E Seli

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Metabolomics and its application for non-invasive embryo assessment in IVF
    Lucy Botros
    Molecular Biometrics LLC, Montreal, Quebec, Canada
    Mol Hum Reprod 14:679-90. 2008
  2. pmc Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary
    Saioa Torrealday
    MD, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304B, New Haven, Connecticut 06520 8063
    Endocrinology 154:3877-87. 2013
  3. ncbi request reprint Fertility preservation options for female patients with malignancies
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 17:299-308. 2005
  4. pmc Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte
    Emre Seli
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 George Street, Suite 770J, New Haven, CT 06511, USA
    Mol Hum Reprod 14:393-8. 2008
  5. doi request reprint Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Fertil Steril 90:2183-9. 2008
  6. ncbi request reprint Treatment of PCOS with metformin and other insulin-sensitizing agents
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Curr Diab Rep 4:69-75. 2004
  7. ncbi request reprint Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 88:1350-7. 2007
  8. pmc Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome
    Emre Seli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520 8063, USA
    J Assist Reprod Genet 28:137-44. 2011
  9. doi request reprint Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 94:535-42. 2010
  10. ncbi request reprint Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction
    F Aydiner
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Curr Mol Med 10:206-15. 2010

Research Grants

Collaborators

Detail Information

Publications37

  1. pmc Metabolomics and its application for non-invasive embryo assessment in IVF
    Lucy Botros
    Molecular Biometrics LLC, Montreal, Quebec, Canada
    Mol Hum Reprod 14:679-90. 2008
    ....
  2. pmc Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary
    Saioa Torrealday
    MD, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304B, New Haven, Connecticut 06520 8063
    Endocrinology 154:3877-87. 2013
    ..Our findings suggest that the mechanism of action of GnRHa in the ovary is either below the detection level of our experimental design or is different from that in the pituitary. ..
  3. ncbi request reprint Fertility preservation options for female patients with malignancies
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 17:299-308. 2005
    ..This review summarizes available options and discusses recently published data concerning experimental methods. Specific strategies for fertility preservation in women with gynecologic malignancies are also presented...
  4. pmc Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte
    Emre Seli
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 George Street, Suite 770J, New Haven, CT 06511, USA
    Mol Hum Reprod 14:393-8. 2008
    ..Our findings suggest that SNPs may alter the ratio between alternative splicing variants of oocyte-specific proteins. The role that these subtle differences play in determining individual reproductive outcome remains to be determined...
  5. doi request reprint Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Fertil Steril 90:2183-9. 2008
    ..To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media...
  6. ncbi request reprint Treatment of PCOS with metformin and other insulin-sensitizing agents
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Curr Diab Rep 4:69-75. 2004
    ..Other insulin-sensitizing agents studied in women with PCOS include troglitazone, rosiglitazone, pioglitazone, and D-chiro-inositol...
  7. ncbi request reprint Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 88:1350-7. 2007
    ..To determine if metabolomic profiling of embryo culture media correlates with reproductive potential of individual embryos...
  8. pmc Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome
    Emre Seli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520 8063, USA
    J Assist Reprod Genet 28:137-44. 2011
    ....
  9. doi request reprint Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 94:535-42. 2010
    ..To determine whether metabolomic profiling of spent embryo culture media correlates with reproductive potential of human embryos...
  10. ncbi request reprint Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction
    F Aydiner
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Curr Mol Med 10:206-15. 2010
    ..As the number of ART cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer become an increasingly more important goal for reproductive medicine...
  11. ncbi request reprint Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 83:1201-5. 1998
    ..We propose that IL-8 may act as an autocrine growth factor in the endometrium, and suggest that it may also play a role in the pathogenesis of endometriosis...
  12. ncbi request reprint Interleukin-8 in the human endometrium
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 83:1783-7. 1998
    ..We speculate that IL-8 may modulate the timely recruitment of neutrophils and lymphocytes into the endometrium...
  13. ncbi request reprint Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Biol Reprod 61:85-90. 1999
    ..In summary, we found that E2 inhibits MCP-1 expression in endometrial stromal cells, and we speculate that E2 may control endometrial macrophage migration by regulating MCP-1 expression...
  14. ncbi request reprint Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
    E Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 75:1172-6. 2001
    ..To determine whether aminopeptidase N (APN) regulates the cycle-dependent bioavailability of interleukin-8 (IL-8) in the endometrium...
  15. ncbi request reprint Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Fertil Steril 82:378-83. 2004
    ..To determine whether the extent of ongoing apoptotic cell death measured as the presence of DNA strand breaks in spermatozoa affects embryo development to the blastocyst stage in IVF...
  16. ncbi request reprint The presence of abnormal spermatozoa in the ejaculate: did apoptosis fail?
    Denny Sakkas
    Department of Obstetrics and Gynaecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Hum Fertil (Camb) 7:99-103. 2004
    ..More importantly, the impact of such sperm, if selected to perform ICSI, needs to be better understood so that any detrimental paternal effects can be avoided...
