NgR...
  34. ncbi request reprint Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals
    Jill S Cameron
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 27:13033-41. 2007
    ....
  35. pmc Axon regeneration in the peripheral and central nervous systems
    Eric A Huebner
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA
    Results Probl Cell Differ 48:339-51. 2009
    ..Both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success. This chapter discusses determinants of axon regeneration in the PNS and CNS...
  36. pmc Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth
    Xingxing Wang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06520, USA
    J Neurotrauma 26:81-95. 2009
    ..Thus, administration of ibuprofen improves the recovery of rats from a clinically relevant spinal cord trauma by protecting tissue, stimulating axonal sprouting, and allowing a minor degree of raphespinal regeneration...
  37. pmc Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci 29:13850-9. 2009
    ..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS...
  38. pmc Beta-amyloid oligomers and cellular prion protein in Alzheimer's disease
    Erik C Gunther
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 295 Congress Ave, BCMM 436, New Haven, CT 06536 0812, USA
    J Mol Med (Berl) 88:331-8. 2010
    ..Here, we review the importance of A beta oligomers in AD, commonalities between AD and CJD, and the newly emergent role of PrP(C) as a receptor for A beta oligomers...
  39. pmc Delayed Nogo receptor therapy improves recovery from spinal cord contusion
    Xingxing Wang
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann Neurol 60:540-9. 2006
    ..Myelin-associated inhibitors play a role in limiting axonal growth in the adult central nervous system. Blocking these inhibitors may promote neurological recovery from spinal cord contusion...
  40. pmc Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans
    William B J Cafferty
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 27:2176-85. 2007
    ..CSPGs appear to function in a spatially distinct role from myelin inhibitors, implying that combination-based therapy will be especially advantageous for CNS injuries...
  41. pmc Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells
    Robert Qing Miao
    Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 103:10997-1002. 2006
    ..Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis...
  42. pmc The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth
    William B J Cafferty
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:12242-50. 2006
    ..This fiber growth correlates with recovery of fine motor skill in the affected forelimb. Thus nogo-ab and ngr1 play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in various lesion models...
  43. ncbi request reprint Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth
    Iris E Bonilla
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1303-15. 2002
    ..In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth. Neuronal SPRR1A may be a significant contributor to successful nerve regeneration...
  44. pmc Extracellular regulators of axonal growth in the adult central nervous system
    Betty P Liu
    Department of Neurology, Yale University School of Medicine, PO Box 208018, 333 Cedar Street, New Haven, CT 06520, USA
    Philos Trans R Soc Lond B Biol Sci 361:1593-610. 2006
    ..After CNS injury, such interventions support a partial return of neurological function...
  45. pmc Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease
    Haakon B Nygaard
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06536 0812, USA
    Arch Neurol 66:1325-8. 2009
    ..We further discuss the relationship between AD and PrP(c) and the potential clinical implications. Cellular prion protein may provide a novel target for therapeutic intervention in AD...
  46. pmc Memory impairment in transgenic Alzheimer mice requires cellular prion protein
    David A Gimbel
    Cellular Neuroscience, Neurodegeneration, and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 30:6367-74. 2010
    ..Thus, deletion of PrP(C) expression dissociates Abeta accumulation from behavioral impairment in these AD mice, with the cognitive deficits selectively requiring PrP(C)...
  47. ncbi request reprint Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth
    Katsuhisa Tanabe
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:9675-86. 2003
    ..The neurite outgrowth-promoting effect of Fn14 is enhanced by Rac1 activation and suppressed by Rac1 inactivation. These findings suggest that Fn14 contributes to nerve regeneration via a Rac1 GTPase-dependent mechanism...
  48. pmc Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model
    Yongfang Zhang
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:19014-9. 2010
    ..Our results suggest that STEP inhibitors may prove therapeutic for this devastating disorder...
  49. pmc Nogo receptor interacts with brain APP and Abeta to reduce pathologic changes in Alzheimer's transgenic mice
    James H Park
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Curr Alzheimer Res 4:568-70. 2007
    ..The NgR provides a novel site for modifying the course of AD and highlights the role of axonal dysfunction in the disease...
  50. pmc ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases
    Andre Schmandke
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology Yale University School of Medicine, New Haven, CT 06510, USA
    Neuroscientist 13:454-69. 2007
    ..The ROCK pathway also provides a potential site for therapeutic intervention to promote neuronal regeneration and to limit degeneration...
  51. pmc The CRMP family of proteins and their role in Sema3A signaling
    Eric F Schmidt
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Exp Med Biol 600:1-11. 2007
    ..In addition, the collapsin-response-mediator protein (CRMP) family of cytosolic phosphoproteins plays a crucial role in Sema3A/NP1/PlexA signal transduction. Current knowledge regarding CRMP functions are reviewed here...
  52. ncbi request reprint A new role for Nogo as a regulator of vascular remodeling
    Lisette Acevedo
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 10:382-8. 2004
    ..Our discovery that Nogo-B is a regulator of vascular homeostasis and remodeling broadens the functional scope of this family of proteins...
