Mehmet Sofuoglu

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Lack of effect of 5HT3 antagonist in mediating subjective and behavioral responses to cotinine
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue, 201, Minneapolis, MN 55414, USA
    Pharmacol Biochem Behav 75:1-7. 2003
  2. pmc Pharmacological treatment of comorbid PTSD and substance use disorder: recent progress
    Mehmet Sofuoglu
    VA Connecticut Healthcare System, West Haven, CT, United States Yale University, School of Medicine, Department of Psychiatry, New Haven, CT, United States Electronic address
    Addict Behav 39:428-33. 2014
  3. pmc Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 37:1509-16. 2012
  4. pmc Galantamine attenuates some of the subjective effects of intravenous nicotine and improves performance on a Go No-Go task in abstinent cigarette smokers: a preliminary report
    Mehmet Sofuoglu
    School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT, USA
    Psychopharmacology (Berl) 224:413-20. 2012
  5. pmc The reinforcement threshold for nicotine as a target for tobacco control
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT 06516, United States
    Drug Alcohol Depend 125:1-7. 2012
  6. pmc Cognitive enhancement as a treatment for drug addictions
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Neuropharmacology 64:452-63. 2013
  7. ncbi request reprint Cocaine withdrawal symptoms predict medication response in cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Drug Alcohol Abuse 32:617-27. 2006
  8. pmc Cognitive function as an emerging treatment target for marijuana addiction
    Mehmet Sofuoglu
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Exp Clin Psychopharmacol 18:109-19. 2010
  9. ncbi request reprint Self-administration of intravenous nicotine in male and female cigarette smokers
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 33:715-20. 2008
  10. pmc Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Hum Psychopharmacol 24:559-64. 2009

Research Grants

  1. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
  2. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
  3. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010

Detail Information

Publications62

  1. ncbi request reprint Lack of effect of 5HT3 antagonist in mediating subjective and behavioral responses to cotinine
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue, 201, Minneapolis, MN 55414, USA
    Pharmacol Biochem Behav 75:1-7. 2003
    ..The data do not strongly support the hypothesis that 5HT(3) agonism is the mechanism by which cotinine offsets the effects of nicotine...
  2. pmc Pharmacological treatment of comorbid PTSD and substance use disorder: recent progress
    Mehmet Sofuoglu
    VA Connecticut Healthcare System, West Haven, CT, United States Yale University, School of Medicine, Department of Psychiatry, New Haven, CT, United States Electronic address
    Addict Behav 39:428-33. 2014
    ..The safety and efficacy of these medications for the treatment of PTSD and SUD need to be tested in controlled clinical trials. ..
  3. pmc Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 37:1509-16. 2012
    ..These findings warrant further investigation, especially in treatment-seeking smokers undergoing cessation treatment...
  4. pmc Galantamine attenuates some of the subjective effects of intravenous nicotine and improves performance on a Go No-Go task in abstinent cigarette smokers: a preliminary report
    Mehmet Sofuoglu
    School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT, USA
    Psychopharmacology (Berl) 224:413-20. 2012
    ..The goal of this study was to characterize GAL's actions on multiple outcomes, including withdrawal severity and cognitive performance, as well as subjective and physiological responses to nicotine administered intravenously...
  5. pmc The reinforcement threshold for nicotine as a target for tobacco control
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT 06516, United States
    Drug Alcohol Depend 125:1-7. 2012
    ..While the potential public health benefits of this approach are enormous, the guiding concepts and relevant empirical evidence needed to support the implementation of a nicotine reduction policy require a critical examination...
  6. pmc Cognitive enhancement as a treatment for drug addictions
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Neuropharmacology 64:452-63. 2013
    ..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  7. ncbi request reprint Cocaine withdrawal symptoms predict medication response in cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Drug Alcohol Abuse 32:617-27. 2006
    ..This hypothesis needs to be tested in prospective clinical trials...
