K C Slep

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
    K C Slep
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA
    Nature 409:1071-7. 2001
  2. ncbi request reprint Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast
    D M Apanovitch
    Department of Pharmacology and Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Biochemistry 37:4815-22. 1998
  3. ncbi request reprint Prediction and confirmation of a site critical for effector regulation of RGS domain activity
    M E Sowa
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Biol 8:234-7. 2001

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
    K C Slep
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA
    Nature 409:1071-7. 2001
    ..Effector binding to a nucleotide-dependent site on alpha(t) sequesters PDEgamma residues implicated in PDE inhibition, and potentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal termination...
  2. ncbi request reprint Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast
    D M Apanovitch
    Department of Pharmacology and Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Biochemistry 37:4815-22. 1998
    ..These experiments represent the first biochemical characterization of Gpa1 and Sst2, and provide a molecular basis for their well-established biological roles in signaling and desensitization...
  3. ncbi request reprint Prediction and confirmation of a site critical for effector regulation of RGS domain activity
    M E Sowa
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Biol 8:234-7. 2001
    ..These results demonstrate the effectiveness of ET for identifying binding sites and efficiently focusing mutational studies on their key residues, thereby linking raw sequence and structure data to functional information...