Julie Staley

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain
    J K Staley
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Nucl Med Biol 27:547-56. 2000
  2. ncbi request reprint Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking
    Julie K Staley
    Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 62:877-88. 2005
  3. ncbi request reprint 123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    J Nucl Med 46:1466-72. 2005
  4. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
  5. ncbi request reprint Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
    J K Staley
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Synapse 41:275-84. 2001
  6. ncbi request reprint Sex differences in diencephalon serotonin transporter availability in major depression
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA
    Biol Psychiatry 59:40-7. 2006
  7. pmc Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT
    Effie M Mitsis
    Yale University School of Medicine, New Haven, CT 06510, USA
    Neurobiol Aging 30:1490-7. 2009
  8. ncbi request reprint [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain
    Effie M Mitsis
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1097:168-70. 2007
  9. ncbi request reprint Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma
    Ronald M Baldwin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Nucl Med Biol 33:549-54. 2006
  10. doi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment
    Effie M Mitsis
    Alzheimer s Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 50:1455-63. 2009

Research Grants

Detail Information

Publications35

  1. ncbi request reprint SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain
    J K Staley
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Nucl Med Biol 27:547-56. 2000
    ....
  2. ncbi request reprint Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking
    Julie K Staley
    Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 62:877-88. 2005
    ..Adaptations in gamma-aminobutyric acid type A (GABA(A))-benzodiazepine receptors contribute to the neurobiology of human alcohol dependence and withdrawal...
  3. ncbi request reprint 123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    J Nucl Med 46:1466-72. 2005
    ..The feasibility and reproducibility of the bolus-plus-constant-infusion paradigm for equilibrium modeling of (123)I-5-IA using SPECT in healthy nonsmokers was studied...
  4. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
    ..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence...
  5. ncbi request reprint Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
    J K Staley
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Synapse 41:275-84. 2001
    ..Although these findings are preliminary and need validation with a more selective 5-HT transporter radiotracer, the results suggest that brainstem 5-HT transporters may be regulated by smoking in a sex-specific manner...
  6. ncbi request reprint Sex differences in diencephalon serotonin transporter availability in major depression
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA
    Biol Psychiatry 59:40-7. 2006
    ..The present study evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) transporter availability in depressed patients would be confirmed in a larger sample and also evaluated sex differences...
  7. pmc Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT
    Effie M Mitsis
    Yale University School of Medicine, New Haven, CT 06510, USA
    Neurobiol Aging 30:1490-7. 2009
    ..These results in living human subjects corroborate postmortem reports of decline in high affinity nicotine binding with age and may aid in elucidating the role of beta(2)-nAChRs in cognitive aging...
  8. ncbi request reprint [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain
    Effie M Mitsis
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1097:168-70. 2007
    ..Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging...
  9. ncbi request reprint Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma
    Ronald M Baldwin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Nucl Med Biol 33:549-54. 2006
    ....
  10. doi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment
    Effie M Mitsis
    Alzheimer s Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 50:1455-63. 2009
    ..However, the status of this receptor in mild or prodromal AD has remained the subject of controversy...
  11. doi request reprint Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
    Am J Psychiatry 169:326-34. 2012
    ..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia...
  12. ncbi request reprint Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
    John H Krystal
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 63:957-68. 2006
    ..Advances in molecular neuroscience, genetics, and neuroimaging provide new insights into the role of brain GABA systems in short- and long-term alcohol effects...
  13. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009
    ..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence...
  14. pmc GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
    Synapse 63:1089-99. 2009
    ..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression...
  15. doi request reprint Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET
    Lekshmi Santhosh
    Alzheimer s Disease Research Unit, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychiatry Res 173:212-7. 2009
    ..However, in a limited AD patient sample, they fail to demonstrate a relationship between regional 5-HT(2A) binding and major behavioral symptoms...
  16. ncbi request reprint Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, Cognitive Disorders Clinic, New Haven, CT 06510, USA
    Am J Psychiatry 159:309-12. 2002
    ..The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder...