  8. pmc Cognitive function as an emerging treatment target for marijuana addiction
    Mehmet Sofuoglu
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Exp Clin Psychopharmacol 18:109-19. 2010
    ..Future clinical studies optimally designed to measure cognitive function as well as drug use behavior would be needed to test the efficacy of these treatments for marijuana addiction...
  9. ncbi request reprint Self-administration of intravenous nicotine in male and female cigarette smokers
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 33:715-20. 2008
    ..4 and the 0.7 mg nicotine doses over placebo. Our model may be useful in the evaluation of the effects of both behavioral and pharmacological manipulations on nicotine self-administration in humans...
  10. pmc Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Hum Psychopharmacol 24:559-64. 2009
    ..The goal of this study was to determine the effects of progesterone, on acute physiological and subjective responses to intravenous (IV) nicotine in overnight abstinent male and female smokers...
  11. pmc Riluzole and D-amphetamine interactions in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:16-22. 2008
    ..The mechanism accounting for these findings is unclear, but may involve processes other than decreased glutamate release by riluzole. The effects of glutamate medications on psychostimulant responses need to be further examined...
  12. pmc Cognitive enhancement as a pharmacotherapy target for stimulant addiction
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Addiction 105:38-48. 2010
    ..Attenuation of drug reward has been the main strategy for medications development, but this approach has not led to effective treatments. Thus, there is a need to identify novel treatment targets in addition to the brain reward system...
  13. ncbi request reprint Modafinil and nicotine interactions in abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, West Haven, Connecticut 06516, USA
    Hum Psychopharmacol 23:21-30. 2008
    ..In addition, modafinil speeded reaction times on a modified Stroop task. The clinical utility of modafinil for smoking cessation needs to be determined in future studies...
  14. pmc Atomoxetine attenuates dextroamphetamine effects in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Drug Alcohol Abuse 35:412-6. 2009
    ..Although preclinical studies support the contribution of the noradrenergic system activation in mediating the acute effects of amphetamines, these findings have not been followed up in clinical studies...
  15. pmc Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University School of Medicine, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 207:153-62. 2009
    ..How varenicline affects the pharmacological effects of pure nicotine has not been examined in humans. The goal of this study was to characterize varenicline's actions on nicotine's dose-dependent effects in abstinent smokers...
  16. pmc Minocycline reduced craving for cigarettes but did not affect smoking or intravenous nicotine responses in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, West Haven, CT, USA
    Pharmacol Biochem Behav 92:135-40. 2009
    ..These findings provide limited support for the potential use of minocycline as a treatment of nicotine dependence...
  17. ncbi request reprint Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study
    Mehmet Sofuoglu
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, Connecticut, USA
    Exp Clin Psychopharmacol 15:453-60. 2007
    ..60 vs. 0.73; U=4837, p<.04). These preliminary findings do not support the efficacy of progesterone in male cocaine users. The efficacy of progesterone in female cocaine users remains to be determined in future studies...
  18. pmc Disulfiram enhances subjective effects of dextroamphetamine in humans
    Mehmet Sofuoglu
    Yale University, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, United States
    Pharmacol Biochem Behav 90:394-8. 2008
    ..How these enhanced subjective amphetamine responses affect cocaine use behavior remains to be determined in future clinical trials...
  19. pmc Cholinergic functioning in stimulant addiction: implications for medications development
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    CNS Drugs 23:939-52. 2009
    ..Further studies testing the efficacy of cholinergic medications for stimulant addiction are warranted...
  20. pmc Norepinephrine and stimulant addiction
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, USA and VA Connecticut Healthcare System, USA
    Addict Biol 14:119-29. 2009
    ..These findings warrant further studies evaluating noradrenergic medications as treatments for stimulant addiction...
  21. ncbi request reprint Adrenergic blocker carvedilol attenuates the cardiovascular and aversive effects of nicotine in abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry and Veterans Administration Connecticut Healthcare System, School of Medicine, Yale University, West Haven, CT 06515, USA
    Behav Pharmacol 17:731-5. 2006
    ..Attenuation of the rating of 'bad effects' by carvedilol suggests that noradrenergic activation may also mediate the aversive effects of nicotine...
