R Sinha

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Subcortical processes of motor response inhibition during a stop signal task
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, Connecticut 06519, USA
    Neuroimage 41:1352-63. 2008
  2. pmc Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation
    Lori Lowthert
    Department of Psychiatry, New Haven, CT, 06511, USA
    Biol Mood Anxiety Disord 2:15. 2012
  3. pmc The clinical neurobiology of drug craving
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, Yale Stress Center, 2 Church Street South, Suite 209, New Haven, CT 06519, United States
    Curr Opin Neurobiol 23:649-54. 2013
  4. pmc Stress as a common risk factor for obesity and addiction
    Rajita Sinha
    Yale Stress Center, Department of Psychiatry, Neurobiology and Child Study, Yale University School of Medicine, New Haven, CT 06519, USA
    Biol Psychiatry 73:827-35. 2013
  5. pmc Modeling relapse situations in the human laboratory
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street Room S110, New Haven, CT 06519, USA
    Curr Top Behav Neurosci 13:379-402. 2013
  6. pmc New findings on biological factors predicting addiction relapse vulnerability
    Rajita Sinha
    Yale Interdisciplinary Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06515, USA
    Curr Psychiatry Rep 13:398-405. 2011
  7. ncbi request reprint Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 183:171-80. 2005
  8. pmc Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes
    Rajita Sinha
    Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 68:942-52. 2011
  9. ncbi request reprint Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    Arch Gen Psychiatry 63:324-31. 2006
  10. ncbi request reprint Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 190:569-74. 2007

Detail Information

Publications86

  1. pmc Subcortical processes of motor response inhibition during a stop signal task
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, Connecticut 06519, USA
    Neuroimage 41:1352-63. 2008
    ..Thus, fMRI delineated contrasting roles of the prefrontal-caudate and striato-thalamic activities in mediating motor response inhibition...
  2. pmc Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation
    Lori Lowthert
    Department of Psychiatry, New Haven, CT, 06511, USA
    Biol Mood Anxiety Disord 2:15. 2012
    ..abstract:..
  3. pmc The clinical neurobiology of drug craving
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, Yale Stress Center, 2 Church Street South, Suite 209, New Haven, CT 06519, United States
    Curr Opin Neurobiol 23:649-54. 2013
    ....
  4. pmc Stress as a common risk factor for obesity and addiction
    Rajita Sinha
    Yale Stress Center, Department of Psychiatry, Neurobiology and Child Study, Yale University School of Medicine, New Haven, CT 06519, USA
    Biol Psychiatry 73:827-35. 2013
    ..Future directions in research are identified to increase understanding of the mechanisms by which stress might increase risk of weight gain and obesity...
  5. pmc Modeling relapse situations in the human laboratory
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street Room S110, New Haven, CT 06519, USA
    Curr Top Behav Neurosci 13:379-402. 2013
    ..Finally, the significant implications of these findings for the development of novel treatment interventions that target stress processes and alcohol craving to improve alcoholism relapse outcomes are discussed...
  6. pmc New findings on biological factors predicting addiction relapse vulnerability
    Rajita Sinha
    Yale Interdisciplinary Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06515, USA
    Curr Psychiatry Rep 13:398-405. 2011
    ..Such markers may then be used to assess treatment response and develop specific treatments that will normalize these neural and biological sequelae so as to significantly improve relapse outcomes...
  7. ncbi request reprint Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 183:171-80. 2005
    ..Identifying neural activity associated with stress and stress-induced cocaine craving is important in understanding the neurobiology of cocaine craving and relapse...
  8. pmc Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes
    Rajita Sinha
    Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 68:942-52. 2011
    ..Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, increased anxiety, and high alcohol craving have been documented during early alcohol recovery, but their influence on relapse risk has not been well studied...
  9. ncbi request reprint Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    Arch Gen Psychiatry 63:324-31. 2006
    ..Stress and drug cue exposure are known to increase cocaine craving and stress arousal, but the association between these responses and cocaine relapse has not been previously studied...
  10. ncbi request reprint Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 190:569-74. 2007
    ..A preliminary study examined whether lofexidine decreases stress-induced and cue-induced opioid craving and improves opioid abstinence in naltrexone-treated opioid-dependent individuals...
  11. ncbi request reprint Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Drug Alcohol Rev 26:25-31. 2007
    ..Efficacy of pharmacological and behavioral treatments that specifically target stress and cue-induced craving and arousal responses may also be assessed via alterations in these brain correlates...
