Research Topics
| Erik M ShapiroSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Convertible manganese contrast for molecular and cellular MRIErik M Shapiro
Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8043, USA
Magn Reson Med 60:265-9. 2008..These particles are the potential building blocks for an entire class of new environmentally responsive MRI contrast agents...
Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRIErik M Shapiro
Molecular and Cellular Imaging Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
Contrast Media Mol Imaging 2:147-53. 2007..Therefore, the use of MPIOs for achieving high iron concentrations for cellular MRI is potentially an effective new modality for non-invasive imaging of lymphocytes...- Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brainErik M Shapiro
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 32:1150-7. 2006..This work demonstrates that in vivo cell labeling of progenitor cells for MRI is possible and enables the serial, non-invasive visualization of endogenous progenitor/precursor cell migration... - In vivo detection of single cells by MRIErik M Shapiro
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Magn Reson Med 55:242-9. 2006..Detecting single cells in vivo opens the door to a number of experiments, such as monitoring rare cellular events, assessing the kinetics of stem cell homing, and achieving early detection of metastases... - Sizing it up: cellular MRI using micron-sized iron oxide particlesErik M Shapiro
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Magn Reson Med 53:329-38. 2005..We demonstrate that these large particles and the cells labeled with them can be detected by spin echo (SE)-based imaging methods. These measurements indicate that MPIOs should be useful for improving cell tracking by MRI... - In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotypeJames P Sumner
Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
Neuroimage 44:671-8. 2009..Using MRI to visualize neural progenitor cell behavior in individual animals during plasticity or disease models should be a useful tool, especially in combination with other information that MRI can supply... - Enhanced magnetic cell labeling efficiency using -NH2 coated MPIOsKevin S Tang
Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06510, USA
Magn Reson Med 65:1564-9. 2011..Yet the most robust labeling was achieved with the MPIO-NH(2). Interestingly, even for particle formulations which still had negative zeta potential, enhancement of magnetic cell labeling was achieved... - Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imagingJames P Sumner
National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory of Functional and Molecular Imaging, Bethesda, Maryland 20892, USA
J Biomed Opt 12:051504. 2007..These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking... - On the use of micron-sized iron oxide particles (MPIOS) to label resting monocytes in bone marrowKevin S Tang
Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, USA
Mol Imaging Biol 13:819-24. 2011.... - Controlled aggregation of ferritin to modulate MRI relaxivityKevin M Bennett
Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD 20892 1065, USA
Biophys J 95:342-51. 2008..The modulation of ferritin aggregation by binding to cytoskeletal elements may be a useful strategy to make a functional reporter gene for magnetic resonance imaging... - Serial monitoring of endogenous neuroblast migration by cellular MRIDorit Granot
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
Neuroimage 57:817-24. 2011..By 8days, this volume nearly doubled to 0.49% and plateaued. These MRI results are in accordance with our data on iron quantification from the OB and with those from purely immunohistochemical studies... - MRI detection of single particles for cellular imagingErik M Shapiro
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:10901-6. 2004..These results demonstrate that MRI can detect single particles and indicate that single-particle detection will be useful for cellular imaging... - Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cellsKathleen A Hinds
Hematology Branch, Laboratory of Molecular Biology, Laboratory National Heart, Lung, and Blood Institute (NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
Blood 102:867-72. 2003..MRI studies could detect labeled CD34+ cells and mesenchymal stem cells (MSCs) at single cell resolution. This appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI... - Specific chemotaxis of magnetically labeled mesenchymal stem cells: implications for MRI of gliomaMargaret F Bennewitz
Department of Biomedical Engineering, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
Mol Imaging Biol 14:676-87. 2012..We propose a novel approach for tumor detection using magnetic resonance imaging (MRI) based on imaging specific tumor tropism of mesenchymal stem cells (MSCs) labeled with micron-sized iron oxide particles (MPIOs)... - Magnetic poly(lactide-co-glycolide) and cellulose particles for MRI-based cell trackingMichael K Nkansah
Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA
Magn Reson Med 65:1776-85. 2011.... - Release activation of iron oxide nanoparticles: (REACTION) a novel environmentally sensitive MRI paradigmDorit Granot
Molecular and Cellular MRI Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Magn Reson Med 65:1253-9. 2011..These results warrant exploration of genetic avenues toward achieving release activation of iron oxide nanoparticles... 
The effect of cryoprotection on the use of PLGA encapsulated iron oxide nanoparticles for magnetic cell labelingKevin S Tang
Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
Nanotechnology 24:125101. 2013..These studies suggest that cryoprotection with 1% dextrose is an optimal compromise that preserves monodispersity following resuspension and high magnetic cell labeling...- Assessment of early diastolic strain-velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV)Ziheng Zhang
Department of Diagnostic Radiology, Yale University School of Medicine, PO Box 208043, TAC N153, New Haven, Connecticut 06520 8043, USA
Magn Reson Med 66:1627-38. 2011..These studies shed insight into the regional volumetric and pressure difference changes in the left ventricle during early diastolic filling... - Self-assembling DNA quadruplex conjugated to MRI contrast agentsJianfeng Cai
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, USA
Bioconjug Chem 20:205-8. 2009..Importantly, the DNA quadruplex scaffold is approximately 2.5 nm(3) in size, potentially enabling this type of contrast agent to be used for targeted delivery in vivo to detect specific cells or tissues, even behind intact blood vessels... - Cellular magnetic resonance imaging: nanometer and micrometer size particles for noninvasive cell localizationJonathan R Slotkin
Department of Neurosurgery, The Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Neurotherapeutics 4:428-33. 2007..The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted... - Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRIIchio Aoki
Department of Neurosurgery, Meiji University of Oriental Medicine, Kyoto, Japan
Magn Reson Med 50:7-12. 2003..0 +/- 17.5% in MCAO group and 108.4 +/- 13.2% in the sham group. In addition, the enhanced region was much smaller than the area which was detected as having a reduced ADC... - 23Na MRI accurately measures fixed charge density in articular cartilageErik M Shapiro
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Magn Reson Med 47:284-91. 2002..Both methodologies gave similar results, with the average sodium concentration of normal human patellar cartilage ranging from approximately 240 to 260 mM. This corresponds to FCDs of -158 mM to -182 mM...