N R Sibson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling
    N R Sibson
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    Proc Natl Acad Sci U S A 94:2699-704. 1997
  2. pmc Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
    N R Sibson
    Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:316-21. 1998
  3. ncbi request reprint Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity
    N R Sibson
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Newhaven, Conn, USA
    Dev Neurosci 20:321-30. 1998
  4. ncbi request reprint In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during
    N R Sibson
    Departments of Molecular Biophysics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 76:975-89. 2001
  5. ncbi request reprint Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein
    G F Mason
    Department of Psychiatry, Magnetic Resonance Center for Research in Metabolism and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 914:81-91. 2001

Detail Information

Publications5

  1. pmc In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling
    N R Sibson
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    Proc Natl Acad Sci U S A 94:2699-704. 1997
    ....
  2. pmc Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
    N R Sibson
    Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:316-21. 1998
    ..Another implication of this result is that brain activation studies, which map cortical oxidative Glc metabolism, provide a quantitative measure of synaptic glutamate release...
  3. ncbi request reprint Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity
    N R Sibson
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Newhaven, Conn, USA
    Dev Neurosci 20:321-30. 1998
    ..These findings bear upon a number of hypotheses concerning the neurophysiological basis of brain functional imaging methods...
  4. ncbi request reprint In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during
    N R Sibson
    Departments of Molecular Biophysics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 76:975-89. 2001
    ..These findings indicate that anaplerotic glutamine synthesis is coupled to nitrogen removal from the brain (ammonia detoxification) under hyperammonemic conditions...
  5. ncbi request reprint Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein
    G F Mason
    Department of Psychiatry, Magnetic Resonance Center for Research in Metabolism and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 914:81-91. 2001
    ..GAD(67) could account for 56-85% of cortical GABA synthesis flux under basal conditions and the entire flux after vigabatrin treatment...