  12. pmc Chronic stress, drug use, and vulnerability to addiction
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06515, USA
    Ann N Y Acad Sci 1141:105-30. 2008
    ....
  13. pmc Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 34:1198-208. 2009
    ....
  14. ncbi request reprint The role of stress in addiction relapse
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Curr Psychiatry Rep 9:388-95. 2007
    ..Finally, significant implications of these findings for clinical practice are discussed, with a specific focus on the development of novel interventions that target stress processes and drug craving to improve addiction relapse outcomes...
  15. ncbi request reprint Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibility
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Exp Clin Psychopharmacol 15:445-52. 2007
    ....
  16. ncbi request reprint Neural circuits underlying emotional distress in humans
    Rajita Sinha
    Program of Research on Stress, Addiction and Psychopathology, Departmetn of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06519, USA
    Ann N Y Acad Sci 1032:254-7. 2004
    ..The study also provides a feasible method to study brain correlates of emotional stress processing in healthy individuals and clinical samples...
  17. ncbi request reprint Substance abuse treatment characteristics of probation-referred young adults in a community-based outpatient program
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Drug Alcohol Abuse 29:585-97. 2003
    ..The findings suggest that specialized treatment approaches that focus on enhancing treatment readiness and motivation to change substance use behaviors may be of particular benefit to substance abusing young adults...
  18. ncbi request reprint Psychological stress, drug-related cues and cocaine craving
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 152:140-8. 2000
    ..While several environmental situations may produce cocaine craving, there is little research on whether patterns of drug cue reactivity are similar across different environmental situations...
  19. ncbi request reprint Naturalistic follow-up of drinking behavior following participation in an alcohol administration study
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Subst Abuse Treat 17:159-62. 1999
    ....
  20. ncbi request reprint Substance abuse and criminality
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Am Acad Psychiatry Law 27:513-26. 1999
    ..Finally, key components of a forensic substance abuse evaluation are presented...
  21. ncbi request reprint Stress-induced craving and stress response in cocaine dependent individuals
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 142:343-51. 1999
    ..The studies also provide a promising method for examining the association between stress and drug craving in the laboratory...
  22. ncbi request reprint Sex differences in depressed substance abusers
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Clin Psychiatry 63:616-27. 2002
    ..The second goal is to make recommendations for future research in the area of gender-specific aspects of comorbid depression and substance abuse...
  23. ncbi request reprint Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, S 112 Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 170:62-72. 2003
    ..This study examined the response of brain stress circuits to environmental stimuli that are known to increase cocaine craving in cocaine dependent individuals...
  24. ncbi request reprint Engaging young probation-referred marijuana-abusing individuals in treatment: a pilot trial
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Am J Addict 12:314-23. 2003
    ..Participants in both conditions reported significant reductions in marijuana use and improvement in legal problems. These findings suggest that young marijuana abusers benefit from scientifically validated treatments...
  25. ncbi request reprint Alcohol and eating disorders: implications for alcohol treatment and health services research
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Alcohol Clin Exp Res 24:1312-9. 2000
    ..Crucial questions related to pharmacological and behavioral treatments for this subgroup of alcoholic women with eating disorders are raised from a health services research perspective...
  26. ncbi request reprint How does stress increase risk of drug abuse and relapse?
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, 1 Long Wharf, Box 18, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 158:343-59. 2001
    ..Although clinical observations suggest that exposure to stress increases drug use, and are associated with craving and relapse in addicts, human research in this area is largely correlational and at times contradictory...
  27. pmc Sex-specific dissociations in autonomic and HPA responses to stress and cues in alcohol-dependent patients with cocaine abuse
    Helen C Fox
    Yale Stress Center, Yale University School of Medicine, New Haven, CT 06519, USA
    Alcohol Alcohol 44:575-85. 2009
    ..To date, gender variations in these systems have not been fully assessed in abstinent alcohol-dependent individuals who also met criteria for cocaine abuse...
  28. pmc Craving predicts time to cocaine relapse: further validation of the Now and Brief versions of the cocaine craving questionnaire
    Prashni Paliwal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 93:252-9. 2008
    ....
  29. ncbi request reprint Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis
    STEPHANIE S O'MALLEY
    Yale University School of Medicine, Connecticut Mental Health Center, Substance Abuse Center S202, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 160:19-29. 2002
    ..This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence...
