N R Sibson
Affiliation: Yale University
- In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cyclingN R Sibson
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520 8043, USA
Proc Natl Acad Sci U S A 94:2699-704. 1997....
- Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activityN R Sibson
Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 95:316-21. 1998..Another implication of this result is that brain activation studies, which map cortical oxidative Glc metabolism, provide a quantitative measure of synaptic glutamate release...
- Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivityN R Sibson
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Newhaven, Conn, USA
Dev Neurosci 20:321-30. 1998..These findings bear upon a number of hypotheses concerning the neurophysiological basis of brain functional imaging methods...
- In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain duringN R Sibson
Departments of Molecular Biophysics, Yale University School of Medicine, New Haven, Connecticut, USA
J Neurochem 76:975-89. 2001..These findings indicate that anaplerotic glutamine synthesis is coupled to nitrogen removal from the brain (ammonia detoxification) under hyperammonemic conditions...
- Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) proteinG F Mason
Department of Psychiatry, Magnetic Resonance Center for Research in Metabolism and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Brain Res 914:81-91. 2001..GAD(67) could account for 56-85% of cortical GABA synthesis flux under basal conditions and the entire flux after vigabatrin treatment...