Research Topics
Genomes and GenesSpecies | Susan S SpencerSummaryAffiliation: Yale University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Epilepsy: clinical observations and novel mechanismsSusan Spencer
Yale Univeristy School of Medicine, New Haven, CT 06520-8018, USA
Lancet Neurol 6:14-6. 2007
Health-related quality of life over time since resective epilepsy surgerySusan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
Ann Neurol 62:327-34. 2007..Health-related quality of life (HRQOL) improves after resective epilepsy surgery, but data are limited to short follow-up in mostly retrospective reports, with minimal consideration of other potential factors that might influence HRQOL...
Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter studyS S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
Neurology 65:912-8. 2005..In a seven-center prospective observational study of resective epilepsy surgery, the authors examined probability and predictors of entering 2-year remission and the risk of subsequent relapse...
Initial outcomes in the Multicenter Study of Epilepsy SurgeryS S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
Neurology 61:1680-5. 2003..To obtain prospective data regarding seizures, anxiety, depression, and quality of life (QOL) outcomes after resective epilepsy surgery...
When should temporal-lobe epilepsy be treated surgically?Susan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
Lancet Neurol 1:375-82. 2002....
Interictal spikes on intracranial recording: behavior, physiology, and implicationsSusan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Epilepsia 49:1881-92. 2008..We systematically analyzed the frequency, occurrence, and distribution of IISs recorded from multiple intracranial electrodes in 34 refractory epileptic patients with respect to seizures and antiepileptic drug (AED) changes...
Outcomes of epilepsy surgery in adults and childrenSusan Spencer
Yale University, School of Medicine, New Haven, CT 06520 8018, USA
Lancet Neurol 7:525-37. 2008..In this Review, we consider the outcomes of surgery in adults and children with epilepsy and review studies of neurological and cognitive sequelae, psychiatric and behavioural outcomes, and overall health-related quality of life...
Neural networks in human epilepsy: evidence of and implications for treatmentSusan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520-8018, USA
Epilepsia 43:219-27. 2002
Multiple subpial transection for intractable partial epilepsy: an international meta-analysisSusan S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
Epilepsia 43:141-5. 2002....
Background intracranial EEG spectral changes with anti-epileptic drug taperHitten P Zaveri
Department of Neurology, Yale University, New Haven, CT 06520, USA
Clin Neurophysiol 121:311-7. 2010..Here, we expand the measures evaluated to icEEG power and frequency band power...
Localization-related epilepsy exhibits significant connectivity away from the seizure-onset areaHitten P Zaveri
Departments of Neurology, Yale University, New Haven, CT 06520, USA
Neuroreport 20:891-5. 2009..We show significant nonzero connectivity not only for the seizure-onset area but also several centimeters from it, for example, for the beta-frequency band (P<10(-5)), suggesting a nonlocal character to this disorder...
Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS)Kelly A McNally
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520-8018, USA
Epilepsia 46:1450-64. 2005..CONCLUSIONS: ISAS provides a validated and readily available method for epilepsy SPECT analysis and interpretation. The results also emphasize the need to obtain SPECT injections during seizures to achieve unambiguous localization...
Suicide outcomes after resective epilepsy surgeryHamada Hamid
Yale University School of Medicine, New Haven, CT, USA
Epilepsy Behav 20:462-4. 2011..Two of the patients reported moderate to severe anxiety symptoms (BAI=17 and 21, respectively). Suicide may occur after epilepsy surgery, even when patients report excellent seizure control...
Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsiesIrina I Goncharova
Departments of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
Epilepsia 50:2575-85. 2009..To test this hypothesis, we studied the spatial distribution of intracranially recorded interictal spikes in patients with medial temporal (MT) and lateral temporal (LT) neocortical seizure onset...
A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoringHitten P Zaveri
Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
Epilepsy Res 86:153-62. 2009..We measured change in signal energy of icEEGs in response to AED taper to quantify changes in excitation which accompany the increased propensity for seizures...
Positive and negative network correlations in temporal lobe epilepsyHal Blumenfeld
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
Cereb Cortex 14:892-902. 2004..These results suggest that impaired consciousness in temporal lobe seizures may result from focal abnormal activity in temporal and subcortical networks linked to widespread impaired function of the association cortex...
GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampusTih-Shih Lee
Department of Psychiatry, Yale University School of Medicine, Park Street, New Haven, CT 06520, USA
Acta Neuropathol (Berl) 111:351-63. 2006....
Hypothalamic hamartomas: seven cases and review of the literatureDang Nguyen
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520-8018, USA
Epilepsy Behav 4:246-58. 2003..Gamma knife surgery may be especially useful for small sessile lesions, failed partial resections, or patients not appropriate or refusing open surgery...
Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytesTih Shih Lee
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8082, USA
Mol Med 13:1-13. 2007..Such glutamate release may excite surrounding neurons and elicit seizure activity...
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patientsIdil Cavus
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Epilepsia 49:1358-66. 2008..Temporal lobe epilepsy (TLE) is associated with smaller hippocampal volume and with elevated extracellular (EC) glutamate levels. We investigated the relationship between the hippocampal volume and glutamate in refractory TLE patients...
Temporal lobe tumoral epilepsy: characteristics and predictors of surgical outcomeMegdad M Zaatreh
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520-8018, USA
Neurology 61:636-41. 2003..Extent of tumor resection was significantly predictive of outcome, whereas early intervention and presence of simple partial seizures showed trends as predictive factors...
Temporal distributions of seizure occurrence from various epileptogenic regionsT S Durazzo
Department of Neurology, Yale University, New Haven, CT 06520, USA
Neurology 70:1265-71. 2008..For these ends, we determined and analyzed detailed temporal distributions of seizures arising from the frontal, parietal, occipital, neocortical temporal, and mesial temporal lobes...
Levetiracetam efficacy in refractory partial-onset seizures, especially after failed epilepsy surgeryMahmood Motamedi
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, U.S.A
Epilepsia 44:211-4. 2003..Patients should be under close psychiatric observation in this clinical setting...
Selective frontal, parietal, and temporal networks in generalized seizuresHal Blumenfeld
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Neuroimage 19:1556-66. 2003..Relative sparing of many brain regions during both spontaneous and induced seizures suggests that specific networks may be more important than others in so-called generalized seizures...
A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategoriesNihal C de Lanerolle
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8082, U S A
Epilepsia 44:677-87. 2003..We attempted to relate neuronal density, immunohistochemistry, electrophysiologic data, and surgical outcome...
Racial differences in patient expectations prior to resective epilepsy surgeryChristine Bower Baca
Department of Neurology, University of California at Los Angeles, 911 Broxton Avenue, Los Angeles, CA 90024, USA
Epilepsy Behav 15:452-5. 2009..Elucidating the reason for these differences can aid in the clinical decision-making process for resective surgery and potentially address disparities in its utilization...
Health care costs decline after successful epilepsy surgeryJ T Langfitt
Department of Neurology, University of Rochester, Rochester, NY 14642, USA
Neurology 68:1290-8. 2007..There is little information about how health care costs are affected by evaluation and surgery...
Recent advances in the treatment of epilepsyDang K Nguyen
Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA
Arch Neurol 60:929-35. 2003
Effects of working memory load on oscillatory power in human intracranial EEGJed A Meltzer
Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA
Cereb Cortex 18:1843-55. 2008....
On the use of bipolar montages for time-series analysis of intracranial electroencephalogramsHitten P Zaveri
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Clin Neurophysiol 117:2102-8. 2006....
Impaired consciousness in temporal lobe seizures: role of cortical slow activityDario J Englot
Department of Neurosurgery, University of California, San Francisco, CA 94122, USA
Brain 133:3764-77. 2010..Further investigations will be needed to fully determine the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments to prevent this important negative consequence of temporal lobe epilepsy...
Cortical and subcortical networks in human secondarily generalized tonic-clonic seizuresH Blumenfeld
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
Brain 132:999-1012. 2009..Understanding the networks involved in generalized tonic-clonic seizures can provide insights into mechanisms of behavioural changes, and may elucidate targets for improved therapies...
Expectations prior to epilepsy surgery: an exploratory comparison of men and womenC M Bower
Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA
Seizure 18:228-31. 2009..05). Exploratory factor analysis indicated a different pattern of associations among the 12 importance items for men and women. Whether gender differences in presurgical values are associated with outcomes needs exploration...
Intracranial EEG power and metabolism in human epilepsyJ W Pan
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
Epilepsy Res 87:18-24. 2009..These data are also consistent with the hypothesis that high frequency activity is an abnormal manifestation of tissue injury...
Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizuresG I Varghese
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
Brain 132:2102-13. 2009..These findings suggest that, with appropriate cautious interpretation, ictal SPECT in secondarily generalized seizures can help localize the region of seizure onset...
Multiple subpial transections: the Yale experienceL P Mulligan
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520
Epilepsia 42:226-9. 2001..CONCLUSIONS: In selected patients, MST may be a viable alternative when the epileptogenic focus lies in unresectable cortex. A multicenter study with appreciable patient numbers will be necessary to define predictive factors for success...
Clinical applications: MRI, SPECT, and PETS S Spencer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Magn Reson Imaging 13:1119-24. 1995..Preliminary evidence also indicates that the distribution of hyperperfusion on ictal SPECT can differentiate subtypes of TLE. Combining the results of refined imaging techniques holds great promise in epilepsy localization and diagnosis...
The effect of a scalp reference signal on coherence measurements of intracranial electroencephalogramsH P Zaveri
Department of Neurology, Yale University School of Medicine, CT 06520, New Haven, USA
Clin Neurophysiol 111:1293-9. 2000..To determine the effect of a scalp reference signal, such as that recorded from the mastoid or ear, on the coherence of referential intracranial electroencephalograms (EEGs)...
Ictal neocortical slowing in temporal lobe epilepsyH Blumenfeld
Department of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT, USA
Neurology 63:1015-21. 2004..Temporal lobe epilepsy (TLE) may affect brain regions outside the temporal lobe, causing impaired neocortical function during seizures...
Measuring the coherence of intracranial electroencephalogramsH P Zaveri
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Clin Neurophysiol 110:1717-25. 1999..The performance characteristics of the coherence estimator and statistical testing of coherence estimates are described in this manuscript...
Distinguishing subtypes of temporal lobe epilepsy with background hippocampal activityH P Zaveri
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, U S A
Epilepsia 42:725-30. 2001..This report describes a retrospective study to investigate the feasibility of doing so during intracranial monitoring...
Interictal 99mTc-HMPAO SPECT in temporal lobe epilepsy: relation to clinical variablesR A Avery
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520-8018, USA
Epilepsia 42:869-74. 2001..CONCLUSIONS: Significant correlation of age at onset and duration of epilepsy with AIs in RTLE but not LTLE suggests physiologic processes may be determined in part by laterality of TLE. Clinical applications are problematic...
Economic impact of replacing CT with MR imaging for refractory epilepsyR A Bronen
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Magn Reson Imaging 15:857-62. 1997..To evaluate the economic costs of using computed tomography (CT) vs. magnetic resonance (MR) imaging in the preoperative evaluation of refractory epilepsy patients...
MR characteristics of neoplasms and vascular malformations associated with epilepsyR A Bronen
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Magn Reson Imaging 13:1153-62. 1995..The temporal lobe location, cortical involvement, and calvarial remodelling are findings typical of NVL. MR characteristics can successfully predict the pathologic substrate of these lesions...
Ratio-images calculated from interictal positron emission tomography and single-photon emission computed tomography for quantification of the uncoupling of brain metabolism and perfusion in epilepsyI G Zubal
Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, Connecticut, USA
Epilepsia 41:1560-6. 2000..Uncoupling of these two functions has been demonstrated to be a characteristic of epileptogenic tissue in temporal lobe epilepsy and has the potential to serve as a diagnostic measure for localization in other areas as well...
Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcomeMegdad M Zaatreh
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
Epilepsia 43:727-33. 2002..To review the clinical, neurophysiologic features and surgical outcomes in patients with frontal lobe tumors and chronic intractable seizures...
Long-term seizure outcome in patients initially seizure-free after resective epilepsy surgeryH H Yoon
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8018, USA
Neurology 61:445-50. 2003..Longer preoperative illness and normal pathology predicted poorer outcome...
Worsening of quality of life after epilepsy surgery: effect of seizures and memory declineJ T Langfitt
Department of Neurology, University of Rochester, Rochester, NY 14642, USA
Neurology 68:1988-94. 2007..The relative impact of these unfavorable outcomes on HRQOL has not been described...
Surgical management of parietal lobe epilepsyHahnah J Kasowski
Department of Neurosurgery, Yale University, New Haven, Connecticut, USA
Adv Neurol 93:347-56. 2003..Therefore, one must consider cortical plasticity and functional redistribution as possible reasons for this, particularly when most of these substrates are of developmental origin...
