V I Slepnev

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Accessory factors in clathrin-dependent synaptic vesicle endocytosis
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 1:161-72. 2000
  2. ncbi request reprint The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module
    J A Rosenthal
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 274:33959-65. 1999
  3. ncbi request reprint The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven Connecticut 06510, USA
    J Biol Chem 274:3257-60. 1999
  4. ncbi request reprint Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 275:17583-9. 2000
  5. ncbi request reprint Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 394:793-7. 1998
  6. ncbi request reprint Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2
    S R Floyd
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 276:8104-10. 2001
  7. pmc A functional link between dynamin and the actin cytoskeleton at podosomes
    G C Ochoa
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 150:377-89. 2000
  8. ncbi request reprint Role of phosphorylation in regulation of the assembly of endocytic coat complexes
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Science 281:821-4. 1998

Collaborators

  • H Chen
  • L Pellegrini
  • G C Ochoa
  • P De Camilli
  • S R Floyd
  • J A Rosenthal
  • L H Tsai
  • E B Porro
  • R Baron
  • W Kim
  • M McNiven
  • L Neff
  • L Daniell
  • K Takei
  • N Ringstad
  • H Cao
  • P P Di Fiore
  • A E Salcini

Detail Information

Publications8

  1. ncbi request reprint Accessory factors in clathrin-dependent synaptic vesicle endocytosis
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 1:161-72. 2000
    ..This review summarizes these advances with a special focus on accessory factors and highlights new aspects of clathrin-mediated endocytosis revealed by the study of these factors...
  2. ncbi request reprint The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module
    J A Rosenthal
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 274:33959-65. 1999
    ..High overexpression of green fluorescent protein-epsin 2 mislocalizes components of the clathrin coat and inhibits clathrin-mediated endocytosis. The epsins define a new protein family implicated in membrane dynamics at the cell surface...
  3. ncbi request reprint The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven Connecticut 06510, USA
    J Biol Chem 274:3257-60. 1999
    ....
  4. ncbi request reprint Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 275:17583-9. 2000
    ....
  5. ncbi request reprint Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 394:793-7. 1998
    ..We propose that epsin may participate, together with Eps15, in the molecular rearrangement of the clathrin coats that are required for coated-pit invagination and vesicle fission...
  6. ncbi request reprint Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2
    S R Floyd
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 276:8104-10. 2001
    ....
  7. pmc A functional link between dynamin and the actin cytoskeleton at podosomes
    G C Ochoa
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 150:377-89. 2000
    ..These data demonstrate a functional link between a member of the dynamin family and actin at attachment sites between cells and the substratum...
  8. ncbi request reprint Role of phosphorylation in regulation of the assembly of endocytic coat complexes
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Science 281:821-4. 1998
    ..Thus, phosphorylation regulates the association and dissociation cycle of the clathrin-based endocytic machinery, and calcium-dependent dephosphorylation of endocytic proteins could prepare nerve terminals for a burst of endocytosis...