Mark Shlomchik

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells
    Shannon M Anderson
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 176:4515-9. 2006
  2. doi request reprint T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
    Robin A Herlands
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunity 29:249-60. 2008
  3. doi request reprint Germinal center selection and the development of memory B and plasma cells
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunol Rev 247:52-63. 2012
  4. pmc Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice
    H Wang
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    J Exp Med 190:639-49. 1999
  5. pmc Activating systemic autoimmunity: B's, T's, and tolls
    Mark J Shlomchik
    Yale University School of Medicine, Department of Laboratory Medicine, Box 208035, New Haven, CT 06520, USA
    Curr Opin Immunol 21:626-33. 2009
  6. doi request reprint Sites and stages of autoreactive B cell activation and regulation
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 28:18-28. 2008
  7. ncbi request reprint Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    Jacqueline William
    Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, Box 208035, New Haven, CT 06520 8035, USA
    Science 297:2066-70. 2002
  8. ncbi request reprint Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35
    Joerg Rossbacher
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, USA
    Eur J Immunol 36:2384-93. 2006
  9. ncbi request reprint B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation
    Jun Yan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8031, USA
    J Immunol 177:4481-7. 2006
  10. ncbi request reprint B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation
    Jacqueline William
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 176:2142-51. 2006

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells
    Shannon M Anderson
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 176:4515-9. 2006
    ..Our studies indicate that localization of Ag on follicular dendritic cells is not necessary for development and maintenance of B cell memory...
  2. doi request reprint T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
    Robin A Herlands
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunity 29:249-60. 2008
    ..T cell-independent activation of certain autoreactive B cells, which gain stimuli via endogenous TLR ligands instead of T cells, may be the initial step in the generation of canonical autoantibodies...
  3. doi request reprint Germinal center selection and the development of memory B and plasma cells
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunol Rev 247:52-63. 2012
    ..We will discuss B-cell receptor signaling in the GC as it relates to potential mechanisms for affinity-based selection during the reaction...
  4. pmc Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice
    H Wang
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    J Exp Med 190:639-49. 1999
    ..These data also establish the relevance of ignorant self-specific B cells to autoantibody production in disease and prove that in the case of the RF specificity, the nominal autoantigen IgG2a is the driving autoantigen in vivo...
  5. pmc Activating systemic autoimmunity: B's, T's, and tolls
    Mark J Shlomchik
    Yale University School of Medicine, Department of Laboratory Medicine, Box 208035, New Haven, CT 06520, USA
    Curr Opin Immunol 21:626-33. 2009
    ..These activated B cells then break T cell tolerance, resulting in full-blown autoimmunity...
  6. doi request reprint Sites and stages of autoreactive B cell activation and regulation
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 28:18-28. 2008
    ..Integrating classic work with recent insights, emphasis is placed on efforts to pinpoint the precursor cells for autoantibody-secreting cells and the unique stimuli and pathways by which they are activated...
  7. ncbi request reprint Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    Jacqueline William
    Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, Box 208035, New Haven, CT 06520 8035, USA
    Science 297:2066-70. 2002
    ..Fas(lpr) mice proliferated and underwent active somatic hypermutation at the T zone-red pulp border rather than in GCs. Our results implicate this region as an important site for hypermutation and the loss of B cell self-tolerance...
  8. ncbi request reprint Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35
    Joerg Rossbacher
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, USA
    Eur J Immunol 36:2384-93. 2006
    ..Unexpectedly, chimera experiments also showed a critical role for Cr on follicular dendritic cells (FDC), even in the absence of IC, indicating novel functions for FDC-expressed Cr beyond the capture of C3-coated IC...
  9. ncbi request reprint B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation
    Jun Yan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8031, USA
    J Immunol 177:4481-7. 2006
    ..Subsequently, DCs and other professional APCs may then amplify and perpetuate the autoimmune T cell response...
  10. ncbi request reprint B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation
    Jacqueline William
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 176:2142-51. 2006
    ..Both of these checkpoints fail in autoimmunity...