  17. pmc Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH
    Tsilya Gerasimova
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room FMB 329J, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 95:529-36. 2010
    ....
  18. ncbi request reprint Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis
    Denny Sakkas
    Department of Obstetrics and Gynaecology, Yale University School of Medicine, New Haven, CT 6520 8063, USA
    Reprod Biomed Online 7:428-32. 2003
    ..Understanding the mechanisms responsible for producing abnormal spermatozoa in the human will improve knowledge about certain causes of male infertility...
  19. doi request reprint Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations
    Dorothy A Greenfeld
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Fertil Steril 95:225-9. 2011
    ..To medically and psychologically assess gay men seeking parenthood through assisted reproduction and to provide guidelines for the assessment...
  20. ncbi request reprint Growth-regulated alpha expression in the peritoneal environment with endometriosis
    E Oral
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 88:1050-6. 1996
    ..To investigate the presence and modulation of growth-regulated alpha, a member of the chemokine family with neutrophil chemotactic activity, in the peritoneal fluid of women with or without endometriosis...
  21. ncbi request reprint Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect
    E Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 6520-8063, USA
    Menopause 8:296-301. 2001
    ..CONCLUSION: Our findings suggest that one of the mechanisms by which estrogen prevents atherosclerosis is by down-regulating MCP-1 expression, thus decreasing macrophage recruitment to the arterial wall...
  22. ncbi request reprint Spermatozoal nuclear determinants of reproductive outcome: implications for ART
    Emre Seli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Reprod Update 11:337-49. 2005
    ..These recent findings point to the need for novel and more personalized approaches to test and treat male factor infertility...
  23. ncbi request reprint Optimizing ovulation induction in women with polycystic ovary syndrome
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Obstet Gynecol 14:245-54. 2002
    ..In clomiphene-resistant subjects, one can consider laparoscopic ovarian drilling and other forms of partial ovarian resection or destruction...
  24. ncbi request reprint Should patients with polycystic ovarian syndrome be treated with metformin?
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Hum Reprod 17:2230-6. 2002
    ..The highly promising therapeutic profile of metformin is related to the role of this agent in controlling an important aetiologic factor in the pathogenesis of PCOS: hyperinsulinaemia...
  25. pmc An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Proc Natl Acad Sci U S A 102:367-72. 2005
    ..The expression of mouse ePAB before zygotic gene activation argues for its importance in translational activation of maternally derived mRNAs during mammalian oocyte and early preimplantation embryo development...
  26. doi request reprint Identification and characterization of human embryonic poly(A) binding protein (EPAB)
    Ozlem Guzeloglu-Kayisli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Hum Reprod 14:581-8. 2008
    ..Our findings suggest that the unique translational regulatory pathways that control gene expression during oogenesis and early embryo development may be common between model organisms and humans...
  27. ncbi request reprint Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Genes Dev 20:138-46. 2006
  28. ncbi request reprint Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window
    Emre Seli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Hum Reprod 20:3012-7. 2005
    ..In this study, we hypothesized that the adverse effects of hydrosalpinges on fertility may be in part mediated by inappropriate endometrial expression of leukaemia inhibitory factor (LIF), a cytokine implicated in implantation...
  29. ncbi request reprint Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
    Gaurang S Daftary
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 87:367-72. 2007
    ..Increased endometrial HOXA10 expression may be one mechanism by which salpingectomy results in increased implantation rates in IVF...
  30. ncbi request reprint Stem cells and fertility: what does the future hold?
    Umit A Kayisli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 18:338-43. 2006
    ..In addition, we will entertain possible future directions, underlining clinical implications of de-novo oocyte formation during adulthood...
  31. doi request reprint Third party reproduction and the aging couple
    Janelle Luk
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Maturitas 66:389-96. 2010
    ....
  32. ncbi request reprint Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 88:1190-6. 2007
    ..To investigate the effect of estrogen (E) on vascular apoptosis during atherosclerotic plaque formation...
  33. ncbi request reprint Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Conn, USA
    Am J Obstet Gynecol 187:1544-9. 2002
    ....
  34. ncbi request reprint Evidence-based diagnosis and management of tubal factor infertility
    Pinar H Kodaman
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Obstet Gynecol 16:221-9. 2004
    ..The investigation for potential tubal disease is an essential step in the work-up of infertility. This review article provides an evidence-based overview of the diagnosis and management of tubal factor infertility...
  35. doi request reprint Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics
    Jason G Bromer
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 20:234-41. 2008
    ..After an overview of studies evaluating embryo metabolism as a predictor of embryo viability, use of metabolomics and additional emerging approaches for rapid, noninvasive, embryo assessment are discussed...
  36. doi request reprint Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study
    Richard Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 90:77-83. 2008
    ..To determine if metabolomic profiling of embryonic development was associated with implantation rates in IVF...
  37. ncbi request reprint The significance of sperm nuclear DNA strand breaks on reproductive outcome
    Marcello Spano
    BIOTEC MED, ENEA CR Casaccia, Rome, Italy
    Curr Opin Obstet Gynecol 17:255-60. 2005
    ....

Research Grants2