  30. ncbi request reprint Difficulties in emotion regulation and impulse control during cocaine abstinence
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Drug Alcohol Depend 89:298-301. 2007
    ..Prior research has shown that cocaine dependence is associated with dysfunction of brain systems involved in emotions and motivational states...
  31. pmc Error-specific medial cortical and subcortical activity during the stop signal task: a functional magnetic resonance imaging study
    C S R Li
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuroscience 155:1142-51. 2008
    ..The results also suggest that the relationship between error-related activity and post-error behavioral adjustment may be more complicated than has been conceptualized by the conflict monitoring hypothesis...
  32. pmc Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress
    K J Rudenga
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Int J Obes (Lond) 37:309-16. 2013
    ..However, it is not known whether stress influences amygdala responses to palatable foods, and whether this response is associated with chronic stress or BMI...
  33. ncbi request reprint Motivation to change substance use among offenders of domestic violence
    C Easton
    Department of Psychiatry, Yale University School of Medicine, SATU, New Haven, CT 06511, USA
    J Subst Abuse Treat 19:1-5. 2000
    ..The results illustrate the importance of assessing and treating substance use among offenders of domestic violence, as this may be an important indicator for higher dropout rates and reoffenses among this population...
  34. ncbi request reprint Reliability of salivary cortisol assessments in cocaine dependent individuals
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Psychopharmacol 20:650-5. 2006
    ..These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals...
  35. ncbi request reprint Difficulties in emotion regulation and impulse control in recently abstinent alcoholics compared with social drinkers
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Addict Behav 33:388-94. 2008
    ..The aim of the current study was to examine potential difficulties in emotion regulation during early alcohol abstinence using the recently validated Difficulties of Emotion Regulation Scale (DERS)...
  36. pmc Modeling stress and drug craving in the laboratory: implications for addiction treatment development
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Addict Biol 14:84-98. 2009
    ..Finally, the significant implications of these findings for the development of novel treatment interventions that target stress processes and drug craving to improve addiction relapse outcomes are discussed...
  37. pmc Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center S103, New Haven, CT 06519, USA
    Neurosci Biobehav Rev 32:581-97. 2008
    ..Further studies that examine the functional relationships of these neural systems will likely provide the key to understanding the mechanisms underlying compulsive drug use behaviors in psycho-stimulant dependence...
  38. pmc Neural correlates of post-error slowing during a stop signal task: a functional magnetic resonance imaging study
    Chiang Shan Ray Li
    Connecticut Mental Health Center, S103, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    J Cogn Neurosci 20:1021-9. 2008
    ..These results delineate the neural circuitry specifically involved in error-associated behavioral modifications...
  39. pmc Stress-related factors in cannabis use and misuse: implications for prevention and treatment
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Treatment Unit, 1 Long Wharf Drive, Box 18, New Haven, CT 06511, USA
    J Subst Abuse Treat 36:400-13. 2009
    ..Overall, stress-coping interventions and harm reduction focused on reducing the amount ingested may facilitate prevention and recovery efforts...
  40. pmc Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes
    Helen C Fox
    Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 209, Room 209Q, New Haven, CT 06519, USA
    Psychoneuroendocrinology 34:1198-207. 2009
    ....
  41. pmc Behavioral arousal in response to stress and drug cue in alcohol and cocaine addicted individuals versus healthy controls
    Tara M Chaplin
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Hum Psychopharmacol 25:368-76. 2010
    ..Negative emotional arousal in response to stress and drug cues is known to play a role in the development and continuation of substance use disorders. However, studies have not examined behavioral indicators of such arousal...
  42. pmc Self-reports of interoceptive responses during stress and drug cue-related experiences in cocaine- and alcohol-dependent individuals
    Keri L Bergquist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Exp Clin Psychopharmacol 18:229-37. 2010
    ....
  43. pmc Increased error-related thalamic activity during early compared to late cocaine abstinence
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT 06519 USA
    Drug Alcohol Depend 109:181-9. 2010
    ..These findings support the hypothesis that heightened thalamic reactivity to salient stimuli co-occur with cocaine craving and loss of self control...
  44. pmc A stress-coping profile of opioid dependent individuals entering naltrexone treatment: a comparison with healthy controls
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Psychol Addict Behav 23:613-9. 2009
    ..Analyses of variance (ANOVA) and covariance (ANCOVA), and stepwise multiple regression were conducted...