  11. ncbi request reprint Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  12. pmc Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, United States
    Semin Immunol 19:11-23. 2007
    ..We describe positive feedback loops involving B cells, T cells, DCs, and soluble mediators, and how these networks are regulated by TLR signals...
  13. ncbi request reprint Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center
    Jacqueline William
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:6879-87. 2005
    ..These studies provide insights into the unique nature of an ongoing autoimmune response and may be a model for understanding the response to therapies such as B cell depletion...
  14. ncbi request reprint Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity
    Jacqueline William
    Section of Immunobiology and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:6872-8. 2005
    ..These studies are among the first to define the early events of a spontaneous B cell autoimmune response...
  15. ncbi request reprint Depletion of B cells in murine lupus: efficacy and resistance
    Anupama Ahuja
    Department of Laboratory Medicine, Yale University, New Haven, CT 06510, USA
    J Immunol 179:3351-61. 2007
    ..Thus, whereas successful B cell depletion is a promising therapy for lupus, at least some patients might be resistant to the therapy as a byproduct of the autoimmune condition itself...
  16. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
    ..Thus, TGFbeta1 derived from LCs acts directly on LCs through an autocrine/paracrine loop, and it is required for LC development and/or survival...
  17. pmc Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites
    Robin A Herlands
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Eur J Immunol 37:3339-51. 2007
    ..This system provides a window on the initiation of an autoantibody response and reveals authentic initiators of it...
  18. ncbi request reprint Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities
    Mary M Tomayko
    Department of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA
    J Immunol 181:27-38. 2008
    ..Thus, memory and naive B cells are intrinsically wired to signal differently from one another and express a functional signaling pathway that is known to maintain stem cells in other lineages...
  19. ncbi request reprint Rheumatoid factors in health and disease: structure, function, induction and regulation
    Ann M Haberman
    Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, New Haven, Conn, USA
    Curr Dir Autoimmun 6:169-95. 2003
  20. ncbi request reprint Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven Connecticut 06520, USA
    Ann N Y Acad Sci 987:38-50. 2003
    ..We discuss the implications of this for the regulation of autoreactive B cells as well as for the regulation of hypermutation...
  21. ncbi request reprint Reassessing the function of immune-complex retention by follicular dendritic cells
    Ann M Haberman
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Immunol 3:757-64. 2003
    ..Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed...
  22. pmc The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo
    Joerg Rossbacher
    Serction of Immunobiology and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Exp Med 198:591-602. 2003
    ..These results demonstrate a new BCR-dependent pathway that is sufficient and perhaps necessary to provide a CR1/2 ligand that promotes efficient B cell activation...
  23. pmc Langerhans cells are not required for efficient skin graft rejection
    Jagdeep S Obhrai
    Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Invest Dermatol 128:1950-5. 2008
    ..Thus, LCs in the donor graft are required for long-term skin engraftment, which supports a regulatory role for LCs in skin graft acceptance...
  24. ncbi request reprint Antigen presentation and transfer between B cells and macrophages
    Bohdan P Harvey
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Eur J Immunol 37:1739-51. 2007
    ..Overall, these results define a novel mechanism by which B cells can focus immunity toward a specific antigen and transfer the ability to activate CD4 T cells to other APC...
  25. pmc New markers for murine memory B cells that define mutated and unmutated subsets
    Shannon M Anderson
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 204:2103-14. 2007
    ..The apparent heterogeneity in the memory compartment implies either different origins and/or different functions, which we discuss...
  26. doi request reprint Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics
    Kim L Good-Jacobson
    Department of Laboratory Medicine, Yale University, New Haven, CT 06519, USA
    J Immunol 185:3117-25. 2010
    ....
  27. doi request reprint Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
    Shannon M Anderson
    Departments of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 183:7314-25. 2009
    ..Control over survival rather than proliferation of low- and high-affinity B cells in the GC allows greater diversity not only in the primary response but also in the memory response...
  28. ncbi request reprint Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:417-28. 2006
    ..These findings reveal opposing inflammatory and regulatory roles for TLR7 and TLR9, despite similar tissue expression and signaling pathways. These results have important implications for TLR-directed therapy of autoimmune disease...