  22. pmc Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA
    Psychoneuroendocrinology 36:123-32. 2011
    ..The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers...
  23. ncbi request reprint Association of cocaine withdrawal symptoms with more severe dependence and enhanced subjective response to cocaine
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, School of Medicine, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Drug Alcohol Depend 69:273-82. 2003
    ..4 mg/kg of smoked cocaine. These results suggest that history of cocaine withdrawal symptoms may be associated with enhanced cocaine responses and greater severity of cocaine dependence...
  24. ncbi request reprint Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA
    Pharmacol Biochem Behav 75:801-8. 2003
    ..These results suggest that isradipine alone or in combination with naltrexone attenuates some of the physiological effects of cocaine...
  25. ncbi request reprint Labetalol treatment enhances the attenuation of tobacco withdrawal symptoms by nicotine in abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry, Yale University, USA
    Nicotine Tob Res 5:947-53. 2003
    ..The utility of adrenergic blockers, in combination with nicotine replacement therapies, for smoking cessation needs to be examined further in controlled clinical trials...
  26. ncbi request reprint Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, West Haven, Connecticut 06516, USA
    Am J Drug Alcohol Abuse 29:713-27. 2003
    ..These results suggest that baseline cocaine urine results should be considered as stratifying variables in clinical trials for cocaine dependence...
  27. ncbi request reprint Effects of progesterone treatment on cocaine responses in male and female cocaine users
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, West Haven, CT 06516, USA
    Pharmacol Biochem Behav 78:699-705. 2004
    ..The effects of progesterone treatment on cocaine dependence need to be further studied in controlled trials...
  28. ncbi request reprint Pharmacologic management of relapse prevention in addictive disorders
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, West Haven, CT, USA
    Psychiatr Clin North Am 27:627-48. 2004
    ..Further research is needed to develop new pharmacotherapies for substance use disorders and establish clinical guidelines on how to use these medications most effectively...
  29. ncbi request reprint The effect of individual cocaine withdrawal symptoms on outcomes in cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Addict Behav 30:1125-34. 2005
    ..Our findings support two dimensions in cocaine withdrawal symptoms with differential effects on cocaine dependence outcomes...
  30. ncbi request reprint Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 181:504-10. 2005
    ..These preclinical studies have not been followed up in systematic human studies...
  31. pmc Galantamine improves sustained attention in chronic cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Avenue, Bldg 36 116A4, West Haven, CT 06516, USA
    Exp Clin Psychopharmacol 19:11-9. 2011
    ..g., sustained attention) in abstinent cocaine users. The potential efficacy of galantamine as a treatment for cocaine abuse needs to be further evaluated in clinical trials...
  32. ncbi request reprint Tiagabine affects the subjective responses to cocaine in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT, USA
    Pharmacol Biochem Behav 82:569-73. 2005
    ..GABA medications, including tiagabine, are currently being evaluated in controlled clinical trials for the treatment of cocaine dependence...
  33. ncbi request reprint Effects of topiramate in combination with intravenous nicotine in overnight abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, School of Medicine, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 184:645-51. 2006
    ..While a recent clinical study has demonstrated the potential utility of topiramate for smoking cessation in alcohol-dependent smokers, the effects of topiramate on tobacco addiction have not been systematically examined in humans...
  34. pmc Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 213:61-8. 2011
    ..The goal of this study was to determine minocycline's effects on the acute physiological, behavioral, and subjective responses to dextroamphetamine (DAMP) in healthy volunteers...
  35. ncbi request reprint Emerging pharmacological strategies in the fight against cocaine addiction
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, Yale University, School of Medicine, West Haven, CT 06516, USA
    Expert Opin Emerg Drugs 11:91-8. 2006
    ..Last, a cocaine vaccine that slows entry of cocaine into the brain holds promise. These promising findings need to be further tested in controlled clinical trials...
