JOAN STEITZ

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling
    Victor Fok
    Department of Molecular Biophysics and Biochemistry and 2Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 173:319-25. 2006
  2. pmc Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production
    Jan M Pawlicki
    Department of Pharmacology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 182:61-76. 2008
  3. pmc Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing
    Anita Nag
    Department of Molecular Biophysics and Biochemistry MB and B, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT, USA
    RNA Biol 9:334-42. 2012
  4. pmc A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression
    Sumit Borah
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002300. 2011
  5. pmc Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA
    Walter N Moss
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    BMC Genomics 14:543. 2013
  6. doi request reprint miRNPs: versatile regulators of gene expression in vertebrate cells
    Joan A Steitz
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, BCMM, New Haven, CT 06536, USA
    Biochem Soc Trans 37:931-5. 2009
  7. pmc Where in the cell is the minor spliceosome?
    Joan A Steitz
    Yale University and Howard Hughes Medical Institute, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 105:8485-6. 2008
  8. ncbi request reprint Switching from repression to activation: microRNAs can up-regulate translation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 318:1931-4. 2007
  9. pmc AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Cell 128:1105-18. 2007
  10. pmc Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA
    Demian Cazalla
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 328:1563-6. 2010

Research Grants

  1. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
  2. Small RNP Mediators of Gene Expression
    Joan A Steitz; Fiscal Year: 2010
  3. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2006
  4. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2004
  5. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2002
  6. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2000
  7. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
  8. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2007
  9. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2005
  10. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2003