  29. pmc Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
    Chang yun Hu
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:3857-67. 2007
    ..Our results demonstrate clinical efficacy even in established disease and identify mechanisms for therapeutic action that will guide design and evaluation of parallel studies in patients...
  30. ncbi request reprint Intrinsic properties of human and murine memory B cells
    Shannon M Anderson
    Section of Immunobiology and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Immunol Rev 211:280-94. 2006
    ....
  31. ncbi request reprint The role of antibodies and B cells in the pathogenesis of lupus nephritis
    Mark J Shlomchik
    Department of Pathology and Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Springer Semin Immunopathol 24:363-75. 2003
    ..This review focuses on the properties of nephritogenic autoantibodies, their mechanisms of immune deposit formation, and the contribution of B cells expressing autoantibodies to lupus nephritis...
  32. pmc Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice
    Diana L Vesely
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, TAC S 520, 300 Cedar Street, New Haven, CT 06520, USA
    Infect Immun 77:1881-7. 2009
    ....
  33. pmc Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 202:321-31. 2005
    ..These results demonstrate a specific requirement for TLR9 in autoantibody formation in vivo and indicate a critical role for innate immune activation in autoimmunity...
  34. ncbi request reprint In vivo imaging studies shed light on germinal-centre development
    Anja E Hauser
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Nat Rev Immunol 7:499-504. 2007
    ..In this Progress article, we describe how several recent studies using time-resolved multiphoton microscopy to track GC B-cell movement within lymph nodes have shed light on the processes that influence GC B-cell dynamics...
  35. ncbi request reprint Histone modifications associated with somatic hypermutation
    Valerie H Odegard
    Section of Immunobiology, Yale University School of Medicine, Box 208011, New Haven, Connecticut 06520, USA
    Immunity 23:101-10. 2005
    ..These findings indicate that SHM and CSR trigger distinct DNA damage responses and identify a novel histone modification pattern for SHM consisting of H2B(Ser14P) in the absence of gammaH2AX...
  36. ncbi request reprint Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
    Anja E Hauser
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    Immunity 26:655-67. 2007
    ..The results suggest a revision to our views of B cell circulation within GCs and the functional relationship of its two major compartments...
  37. pmc PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    Kim L Good-Jacobson
    Department of Laboratory Medicine, Yale University, New Haven, Connecticut, USA
    Nat Immunol 11:535-42. 2010
    ..PD-1 expression on T cells and PD-L2 expression on B cells controlled T(FH) cell and PC numbers. Thus, PD-1 regulates selection and survival in the GC, affecting the quantity and quality of long-lived PCs...
  38. pmc Maintenance of the plasma cell pool is independent of memory B cells
    Anupama Ahuja
    Departments of Laboratory Medicine and Immunobiology, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:4802-7. 2008
    ..This observation settles an important controversy in B cell biology and has implications for the design of vaccines and for B cell depletion therapy in patients...
  39. doi request reprint TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    Kevin M Nickerson
    Department of Laboratory Medicine, Yale University, New Haven, CT 06519, USA
    J Immunol 184:1840-8. 2010
    ..These results suggest new models for how Tlr9 regulates and Tlr7 enhances disease and provide insight into aspects of autoimmune disease that are, and are not, influenced by TLR signals...
  40. pmc Memory CD4+ T cells do not induce graft-versus-host disease
    Britt E Anderson
    Sections of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 112:101-8. 2003
    ..If these murine results are applicable to human alloSCT, selective administration of memory T cells could greatly improve post-transplant immune reconstitution...
  41. doi request reprint Improved methods for detecting selection by mutation analysis of Ig V region sequences
    Uri Hershberg
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Int Immunol 20:683-94. 2008
    ..These results show that selection can be detected in vivo with high specificity using the new method proposed here, allowing greater insight into the existence and direction of antigen-driven selection...
  42. pmc Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    Britt E Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 111:5242-51. 2008
    ..Taken together, these data argue against the hypothesis that T(EM) fail to induce GVHD because of inefficient trafficking to LN and PP...