  45. pmc Emotional arousal in cocaine exposed toddlers: prediction of behavior problems
    Tara M Chaplin
    Psychiatry Department, Yale University School of Medicine, New Haven, CT 06519, USA
    Neurotoxicol Teratol 31:275-82. 2009
    ..Prenatal cocaine exposure (PCE) may be associated with alterations in children's developing emotional arousal and regulation systems...
  46. pmc Sex differences in sleep and sleep-dependent learning in abstinent cocaine users
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 93:54-8. 2009
    ..The absence of sleep disturbances in women suggests a need to understand the mechanisms underlying these differences, as such knowledge could lead to novel therapies in cocaine dependence...
  47. pmc Mindfulness training and stress reactivity in substance abuse: results from a randomized, controlled stage I pilot study
    Judson A Brewer
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Subst Abus 30:306-17. 2009
    ..This pilot study provides evidence of the feasibility of MT in treating SUDs and suggests that MT may be efficacious in targeting stress...
  48. pmc Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women
    Helen C Fox
    Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Harv Rev Psychiatry 17:103-19. 2009
    ..The implications of these sex-specific variations in stress and reward system function are discussed in terms of both comorbid psychopathology and treatment outcome...
  49. pmc Parental history of anxiety and alcohol-use disorders and alcohol expectancies as predictors of alcohol-related problems
    Meghan E Morean
    Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, Connecticut 06520, USA
    J Stud Alcohol Drugs 70:227-36. 2009
    ..Expectancies of global positive changes and tension reduction were hypothesized to moderate the influence of parental history of alcoholism and anxiety, respectively...
  50. pmc Altered impulse control in alcohol dependence: neural measures of stop signal performance
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 33:740-50. 2009
    ..In particular, we examined the processes of risk taking and cognitive control as the neural endophenotypes of alcohol dependence...
  51. pmc Gender differences in response to emotional stress: an assessment across subjective, behavioral, and physiological domains and relations to alcohol craving
    Tara M Chaplin
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 32:1242-50. 2008
    ..The present study examines gender differences in emotional and alcohol craving responses to stress that may relate to this gender divergence in disorders...
  52. pmc Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men
    Scott M Hyman
    Yale Research Program on Stress, Addiction, and Psychopathology, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, Room S110, New Haven, CT 06511, USA
    Drug Alcohol Depend 92:208-16. 2008
    ..Comprehensive assessments of childhood trauma and specialized treatments that address trauma-related pathophysiology could be of benefit in improving cocaine treatment outcomes in women...
  53. pmc Alexithymia and stress-induced brain activation in cocaine-dependent men and women
    Chiang Shan Ray Li
    Connecticut Mental Health Center, Department of Psychiatry, Yale University, New Haven, Connecticut 06519, USA
    J Psychiatry Neurosci 31:115-21. 2006
    ..Both stress and an alexithymic response to stress can contribute to relapse into drug abuse, but to our knowledge the neural processing of an alexithymic response to stress in cocaine-dependent individuals has not been examined...
  54. ncbi request reprint Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals
    Helen C Fox
    Substance Abuse Center, Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 185:348-57. 2006
    ..Extensive research suggests that gender may affect neuroendocrine and cardiovascular arousal mechanisms underlying biological responses to stress...
  55. ncbi request reprint Antisocial personality and stress-induced brain activation in cocaine-dependent patients
    Chiang Shan R Li
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Neuroreport 17:243-7. 2006
    ..These results highlight important sex differences in the association between antisocial personality and distress processing in cocaine-dependent individuals...
  56. ncbi request reprint Imaging response inhibition in a stop-signal task: neural correlates independent of signal monitoring and post-response processing
    Chiang Shan Ray Li
    Department of Psychiatry, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06519, USA
    J Neurosci 26:186-92. 2006
    ..These brain regions may represent the neural substrata of response inhibition independent of other cognitive and affective functions...
  57. ncbi request reprint Neuroimaging study of sex differences in the neuropathology of cocaine abuse
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Gend Med 2:174-82. 2005
    ..Female and male substance abusers differ in their disease patterns and clinical outcomes. An important question in addiction neuroscience thus concerns the neural substrates underlying these sex differences...
  58. ncbi request reprint Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Room S103, 34 Park Street, New Haven, CT 06519, USA
    Psychiatry Res 140:271-80. 2005
    ..The results suggest an abnormal cognitive control mechanism during affective processing in association with heavy cannabis use...