Collaborators

Detail Information

Publications44

  1. pmc Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling
    Victor Fok
    Department of Molecular Biophysics and Biochemistry and 2Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 173:319-25. 2006
    ..To ensure that small RNA shuttling can be detected in cells that are negative for EBER shuttling, we demonstrate the shuttling of U1 small nuclear RNA...
  2. pmc Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production
    Jan M Pawlicki
    Department of Pharmacology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 182:61-76. 2008
    ..Together, our results suggest that pri-miRNA processing is enhanced by coupling to transcription...
  3. pmc Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing
    Anita Nag
    Department of Molecular Biophysics and Biochemistry MB and B, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT, USA
    RNA Biol 9:334-42. 2012
    ..Together our results suggest recruitment of the nuclear decay machinery to the spliceosome to ensure production of properly spliced mRNA...
  4. pmc A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression
    Sumit Borah
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002300. 2011
    ..Our results add to the repertoire of functions ascribed to long noncoding RNAs and suggest a mechanism of action for nuclear noncoding RNAs in gamma herpesvirus infection...
  5. pmc Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA
    Walter N Moss
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    BMC Genomics 14:543. 2013
    ..Little is known concerning the roles of RNA structure in this important human pathogen. This study provides the first comprehensive genome-wide survey of RNA and RNA structure in EBV...
  6. doi request reprint miRNPs: versatile regulators of gene expression in vertebrate cells
    Joan A Steitz
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, BCMM, New Haven, CT 06536, USA
    Biochem Soc Trans 37:931-5. 2009
    ..The activating role of miRNAs is now being confirmed in the immature Xenopus oocyte, which mimics the quiescent state...
  7. pmc Where in the cell is the minor spliceosome?
    Joan A Steitz
    Yale University and Howard Hughes Medical Institute, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 105:8485-6. 2008
  8. ncbi request reprint Switching from repression to activation: microRNAs can up-regulate translation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 318:1931-4. 2007
    ..Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle...
  9. pmc AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Cell 128:1105-18. 2007
    ..This novel cell-growth-dependent translation activation role for FXR1 and AGO2 allows new insights into ARE-mediated signaling and connects two important posttranscriptional regulatory systems in an unexpected way...
  10. pmc Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA
    Demian Cazalla
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 328:1563-6. 2010
    ..This viral strategy illustrates use of a ncRNA to manipulate host-cell gene expression via the miRNA pathway...
  11. pmc Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay
    Tetsuro Hirose
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 101:17976-81. 2004
    ..These findings suggest a common pathway for EJC assembly by the two spliceosomes and highlight the evolutionary age of the EJC and its downstream functions in gene expression...
  12. pmc Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR
    J Robin Lytle
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 104:9667-72. 2007
    ..Our results suggest that association with any position on a target mRNA is mechanistically sufficient for a microribonucleoprotein to exert repression of translation at some step downstream of initiation...
  13. ncbi request reprint The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila
    Leo R Otake
    Department of Cell Biology, Yale University, Howard Hughes Medical Institute, New Haven, CT 06536, USA
    Mol Cell 9:439-46. 2002
    ..Thus, we demonstrate the requirement for the U12 spliceosome in the development of a metazoan organism...
  14. ncbi request reprint Splicing-dependent and -independent modes of assembly for intron-encoded box C/D snoRNPs in mammalian cells
    Tetsuro Hirose
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Mol Cell 12:113-23. 2003
    ..In vivo analyses confirm that a stable stem can compensate for the unusual position of those few box C/D snoRNAs located far from the 3' splice site of their host intron...
  15. pmc Branchpoint selection in the splicing of U12-dependent introns in vitro
    Timothy S McConnell
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536, USA
    RNA 8:579-86. 2002
    ..Analysis of these three additional introns therefore rules out simple models for branchpoint selection by the U12-type spliceosome...
  16. pmc Cell-cycle control of microRNA-mediated translation regulation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Cell Cycle 7:1545-9. 2008
    ....
  17. pmc U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation
    Kyle Friend
    Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA
    Mol Cell 28:240-52. 2007
    ..Finally, we show that U2 snRNP associates with histone pre-mRNAs in vivo. We conclude that U2 snRNP plays a nonsplicing role in histone mRNA maturation...
  18. pmc Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(a)-binding protein are distinct processes mediated by two epstein barr virus proteins
    Richard Park
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 9:e92593. 2014
    ..Using a click chemistry-based assay for new protein synthesis, we show that ZEBRA and BGLF5 each function as viral host shutoff factors. ..
  19. ncbi request reprint Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP
    Lara B Weinstein Szewczak
    Department of Molecular Biophysics and Biochemistry, New Haven, CT 06536, USA
    Chem Biol 9:1095-107. 2002
    ..Our results argue that the 15.5 kD protein interacts asymmetrically with the two sets of conserved box C/D elements and that its binding is primarily responsible for the stability of box C/D snoRNAs in vivo...
  20. ncbi request reprint In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site
    Nikolay G Kolev
    Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA
    Nat Struct Mol Biol 13:347-53. 2006
    ....
  21. pmc Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci
    Jan M Pawlicki
    Department of Pharmacology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Cell Cycle 8:345-56. 2009
    ..We discuss the implications of our findings relative to recent insights into miRNA biogenesis, mRNA metabolism, and the nuclear organization of gene expression...
  22. pmc A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles
    Kazimierz T Tycowski
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Mol Cell 34:47-57. 2009
    ..We demonstrate a requirement for WDR79 binding in the CB localization of a scaRNA. This and other recent reports establish WDR79 as a central player in the localization and processing of nuclear RNPs...
  23. ncbi request reprint SRprises along a messenger's journey
    Yingqun Huang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Mol Cell 17:613-5. 2005
    ..Recent work, however, has implicated these proteins in numerous additional steps of mRNA metabolism, including nuclear export, RNA stability, mRNA quality control, and translation...
  24. pmc Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function
    Jan M Pawlicki
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Trends Cell Biol 20:52-61. 2010
    ..This review discusses the extensive molecular interactions that couple the earliest steps in gene expression and therefore influence the final fate and function of the mature messenger RNA or microRNA produced...
  25. pmc A molecular link between SR protein dephosphorylation and mRNA export
    Yingqun Huang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:9666-70. 2004
    ..TAP preferentially binds spliced mRNA-protein complexes compared with pre-mRNA-protein complexes. Thus, the phosphorylation state of the SR protein adapters may underlie the selectivity of TAP-mediated export of spliced mRNA...
  26. pmc The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element-containing mRNA levels in virally transformed T cells
    Heidi L Cook
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536, USA
    Mol Cell Biol 24:4522-33. 2004
    ..This is the first example of posttranscriptional regulation of the expression of an Sm small nuclear RNA...
  27. ncbi request reprint Splicing double: insights from the second spliceosome
    Abhijit A Patel
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA
    Nat Rev Mol Cell Biol 4:960-70. 2003
  28. pmc Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation
    Nikolay G Kolev
    Howard Hughes Medical Institute, Yale University, 295 Congress Avenue, New Haven, Connecticut 06519, USA
    EMBO Rep 9:1013-8. 2008
    ..This indicates that CPSF73 and CPSF100 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers...
  29. pmc Comprehensive analysis of Rhesus lymphocryptovirus microRNA expression
    Kasandra J L Riley
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Virol 84:5148-57. 2010
    ..We further demonstrate that rLCV mature miRNAs associate with Argonaute proteins in rLCV-infected B cells...
  30. ncbi request reprint Small nuclear RNAs encoded by Herpesvirus saimiri upregulate the expression of genes linked to T cell activation in virally transformed T cells
    Heidi L Cook
    Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA
    Curr Biol 15:974-9. 2005
    ..These changes indicate an unexpected role for the HSURs in regulating a remarkably defined and physiologically relevant set of host targets involved in the activation of virally transformed T cells during latency...
  31. pmc Assembly of the U1 snRNP involves interactions with the backbone of the terminal stem of U1 snRNA
    Timothy S McConnell
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06536, USA
    RNA 9:193-201. 2003
    ..We suggest that the stem loop of all Sm snRNAs may act as a clamp to hold the ring of Sm proteins in place...
  32. ncbi request reprint SR splicing factors serve as adapter proteins for TAP-dependent mRNA export
    Yingqun Huang
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06536, USA
    Mol Cell 11:837-43. 2003
    ..Thus, multiple adapters including SR proteins most likely cooperate to recruit multiple copies of TAP/NXF1 for efficient mRNA export...
  33. pmc An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes
    Petra Scamborova
    Department of Molecular Biophysics and Biochemistry, Yale University Howard Hughes Medical Institute, New Haven, Connecticut 06536 9812, USA
    Mol Cell Biol 24:1855-69. 2004
    ..Thus, we have identified an intron region critical for prospero twintron splicing as a first step towards elucidating the molecular mechanism of splicing regulation involving competition between the two kinds of spliceosomes...
  34. pmc Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR
    Ana Rebane
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 10:590-9. 2004
    ..Possible nucleocytoplasmic shuttling mechanisms for hnRNP A1 and HuR are discussed...
  35. pmc Premature termination codons do not affect the rate of splicing of neighboring introns
    J Robin Lytle
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 10:657-68. 2004
    ..Our results are discussed with respect to existing evidence for nuclear surveillance mechanisms...
  36. pmc Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses
    Stavroula Mili
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, 295 Congress Ave, Box 9812, New Haven, Connecticut 06536 9812, USA
    RNA 10:1692-4. 2004
    ..The existence of such postlysis reassortments thus demonstrates that co-immunoprecipitation does not always recapitulate the in vivo state of ribonucleoprotein complexes...
  37. ncbi request reprint Guide RNAs with 5' caps and novel box C/D snoRNA-like domains for modification of snRNAs in metazoa
    Kazimierz T Tycowski
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA
    Curr Biol 14:1985-95. 2004
    ..Each particle is composed of a short guide RNA and a set of several proteins. All previously characterized modification guide RNAs in metazoa are encoded in and processed from introns...
  38. pmc Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein
    Lara B Weinstein Szewczak
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06536, USA
    RNA 11:1407-19. 2005
    ..An intramolecular RNA-RNA contact via a 2'-hydroxyl may supercede a putative Type I A-minor interaction in stabilizing the RNA-protein complex...
  39. pmc Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs
    Nikolay G Kolev
    Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA
    Genes Dev 19:2583-92. 2005
    ..Thus, a common molecular machinery contributes to the nuclear maturation of mRNAs both lacking and possessing poly(A), as well as to cytoplasmic poly(A) tail elongation...
  40. ncbi request reprint Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Genes Dev 20:138-46. 2006
  41. pmc Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22
    Victor Fok
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 12:872-82. 2006
    ..The existence of multiple L22 binding sites on EBER 1 inside cells is demonstrated by in vivo UV cross-linking. Our results are discussed with respect to the function of EBER 1 in EBV-infected human B cells...
  42. pmc The splicing of U12-type introns can be a rate-limiting step in gene expression
    Abhijit A Patel
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    EMBO J 21:3804-15. 2002
    ..These results provide evidence that the level of gene expression in vivo is lowered by the presence of a U12-type intron and implicate the U12-type spliceosome as a target in the post-transcriptional regulation of gene expression...
  43. pmc Minor-class splicing occurs in the nucleus of the Xenopus oocyte
    Kyle Friend
    RNA 14:1459-62. 2008
    ..We further demonstrate that splicing of both a major-class and a minor-class intron is inhibited after nuclear envelope breakdown during meiosis...
  44. ncbi request reprint A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing
    Tetsuro Hirose
    Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, 135 0064, Japan
    Mol Cell 23:673-84. 2006
    ..IBP160 binding directly to a snoRNA located too close to the intron branch site interferes with snoRNP assembly. Thus, IBP160 is the key factor linking snoRNP biogenesis and perhaps other postsplicing events to pre-mRNA splicing...

