Affiliation: Yale University
- Aging of the innate immune systemAlbert C Shaw
Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, 300 Cedar St Box 208022, New Haven, CT 06520, USA
Curr Opin Immunol 22:507-13. 2010..Thus, immunosenescence in the innate immune system appears to reflect dysregulation, rather than exclusively impaired function...
- Dysregulation of human Toll-like receptor function in agingAlbert C Shaw
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Ageing Res Rev 10:346-53. 2011..These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients...
- Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adultsDana W Dunne
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 5:e11343. 2010..We studied monocyte Toll-like receptor (TLR) expression and cytokine production in 137 patients with autoimmune diseases who were maintained on immunosuppressive medications and 419 non-immunosuppressed individuals...
- SIGNAL TRANSDUCTION PATHWAYS IN EARLY B CELL DEVELOPMENTALBERT SHAW; Fiscal Year: 2002..These experiments should have implications not only for B cell development, but also for the understanding of immunodeficiency syndromes and lymphoid malignancies. ..
- Top3 Homologues in Lymphocyte Genome Stability and AgingALBERT SHAW; Fiscal Year: 2009..abstract_text> ..