Eugene Shapiro

..Because case-control studies of the effectiveness of vaccines are nonexperimental, it is difficult to assure that bias does not affect the validity of the results...

..In the vast majority of cases simple treatment with a relatively short course of orally administered antimicrobials results in long-term cure with no adverse sequelae...

..Consequently, misdiagnosis is frequent and is the most common cause of failure of treatment. The prognosis for most persons with Lyme disease is excellent...

..Approaches are presented to conducting and analyzing case-control studies to evaluate interventions to prevent inflicted TBI while assessing and minimizing possible bias...

..Because of ongoing outbreaks of varicella, a second dose of varicella vaccine was added to the routine immunization schedule for children in June 2006 by the Centers for Disease Control and Prevention...

..The high visibility of controversies regarding vaccination makes it increasingly important to understand how parents decide whether to vaccinate their infants...

..Only 3% thought a smallpox attack in the next 5 years was likely or very likely. Physicians did not accept the smallpox vaccine because they did not believe the potential benefits were sufficient...

..Reports of outbreaks of varicella in highly immunized groups have increased concern about the effectiveness of varicella vaccine...

..Checking one's body for ticks and spraying property with acaricides were not effective. We concluded that use of protective clothing and of tick repellents (on skin or clothing) are effective in preventing LD...

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..07; 95% CI 0.01, 0.4). CONCLUSION: Using data from the EMR, we could assess adherence to the guidelines for antibiotic use and identify areas to target for improving diagnostic testing and reducing overuse of antibiotics in our clinic...

..This report describes methodological issues related to design and analysis that were used to determine the effects of time since vaccination and age at the time of vaccination...

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..To describe parents' and adolescents' perceptions about vaccination...

..There is little information about the long-term outcomes of children with facial nerve palsy attributable to Lyme disease, a group putatively at high risk for poor neurologic outcomes...

..00 case/1000 person-years. Overall, the incidence of HZ in this cohort, therefore, is similar to published data for the US population in the prevaccine era...

..No previous study has evaluated the association between overweight and acute ankle injuries in children. We hypothesized that being overweight is associated with an increased risk of ankle injury in children...

..0 [95% confidence interval, 3.4-74.4]; P=.0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease...

..215). WU virus was detected in 26/367 (7.1%) symptomatic and 6/96 (6.3%) asymptomatic children (p = 1.00). These human polyomaviruses may not independently cause respiratory tract disease in young children...

..None of these trials were conducted in an emergency department...

The goals of Dr. Eugene Shapiro are: 1) to conduct high quality patient-oriented research to answer important clinical questions and 2) to mentor young physicians who conduct patient-oriented research to help them become successful ..

..Ultimately, the Yale CRS Program will help to increase the pool of physician-investigators who will be uniquely poised to conduct research to directly improve the health of all Americans. ..

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The goals of Dr. Eugene Shapiro, the principal investigator, are: 1) to conduct high quality research to answer important questions about a) the effectiveness of licensed vaccines as they are used in clinical practice and b) the clinical ..

..Such information is critical for assessing the cost-effectiveness of the vaccine and will be useful both for educating physicians and for counselling parents who may be concerned about having their children vaccinated. ..