Research Grants23

  1. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations. ..
  2. Small RNP Mediators of Gene Expression
    Joan A Steitz; Fiscal Year: 2010
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations. ..
  3. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2006
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in snRNP biogenesis, functions and associations. ..
  4. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2004
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in snRNP biogenesis, functions and associations. ..
  5. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2002
    ..Perturbations in the biogenesis and functioning of snRNPs and snoRNPs are determinants in certain human diseases and perhaps aging. ..
  6. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2000
    ..Perturbations in the biogenesis and functioning of snRNPs and snoRNPs are determinants in certain human diseases and perhaps aging. ..
  7. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations. ..
  8. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2007
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations. ..
  9. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2005
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in snRNP biogenesis, functions and associations. ..
  10. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2003
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in snRNP biogenesis, functions and associations. ..
  11. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 2001
    ..Perturbations in the biogenesis and functioning of snRNPs and snoRNPs are determinants in certain human diseases and perhaps aging. ..
  12. MOLECULAR MECHANISMS IN GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 1980
    ..coli. Knowledge of DNA sequences within the termini of the element and at its insertion sites, as well as identification of protein(s) encoded by gamma delta, should assist in elucidating the molecular requirements for translocation...
  13. SNRNP MEDIATORS OF VERTEBRATE GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 1999
    ..Perturbations in the biogenesis and functioning of snRNPs and snoRNPs are determinants in certain human diseases and perhaps aging. ..