  36. ncbi request reprint Effects of progesterone treatment on smoked cocaine response in women
    Mehmet Sofuoglu
    Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
    Pharmacol Biochem Behav 72:431-5. 2002
    ..Further studies are warranted to examine the effects of progesterone treatment on cocaine dependence...
  37. pmc Subjective responses to intravenous nicotine: greater sensitivity in women than in men
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Exp Clin Psychopharmacol 17:63-9. 2009
    ..Further studies are warranted to examine the role of this differential nicotine sensitivity to development of nicotine dependence and response to nicotine replacement treatments in men and women...
  38. pmc Preliminary study of buprenorphine and bupropion for opioid-dependent smokers
    Marc E Mooney
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Am J Addict 17:287-92. 2008
    ..These preliminary findings do not support the efficacy of BUPRO, in combination with BUPRE, for the concurrent treatment of opioid and tobacco addiction...
  39. ncbi request reprint Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population
    James Poling
    Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 63:219-28. 2006
    ..No effective pharmacotherapies exist for cocaine dependence, although contingency management (CM) has demonstrated efficacy...
  40. ncbi request reprint Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients
    Gerardo Gonzalez
    Department of Psychiatry, Yale University, New Haven, CT 06511, USA
    Drug Alcohol Depend 87:1-9. 2007
    ..GABAergic medications appear to reduce the reinforcing effects of cocaine by attenuating cocaine-induced dopamine release. This study evaluated gabapentin and tiagabine compared to placebo in reducing cocaine taking behavior...
  41. ncbi request reprint Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response
    Thomas Kosten
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 14:8-17. 2005
    ..The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth...
  42. ncbi request reprint Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study
    Gerardo Gonzalez
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Addiction 98:1625-32. 2003
    ..We sought to evaluate the safety and efficacy of the GABAergic agent tiagabine in reducing cocaine use among methadone-treated patients...
  43. pmc The safety of modafinil in combination with oral ∆9-tetrahydrocannabinol in humans
    Dawn E Sugarman
    Yale University School of Medicine, Department of Psychiatry, 300 George St, New Haven, CT 06511, USA
    Pharmacol Biochem Behav 98:94-100. 2011
    ..These findings support the safety of modafinil in combination with THC. The effects of modafinil in combination with a range of doses of THC need to be determined in future studies...
  44. ncbi request reprint Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 16:187-94. 2007
    ..The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse...
  45. pmc The safety and efficacy of varenicline in cocaine using smokers maintained on methadone: a pilot study
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Addict 19:401-8. 2010
    ..These preliminary findings may point to potential therapeutic value of varenicline for smoking cessation in cocaine users maintained on methadone...
  46. pmc Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers
    Aryeh I Herman
    School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 220:611-7. 2012
    ..The goal of this study was to determine pregabalin's effects on smoking behavior, nicotine withdrawal, craving for cigarettes, and cognitive performance...
  47. pmc Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
    Sherry A McKee
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Psychopharmacol 25:490-502. 2011
    ..These findings have implications for understanding the impact of stress on smoking relapse and model development to assess smoking lapse behavior...
  48. ncbi request reprint Novel approaches to the treatment of cocaine addiction
    Mehmet Sofuoglu
    School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    CNS Drugs 19:13-25. 2005
    ..The efficacy of this vaccine for relapse prevention is under investigation. Many initial promising findings need to be replicated in larger, controlled clinical trials...
  49. pmc The impact of cigarette smoking on stimulant addiction
    Andrea H Weinberger
    Program for Research on Smokers with Mental Illness PRISM, Substance Abuse Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Drug Alcohol Abuse 35:12-7. 2009
    ..Stimulant users smoke cigarettes at high rates; however, little is known about the relationship between tobacco and stimulants...