  17. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers...
  18. pmc Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
    Synapse 64:729-32. 2010
    ..The decrease in beta(2)*-nAChR availability is influenced by alcohol consumption, suggesting the chronicity and severity of alcohol consumption may underlie persistent changes in beta(2)*-nAChR availability...
  19. pmc Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
    Kelly P Cosgrove
    Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
    Nicotine Tob Res 12:535-9. 2010
    ....
  20. pmc SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain
    Kelly P Cosgrove
    Yale University School of Medicine, VA Connecticut HCS 116A6, West Haven, CT 06516, USA
    Nucl Med Biol 37:587-91. 2010
    ..The purpose of this study was to characterize and determine the in vivo selectivity of iodine-123-labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane, [(123)I]p ZIENT, in nonhuman primate brain...
  21. pmc Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    J Nucl Med 51:1226-33. 2010
    ..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety...
  22. pmc Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study
    Kelly P Cosgrove
    Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
    Psychiatry Res 184:192-5. 2010
    ..Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found...
  23. doi request reprint Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2218-26. 2009
    ..Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol...
  24. ncbi request reprint Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
    Am J Psychiatry 160:1522-4. 2003
    ..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood...
  25. ncbi request reprint Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Biol Psychiatry 56:497-502. 2004
    ..This study used brain imaging to examine the relationship between pretreatment brain SERT availability and transporter occupancy by SSRIs with treatment response in two independent depressed populations...
  26. ncbi request reprint Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:525-31. 2004
    ..In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear...
  27. ncbi request reprint Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, One Church Street, New Haven, CT 06510, USA
    J Nucl Med 46:745-51. 2005
    ..Previous investigations of the effects of the SLC6A3 polymorphism on DAT availability in smaller samples of humans have yielded divergent results...
  28. pmc Evolving knowledge of sex differences in brain structure, function, and chemistry
    Kelly P Cosgrove
    Division of Psychiatry SPECT Imaging, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Biol Psychiatry 62:847-55. 2007
    ....
  29. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
    ..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women...
  30. doi request reprint beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
    Christoph Czermak
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Int J Neuropsychopharmacol 11:419-24. 2008
    ..66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development...
  31. pmc Synthesis, radiolabeling and baboon SPECT imaging of 2beta-carbomethoxy-3beta-(3'-[(123)I]iodophenyl)tropane ([(123)I]YP256) as a serotonin transporter radiotracer
    Frederic Bois
    Yale University, School of Medicine, VA Connecticut HCS 116A2, West Haven, CT 06516, USA
    Nucl Med Biol 35:53-9. 2008
    ..Although the ligand displayed high selectivity for 5-HTT over dopamine transporter in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo...
  32. pmc Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER
    Gilles D Tamagnan
    Institute for Degenerative Diseases, New Haven, CT 06520, USA
    Bioorg Med Chem Lett 17:533-7. 2007
    ..The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging...
  33. ncbi request reprint Synthesis and receptor binding studies of halogenated N,N-dialkylel-(2-phenyl-1H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET
    Idriss Bennacef
    Yale School of Medicine, VA Connecticut HCS 116A2, West Haven, CT 06516, USA
    Bioorg Med Chem 14:7582-91. 2006
    ..4 in the range of 1.6-2.4). The iodinated derivative 11 (Ki = 2.6 nM) and the fluorinated analog 26 (Ki = 6.2 nM) displayed higher affinity than reference compounds...
  34. ncbi request reprint Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET
    Thomas Chaly
    Department of Medicine, North Shore University Hospital, NYU Medical College, PET Research, Manhasset, NY 11030, USA
    Nucl Med Biol 31:125-31. 2004
    ..18F]FPCBT displayed good brain uptake and its high target to non target ratio indicate that it is a potential candidate for DAT imaging...
  35. ncbi request reprint Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequences
    Dieter J Meyerhoff
    Department of Radiology, University of California at San Francisco, San Francisco, California, USA
    Alcohol Clin Exp Res 30:253-64. 2006
    ....

Research Grants11

  1. PET AND SPECT IMAGING IN ALCOHOLIC SMOKERS
    Julie Staley; Fiscal Year: 2003
    ..abstract_text> ..
  2. Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy
    Julie Staley; Fiscal Year: 2007
    ..In addition they will provide critical information about the interaction of nicotine with p2-nAChR and the relationship to improvements in cognitive performance. ..
  3. Neuroreceptor Imaging of Tobacco Smokers
    Julie Staley; Fiscal Year: 2007
    ..These investigations illustrate the impact this career award will have in furthering not only my scientific career, but also our fundamental understanding of the neurochemical mechanisms underlying habitual tobacco smoking. ..
  4. Tobacco Smoking & Nicotinic Acetylcholine Receptors
    Julie Staley; Fiscal Year: 2007
    ..abstract_text> ..