  43. ncbi request reprint Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
    Britt E Anderson
    Section of Immunobiology, The Department of Dermatology, Yale University School of Medicine, 333 Cedar St, Box 208035, New Haven, CT 06520 8035, USA
    Blood 105:2227-34. 2005
    ..These results identify differences in APC requirements between CD8-mediated aGVHD and CD4-mediated cGVHD. They further highlight donor APCs as additional targets for GVHD therapy...
  44. ncbi request reprint Estimating hypermutation rates from clonal tree data
    Steven H Kleinstein
    Department of Computer Science, Princeton University, Princeton, NJ 08544, USA
    J Immunol 171:4639-49. 2003
    ..In addition to comparing the results of the two procedures, we investigate the effect on our estimate of assumptions, such as the fraction of lethal mutations...
  45. ncbi request reprint Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells
    Chandran Ramakrishna
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Immunol 168:1204-11. 2002
    ..B cells themselves may also play a subtle role in modulating pathogenesis by influencing tropism...
  46. ncbi request reprint B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells
    Britte C Beaudette-Zlatanova
    Renal Section, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Immunol 177:45-52. 2006
    ..Additionally, although the precise nature of the neoantigen is not known, the T cells described in this report may provide a useful tool for examining the role of T cells in the RF autoantibody response...
  47. pmc RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    Christina M Lau
    Department of Microbiology, Boston University School of Medicine, MA 02118, USA
    J Exp Med 202:1171-7. 2005
    ..As further evidence that TLRs play a key role in autoantibody responses in SLE, we found that autoimmune-prone mice, lacking the TLR adaptor protein MyD88, had markedly reduced chromatin, Sm, and rheumatoid factor autoantibody titers...
  48. ncbi request reprint Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
    ..The unique features of this dual-engagement pathway should facilitate the development of therapies that specifically target autoreactive B cells...
  49. pmc Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced
    Joseph M Dal Porto
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 195:1215-21. 2002
    ..The failure to observe such B cells normally in late primary responses and in memory B cell populations is the result of competition, rather than an intrinsic inability of low affinity B cells...
  50. ncbi request reprint Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis
    Shannon K O'Neill
    Department of Immunology Microbiology, Rush University Medical Center, Cohn Research Building, Chicago, IL 60612, USA
    J Immunol 174:3781-8. 2005
    ..However, both autoreactive T cells and autoantibody are required to cause severe arthritis, indicating that both B cell-mediated effector pathways contribute synergistically to autoimmune disease...
  51. ncbi request reprint Activation of autoreactive B cells by CpG dsDNA
    Gregory A Viglianti
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Immunity 19:837-47. 2003
    ....
  52. pmc The role of innate immunity in autoimmunity
    Jean Francois Bach
    INSERM U580, Hopital Necker, Paris, France
    J Exp Med 200:1527-31. 2004
    ....
  53. ncbi request reprint Autoimmunity: The genes and phenotypes of autoimmunity
    Mark J Shlomchik
    Curr Opin Immunol 16:738-40. 2004
  54. ncbi request reprint Investigation of the role of B-cells in type 1 diabetes in the NOD mouse
    F Susan Wong
    Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Diabetes 53:2581-7. 2004
    ..This may relate to reduced ability to activate an islet-specific T-cell repertoire, presumably due to the reduced islet-specific B-cell repertoire. Our results implicate a specific antigen-presenting function for B-cells...

Research Grants48

  1. Mechanisms of Autoimmune Activation and Regulation by Innate Immune Receptors
    Mark J Shlomchik; Fiscal Year: 2011
    ..We are using state of the art genetic tools to generate specific types of mutant mice to test how the two major limbs of the immune system, innate and adaptive, interact to cause autoimmune diseases. ..
  2. Role of B cells and DCs in Lupus pathogenesis
    Mark Shlomchik; Fiscal Year: 2007
    ..These studies should give us much better insight into the mechanisms and problems of B cell depletion during ongoing disease and should shed new light on the roles of both pDCs and conventional DCs in promoting murine lupus. ..
  3. LSRII Flow Cytometric Analyzer
    Mark Shlomchik; Fiscal Year: 2007
    ..This instrument will enable the research of 27 NIH-funded PIs who require sophisticated FACS analysis and specific features of the LSRII, which otherwise may not be available due to limited capacity or capability of our existing machine ..