  50. pmc Comparison of available treatments for tobacco addiction
    Aryeh I Herman
    Department of Psychiatry, VA Connecticut Healthcare System, Yale University, West Haven, CT 06516, USA
    Curr Psychiatry Rep 12:433-40. 2010
    ..However, effective treatments for many subpopulations, including smokers with psychiatric comorbidities as well as adolescent, pregnant, or postpartum smokers, remain to be developed and represent an important challenge...
  51. pmc Cognitive effects of nicotine: genetic moderators
    Aryeh I Herman
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, West Haven, CT 06516, USA
    Addict Biol 15:250-65. 2010
    ..Future research will provide a clearer understanding of the mechanism underlying the cognitive-enhancing actions of nicotine...
  52. ncbi request reprint Bupropion for the treatment of nicotine withdrawal and craving
    Marc E Mooney
    University of Minnesota, Department of Psychiatry, Tobacco Use Research Center 2701 University Avenue, Suite 201, Minneapolis, MN 55414, USA
    Expert Rev Neurother 6:965-81. 2006
    ..Ultimately, the efficacy of bupropion may be augmented by combination with other agents that target withdrawal and craving through complementary neurobiological processes...
  53. ncbi request reprint Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibility
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Exp Clin Psychopharmacol 15:445-52. 2007
    ....
  54. pmc Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms
    Alison Oliveto
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Addiction 107:131-41. 2012
    ..Whether the selective serotonin re-uptake inhibitor sertraline at 200 mg/day delays relapse in recently abstinent cocaine-dependent individuals...
  55. pmc The drug effects questionnaire: psychometric support across three drug types
    Meghan E Morean
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Office S 229, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 227:177-92. 2013
    ..Thus, the field would benefit from demonstrating the reliability and validity of the DEQ for use across multiple substances...
  56. pmc The effect of cannabis compared with alcohol on driving
    R Andrew Sewell
    VA Connecticut Healthcare Yale University School of Medicine, West Haven, Connecticut, USA
    Am J Addict 18:185-93. 2009
    ..Future research should focus on resolving contradictions posed by previous studies, and patients who smoke cannabis should be counseled to wait several hours before driving, and avoid combining the two drugs...
  57. ncbi request reprint Treatment outcome predictors for cocaine dependence
    James Poling
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System West Haven, CT 06516, USA
    Am J Drug Alcohol Abuse 33:191-206. 2007
    ..Initial promising findings with genetic polymorphism, brain activation, and stress response have also been found and need to be replicated in future studies...
  58. doi request reprint Pharmacogenetics of nicotine addiction: role of dopamine
    Aryeh I Herman
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, VA Medical Center, 950 Campbell Avenue, West Haven, CT 06516, USA
    Pharmacogenomics 15:221-34. 2014
    ..Future work should be conducted addressing these limitations to more effectively utilize DA genetic information to unlock the potential of smoking cessation pharmacogenetics. ..
  59. pmc The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA Electronic address
    Psychoneuroendocrinology 38:1532-44. 2013
    ..Thus, we conducted a double-blind placebo-controlled study assessing the efficacy of progesterone in reducing provoked drug craving, stress system arousal and improving cognitive performance in cocaine dependent men and women...
  60. pmc Neuroscience of behavioral and pharmacological treatments for addictions
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuron 69:695-712. 2011
    ..We then propose new directions for treatment development and targets that are informed by recent evidence regarding the heterogeneity of addictions and the neurobiological contributions to these disorders...
  61. ncbi request reprint Preliminary observations of paranoia in a human laboratory study of cocaine
    Marc Mooney
    University of California, San Francisco, 401 Parnassus Avenue, Box 0984, San Francisco, CA 94143 0984, USA
    Addict Behav 31:1245-51. 2006
    ..Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals...
  62. ncbi request reprint Biological treatments for amfetamine dependence : recent progress
    Kevin P Hill
    Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    CNS Drugs 21:851-69. 2007
    ..Exciting preclinical findings and a steady progression of clinical results offer hope for the development of a treatment for amfetamine dependence...

Research Grants13

  1. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  2. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2007
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  3. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..