William Sessa


Affiliation: Yale University
Country: USA


  1. Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A. 2017;114:10737-10742 pubmed publisher
    ..Together, our data demonstrate the unique advantages of cavtratin in antiangiogenic therapy to treat neovascular diseases. ..
  2. Luciano A, Zhou W, Santana J, Kyriakides C, Velazquez H, Sessa W. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. J Biol Chem. 2018;293:9126-9136 pubmed publisher
    ..Thus, CLOCK phosphorylation by AKT on Ser-845 regulates its nuclear translocation and the expression levels of certain core circadian genes in insulin-sensitive tissues. ..
  3. Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, et al. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016;8:643-53 pubmed publisher
    ..Collectively, these data support the idea that antagonizing miR-29 may promote beneficial plaque remodeling as an independent approach to stabilize vulnerable atherosclerotic lesions. ..
  4. Grabińska K, Park E, Sessa W. cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. J Biol Chem. 2016;291:18582-90 pubmed publisher
  5. Kuo A, Lee M, Sessa W. Lipid Droplet Biogenesis and Function in the Endothelium. Circ Res. 2017;120:1289-1297 pubmed publisher
    ..Moreover, LD formation protects EC from lipotoxic stress, regulates EC glycolysis, and provides a source of FA for adjacent cells in the vessel wall or tissues. ..
  6. Kraehling J, Sessa W. Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circ Res. 2017;120:1174-1182 pubmed publisher
    ..We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications. ..
  7. Kuo A, Lee M, Yang K, Gross R, Sessa W. Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin-stimulated, cAMP-mediated lipolysis. J Biol Chem. 2018;293:973-983 pubmed publisher
  8. Lee M, Gamez Mendez A, Zhang J, Zhuang Z, Vinyard D, Kraehling J, et al. Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Arterioscler Thromb Vasc Biol. 2018;38:870-879 pubmed publisher
    ..Endothelial Akt1 signaling is necessary for ischemic resolution post-injury and likely reflects the consequence of NO insufficiency critical for vascular repair. ..
  9. Grabińska K, Edani B, Park E, Kraehling J, Sessa W. A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity. J Biol Chem. 2017;292:17351-17361 pubmed publisher
    ..The strong conservation of the RXG motif among NgBR orthologs indicates that this subunit is critical for the synthesis of polyprenol diphosphates and cellular function. ..

More Information


  1. Park E, Grabińska K, Guan Z, Stránecký V, Hartmannova H, Hodanova K, et al. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 2014;20:448-57 pubmed publisher
    ..Thus, these data provide a genetic basis for the essential role of NgBR in dolichol synthesis and protein glycosylation. ..
  2. Siragusa M, Fröhlich F, Park E, Schleicher M, Walther T, Sessa W. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Sci Signal. 2015;8:ra81 pubmed publisher
    ..Thus, our data describe a function for SDF2 as a component of the Hsp90-eNOS complex that is critical for signal transduction in endothelial cells. ..
  3. Landskroner Eiger S, Qiu C, Perrotta P, Siragusa M, Lee M, Ulrich V, et al. Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proc Natl Acad Sci U S A. 2015;112:12812-7 pubmed publisher
    ..Collectively, these data provide insights into miRNA regulation of arterialization and highlight the importance of vascular WNT signaling in maintaining arterial blood flow. ..
  4. Park E, Grabińska K, Guan Z, Sessa W. NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Rep. 2016;17:167-77 pubmed publisher
    ..Moreover, NgBR functions in endothelial cells during embryogenesis are Nogo-B independent. These data uniquely show the importance of NgBR and protein glycosylation during vascular development. ..
  5. MacLauchlan S, Calabro N, Huang Y, Krishna M, Bancroft T, Sharma T, et al. HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2. Matrix Biol. 2018;65:45-58 pubmed publisher
    ..These findings identify a novel, ischemia-induced pro-angiogenic mechanism involving the transcriptional repression of TSP2 by HIF-1α. ..