  53. pmc Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins
    William A Barton
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    EMBO J 22:3291-302. 2003
    ..The NgR structure analysis, as well as a comparison of NgR surface residues not conserved in NgR2 and NgR3, identifies potential protein interaction sites important in the assembly of a functional signaling complex...
  54. ncbi request reprint Regenerating nerves follow the road more traveled
    Alyson E Fournier
    Nat Neurosci 5:821-2. 2002
  55. pmc Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury
    Benxiu Ji
    Department of Pharmacology, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Eur J Neurosci 22:587-94. 2005
    ..The data demonstrate that NgR(310)ecto-Fc and MP act in a temporally and mechanistically distinct manner and suggest that they may have complementary effects...
  56. pmc Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199
    William B J Cafferty
    Neuron 54:195-9. 2007
  57. ncbi request reprint A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin
    Weiwei Li
    Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 279:43780-8. 2004
    ..Thus, specific anti-NgR1 antibodies may represent a useful therapeutic approach for promoting CNS repair after injury...
  58. pmc Structural bases for CRMP function in plexin-dependent semaphorin3A signaling
    Rahul C Deo
    Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA
    EMBO J 23:9-22. 2004
    ..This mutant CRMP mimics the DRG neurite outgrowth-inhibiting effects of Sema3A and reduces Sema3A-induced axonal repulsion. These data provide a structural view of CRMP function in Plex-dependent Sema3A signaling...
  59. ncbi request reprint Targeting the Nogo receptor to treat central nervous system injuries
    Daniel H S Lee
    Biogen Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Drug Discov 2:872-8. 2003
  60. pmc No association between schizophrenia and polymorphisms of the PlexinA2 gene in Chinese Han Trios
    Stephane Budel
    Schizophr Res 99:365-6. 2008
  61. pmc Nogo-A marks motor neuron disease
    Noam Y Harel
    Ann Neurol 62:1-2. 2007
  62. pmc Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 197:70-83. 2006
    ....

Research Grants40

  1. Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration
    Stephen Strittmatter; Fiscal Year: 2007
    ..Such data will inform our understanding of the stability of connectivity within the CNS and illuminate the possibility of harnessing this knowledge for therapeutic interventions. ..
  2. AXONAL GROWTH CONE SIGNAL TRANSDUCTION
    Stephen Strittmatter; Fiscal Year: 2007
    ..These findings will have implications for the understanding developmental disorders of the brain arid will aid in the design of therapies based on axonal growth and regeneration ..
  3. MOLECULAR DETERMINANTS OF AXONAL REGENERATION
    Stephen Strittmatter; Fiscal Year: 2007
    ....
  4. Nogo Receptor Antagonist for Ischemic Stroke Recovery
    Stephen Strittmatter; Fiscal Year: 2007
    ..Overall, this work will determine the extent to which enhanced axonal plasticity created by blockade of NgR function improves stroke recovery. (End of Abstract) ..
  5. Nogo Receptor in Axonal Regeneration
    Stephen Strittmatter; Fiscal Year: 2005
    ..This research may also prove applicable to a wide range of chronic brain axonal injuries, such as traumatic brain injury, white matter strokes and chronic progressive multiple sclerosis. ..
  6. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
    ..This work is critical to optimize the opportunity for development of clinical methods to increase axonal growth and improve functional recovery from neurological damage. ..
  7. Nogo Receptor Antagonist for Ischemic Stroke Recovery
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Overall, this work will determine the extent to which enhanced axonal plasticity created by blockade of NgR function improves stroke recovery. ..
  8. Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Such data will inform our understanding of the stability of connectivity within the CNS and illuminate the possibility of harnessing this knowledge for therapeutic interventions. ..
  9. Conference on Axonal Connections
    Stephen Strittmatter; Fiscal Year: 2005
    ..Topics will include basic research on molecular cues, and resulting new approaches toward therapeutic axon repair. ..
  10. CONTROL OF GROWTH CONE FUNCTION BY GTP-BINDING PROTEINS
    Stephen Strittmatter; Fiscal Year: 1993
    ..It is also probable that the same system contributes to synaptic plasticity in the adult nervous system, and a failure of this system might therefore account for some unexplained degenerative disorders of the nervous system...
  11. NEURONAL GROWTH CONE SIGNAL TRANSDUCTION MECHANISMS
    Stephen Strittmatter; Fiscal Year: 1999
    ..The same mechanisms are likely to function during adult nervous system injury and improve function in degenerative neurologic diseases. ..
  12. AXONAL GROWTH CONE SIGNAL TRANSDUCTION
    Stephen Strittmatter; Fiscal Year: 2004
    ....
  13. MOLECULAR DETERMINANTS OF AXONAL REGENERATION
    Stephen Strittmatter; Fiscal Year: 2004
    ..Similar assays will be performed while reducing the expression of these proteins in cultured cells with trituration-loaded antibodies or antisense oligonucleotides. ..
  14. Prion Protein in Alzheimer's Disease Pathophysiology
    Stephen M Strittmatter; Fiscal Year: 2010
    ..In this project, we test the hypothesis that cellular Prion protein mediates amyloid- action. If validated, this hypothesis predicts that Prion protein will be a novel target for therapeutic development for Alzheimer's disease. ..