M W State

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Common genetic variants, acting additively, are a major source of risk for autism
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Autism 3:9. 2012
  2. doi request reprint The conundrums of understanding genetic risks for autism spectrum disorders
    Matthew W State
    Program on Neurogenetics, Departments of Child Psychiatry, Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 14:1499-506. 2011
  3. pmc The genetics of Tourette disorder
    Matthew W State
    Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06520, United States
    Curr Opin Genet Dev 21:302-9. 2011
  4. pmc The genetics of child psychiatric disorders: focus on autism and Tourette syndrome
    Matthew W State
    Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 68:254-69. 2010
  5. ncbi request reprint Obsessive-compulsive symptoms in Prader-Willi and "Prader-Willi-Like" patients
    M W State
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 38:329-34. 1999
  6. pmc Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
    Thomas Fernandez
    Am J Hum Genet 82:1385. 2008
  7. pmc A surprising METamorphosis: autism genetics finds a common functional variant
    Matthew W State
    Program on Neurogenetics, Departments of Child Psychiatry and Genetics, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:16621-2. 2006
  8. pmc Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
    Matthew W State
    Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4684-9. 2003
  9. pmc Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
    Thomas Fernandez
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 74:1286-93. 2004
  10. ncbi request reprint Tourette's syndrome and related disorders
    M W State
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Child Adolesc Psychiatr Clin N Am 10:317-31, ix. 2001

