Erik M Shapiro

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Convertible manganese contrast for molecular and cellular MRI
    Erik M Shapiro
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8043, USA
    Magn Reson Med 60:265-9. 2008
  2. ncbi request reprint Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI
    Erik M Shapiro
    Molecular and Cellular Imaging Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Contrast Media Mol Imaging 2:147-53. 2007
  3. ncbi request reprint Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 32:1150-7. 2006
  4. pmc In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotype
    James P Sumner
    Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroimage 44:671-8. 2009
  5. ncbi request reprint In vivo detection of single cells by MRI
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 55:242-9. 2006
  6. ncbi request reprint Sizing it up: cellular MRI using micron-sized iron oxide particles
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:329-38. 2005
  7. pmc Enhanced magnetic cell labeling efficiency using -NH2 coated MPIOs
    Kevin S Tang
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06510, USA
    Magn Reson Med 65:1564-9. 2011
  8. pmc Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging
    James P Sumner
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory of Functional and Molecular Imaging, Bethesda, Maryland 20892, USA
    J Biomed Opt 12:051504. 2007
  9. pmc Specific chemotaxis of magnetically labeled mesenchymal stem cells: implications for MRI of glioma
    Margaret F Bennewitz
    Department of Biomedical Engineering, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
    Mol Imaging Biol 14:676-87. 2012
  10. doi request reprint The effect of cryoprotection on the use of PLGA encapsulated iron oxide nanoparticles for magnetic cell labeling
    Kevin S Tang
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Nanotechnology 24:125101. 2013