Visual memory in patients after anterior right temporal lobectomy and adult normative data for the Brown Location TestFranklin C Brown
Department of Neurosurgery, Yale University, School of Medicine, New Haven, CT, USA
Epilepsy Behav 17:215-20. 2010..The present findings support a role for the right anterior mesial temporal lobe in dot location learning and memory...
Comparison of statistical parametric mapping and SPECT difference imaging in patients with temporal lobe epilepsyDavid J Chang
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06501, USA
Epilepsia 43:68-74. 2002..Difference analysis using SPM could serve as a useful diagnostic tool in the evaluation of seizure focus in temporal lobe epilepsy...
Reduction of AEDs in postsurgical patients who attain remissionAnne T Berg
BIOS, NIU, DeKalb, Illinois 60115, USA
Epilepsia 47:64-71. 2006..Little evidence guides practice regarding the reduction of antiepileptic drugs (AEDs) in individuals who achieve significant periods of remission after resective surgery...
Epilepsy in North America: a report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health OrganizationWilliam H Theodore
National Institutes of Health, Bethesda, Maryland 20892, USA
Epilepsia 47:1700-22. 2006....
Interrater reliability among epilepsy centers: multicenter study of epilepsy surgerySheryl R Haut
Comprehensive Epilepsy Management Center and Departments of Neurology and Pediatrics of the Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA
Epilepsia 43:1396-401. 2002..We believe that this study demonstrates the feasibility of implementing multicenter protocols for neurologic management, especially those involving localization, as well as protocols combining study results with clinical decision making...
Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsyGauri H Malthankar-Phatak
Department of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, Idaho 83209, USA
Epilepsia 47:1292-9. 2006..It is proposed that significant alterations in the enzyme activities may be contributing to decreased metabolism of glutamate, leading to its accumulation...
The multicenter study of epilepsy surgery: recruitment and selection for surgeryAnne T Berg
BIOS NIU, DeKalb, Illinois 60115, USA
Epilepsia 44:1425-33. 2003..Such information is necessary for providing the epidemiologic and clinical context in which epilepsy surgery is currently performed in the United States and in other developed countries...
Stopping antiepileptic drugs after epilepsy surgery: a survey of U.S. epilepsy center neurologistsAnne T Berg
Department of Biology, Northern Illinois University, DeKalb, IL, USA
Epilepsy Behav 10:219-22. 2007..g., focal pathology in favor of and persistent auras against stopping antiepileptic drugs), it is unclear how well these factors determine seizure outcome in this setting...
Gamma knife radiosurgery for refractory medial temporal lobe epilepsy: too little, too late?Susan S Spencer
Neurology 70:1654-5. 2008
Local spatial effect of 50 Hz cortical stimulation in humansRyder P Gwinn
Epilepsy Center, Seattle Neuroscience Institute, Seattle, Washington, USA
Epilepsia 49:1602-10. 2008..To help characterize this effect, we analyzed electrocorticography (ECoG) recorded adjacent to stimulated contacts during and after bipolar stimulation in patients undergoing functional cortical mapping with subdural electrodes...
An approach to the evaluation of a patient for seizures and epilepsyS Nizam Ahmed
Comprehensive Adult Epilepsy Program, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
WMJ 103:49-55. 2004..This article provides directions and guidelines both for the family practice physician and the specialist in evaluating this patient population in the clinics...
Employment outcomes following resective epilepsy surgeryPeter S Chin
Robert Wood Johnson Clinical Scholars Program, Department of Medicine, University of California Los Angeles and the Greater Los Angeles VA Health Care System, Los Angeles, California 90095 1769, USA
Epilepsia 48:2253-7. 2007..Analyze determinates of employment changes from before to 2 years after surgery in refractory focal epilepsy patients...
Research Grants
- A MULTI-CENTER STUDY OF EPILEPSY SURGERYSusan Spencer; Fiscal Year: 2005....
- MULTICENTER STUDY OF EPILEPSY SURGERYSusan Spencer; Fiscal Year: 2000....
- Anticipating Seizures in Epileptic NetworksSusan Spencer; Fiscal Year: 2007..Fifteen patients will be studied in the retrospective studies, and 45 patients will be studied in the prospective studies. ..