Collaborators

Detail Information

Publications30

  1. pmc Common genetic variants, acting additively, are a major source of risk for autism
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Autism 3:9. 2012
    ..abstract:..
  2. doi request reprint The conundrums of understanding genetic risks for autism spectrum disorders
    Matthew W State
    Program on Neurogenetics, Departments of Child Psychiatry, Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 14:1499-506. 2011
    ....
  3. pmc The genetics of Tourette disorder
    Matthew W State
    Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06520, United States
    Curr Opin Genet Dev 21:302-9. 2011
    ..Finally, analysis of a cohort of sufficient size to identify common polymorphisms of plausible effect is underway, promising key information regarding the contribution of common alleles to TD...
  4. pmc The genetics of child psychiatric disorders: focus on autism and Tourette syndrome
    Matthew W State
    Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 68:254-69. 2010
    ....
  5. ncbi request reprint Obsessive-compulsive symptoms in Prader-Willi and "Prader-Willi-Like" patients
    M W State
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 38:329-34. 1999
    ..To compare obsessive-compulsive (OC) symptoms in patients with Prader-Willi syndrome (PWS) and symptoms in a group of patients presenting with "Prader-Willi-like" features but without the genetic abnormalities associated with PWS...
  6. pmc Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
    Thomas Fernandez
    Am J Hum Genet 82:1385. 2008
  7. pmc A surprising METamorphosis: autism genetics finds a common functional variant
    Matthew W State
    Program on Neurogenetics, Departments of Child Psychiatry and Genetics, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:16621-2. 2006
  8. pmc Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
    Matthew W State
    Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4684-9. 2003
    ....
  9. pmc Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
    Thomas Fernandez
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 74:1286-93. 2004
    ..Our results demonstrate the association of CNTN4 disruption with the 3p deletion syndrome phenotype and strongly suggest a causal relationship. These findings point to an important role for CNTN4 in normal and abnormal CNS development...
  10. ncbi request reprint Tourette's syndrome and related disorders
    M W State
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Child Adolesc Psychiatr Clin N Am 10:317-31, ix. 2001
    ..Because it may be easier to influence the environment and behavior rather than to change genes, exploration of such gene-environment interactions may lead to the most significant clinical contributions in the near term...
  11. doi request reprint Molecular characterization of a patient with 3p deletion syndrome and a review of the literature
    Thomas V Fernandez
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    Am J Med Genet A 146:2746-52. 2008
    ....
  12. doi request reprint A novel heterozygous deletion within the 3' region of the PAX6 gene causing isolated aniridia in a large family group
    Fatih Bayrakli
    Department of Neurosurgery, Van Military Hospital, Van, Turkey
    J Clin Neurosci 16:1610-4. 2009
    ..Our results support the notion that assessing copy number variation of the PAX6 gene itself and also of flanking regions, may contribute to the molecular diagnosis of aniridia...
  13. doi request reprint Autism genetics: strategies, challenges, and opportunities
    Brian J O'Roak
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Autism Res 1:4-17. 2008
    ..Finally, we describe key advances in genomic technologies that are transforming all areas of human genetics and consider both the opportunities and challenges for autism research posed by these rapid changes...
  14. pmc Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts
    D Moreno-De-Luca
    1 Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA 2 Programs in Neurogenetics and Human Genetics and Genomics, Child Study Center and Departments of Psychiatry and Genetics, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 18:1090-5. 2013
    ....
  15. ncbi request reprint Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)
    X Lin
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, 06520 7900, USA
    Genomics 60:96-104. 1999
    ..Expression in the developing human hypothalamus was confirmed by immunohistochemistry...
  16. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
    ..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...
  17. pmc L-histidine decarboxylase and Tourette's syndrome
    A Gulhan Ercan-Sencicek
    Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 362:1901-8. 2010
    ..Our findings, together with previously published data from model systems, point to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics...
  18. ncbi request reprint Rapid array-based genomic characterization of a subtle structural abnormality: a patient with psychosis and der(18)t(5;18)(p14.1;p11.23)
    Carolyn M Drazinic
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Med Genet A 134:282-9. 2005
    ..While these methods do not eliminate the requirement for traditional fine-mapping, they provide an efficient approach to identifying the origin and extent of deleted and duplicated material in chromosomal rearrangements...
  19. pmc The genetics of autism: key issues, recent findings, and clinical implications
    Paul El-Fishawy
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Psychiatr Clin North Am 33:83-105. 2010
    ..This article reviews the origins of the common versus rare variant debate, highlights recent findings in the field, and addresses the clinical implications of common and rare variant discoveries...
  20. ncbi request reprint [Autism: genetics]
    Abha R Gupta
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Rev Bras Psiquiatr 28:S29-38. 2006
    ..This paper will review the literature to date summarizing the results of linkage, cytogenetic, and candidate gene studies with a focus on recent progress. In addition, promising avenues for future research are considered...
  21. ncbi request reprint Recent advances in the genetics of autism
    Abha R Gupta
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:429-37. 2007
    ..In addition, promising avenues for future research and the potential contribution of emerging genomic technologies are considered...
  22. doi request reprint Progress in cytogenetics: implications for child psychopathology
    Ellen J Hoffman
    Program on Neurogenetics, Child Study Center, and Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 49:736-51; quiz 856-7. 2010
    ....
  23. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
    ....
  24. pmc Functional and evolutionary insights into human brain development through global transcriptome analysis
    Matthew B Johnson
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 62:494-509. 2009
    ..These data provide a wealth of biological insights into the complex transcriptional and molecular underpinnings of human brain development and evolution...
  25. ncbi request reprint Rapid identification of disease-causing mutations using copy number analysis within linkage intervals
    Fatih Bayrakli
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Hum Mutat 28:1236-40. 2007
    ..Herein, we demonstrate the utility of this technique by rapidly identifying a disease causing microdeletion within the PARK2 gene in a family with autosomal recessive Parkinsonism...
  26. pmc Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome
    Althea A Stillman
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 513:21-37. 2009
    ....
  27. pmc Susceptibility loci for intracranial aneurysm in European and Japanese populations
    Kaya Bilguvar
    Department of Neurosurgery, Neurobiology, Yale Center for Human Genetics and Genomics, Yale University School of Medicine, New Haven, CT 06510, USA
    Nat Genet 40:1472-7. 2008
    ..These findings have implications for the pathophysiology, diagnosis and therapy of intracranial aneurysm...
  28. ncbi request reprint Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome
    William C Speed
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Am J Med Genet B Neuropsychiatr Genet 147:463-6. 2008
    ..Although there is no evidence of selection, the haplotype frequency variation seen around the world will need to be considered in any future association studies of this locus with GTS or any other neuropsychiatric disorder...
  29. doi request reprint Novel VLDLR microdeletion identified in two Turkish siblings with pachygyria and pontocerebellar atrophy
    Luis E Kolb
    Department of Neurosurgery, Neurobiology, Program on Neurogenetics Yale University School of Medicine, New Haven, CT, USA
    Neurogenetics 11:319-25. 2010
    ..Discovery of disease causing homozygous deletions in the present Turkish family capable of maintaining bipedal movement exemplifies the phenotypic heterogeneity of VLDLR-associated cerebellar hypoplasia and ataxia...
  30. ncbi request reprint Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22
    Adam Cuker
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 130:37-9. 2004
    ....

Research Grants15

  1. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2002
    ..abstract_text> ..
  2. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew State; Fiscal Year: 2009
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..
  3. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew State; Fiscal Year: 2007
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..
  4. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew State; Fiscal Year: 2006
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..
  5. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2006
    ..abstract_text> ..
  6. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2006
    ..abstract_text> ..
  7. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2005
    ..abstract_text> ..
  8. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2005
    ..abstract_text> ..
  9. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2004
    ..abstract_text> ..
  10. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2004
    ..abstract_text> ..
  11. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2003
    ..abstract_text> ..
  12. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2003
    ..abstract_text> ..
  13. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2002
    ..abstract_text> ..
  14. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew W State; Fiscal Year: 2010
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..