  59. ncbi request reprint Cue-induced brain activity changes and relapse in cocaine-dependent patients
    Thomas R Kosten
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:644-50. 2006
    ..This physiological activation was a better predictor of relapse than subjective reports of craving, and may be a useful target for treatment development...
  60. ncbi request reprint Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, 06519, USA
    Psychoneuroendocrinology 30:880-91. 2005
    ..The current study examined whether frequency of cocaine and alcohol abuse alters drug craving and associated arousal with laboratory exposure to stress and to drug related cues...
  61. pmc A gender specific psychometric analysis of the early trauma inventory short form in cocaine dependent adults
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Treatment Unit, 1 Long Wharf Drive, Box 18, New Haven, CT 06511, United States
    Addict Behav 30:847-52. 2005
    ..The findings support the utility of the ETI-SF as a clinical research tool to obtain data on specific types of early trauma in drug abusing samples...
  62. ncbi request reprint The role of depression symptoms in predicting drug abstinence in outpatient substance abuse treatment
    Rebecca Dodge
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Subst Abuse Treat 28:189-96. 2005
    ..This study examined the role of depressive symptoms in the context of specific demographic and individual treatment characteristics in predicting drug abstinence at discharge from outpatient substance abuse treatment...
  63. ncbi request reprint Sex differences in brain activation during stress imagery in abstinent cocaine users: a functional magnetic resonance imaging study
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, Connecticut 06519, USA
    Biol Psychiatry 57:487-94. 2005
    ....
  64. pmc Prenatal cocaine exposure, gender, and adolescent stress response: a prospective longitudinal study
    Tara M Chaplin
    Department of Psychiatry, Yale University School of Medicine, USA
    Neurotoxicol Teratol 32:595-604. 2010
    ..The findings suggest that prenatal drug exposure is associated with altered stress response in adolescence and that gender moderates this association...
  65. ncbi request reprint Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Drug Alcohol Depend 85:205-12. 2006
    ..These results suggest that diminished performance monitoring can be a critical cognitive mechanism underlying impaired response inhibition in cocaine dependent patients...
  66. ncbi request reprint Gender differences in the neural correlates of response inhibition during a stop signal task
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Neuroimage 32:1918-29. 2006
    ..Men activated the motor circuitry while women appeared to involve visual association or habit learning during stop signal performance...
  67. pmc Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men
    Chiang Shan Ray Li
    Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:1798-806. 2008
    ..Relative hypoactivation of the rACC during response inhibition may represent a useful neural marker of difficulties in impulse control in abstinent cocaine-dependent men who are at risk of relapse...
  68. pmc Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 195:527-36. 2008
    ..There is growing evidence of alterations in brain stress and reward circuits associated with cocaine dependence. Sex differences are also documented and sex steroid hormones have been linked to cocaine reinforcement...
  69. pmc Greater activation of the "default" brain regions predicts stop signal errors
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, S103, 34 Park Street, New Haven, CT 06519, USA
    Neuroimage 38:640-8. 2007
    ....
  70. pmc Enhancing brief cognitive-behavioral therapy with motivational enhancement techniques in cocaine users
    Sherry A McKee
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519, USA
    Drug Alcohol Depend 91:97-101. 2007
    ..We investigated the impact of enhancing brief cognitive-behavioral therapy with motivational interviewing techniques for cocaine abuse or dependence, using a focused intervention paradigm...
  71. ncbi request reprint Contingency management to enhance naltrexone treatment of opioid dependence: a randomized clinical trial of reinforcement magnitude
    Kathleen M Carroll
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Exp Clin Psychopharmacol 10:54-63. 2002
    ..These findings suggest that targeted behavioral therapies can play a substantial role in broadening the utility of available pharmacotherapies...
  72. pmc Enhanced sensitivity to stress and drug/alcohol craving in abstinent cocaine-dependent individuals compared to social drinkers
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:796-805. 2008
    ..These data suggest that recovery from chronic cocaine abuse could be hampered by a hyper-responsive stress- and drug-craving state that increases cocaine relapse susceptibility...
  73. pmc Childhood maltreatment, perceived stress, and stress-related coping in recently abstinent cocaine dependent adults
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Psychol Addict Behav 21:233-8. 2007
    ..Stress and stress-coping focused interventions may be particularly indicated for cocaine dependent individuals with histories of childhood maltreatment...