Collaborators

Detail Information

Publications23

  1. pmc Convertible manganese contrast for molecular and cellular MRI
    Erik M Shapiro
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8043, USA
    Magn Reson Med 60:265-9. 2008
    ..These particles are the potential building blocks for an entire class of new environmentally responsive MRI contrast agents...
  2. ncbi request reprint Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI
    Erik M Shapiro
    Molecular and Cellular Imaging Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Contrast Media Mol Imaging 2:147-53. 2007
    ..Therefore, the use of MPIOs for achieving high iron concentrations for cellular MRI is potentially an effective new modality for non-invasive imaging of lymphocytes...
  3. ncbi request reprint Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 32:1150-7. 2006
    ..This work demonstrates that in vivo cell labeling of progenitor cells for MRI is possible and enables the serial, non-invasive visualization of endogenous progenitor/precursor cell migration...
  4. pmc In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotype
    James P Sumner
    Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroimage 44:671-8. 2009
    ..Using MRI to visualize neural progenitor cell behavior in individual animals during plasticity or disease models should be a useful tool, especially in combination with other information that MRI can supply...
  5. ncbi request reprint In vivo detection of single cells by MRI
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 55:242-9. 2006
    ..Detecting single cells in vivo opens the door to a number of experiments, such as monitoring rare cellular events, assessing the kinetics of stem cell homing, and achieving early detection of metastases...
  6. ncbi request reprint Sizing it up: cellular MRI using micron-sized iron oxide particles
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:329-38. 2005
    ..We demonstrate that these large particles and the cells labeled with them can be detected by spin echo (SE)-based imaging methods. These measurements indicate that MPIOs should be useful for improving cell tracking by MRI...
  7. pmc Enhanced magnetic cell labeling efficiency using -NH2 coated MPIOs
    Kevin S Tang
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06510, USA
    Magn Reson Med 65:1564-9. 2011
    ..Yet the most robust labeling was achieved with the MPIO-NH(2). Interestingly, even for particle formulations which still had negative zeta potential, enhancement of magnetic cell labeling was achieved...
  8. pmc Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging
    James P Sumner
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory of Functional and Molecular Imaging, Bethesda, Maryland 20892, USA
    J Biomed Opt 12:051504. 2007
    ..These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking...
  9. pmc Specific chemotaxis of magnetically labeled mesenchymal stem cells: implications for MRI of glioma
    Margaret F Bennewitz
    Department of Biomedical Engineering, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
    Mol Imaging Biol 14:676-87. 2012
    ..We propose a novel approach for tumor detection using magnetic resonance imaging (MRI) based on imaging specific tumor tropism of mesenchymal stem cells (MSCs) labeled with micron-sized iron oxide particles (MPIOs)...
  10. doi request reprint The effect of cryoprotection on the use of PLGA encapsulated iron oxide nanoparticles for magnetic cell labeling
    Kevin S Tang
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Nanotechnology 24:125101. 2013
    ..These studies suggest that cryoprotection with 1% dextrose is an optimal compromise that preserves monodispersity following resuspension and high magnetic cell labeling...
  11. ncbi request reprint Poly(lactic-co-glycolic acid) encapsulated gadolinium oxide nanoparticles for MRI-based cell tracking
    Margaret F Bennewitz
    Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA
    J Nanosci Nanotechnol 13:3778-83. 2013
    ..R2 enhancements were approximately to twice that of R1 enhancements suggesting the use of very short echo times when using Gd2O3 based contrast agents for MRI-based cell tracking...
  12. pmc On the use of micron-sized iron oxide particles (MPIOS) to label resting monocytes in bone marrow
    Kevin S Tang
    Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, USA
    Mol Imaging Biol 13:819-24. 2011
    ....
  13. pmc Controlled aggregation of ferritin to modulate MRI relaxivity
    Kevin M Bennett
    Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD 20892 1065, USA
    Biophys J 95:342-51. 2008
    ..The modulation of ferritin aggregation by binding to cytoskeletal elements may be a useful strategy to make a functional reporter gene for magnetic resonance imaging...
  14. pmc Serial monitoring of endogenous neuroblast migration by cellular MRI
    Dorit Granot
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Neuroimage 57:817-24. 2011
    ..By 8days, this volume nearly doubled to 0.49% and plateaued. These MRI results are in accordance with our data on iron quantification from the OB and with those from purely immunohistochemical studies...
  15. ncbi request reprint Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells
    Kathleen A Hinds
    Hematology Branch, Laboratory of Molecular Biology, Laboratory National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:867-72. 2003
    ..MRI studies could detect labeled CD34+ cells and mesenchymal stem cells (MSCs) at single cell resolution. This appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI...
  16. pmc MRI detection of single particles for cellular imaging
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:10901-6. 2004
    ..These results demonstrate that MRI can detect single particles and indicate that single-particle detection will be useful for cellular imaging...
  17. pmc Magnetic poly(lactide-co-glycolide) and cellulose particles for MRI-based cell tracking
    Michael K Nkansah
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA
    Magn Reson Med 65:1776-85. 2011
    ....
  18. pmc Release activation of iron oxide nanoparticles: (REACTION) a novel environmentally sensitive MRI paradigm
    Dorit Granot
    Molecular and Cellular MRI Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Magn Reson Med 65:1253-9. 2011
    ..These results warrant exploration of genetic avenues toward achieving release activation of iron oxide nanoparticles...
  19. pmc Assessment of early diastolic strain-velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV)
    Ziheng Zhang
    Department of Diagnostic Radiology, Yale University School of Medicine, PO Box 208043, TAC N153, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 66:1627-38. 2011
    ..These studies shed insight into the regional volumetric and pressure difference changes in the left ventricle during early diastolic filling...
  20. pmc Self-assembling DNA quadruplex conjugated to MRI contrast agents
    Jianfeng Cai
    Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, USA
    Bioconjug Chem 20:205-8. 2009
    ..Importantly, the DNA quadruplex scaffold is approximately 2.5 nm(3) in size, potentially enabling this type of contrast agent to be used for targeted delivery in vivo to detect specific cells or tissues, even behind intact blood vessels...
  21. ncbi request reprint Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI
    Ichio Aoki
    Department of Neurosurgery, Meiji University of Oriental Medicine, Kyoto, Japan
    Magn Reson Med 50:7-12. 2003
    ..0 +/- 17.5% in MCAO group and 108.4 +/- 13.2% in the sham group. In addition, the enhanced region was much smaller than the area which was detected as having a reduced ADC...
  22. ncbi request reprint Cellular magnetic resonance imaging: nanometer and micrometer size particles for noninvasive cell localization
    Jonathan R Slotkin
    Department of Neurosurgery, The Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:428-33. 2007
    ..The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted...
  23. pmc 23Na MRI accurately measures fixed charge density in articular cartilage
    Erik M Shapiro
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:284-91. 2002
    ..Both methodologies gave similar results, with the average sodium concentration of normal human patellar cartilage ranging from approximately 240 to 260 mM. This corresponds to FCDs of -158 mM to -182 mM...