  4. Differential GVHD induction by naive and memory T cells
    Mark Shlomchik; Fiscal Year: 2007
    ..These studies can clearly help set the stage for applying this approach in rationally designed clinical pilot studies. ..
  5. Murine Memory B Cell Development and Function
    Mark Shlomchik; Fiscal Year: 2007
    ....
  6. MECHANISMS OF CHRONIC GVHD INITIATION AND PATHOGENESIS
    Mark Shlomchik; Fiscal Year: 2005
    ..abstract_text> ..
  7. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2011
    ..Since B cells are absolutely required for these diseases, and depleting them can induce remission in humans, this work is at the crux of understanding how autoimmune diseases like lupus occur and how to better treat them. ..
  8. Murine Memory B Cell Development and Function
    Mark J Shlomchik; Fiscal Year: 2010
    ....
  9. Role of B cells and DCs in Lupus pathogenesis
    Mark J Shlomchik; Fiscal Year: 2010
    ..These studies should give us much better insight into the mechanisms and problems of B cell depletion during ongoing disease and should shed new light on the roles of both pDCs and conventional DCs in promoting murine lupus. ..
  10. Mechanisms of Autoimmune Activation and Regulation by Innate Immune Receptors
    Mark J Shlomchik; Fiscal Year: 2010
    ..We are using state of the art genetic tools to generate specific types of mutant mice to test how the two major limbs of the immune system, innate and adaptive, interact to cause autoimmune diseases. ..
  11. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2010
    ..Since B cells are absolutely required for these diseases, and depleting them can induce remission in humans, this work is at the crux of understanding how autoimmune diseases like lupus occur and how to better treat them. ..
  12. Role of B cells and DCs in Lupus pathogenesis
    Mark Shlomchik; Fiscal Year: 2009
    ..These studies should give us much better insight into the mechanisms and problems of B cell depletion during ongoing disease and should shed new light on the roles of both pDCs and conventional DCs in promoting murine lupus. ..
  13. Differential GVHD induction by naive and memory T cells
    Mark Shlomchik; Fiscal Year: 2009
    ..These studies can clearly help set the stage for applying this approach in rationally designed clinical pilot studies. ..
  14. Activation and regulation of autoreactive B cells in health and disease
    Mark Shlomchik; Fiscal Year: 2009
    ..Since B cells are absolutely required for these diseases, and depleting them can induce remission in humans, this work is at the crux of understanding how autoimmune diseases like lupus occur and how to better treat them. ..
  15. Role of B cells and DCs in lupus T cell pathogenesis
    Mark Shlomchik; Fiscal Year: 2005
    ..other DC populations and to DCs that are primed with kidney parenchymal antigens. ..
  16. THE ROLE OF B CELLS IN LUPUS NEPHRITIS AND VASCULITIS
    Mark Shlomchik; Fiscal Year: 2000
    ..Results, the investigator believes, should considerably enhance knowledge of how autoreactive T cells are activated and the relative pathogenic roles of T and B cells. ..
  17. IS ANTIGEN RETAINED ON FDCS REQUIRED FOR B CELL MEMORY
    Mark Shlomchik; Fiscal Year: 2002
    ..These studies propose instead that membrane IgM naturally serves this function, and have devised a system to test this idea in Aim 3. ..
  18. Activation and Regulation of Rheumatoid Factor B cells
    Mark Shlomchik; Fiscal Year: 2002
    ..abstract_text> ..
  19. Testing in Vivo Roles of TLRs in Systemic Autoimmunity
    Mark Shlomchik; Fiscal Year: 2004
    ..Because TLR9 is already strongly implicated in the activation of RF B cells in vitro and also by emerging data in vivo, we will focus on the role of this receptor on B cells. ..
  20. MoFlo High Speed Fluorescence Activated Cell Sorter
    Mark Shlomchik; Fiscal Year: 2003
    ..Twenty-four NIH-funded researchers would benefit from this instrument at YSM. Several young investigators not yet NIH-funded would also benefit. ..