  74. pmc The use of contingency management and motivational/skills-building therapy to treat young adults with marijuana dependence
    Kathleen M Carroll
    Division of Substance Abuse, Yale University School of Medicine, West Haven, CT 06516, USA
    J Consult Clin Psychol 74:955-66. 2006
    ..Participants assigned to MET/CBT continued to reduce the frequency of their marijuana use through a 6-month follow-up...
  75. pmc Gender specific associations between types of childhood maltreatment and the onset, escalation and severity of substance use in cocaine dependent adults
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Treatment Unit, New Haven, CT 06511, USA
    Am J Drug Alcohol Abuse 32:655-64. 2006
    ..All associations were stronger in women. Findings suggest that early intervention for childhood victims, especially females, may delay or prevent the early onset of alcohol use and reduce the risk for a more severe course of addiction...
  76. ncbi request reprint Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 31:395-403. 2007
    ....
  77. ncbi request reprint Naltrexone and cognitive behavioral coping skills therapy for the treatment of alcohol drinking and eating disorder features in alcohol-dependent women: a randomized controlled trial
    STEPHANIE S O'MALLEY
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 31:625-34. 2007
    ..This study investigated the safety and efficacy of naltrexone in combination with Cognitive Behavioral Coping Skills Therapy (CBCST) in a sample of alcohol-dependent women, some with comorbid eating pathology...
  78. pmc Stress and drug-cue-induced craving in opioid-dependent individuals in naltrexone treatment
    Scott M Hyman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Exp Clin Psychopharmacol 15:134-43. 2007
    ..Prior clinical and preclinical research has indicated that both stress and drug-cue-related arousal response is associated with craving and vulnerability to relapse in a range of drug-using populations...
  79. pmc Increased peripheral blood expression of electron transport chain genes in bipolar depression
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Bipolar Disord 12:813-24. 2010
    ..To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD)...
  80. pmc Selective cocaine-related difficulties in emotional intelligence: relationship to stress and impulse control
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, The Connecticut Mental Health Center, New Haven, CT 06519, USA
    Am J Addict 20:151-60. 2011
    ..Findings indicate that specific aspects of EI may be of clinical importance to cocaine dependent populations, impacting relapse-related factors such as stress dysregulation and impulse control. ..
  81. pmc Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy
    Seth R Axelrod
    Department of Psychiatry, School of Medicine, Yale University, New Haven, Connecticut 06511, USA
    Am J Drug Alcohol Abuse 37:37-42. 2011
    ..However, improved emotion regulation with DBT and associations between such improvement and behavioral outcomes such as substance use has not been previously reported...
  82. pmc Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
    Sherry A McKee
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Psychopharmacol 25:490-502. 2011
    ..These findings have implications for understanding the impact of stress on smoking relapse and model development to assess smoking lapse behavior...
  83. ncbi request reprint Can line clinicians master the conceptual complexities of dialectical behavior therapy? An evaluation of a State Department of Mental Health training program
    K A Hawkins
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Psychiatr Res 32:379-84. 1998
    ..Prior education or background in behavior therapy accounted for little variance, indicating that clinicians occupying diverse roles acquired reasonable intellectual mastery over this complex model...
  84. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  85. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress...
  86. ncbi request reprint Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress
    Kathleen T Brady
    Clinical Neuroscience Division, Institute of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 69 President St, Charleston, SC 29425, USA
    Am J Psychiatry 162:1483-93. 2005
    ..Better understanding of the connection between substance use disorders and psychiatric disorders could have a profound effect on prevention and treatment...

Research Grants21

  1. Development of Guanfacine to decrease drug craving, anxiety and cocaine relapse r
    Rajita Sinha; Fiscal Year: 2010
    ....
  2. Chronic Alcohol and Brain Stress Circuit Response
    Rajita Sinha; Fiscal Year: 2009
    ....
  3. Development of Guanfacine to decrease drug craving, anxiety and cocaine relapse r
    Rajita Sinha; Fiscal Year: 2009
    ....
  4. Chronic Alcohol and Brain Stress Circuit Response
    Rajita Sinha; Fiscal Year: 2010
    ....
  5. ORWH: SCOR on Sex and Gender Factors Afecting Women's Health
    Rajita Sinha; Fiscal Year: 2007
    ....
  6. Lofexidine to Prevent Stress-Related Opiate Relapse
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  7. Chronic Alcohol and Brain Stress Circuit Response
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  8. Sex-Specific Pathways Linking Stress and Drug Abuse
    Rajita Sinha; Fiscal Year: 2007
    ..Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families. ..